1. Characterization of Latilactobacillus curvatus MS2 isolated from Korean traditional fermented seafood and cholesterol reduction effect as synbiotics with isomalto-oligosaccharide in BALB/c mice.
- Author
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Kim, Shin-Kwon, Jang, Won Je, Kim, Chae Eun, Lee, Su-Jeong, Jeon, Mi-Hyeon, Kim, Tae-Yong, Lee, Hyun-Tai, Park, Jung-Ha, Kim, Chan-Hee, Lee, Jong Min, and Lee, Eun-Woo
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OLIGOSACCHARIDES , *BLOOD cholesterol , *FUNCTIONAL foods , *SEAFOOD , *CHOLESTEROL , *BILE acids , *SYNBIOTICS , *FERMENTED foods - Abstract
This study investigated the properties of Latilactobacillus curvatus MS2 isolated from Korean traditional fermented seafood as probiotics and the effect of reducing cholesterol as a synbiotic with isomalto-oligosaccharide (IMO) in BALB/c mice. The isolated strain showed high resistance to acids and bile acids and exhibited a high DPPH scavenging capacity of 72.27 ± 0.38 %. In the intestinal adhesion test using HT-29 cells, the adhesion rate of MS2 was 17.10 ± 1.78 %, which was higher than the adhesion rate of the other investigated probiotics. MS2 showed good antimicrobial activity against food-borne pathogens, especially Staphylococcus aureus , S. epidermidis , Escherichia coli , and Vibrio vulnificus. This strain had high availability for IMO among the prebiotics of fructo-oligosaccharide, inulin and IMO. Oral administration of MS2 and IMO to BALB/c mice for 5 weeks resulted in a significant reduction in blood cholesterol levels by regulating liver lipid metabolism. These results suggest that the combination of MS2 and IMO has potential for application in functional foods. [Display omitted] • The probiotic properties of Latilactobacillus curvatus MS2 were investigated. • Dietary supplementation of MS2 downregulated the blood cholesterol levels. • Supplementation with MS2 maintained the intestinal microbial balance of BALB/c mice. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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