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This article discusses recent research on CD4 CAR T cells and their role in CAR T cell therapy (CTT). CD4 CAR T cells have traditionally been seen as providing support to CD8 CAR T cells, but recent studies have shown that CD4 CAR T cells can directly kill tumor cells and control their growth. However, CD4 CAR T cells have also been found to contribute to cytokine release syndrome (CRS), a serious adverse event in CTT. The article highlights the need for a deeper understanding of the roles and mechanisms of CD4 CAR T cells in order to design safer and more effective CAR T cell products. Additionally, the article discusses the impact of CD4 T cells on CAR T cell manufacturing, suggesting that co-culturing CD4 T cells with CD8 T cells can improve the quantity and quality of CAR T cells. The article concludes by emphasizing the importance of leveraging the benefits of CD4 T cells while minimizing their negative effects in CTT. [Extracted from the article]