1. Anti-cytomegalovirus effects of tricin are dependent on CXCL11
- Author
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Murayama, Tsugiya, Li, Ying, Takahashi, Takashi, Yamada, Rie, Matsubara, Keiko, Tuchida, Yuuzo, Li, Zhuan, and Sadanari, Hidetaka
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CYTOMEGALOVIRUSES , *CHEMOKINES , *FIBROBLASTS , *INTERFERONS , *T cells , *VIRUS diseases , *HERPESVIRUSES , *LYMPHOCYTES , *ANTIVIRAL agents - Abstract
Abstract: It has been reported that treatment with tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the mechanisms for the anti-HCMV effects of tricin in MRC-5 cells. Exposure of fibroblasts to tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells. These results suggest that tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of tricin. [Copyright &y& Elsevier]
- Published
- 2012
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