1. Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121.
- Author
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Xiao-Wei Gao, Hong-Xin Liu, Zhang-Hua Sun, Yu-Chan Chen, Yu-Zhi Tan, and Wei-Min Zhang
- Subjects
- *
MARINE fungi , *METABOLITES , *THIAZOLES , *CIRCULAR dichroism , *CELL lines - Abstract
Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1-3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC50 values less than 10 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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