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Nine steroidal components, including a new pregnane glycoside (1), were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined via extensive spectroscopic data including, IR, HRESIMS and 1D, 2D NMR data analysis. Furthermore, their cytotoxic activities against human HepG2 and SW620 tumor cells were evaluated by the MTT method and compounds 2, 3, 5, 8 and 9 showed moderate activity with IC50 values raging from 18.4 to 86.3 μM. [ABSTRACT FROM AUTHOR]

Two new cholestanol glycosides (1 and 2) were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined as 5a-cholest-9(11)-ene-3ß, 26-dihydroxy-16, 22-dione 3-O-ß-D-glucopyranosyl-(1-2)-ß-D-galactopyranoside (1), 5a-cholest-9(11)-ene-3ß, 26-dihydroxy-16, 22-dione 3-O-ß-D-glucopyranosyl-(1-2)-[ß-D-glucopyranosyl-(1-3)]-ß-D-galactopyranoside (2), by physicochemical properties and spectroscopic methods. In addition, the isolated glycosides were tested for their cytotoxic activity against human HepG2 tumor cells and compound 2 showed moderate activity with IC50 value of 59.32 µM. [ABSTRACT FROM AUTHOR]