Search

The challenge of paper sludge disposal has become an important environmental issue; therefore, the combustion characteristics of paper sludge need to be examined. In this paper, the combustion of paper sludge particles under different atmospheres was analysed and investigated using a flat flame burner and optical observation techniques under fast temperature rise conditions. The combustion of paper sludge could be divided into a preheating stage, volatile combustion stage, and coke combustion stage. The changes in oxygen content had different effects on the different stages of combustion. The increase in oxygen content had no significant impact on the ignition time of the sludge particles; however, the flame brightness significantly increased. The CH* free radical appeared in the most intense stage of combustion and was depleted before the volatile flame disappeared. A higher oxygen content correlated to a faster CH* depletion. The influence of the oxygen content on the combustion rate and burnout degree of the sludge particles was investigated by comparing mass loss data and heating data. The maximum temperature and heating rate also increased with increasing oxygen content. The reduced oxygen concentration could not fully penetrate the ash layer on the surface of the particles and react with the interior sludge, resulting in a lesser degree of sludge particle burnout. [ABSTRACT FROM AUTHOR]

A new, sensitive, and cost-effective lab-on-paper-based immunosensor was designed based on electrochemical impedance spectroscopy (EIS) for the detection of exosomes. EIS was selected as the determination method since there was a surface blockage in electron transfer by binding the exosomes to the transducer. Briefly, the carbon working electrode (WE) on the paper electrode (PE) was modified with gold particles (AuPs@PE) and then conjugated with anti-CD9 (Anti-CD9/AuPs@PE) for the detection of exosomes. Variables involved in the biosensor design were optimized with the univariate mode. The developed method presents the limit of detection of 8.7 × 102 exosomes mL−1, which is lower than that of many other available methods under the best conditions. The biosensor was also tested with urine samples from cancer patients with high recoveries. Due to this a unique, low-cost, biodegradable technology is presented that can directly measure exosomes without labeling them for early cancer or metastasis detection. [ABSTRACT FROM AUTHOR]

Water-repellent coatings are essential for enhancing the durability and sustainability of textiles, paper, and bioplastic polymers. Despite the growing use of sustainable materials, their inherent hydrophilicity presents significant challenges. This review explores advanced coating technologies to address these issues, focusing on their mechanisms, properties, and applications. By imparting water resistance and repellency, these coatings improve material performance and longevity. The environmental impact and limitations of current coatings are critically assessed, highlighting the need for sustainable solutions. This review identifies key trends and challenges, offering insights into developing water-resistant materials that align with environmental goals while meeting industry demands. Key focus areas include coating mechanisms, techniques, performance evaluation, applications, environmental impact assessment, and the development of sustainable coating solutions. This research contributes to the development of water-resistant materials that meet the demands of modern industries while minimizing environmental impact. [ABSTRACT FROM AUTHOR]

This work demonstrates the application of urea-powered paper-based fuel cells (PFCs) with Hydrogen Peroxide (H2O2) as the oxidant to drive a flexible electronic circuit (ring oscillator (RO)), for the first time. Herein, the electrochemical performance of four different PFCs has been studied by employing non-precious electrodes as the anode and cathode. These are the membraneless PFC with (i) Toray carbon paper (CP) (ii) Nickel (Ni)-mesh (iii) Nickel Cobalt nanoparticles supported on reduced Graphene Oxide loaded on the CP (Ni Co@rGo@CP) and (iv) membrane-based PFC with Ni Co@rGo@CP as the electrodes. In each PFC the same electrode is employed on both the sides. A single membraneless-PFC with Ni-Co@rGo@CP as electrodes delivered a peak power density (Pmax) of 55 µW cm−2, maximum current density (Jmax) of 371 µA cm−2 and an open-circuit voltage (OCV) of 0.7 V at 3 M urea. While, a single membrane-based PFC assembled on an anion exchange membrane with Ni-Co@rGo@CP electrodes, delivered a Pmax of ≈70 µW cm−2 and Jmax of ≈500 µA cm−2 at an OCV of 0.7 V with 3 M urea. Subsequently, a stack of two membrane-based PFCs delivered an OCV of ≈1.4 V for 400 s. Finally, this stack is employed as a power source to drive a RO. The measured frequency and peak-to-peak voltage are 37.52 kHz and 1.04 V, respectively. This demonstration opens a window to implement self-contained flexible electronic system using PFCs as the power source with minimal e-waste. [ABSTRACT FROM AUTHOR]

In most industrialized countries, power transformers built several decades ago are approaching the end of their operational lifespan. The ongoing energy transition, focused on developing 100% renewable energy sources and accelerating global transportation electrification, further exacerbates these assets. Combined with rising electricity demand, there is an increasing risk of critical transformers' degradation acceleration. In this context, understanding the aging mechanisms of the insulation system inside these essential assets, which form the core of every energy network, becomes paramount for today's managers and engineers responsible for their operations. The acids generated through oil oxidation can be classified into two categories: low molecular weight acids (LMAs), which are inherently more hydrophilic and consequently have a greater impact on the degradation rate of solid insulation through hydrolysis, and high molecular weight acids (HMAs), which do not significantly contribute to the degradation of paper insulation. This study specifically addresses the impact of acids generated through oil oxidation—focusing on LMAs. New oil samples were infused with different ratios of LMAs before impregnation. The impregnated paper samples underwent thermal aging at 115 °C. Different physicochemical and dielectric properties were investigated. The investigations revealed that oils blended with formic acid exhibited more adverse effects on the insulation system compared to other LMAs. This information is essential for industry professionals seeking to mitigate the risks associated with transformer degradation and extend the lifespan of these critical assets during the energy transition. [ABSTRACT FROM AUTHOR]

Amid growing energy demands, innovative solutions are essential to power a variety of devices. Paper‐based microfluidic fuel cells (PμFCs), powered by eco‐friendly alcohols derived from biomass, present a promising option. While lightweight and disposable, they mainly rely on costly noble‐metal catalysts for high efficiency. In this context, the concept of photo paper batteries (pPBs), utilizing affordable sunlight‐activated semiconductors to drive alcohol oxidation on paper, opens the possibility to disposable and affordable energy solutions. Our review highlights recent progress in PμFCs fueled by alcohols like methanol, ethanol, ethylene glycol, and glycerol. We explore semiconductor advancements driving anodic reactions and envision the potential of pPBs. To achieve practical pPBs, refining semiconductors, electrode design, and microfluidic engineering are pivotal. This short review highlights the transformative potential of pPBs and beckons researchers to partake in shaping this new field. [ABSTRACT FROM AUTHOR]

Here, we propose a sensing scheme based on an all-dielectric metamaterial with the smooth reflection and transmission spectral lines in 10-60THz, and verify the applications of the measuring the resonance characteristics of Xuan paper samples. The reflection and thermal conductivity of Xuan paper samples enhance with the concentration of alum water increasing and weaken due to the thickness increasing. These results provide a solid foundation for this metamaterials in measuring the reflective and thermal resonance properties of Xuan paper samples. [ABSTRACT FROM AUTHOR]

Paper‐based cultural relics are of great value and have been facing irreversible damage caused by multiple factors, among which acid hydrolysis and ultraviolet photodegradation are the main processes leading to paper deterioration. Paper protection highly relies on a limited range of materials with single functions, and the design of new materials that ensure long‐term safety and efficiency by simultaneously addressing the issues of acidification and UV degradation in paper is highly desired. In this study, the introduction of carbon dots (CDs)‐enhanced layered double hydroxides (LDH) 0D/2D nanohybrids (CDs/Mg‐Al LDH) is proposed as novel dual‐functional materials for paper protection against UV degradation and acidification. Through a CDs‐assisted in situ growth strategy, CDs/Mg‐Al LDH with ultrathin thickness (≈9.1 nm) and CDs‐intercalated structure are achieved. The CDs/Mg‐Al LDH nanohybrids demonstrate high dispersibility, strong UV absorption, and remarkable photostability, resulting in protected‐paper with decelerated acidification, oxidation, and yellowing degradation processes under both accelerated UV‐aging and dry‐heat conditions. Additionally, the protected‐paper can emit uniform blue light under 365 nm UV excitation allows for easy identification of the distributed CDs/Mg‐Al LDH within the paper, marking a unique and practical feature. This research paces a new direction for the protection of paper‐based relics with emerging carbon dots‐based 0D/2D nanomaterials. [ABSTRACT FROM AUTHOR]

Starch is one of the oldest adhesives, and has been utilised for a variety of applications, including as a consolidant for artworks and archives, after cooking. Although widely available, cost-effective, and versatile it has limitations such as large particle size, which makes it challenging for the adhesive to penetrate deeply into objects. Attempts to increase the concentration of starch adhesives for enhanced strength often lead to increased viscosity, hindering penetration and causing an undesirable film on the surface. Achieving a workable consistency often leads to reduced adhesive power. An approach to using nanosized starch as a binder for paper and cellulose-based objects is presented. Starch nanoparticles (SNPs) from wheat, rice, maize and waxy maize were successfully synthesised using a 'top-down' approach that is facile as well as energy efficient. Size distribution measurements indicate most particles to be less than 50 nm, smaller than the pore size of most historic papers. SNPs could make a better sizing adhesive than traditionally-made starch paste, and they are also a green alternative to a variety of chemically formulated, organic solvent-based adhesives. The compatibility, non-toxicity, and biodegradability of starch remained uncompromised during the modification. [ABSTRACT FROM AUTHOR]

A new indole alkaloid, cigarindole A (1), together with five known indole alkaloids (2–6) were isolated from cigar tobacco. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly, compound 1 exhibited high antibacterial activity with bacteriostatic diameter within the range 20.6–26.7 mm against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Bacillus subtilis, and Proteus spp). Compounds 2–6 exhibited obvious antibacterial activity with bacteriostatic diameter within the range 11.9–21.8 mm. In addition, compound 1 also the potential value for use as an antiseptic agent for cigarette tipping paper. [ABSTRACT FROM AUTHOR]

The development of portable and cost-effective sensing system for Hg2+ quantitation is highly demanded for environmental monitoring. Herein, an on-site, rapid and portable smartphone readout device based Hg2+ sensing system integrating nitrogen-doped carbon quantum dots (NCDs) modified paper strip was proposed, and the physicochemical properties of NCDs were characterized by high resolution TEM, FTIR, UV–vis absorption spectrum and fluorescence spectral analysis. The modified paper strip was prepared via "ink-jet" printing technology and exhibits sensitive fluorescence response to Hg2+ with fluorescence color of bright blue (at the excitation/emission wavelength of 365/440 nm). This portable smartphone-based sensing platform is highly selective and sensitive to Hg2+ with the limit of detection (LOD) of 10.6 nM and the concentration range of 0–130 nM. In addition, the recoveries of tap water and local lake water were in the range of 89.4% to 109%. The cost-effective sensing system based on smartphone shows a great potential for trace amounts of Hg2+ monitoring in environmental water samples. [ABSTRACT FROM AUTHOR]

Heavy metals are particularly damaging contaminants in the environment, and even trace concentrations represent a risk to human health due to their toxicity. To detect the heavy metals of Mn2+ and Co2+ ions, a novel selective reusable paper-based Fluorescence naked-eye sensor based on naphthalene cationic Schiff base (NCSB) was synthesized and confirmed using FT-IR, 1 H-NMR, and MS tools. Based on a blue to colorless color change in the aqueous solution, the NCSB sensor is utilized to Mn2+ and Co2+ cations selectively among other metal ions (Fe2+, Cu2+, Mg2+, Ni2+, Zn2+, Cd2+, Hg2+, Pb2+, Sn2+ and Cr3+). In the aqueous medium, the NCSB sensor displayed high sensitivity, with limits of detection (LOD) values of 0.014 µM (14.08 nM) and 0.041 µM (41.47 nM) for Mn2+ and Co2+ cations, respectively. The paper-based sensor naked-eye detected Mn2+ and Co2+ cations in water at concentrations as low as 0.65 µM (65 nM) and 0.086 µM (86 nM), respectively. It was discovered that 5 min of incubation time and a pH range of 7 to 11 were optimal for the complexation reaction between the Mn2+ and Co2+ ions and the NCSB sensor. Through a static quenching process, the interaction of the different metal ions with the Schiff base group in the NCSB molecule results in the development of a ground-state non-fluorescent complex. NCSB sensor was also successfully applied in analysis of Mn2+ and Co2+ in environmental water with good recoveries of 94.8–105.9%. The theoretical calculations based on density functional theory (DFT) studies are in support of experimental interpretations. The links between the input factors and the anticipated response were evaluated using the quadratic model of the response surface methodology (RSM) modeling. [ABSTRACT FROM AUTHOR]

Cerebral Autoregulation (CA) is an important physiological mechanism stabilizing cerebral blood flow (CBF) in response to changes in cerebral perfusion pressure (CPP). By maintaining an adequate, relatively constant supply of blood flow, CA plays a critical role in brain function. Quantifying CA under different physiological and pathological states is crucial for understanding its implications. This knowledge may serve as a foundation for informed clinical decision-making, particularly in cases where CA may become impaired. The quantification of CA functionality typically involves constructing models that capture the relationship between CPP (or arterial blood pressure) and experimental measures of CBF. Besides describing normal CA function, these models provide a means to detect possible deviations from the latter. In this context, a recent white paper from the Cerebrovascular Research Network focused on Transfer Function Analysis (TFA), which obtains frequency domain estimates of dynamic CA. In the present paper, we consider the use of time-domain techniques as an alternative approach. Due to their increased flexibility, time-domain methods enable the mitigation of measurement/physiological noise and the incorporation of nonlinearities and time variations in CA dynamics. Here, we provide practical recommendations and guidelines to support researchers and clinicians in effectively utilizing these techniques to study CA. [ABSTRACT FROM AUTHOR]

Compared to traditional lithium metal batteries, anode-free lithium metal batteries use bare current collectors as an anode instead of Li metal, making them highly promising for mass production and achieving high-energy density. The current collector, as the sole component of the anode, is crucial in lithium deposition-stripping behavior and greatly impacts the rate of Li depletion from the cathode. In this study, to investigate the lithiophilicity effect of the current collector on the solid electrolyte interface (SEI) film construction and cycling performance of anode-free lithium batteries, various lightweight paper-based current collectors were prepared by electroless plating Cu and lipophilic Ag on low-dust paper (LDP). The areal densities of the as-prepared LDP@Cu, LDP@Cu-Ag, and LDP@Ag were approximately 0.33 mg cm−2. The use of lipophilic Ag-coated collectors with varying loadings allowed for the regulation of lipophilicity. The impacts of these collectors on the distribution of SEI components and Li depletion rate in common electrolytes were investigated. The findings suggest that higher loadings of lipophilic materials, such as Ag, on the current collector increase its lipophilicity but also lead to significant Li depletion during the cycling process in full-cell anode-free Li metal batteries. Thus, moderately lithiophilic current collectors, such as LDP@Cu-Ag, show more potential for Li deposition and striping and stable SEI with a low speed of Li depletion. [ABSTRACT FROM AUTHOR]

This study evaluates the impact of sales promotions that are featured in store flyers distributed by prominent retailers and their capacity to attract consumers to their establishments. A distinctive conceptual framework is introduced that scrutinizes the influence of ethically-minded consumer behavior, digital citizenship/literacy, and a retailer's orientation toward environmental sustainability and explicit ecological concerns. A quasi-experimental design was used to formulate four distinct scenarios from a possible set of eight, stemming from the combinations of three variables: 2 Retailer Positioning (green vs. without explicit ecological claims) × 2 Flyer Mediums (paper vs. digital) × 2 Discount Levels (5% discount vs. 30% discount). Through an online survey, a sample of 269 responses was garnered to gauge consumer reactions to these store flyers, evaluating their attitudes and receptiveness. The findings suggest that attitudes toward paper flyers were more favorable when presented by non-green retailers compared to their green counterparts. This can be attributed to a perceived inconsistency between a green brand positioning and the use of paper flyers. Furthermore, the propensity to transition to digital flyers was notably stronger for green retailers compared to non-green retailers, but this inclination was most pronounced when higher discounts were offered. [ABSTRACT FROM AUTHOR]

In the engine of heavy trucks, the built-in fuel filter assumes the role of "lungs". The core of the filter, namely the fuel filter paper, acts as a filter for small impurities and separates oil and water. In order to be able to separate minute impurities from the fuel, in this study, we prepared a novel fuel oil filter paper with high efficiency and high dust holding capacity based on wet-laid forming by laminating PBT/PP two-component melt-blown nonwoven material and cellulose nanocrystals (CNC)-doped cellulose wood fiber pulp with the fiber mesh combination forming technology. The effects of the CNC mixing ratio, surface density of melt-blown nonwoven material layer, surface density of cellulose wood pulp paper layer and calendaring pressure on the pore size and filtration performance of the composite samples were investigated, and the filtration efficiency of the composite samples on the tiny impurities in the fuel were also studied. The results showed that the novel composite fuel filter paper material prepared by the combined forming technology of fibrous web had high filtration efficiency and dust holding capacity, and the filtration efficiency of the composite samples could respectively reach 99.90% and 99.52% for particles larger than 14 μm and 4 μm in diameter in the fuel. At the same time, the dust holding capacity of the composite sample can reach up to 27.63 mgcm−2. [ABSTRACT FROM AUTHOR]

Background: The mobile device diffusion has increasingly highlighted the opportunity to collect patient-reported outcomes (PROs) through electronic patient-reported outcomes measurements (ePROMs) during the clinical routine. Despite the ePROMs promises and advantages, the equivalence when a PRO measure is moved from the original paper-and-pencil to the electronic version is still little investigated. This study aims at evaluating equivalence between PROMs and ePROMs self-administration in people with multiple sclerosis (PwMS); in addition, preference of self-administration type was evaluated. Methods: The Manual Ability Measure-36 (MAM-36) and Fatigue Severity Scale (FSS) were selected for the equivalence test. The app ABOUTCOME was developed through a user-centered design approach to administer the questionnaires on tablet. Both paper-and-pencil and electronic versions were randomly self-administered. Intrarater reliability between both versions was evaluated through the intraclass correlation coefficient (ICC, excellent for values ≥ 0.75). Results: Fifty PwMS (35 females) participated to the study (mean age: 54.7±11.0 years, disease course: 27 relapsing-remitting and 23 progressive; mean EDSS: 4.7±1.9; mean disease duration: 13.3±9.5 years). No statistically significant differences were found for the means total scores of MAM-36 (p = 0.61) and FSS (p = 0.78). The ICC value for MAM-36 and FSS was excellent (0.98 and 0.94, respectively). Most of participants preferred the tablet version (84%). Conclusion: The results of the study provide evidence about the equivalence between the paper-and-pencil and electronic versions of PROs administration. In addition, PwMS prefer electronic methods rather than paper because the information can be provided more efficiently and accurately. The results could be easily extended to other MS PROs. [ABSTRACT FROM AUTHOR]

Enzymes derived from microbial sources have gained increasing popularity in industrial applications over the past decades. Despite the high production cost, alkaline proteases have wide applications in industries such as tanneries, food production, and detergents. In recent years, there has been a shift towards utilizing natural carbon sources for cultivating microorganisms and extracting proteases in order to reduce production costs. This study aimed to investigate the biochemical and kinetic properties of protease enzymes obtained from Aspergillus niger cultivated in a paper waste medium and compare with the enzyme produced in a basal medium. Glucose is a more favorable carbon source compared to cellulose, so paper waste was pretreated with cellulose-degrading bacteria to convert cellulose into smaller carbohydrates. After the growth of A. niger in basal and combinational media, the enzymatic properties were compared between the extracted enzymes by using casein as substrate. The results demonstrated that A. niger could produce protease enzymes in the paper waste medium similar to the basal medium with more than 5-fold cost saving. The specific activity of the enzymes isolated from the basal and paper waste media was calculated to be 184.95 ± 10.56 U ml−1 and 169.88 ± 11.05 U ml−1, respectively. Carbon sources did not affect the optimum pH and temperature of the protease enzyme, which were found to be 8 and 37 °C, respectively. This study provides valuable insights into the production of alkaline protease from A. niger using a combinational medium (paper waste pretreated by cellulose-degrading bacteria), offering a cost-effective approach for industrial applications. [ABSTRACT FROM AUTHOR]

In the field of book heritage, it is important to develop cleaning/disinfecting treatments that can slow down the degradation of paper to prevent evident and irreversible damage. The objectives of the cleaning treatments are to remove external contaminants and oxidation and decomposition products of the paper, but these processes must not modify the unique characteristics of the book heritage resulting in irreversible changes in the structure of the paper. Recently, several innovative cleaning treatments were developed with the aim of being minimally invasive; however, to assess the effect of these treatments on paper, it is necessary to use a diagnostic non-destructive, rapid, and affordable process. In previous work, we used surface scanning Raman spectroscopy to develop a diagnostic protocol able to follow the aging processes of the paper, discriminating between hydrolysis and oxidation. In this paper, we applied this protocol to study the action of different types of treatments (hydrogel and EUV irradiation), evaluating both their effectiveness and impact on paper parameters. The results reported here demonstrate that the developed in operando diagnostic procedure can follow the changes in the paper structure comparing them to the variability due to the intrinsic inhomogeneity of paper, without sample contact in a rapid and effective way. [ABSTRACT FROM AUTHOR]

We previously used a grinder to prepare cellulose nanofibers (CNFs) that were then added to pulp to improve the wet strength of paper, with subsequent alkali treatment further improving its wet tensile strength. However, mass production of CNF using ultra-fine grinders is not feasible; moreover, fabricating paper sheets by first preparing CNFs and adding them to pulp is a complex process. Therefore, in this study, we directly fibrillated pulp using a refiner instead separately preparing CNFs, with the refined pulp used to make paper sheets, thereby simplifying the process. The resulting dried sheets were subsequently treated with 8 and 16 wt% NaOH, after which the co-reinforcing effect of the refiner and NaOH treatments on the wet tensile strength of paper was examined. Unexpectedly, wet tensile strength of 39 and 45 MPa was achieved. These values are higher than values obtained using the CNFs and NaOH treatment, and comparable to the dry strength of untreated and unrefined pulp sheet. Moreover, the dewatering time of the refiner-treated pulp was significantly shorter than that of the CNF-mixed pulp, which reduces the time required to prepare paper. This study demonstrated that refiner-treated pulp is more suitable than CNF-mixed pulp for improving paper wet strength. [ABSTRACT FROM AUTHOR]

A smooth and dense surface of the base paper is advantageous when the goal is to apply a liquid coating as a barrier layer. For such a base paper, non-wood fibers derived from wheat straw could be an alternative to wood fibers. In this research paper, wheat straw pulp was refined with different beating levels (up to 600 revolutions) followed by different calendering pressure loads (up to 50 N/mm) to test its influence on mechanical and surface properties. Alkyl ketene dimer (AKD) was used as sizing agent with concentrations up to 0.2 wt% followed by a mineral-based precoating to test its influence on the smoothness. Eucalyptus pulp was chosen as a benchmark. After beating, the initial Schopper-Riegler degrees of 28 °SR increased to 56 °SR. Beating also increased the tensile index from 24 to 49 Nm/g, the burst index from 1.2 to 2.8 kPa·m²/g, and the tear index decreased from 3.3 to 2.8 mN·m²/g. Calendering reduced the initial roughness of 370 mL/min to 30 mL/min. When precoated and calendered again, the value was lowered to 15 mL/min. In summary, wheat straw paper is a relevant alternative to wood-derived base paper to produce barrier papers. Compared to eucalyptus, wheat straw paper showed better smoothness and much lower air permeability indicating excellent suitability for barrier coating. [ABSTRACT FROM AUTHOR]

This study developed a novel paper-based sensor for the simultaneous analysis of ascorbic acid (AA) and hydroquinone (HQ). The sensor utilized polyvinyl alcohol (PVA)-stabilized silver nanoparticles (AgNPs-PVA) as the reagent probe and PVA media acted as the filter for separation of the analytes. Polydimethylsiloxane (PDMS) and ethanol serve as the stationary phase and eluent, respectively, exploiting the differences in analyte reactions and solubility to achieve their separation on the filter paper. The circular sensor's central zone was AA's detection area, while HQ was detected in the outer ring region. AA induced an immediate color change in the test kit, whereas HQ required a 20-minute elution with ethanol followed by colorimetric analysis. All analytes exhibited relative standard deviations of repeatability and reproducibility below 2.7% and 9.5%, respectively. Under optimal conditions, the linear detection range for HQ was 0.2-2.0 mg⋅L− 1, while AA was 0.1-2.0 mg⋅L− 1. The detection limit was determined to be 0.05 mg⋅L− 1 for AA and 0.1 mg⋅L− 1 for HQ. The recoveries of AA and HQ in cosmetic cream samples ranged from 80 to 110%. The accuracy of the sensor's measurements was further validated by comparison with the HPLC-DAD method. [ABSTRACT FROM AUTHOR]

[Display omitted] The recycling of paper and board (PB) yields economic and environmental advantages compared to primary paper production. However, PB from lightweight packaging (LWP) waste is currently not comprehensively reintegrated into the paper value stream. To develop an adapted recycling process for PB from LWP, PB quantities, qualities, and fluctuations ranges in LWP are required. Currently, no sufficient database is available. Therefore, we developed a methodical approach and conducted a case study to access the PB potential in LWP sorting plants using manual analysis and sensor-based material flow monitoring. Differences resulting from seasonal variations, materials from different settlement structures, and fluctuation ranges in LWP composition over two weeks have been investigated. PB contents in the input of 6.5 wt% (ww) and 5.9 wt% (ww) were determined for winter and summer sampling campaigns, respectively. The PB product stream amounted to 5.7 wt% (ww, winter) and 4.8 wt% (ww, summer). Around 45 wt% (ww) of PB from the PB product stream was classified as misplaced by the consumer and should have been discarded in separate paper collections. Based on the determined PB quantities and qualities, a potential of usable and in the PB product stream available PB in LWP was determined. The technically available and usable PB potential in German LWP waste amounts to 89,000 to 100,000 tons per year (average PB yield of around 65 wt% (ww)). The methodical approach can be adapted for sorting plant balances. The results can contribute to developing an adapted recycling process for PB from LWP. [ABSTRACT FROM AUTHOR]

Past quantitative studies have shown that most media coverage is of men. Here we ask if the scarce coverage that women get is qualitatively different from that of men. We use computer-coded sentiment scores for 14 million person names covered in 1,323 newspapers to investigate the three-way relationship between gender, fame, and sentiment. Additional large-scale data on occupational categories allow us to compare women and men within the same profession and rank. We propose that as women's fame increases their media coverage becomes negative more quickly when compared to men (a "paper cut"), because their violation of gender hierarchies and social expectations about typical feminine behavior evokes disproportionate scrutiny. We find that while overall media coverage is much more positive for women than for men, this difference disappears and even reverses at higher levels of fame. In encyclopedic sentiment data we find no biographic basis for women's disproportionate decline in media coverage sentiment at high fame, consistent with the conjectured double standard in media discourse. [ABSTRACT FROM AUTHOR]

In this work, solid-surface fluorescence spectra of Rhodamine B (RhB) and fluorescein (FLU), two extensively used fluorophores, were studied and their concentrations were semi-quantitatively determined using the three-dimensional excitation–emission matrix (3D-EEM) data. In order to measure the solid fluorescence spectra, a trace amount of fluorophores was physically adsorbed on a piece of filter paper as a fluorescent paper, and the fluorescence spectra were recorded from the surface of the fluorescent paper instead of the inner parts of the solution. The spectral measurement was performed utilizing a routine spectrofluorimeter designed to measure the fluorescence of solution only by placing the fluorescent paper in a simple handmade holder at an adjusted incident angle of radiation. The results revealed a significant increase in the fluorescence intensity of the fluorescent paper strip compared to the solution phase. Moreover, in the RhB–FLU paper strip the forster resonance energy transfer was observed between FLU and RhB, similar to the observed phenomenon in the solution phase. For quantifying fluorophores, the EEM data were successfully resolved by applying multivariate partial least squares and parallel factor analysis (PARAFAC) modeling, and the results were compared with the univariate method. This study may provide a general guideline in further developing the solid fluorescence measurement of concentrated solutions or solid samples that have fluorescence measurement limitations such as high self-absorption and highly scattered spectra by using a conventional spectrofluorimeter, and also of biological samples where a trace amount of the analyte is available and high sensitivity is required. [ABSTRACT FROM AUTHOR]

In the face of worsening water quality and escalating water environmental emergencies, this study developed a paper-based microfluidic disk for rapid, on-site determination of ammonia nitrogen, nitrates, nitrites, and phosphates in water. The method utilizes centrifugal microfluidics and paper-based technology, thus simplifying the operation while eliminating the need for on-site reagent preparation. Experimental results demonstrate that the disk requires only 80 microliters of a water sample and 2 minutes to complete the quantitative analysis of the four nutrients, with a coefficient of variation below 1.72% and spike recoveries ranging from 92% to 113%. The development of the disk provides an effective and rapid, on-site testing tool for water quality analysis. [ABSTRACT FROM AUTHOR]

ABSTRACT This paper presents an artificial intelligence (AI)‐based framework designed for learning and regenerating analog circuits from academic papers. The framework comprises four distinct modules: circuit extractor, table extractor, text extractor, and simulation executor. The circuit extractor module utilizes deep learning object detection to identify devices and their associated textual descriptions while extracting interconnections between devices. The table extractor module handles textual and image‐based tables, extracting device parameters, and simulation data. The text extractor module leverages optical character recognition (OCR) and AI models to extract supplementary information. The simulation executor employs this information to conduct simulations and optimize circuit performance. In our experiments, our method effectively extracts multimodal circuit design information, achieving an average accuracy of up to 97% in target detection within the circuit extractor module. The improved performance during the simulation process further validates the effectiveness of our framework. [ABSTRACT FROM AUTHOR]

The majority of carbon materials on the market are produced from polyacrylonitrile precursor fibers using high‐temperature oven processes. Despite approaches for green carbon fiber precursors, current stabilization and carbonization processes require large amounts of energy and render carbon materials costly and environmentally not sustainable. Here, a plasma carbonization treatment is employed for papers made from lignin/polyvinylpyrrolidone precursor fibers. The process provides carbonization within a timeframe of a few seconds, while the degrees of porosity, conductivity, and hydrophobicity can be tuned. It is shown that the properties of these carbonized papers are suitable for application as supercapacitor electrodes with capacitances in the range of 40 mF g−1 with very good cycling stability dropping by less than 20% over 4000 cycles. [ABSTRACT FROM AUTHOR]

Bimetallic Au@Ag nano-sea urchins (Au@Ag NSUs) functionalized with methimazole were synthesized and combined with paper tips as efficient surface-enhanced Raman scattering (SERS) substrates for ultrasensitive Cr(VI) detection. The redox reaction between methimazole and Cr(VI) ensured the reliability of quantitative Cr(VI) analysis. When droplets were continuously dropped on the tip of the paper, based on the gravity effect, the nanoparticles achieved enrichment at the front end of the tip, which further improved the sensitivity of detection. The detection limit is as low as 0.956 ng L−1, demonstrating its excellent performance in ultrarace Cr(VI) detection. Additionally, the SERS sensor was successfully applied to the detection of Cr(VI) in real water samples, such as lake water and tap water, indicating its wide application potential in environmental monitoring. This study not only provides an efficient and reliable new method for detecting Cr(VI) but also shows the great prospect of paper-based SERS sensors in practical applications. [ABSTRACT FROM AUTHOR]

Highlights The aerospace industries demand for advanced materials necessitates stringent quality control measures, particularly for composite structures to ensure optimal curing and structural integrity. Traditional methods like differential scanning calorimetry (DSC) and dynamic mechanical analysis, while useful, are limited to laboratory settings. This study explores the use of a printed paper‐based sensor for real‐time cure monitoring of glass fiber‐reinforced phenol‐formaldehyde (PF/GF) prepregs. The sensor, composed of a cellulose paper substrate with screen‐printed electrodes, offers flexibility, ease of integration, and cost‐effectiveness compared to commercial polymer‐based dielectric sensors. Real‐time monitoring with the printed paper‐based sensor was conducted at temperatures ranging from 130 to 180°C, both with and without pressure, and validated against DSC and Fourier‐transform infrared (FTIR) spectroscopy. The results showed a strong correlation between real‐time monitoring and the DSC prediction model, as well as FTIR spectroscopy. Notably, the real‐time monitoring revealed a shorter curing cycle on the production line than the predicted cure kinetic model, which is crucial for large‐scale production, such as fabricating honeycomb panels for aircraft interiors. This research underscores the importance of innovative sensor technologies in improving quality control and manufacturing efficiency in aerospace composites. Cure Monitoring of PF‐based prepregs was carried out using paper‐based sensor. Sensor offered reproducibility and seamless integration in composites. Sensor data showed a strong correlation with DSC and FTIR spectroscopy results. Paper sensors enable online monitoring of composite in aerospace manufacturing. [ABSTRACT FROM AUTHOR]

Conventional affinity-based colorimetric enzyme-linked immunosorbent assay (ELISA) is one of the most widely used methods for the detection of biomarkers. However, rapid point-of-care (POC) detection of multiple cancer biomarkers by conventional ELISA is limited by long incubation time, large reagent volume, and costly instrumentation along with low sensitivity due to the nature of colorimetric methods. Herein, we have developed a reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments. A piece of pre-patterned chromatography paper placed in the PMMA polymer pond facilitates rapid protein immobilization to avoid intricate surface modifications of polymer and can be changed with a fresh paper layer to reuse the device. Reagents can be simply delivered from the top PMMA layer to multiple microwells in the middle PMMA layer via flow-through microwells, thereby increasing the efficiency of washing and avoiding repeated manual pipetting or costly robots. Quantitative colorimetric analysis was achieved by calculating the brightness of images scanned by an office scanner or a smartphone camera. Sandwich-type immunoassay was performed in the PiPP hybrid device after the optimization of multiple assay conditions. Limits of detection of 0.32 ng mL−1 for carcinoembryonic antigen (CEA) and 0.20 ng mL−1 for prostate-specific antigen (PSA) were obtained, which were about 10-fold better than those of commercial ELISA kits. We envisage that this simple but versatile hybrid device can have broad applications in various bioassays in resource-limited settings. [ABSTRACT FROM AUTHOR]

Paper-based microfluidic devices offer an ideal platform for biological and environmental detection because they are low-cost, small, disposable, and fill by natural capillary action. In this tutorial review, we discuss the surface modification of paper-based microfluidic devices with functional polymers using the initiated chemical vapor deposition (iCVD) process. The iCVD process is solventless and therefore ideal for coating cellulose paper because there are no surface tension effects or solvent compatibility issues. The process can also be scaled up for roll-to-roll manufacturing. The chemical functionality of the iCVD coating can be tuned by varying the monomer and the structure of the coating can be tuned by varying the processing parameters. [ABSTRACT FROM AUTHOR]

White detection remains a critical limitation in using colorimetry to determine substances with microfluidic paper-based analytical devices (µPADs). Here, we introduced a simple, safe alcohol ink-modified µPAD for the straightforward and facile detection of white color in precipitation reactions. Although absolute alcohol ink was found to cause device leakage, dilution of the ink with water was the key to successfully precoat wax-created µPADs. Device utility was demonstrated through simultaneous detection of sulfate, phosphate, and water hardness via precipitation reactions. While phosphate interfered with sulfate detection by Ba2+, in situ distance-based quantification of phosphate was implemented. Aside from anions, the modified µPADs could be extended to detect cationic analytes such as total hardness. The limits of detection (LODs) for sulfate, phosphate, and hardness were 0.005 mmol L−1, 0.005 mmol L−1, and 0.5 mmol L−1, respectively, with the linear ranges of 0.01–10.0 mmol L−1, 0.005–1.0 mmol L−1, and 0.001–0.5 mol L−1. The µPADs were applied to real water samples, demonstrating results that were consistent with standard methods at a 95% confidence level. By incorporating white detection, these alcohol ink-modified µPADs offer enhanced versatility for addressing a broader array of analytical challenges in real-world settings. [ABSTRACT FROM AUTHOR]

A paper-based colorimetric sensor array mediated by a novel nanozyme (CuCo2O4) was developed using a screen-printing technology. The aim was to facilitate the identification of different kinds of alkaloids. Typically, three chromogenic substrates (3,3′,5,5′-tetramethylbenzidine, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and o-phenylenediamine) were selected as sensing elements, which can be catalyzed by a CuCo2O4 nanozyme with peroxidase-like activity to yield corresponding oxidized products, thereby inducing color changes. Owing to the varying inhibitory ability of different alkaloids on acetylcholinesterase (AChE), a decrease in choline (Ch) concentration occurs and subsequently results in the restoration of color within the units of sensor array. Color data can be transformed into hue information with a smartphone. The above color variations generated a unique "fingerprint" pattern on five alkaloids (berberine, palmatine, jatrorrhizine, eserine, and harmane), which can be successfully discriminated through linear discriminant analysis in the range 0.2 to 20 µM. Furthermore, the sensor arrays allowed successful discrimination of the above five alkaloids in Chinese herbal medicine samples and recognition of 22 blind samples. This work presents a novel nanozyme-based paper sensor array, which is a user-friendly and reliable platform for probing different alkaloids. In addition, the developed sensing strategy enables the identification of AChE-related diseases, positively contributing to the screening available of AD-associated drugs. [ABSTRACT FROM AUTHOR]

A novel inorganic nonmetallic material boron carbide (B4C) was applied in paper spray ionization to analyze organic molecules in both negative and positive modes. The utilization of B4C has led to a notable enhancement in signal responses for various molecules, including bisphenols and drugs, by approximately two to four times. The limit of detection (LOD) of bisphenol AF and nilotinib standard solutions can reach 1 and 0.5 μg/mL, respectively. Moreover, linear relationships for bisphenol AF was established within the concentration range of 1–100 μg/mL, exhibiting strong correlation coefficients. Recovery experiments for BPAF in water samples from the inlet and outlet of a sewage treatment plant, conducted without any pretreatment, achieved a maximum recovery rate of 98.8% and an RSD below 9.78%. [ABSTRACT FROM AUTHOR]

Purpose: The European Society of Intensive Care Medicine (ESICM) Green Paper aims to address the challenge of environmental sustainability in intensive care and proposes actionable strategies for integrating sustainability into intensive care unit (ICU) stakeholder actions. Methods: The ESICM Executive Committee appointed a task force of topic experts and ESICM committee representatives to develop the ESICM Green Paper. The task force convened biweekly from January to June 2024, identifying key domains for environmental sustainability and prioritizing actions. Drafts were iteratively refined and approved by the ESICM Executive Committee. Results: Climate change will impact activities in intensive care in many ways, but also the impact of ICU activities on the environment is considerable; drivers for this include extensive resource use and waste generation in ICUs from energy consumption, use of disposable items, and advanced therapies for critically ill patients. The ESICM Green Paper outlines a structured approach for ICUs to reduce their environmental impact, emphasizing energy efficiency, waste reduction, and sustainable procurement. Furthermore, it endorses the need for awareness and education among healthcare professionals, integration of sustainability into research, and sustainable policies within scientific societies. Conclusions: The ESICM Green Paper reviewed the relevance of climate change to intensive care and provided suggestions for clinical practice, research, education, and ESICM organizational domains. It underscores that reducing intensive care's ecological footprint can coexist with high-quality patient care. Promoting a resilient, responsible healthcare system is a joint responsibility of all ICU stakeholders. [ABSTRACT FROM AUTHOR]

On 7 September 1847, in Melbourne in the Port Phillip District of the Colony of New South Wales, David John Thomas (1813–1871) presented a paper, 'On the inhalation of the vapour of Æther, with cases', at an ordinary monthly meeting of the Port Phillip Medical Association. This is the earliest known presentation of a paper on etherisation in Australia. The partial publication of the manuscript in October 1847 in the Australian Medical Journal may have led to it being returned to Thomas in Melbourne. The handwritten manuscript is now preserved in the Medical History Museum, University of Melbourne, Melbourne, Victoria. A transcript of the complete manuscript is now recorded with relevant historical notes. [ABSTRACT FROM AUTHOR]

Hot spring bathing practice helps to manage hypertension. However, the details of the relationship between hot spring bathing and hypertension remain unknown. Older people are thought to be less adept than younger people at using digital devices such as mobile applications. Whether mobile application questionnaires, which have been increasing in recent years, can be used by older people is unclear. To address the knowledge gap regarding the management of older patients with hypertension, we prospectively evaluated mobile application and paper questionnaires regarding night-time hot spring bathing in respondents who had a choice of which to use. Changes in blood pressure because of hot spring bathing were evaluated. To investigate the effects of night-time hot spring bathing on blood pressure in adults, 1116 volunteers at 14 institutions in Beppu completed the study, including 562 in the mobile application questionnaire group and 556 in the paper questionnaire group. A total of 474 of 477 (99.3%) respondents aged ≥65 years used paper questionnaires. There was a significantly lower drop in both systolic and diastolic blood pressure after using hot springs in respondents aged ≥65 years than in respondents aged <65 years (p<0.001). An age ≥65 years, hypertension with medication, arrhythmia, depression, and using a chloride hot spring were independently and significantly associated with a lower drop in both systolic and diastolic blood pressure after night-time hot spring bathing (p<0.001). Night-time hot spring bathing was significantly associated with reduced blood pressure in older adults (p<0.001). Extending this research by examining how psychosocial factors in respondents aged ≥65 years influence preferences for mobile and paper questionnaires may be beneficial, and further investigation is warranted. [ABSTRACT FROM AUTHOR]

Sketching is an important tool for engineers during concept generation. Sketch quantity during this early stage of design has been linked with eventual design outcomes and sketch quality has been linked with design perceptions. As such, both are important metrics to track. Prior work has also found gender differences in some of these sketch attributes, and considering gender imbalances in the field, it is important to assess whether there are differences in performance by gender during concept generation and if the use of digital tools exacerbate or mitigate any of these potential differences in performance by gender. Given the increase in use of digital tablets for sketching, it is important to assess how tablet use affects early stage engineering design sketches. This is especially important as tablets can automatically smooth lines and help perfect sketch features, but these features may also take longer to use and may result in fewer sketches produced. This study investigates differences in sketch quality, quantity, and understandability (the effectiveness of the sketch as a communication tool) between sketching on a tablet and sketching with pen on paper during an engineering design concept generation exercise. Results indicate that there is no difference in sketch quantity or understandability between the two tools. However, sketch quality, smoothness, and proportion/accuracy are all higher for the pen and paper condition than for the tablet condition. Finally, no gender differences in performance for either sketch quantity or quality were found. [ABSTRACT FROM AUTHOR]

Previous research has documented that students' reading comprehension performance in learning English as a foreign language (EFL) differs greatly between mobile-assisted and paper-based reading. The present study extends previous work by investigating whether reading cognitive load differs between mobile-assisted and paper-based EFL reading processes and exploring whether cognitive load mediates the relationship between reading medium and EFL reading comprehension performance. The instruments used are reading comprehension tests and questionnaire surveys administered to a sample of 191 first-year college students. A repeated-measures analysis of variance (ANOVA) indicates that cognitive load is significantly greater for mobile-assisted EFL reading than for paper-based EFL reading. In addition, structural equation modeling analyses indicate that cognitive load fully mediates the relationships between medium and reading comprehension performance; these mediation effects are independent of the level of English language proficiency. These results imply that cognitive load is a pivotal factor influencing students' reading comprehension across media. Reasons for differences in reading cognitive load and its role as a mediator are discussed. Recommendations for promoting students' reading experience on mobile phones are provided. [ABSTRACT FROM AUTHOR]

This document is an editorial announcing the new Journal Impact Factor (IF) for Seminars in Thrombosis and Hemostasis (STH) for the year 2023. The 2023 IF for STH is 3.6, which is a decrease from previous years. The decrease in IF is attributed to changes in calculation methods, the inclusion of additional journals, and the impact of the COVID-19 pandemic. The document also highlights the impact of COVID-19 on research and publishing, with STH publishing four issues focused on COVID-19. It emphasizes that the IF is just one measure of journal quality and provides rankings of STH in relevant categories. The document lists the most highly cited papers contributing to the 2023 IF, many of which are related to COVID-19. The inclusion of Young Investigator winners and original studies on the list is noted. The article also discusses the success of select original studies published in STH and the support provided for the Young Investigator Awards. It provides information on submission and acceptance rates for unsolicited manuscripts, as well as data on the number of issues, pages, and cumulative count of papers published in STH. The article concludes by celebrating the 50th anniversary of STH and expressing hopes for its continued success. [Extracted from the article]

This document is a summary of a special issue of the journal Quality & Reliability Engineering International. The issue showcases original research presented at the 2023 International Conference on Quality, Reliability, Risk, Maintenance, and Safety Engineering. The research papers cover a diverse range of topics related to reliability and safety in modern engineering systems. The papers address areas such as reliability modeling and analysis, reliability-based design and optimization, failure/safety analysis and prevention, and maintainability. The authors express their appreciation to the journal and the reviewers for their support and hope that the research presented will be valuable to researchers, engineers, scientists, and students in the field. [Extracted from the article]

Environmental sustainability and the effective use of renewable resources are critical subjects that need to be integrated into our educational systems through practical, hands-on learning. This paper focuses on the fabrication of aluminium-air batteries using waste materials, providing an innovative and cost-effective DIY approach to energy storage education. Utilizing aluminium from food packaging and graphite from pencils, this study demonstrates the construction and functionality of an aluminium-air battery to run an LED, highlighting its potential applications in educational settings and low-cost energy solutions. The paper aims to inspire the adoption of environmentally friendly practices and enhance students' understanding of electrochemical energy conversion through accessible and engaging DIY projects. [ABSTRACT FROM AUTHOR]

Highlights: The large-scale, high-strength, super-tough, and multifunctional nacre-like heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite papers were fabricated using the in-situ assembly of PPy onto the HA/MXene hydrogel template. The "brick-and-mortar" layered structure and abundant hydrogen-bonding interactions among MXene, PPy, and HA respond cooperatively to external stress and effectively increase the mechanical properties of HMP nanocomposite papers. The templating effect from HA/MXene was utilized to guide the assembly of conducting polymers, leading to high electrical conductivity and outstanding electromagnetic interference shielding performance. Robust, ultra-flexible, and multifunctional MXene-based electromagnetic interference (EMI) shielding nanocomposite films exhibit enormous potential for applications in artificial intelligence, wireless telecommunication, and portable/wearable electronic equipment. In this work, a nacre-inspired multifunctional heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper with large-scale, high strength, super toughness, and excellent tolerance to complex conditions is fabricated through the strategy of HA/MXene hydrogel template-assisted in-situ assembly of PPy. Benefiting from the "brick-and-mortar" layered structure and the strong hydrogen-bonding interactions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa), outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect of HA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly, the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dB at an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2 g−1. In addition, the papers also have excellent applications in electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developing high-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management. [ABSTRACT FROM AUTHOR]

AbstractIn the rapidly evolving wireless communication landscape, achieving full-dimensional coverage poses a gamut of challenges such as intricacy, high hardware costs and energy consumption. In addressing these issues, reconfigurable metasurfaces are being considered as a potential solution. However, traditional methods of producing reconfigurable metasurfaces via printed circuit board (PCB) technologies possess limitations such as high cost and extended production cycles. Particularly, in the context of large-scale communication scenarios, reconfigurable metasurfaces can also present high energy consumption issues. Therefore, this paper proposes a novel type of intelligent reflection surface (IRS) characterized by lower production costs, reduced energy consumption, enhanced flexibility, ease of manufacture, and superior electromagnetic wave modulation capabilities. The proposed reconfigurable smart metasurface is a paper-based metasurface printed with conductive ink, which uses conductive ink to draw base metal blocks on a flexible substrate, and uses silver-tin as a metal patch between the metal blocks, and the phase response is reconstructed with silver ink. By adjusting the distribution of these metallic patches, we tailor the phase and amplitude distributions to generate specific scattering effects. This paper presents designs of six patterns that yield single-beam and dual-beam, with experimental results aligning closely with simulated results, validating the feasibility of the proposed method. This low-power, low-cost, and efficient IRS is expected to pave a new path for advanced 5 G/6G wireless communication technologies. [ABSTRACT FROM AUTHOR]

The commentary discusses Shirley Hoxter's paper on puberty experiences, highlighting the changes in adolescent development over the years. It addresses the impact of social media, early puberty, and changing attitudes towards sexuality and dating among teenagers. The paper emphasizes the importance of understanding the intergenerational tensions and conflicts that arise during puberty, as well as the role of therapists in helping adolescents navigate these challenges. The commentary also delves into case studies presented by Hoxter, showcasing the complexities of adolescent psychotherapy and the need for therapists to address issues related to sexuality, identity, and maturation. [Extracted from the article]

Isothermal nucleic acid amplification tests (NAATs) are a vital tool for point-of-care (POC) diagnostics. These assays are well-suited for rapid, low-cost POC diagnostics for infectious diseases compared to traditional PCR tests conducted in central laboratories. There has been significant development of POC NAATs using paper-based diagnostic devices because they provide an affordable, user-friendly, and easy to store format; however, the difficulties in integrating separate liquid components, resuspending dried reagents, and achieving a low limit of detection hinder their use in commercial applications. Several studies report low assay efficiencies, poor detection output, and poorer limits of detection in porous membranes compared to traditional tube-based protocols. Recombinase polymerase amplification is a rapid, isothermal NAAT that is highly suited for POC applications, but requires viscous reaction conditions that has poor performance when amplifying in a porous paper membrane. In this work, we show that we can dramatically improve the performance of membrane-based recombinase polymerase amplification (RPA) of HIV-1 DNA and viral RNA by employing a coin cell-based vibration mixing platform. We achieve a limit of detection of 12 copies of DNA per reaction, nearly 50% reduction in time to threshold (from ∼10 minutes to ∼5 minutes), and an overall fluorescence output increase up to 16-fold when compared to unmixed experiments. This active mixing strategy enables reactions where the target and reaction cofactors are isolated from each other prior to the reaction. We also demonstrate amplification using a low-cost vibration motor for both temperature control and mixing, without the requirement of any additional heating components. [ABSTRACT FROM AUTHOR]

Background: Rib fractures are one of the most common traumatic injuries and may result in significant morbidity and mortality. Despite growing evidence, technological advances and increasing acceptance, surgical stabilization of rib fractures (SSRF) remains not uniformly considered in trauma centers. Indications, contraindications, appropriate timing, surgical approaches and utilized implants are part of an ongoing debate. The present position paper, which is endorsed by the World Society of Emergency Surgery (WSES), and supported by the Chest Wall Injury Society, aims to provide a review of the literature investigating the use of SSRF in rib fracture management to develop graded position statements, providing an updated guide and reference for SSRF. Methods: This position paper was developed according to the WSES methodology. A steering committee performed the literature review and drafted the position paper. An international panel of experts then critically revised the manuscript and discussed it in detail, to develop a consensus on the position statements. Results: A total of 287 studies (systematic reviews, randomized clinical trial, prospective and retrospective comparative studies, case series, original articles) have been selected from an initial pool of 9928 studies. Thirty-nine graded position statements were put forward to address eight crucial aspects of SSRF: surgical indications, contraindications, optimal timing of surgery, preoperative imaging evaluation, rib fracture sites for surgical fixation, management of concurrent thoracic injuries, surgical approach, stabilization methods and material selection. Conclusion: This consensus document addresses the key focus questions on surgical treatment of rib fractures. The expert recommendations clarify current evidences on SSRF indications, timing, operative planning, approaches and techniques, with the aim to guide clinicians in optimizing the management of rib fractures, to improve patient outcomes and direct future research. [ABSTRACT FROM AUTHOR]

The detection of circulating tumor DNA (ctDNA) in blood is significant for non‐invasive cancer diagnosis and treatment monitoring. Herein, MBene nanosheets is synthesized and compared with MXene via Density Functional Theory (DFT) calculations and fluorescence kinetic evaluations, for first time, revealing MBene's exceptional DNA adsorbability and discrimination to single‐stranded DNA (ssDNA) and double‐stranded DNA (dsDNA). Then, a sensitive fluorescence biosensor for ctDNA detection is developed, demonstrating impressive performance. To facilitate point‐of‐care testing (POCT) ctDNA, a paper‐based microfluidic chip incorporated a delay area and a mixing channel is designed. The constricted‐expanded structure channel optimization is guided by numerical simulations and experiments. A WeChat mini program named “ctDNA Detection” is designed for readout assay. Furthermore, cell and mice serum samples are analyzed, with Magnetic Bead@Graphene Oxide (MB@GO) and clutch probes for magnetic pre‐enrichment. The results accuracy is confirmed by its consistency with standard qPCR results (AUC = 1). The successful detection of ctDNA in post‐surgery mouse models underscored the biosensor's potential for cancer treatment monitoring. Thus, this research not only advanced the understanding of the MBene‐DNA interaction in biosensing, but also can pave the way for novel applications in bioimaging and nanopore‐based nucleic acid sequencing, leveraging the digital transformation of DNA base‐MBene adsorption differences. [ABSTRACT FROM AUTHOR]