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An efficient enantioselective Michael addition of benzofuran-2(3 H )-ones to alkylideneindolenines generated in situ from arenesulfonylalkylindoles has been described, and a series of optically active C-3 alkyl-substituted benzofuran-2(3 H )-one derivatives containing indole skeleton with two adjacent stereocenters have been obtained. The resulting adduct can readily be converted to chiral o -hydroxyphenylacetic acid derivative with indole motif. [ABSTRACT FROM AUTHOR]

The title process allows the synthesis of a series of optically active indole derivatives with enantioselectivities up to 94%. [ABSTRACT FROM AUTHOR]

Michael addition of hetero-nucleophiles to active vinylogous imine intermediates generated in situ from 3-(1-arylsulfonylalkyl)-7-azaindoles has been described. This new strategy provides a facile and efficient approach to valuable 3-alkyl substituted 7-azaindole derivatives containing heteroatoms in high yields. [ABSTRACT FROM AUTHOR]

Abstract: A series of bispirooxindole derivatives have been synthesized via a cascade Michael-Cyclization reaction between isothiocyanato oxindoles and methyleneindolinones with high yields (up to 98%) and excellent diastereoselectivities (up to >95:5 dr) under mild conditions. The structure and effect on the reaction of less studied 4-substituted methyleneindolinones have also been investigated. [Copyright &y& Elsevier]

A base-mediated Michael addition of carbon nucleophiles to vinylogous imine intermediates generated in situ from 3-(1-arylsulfonylalkyl)-7-azaindoles has been developed. A series of 3- sec -alkyl substituted 7-azaindoles have been obtained with high yields (up to 98%). Due to the relative inertness of the 3-position of 7-azaindole and the lack of some electrophiles in Friedel–Crafts reaction, this new protocol provides a more convenient and efficient approach to these valuable targets. [ABSTRACT FROM AUTHOR]

Abstract: Enantioselective Michael addition of simple 3(2H)-furanones to α,β-unsaturated aldehydes has been described. The protocol provides a simple and efficient access to complex 3(2H)-furanones containing adjacent quaternary and tertiary stereocenters in high yields with moderate diastereoselectivities and excellent enantioselectivities. [Copyright &y& Elsevier]

Base-mediated Michael addition of hetero-nucleophiles to vinylogous imines provides α-substituted alkylazaindoles efficiently. [ABSTRACT FROM AUTHOR]

The article presents chemical equations for an article related to Synthesis of 3-sec-Alkyl Substituted 7-Azaindoles by Michael Addition of Carbon Nucleophiles to Vinylogous Imine Intermediates by G Luo and others, in a 2015 issue of the journal "Tetrahedron Letters."

The diastereoselective synthesis of bisspirooxindoles (III) and (VI) is accomplished through a consecutive Michael addition/cyclization reaction of methyleneindolinones with 3-isothiocyanato oxindoles in the presence of small amounts of tetramethylguanidine as the catalyst. [ABSTRACT FROM AUTHOR]

Asymmetric Michael addition of furanones to α,β-unsaturated aldehydes followed by reduction of the addition products provides optically active alcohols with high enantioselectivities and low to moderate diastereoselectivities. [ABSTRACT FROM AUTHOR]

A diagram is presented which shows the organocatalytic Michael reaction of alkylideneindolenines and 2-naphthols that were generated from arenesulfonylalkylindoles.