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1. Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation.

Author

Nakahira, Kiichi, Kyung, Sun-Young, Rogers, Angela J., Gazourian, Lee, Youn, Sojung, Massaro, Anthony F., Quintana, Carolina, Osorio, Juan C., Wang, Zhaoxi, Zhao, Yang, Lawler, Laurie A., Christie, Jason D., Meyer, Nuala J., Causland, Finnian R. Mc., Waikar, Sushrut S., Waxman, Aaron B., Chung, Raymond T., Bueno, Raphael, Rosas, Ivan O., and Fredenburgh, Laura E.

Subjects
*MITOCHONDRIAL DNA, *GENETIC markers, *INTENSIVE care units, *LONGITUDINAL method, *COHORT analysis, *DEATH forecasting, *HEALTH risk assessment
Abstract

In this paper, Choi and colleagues analyzed levels of mitochondrial DNA in two prospective observational cohort studies and found that increased mtDNA levels are associated with ICU mortality, and improve risk prediction in medical ICU patients. The data suggests that mtDNA could serve as a viable plasma biomarker in MICU patients. [ABSTRACT FROM AUTHOR]

Published
2013
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