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Objective: To investigate the effects of magnesium sulfate combined with labetalol on coagulation function, oxidative stress and vascular endothelial function in patients with severe preeclampsia. Methods: 94 patients with severe preeclampsia who came to Chaohu Hospital affiliated to Anhui Medical University from January 2020 to September 2022 were selected. The patients were randomly divided into control group (magnesium sulfate treatment, 47 cases) and study group (magnesium sulfate combined with labetalol treatment, 47 cases) by random number table method. Before and after treatment, the changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), 24 h urine protein volume (24hUP), coagulation function, oxidative stress and vascular endothelial function indexes were observed in two groups, and the drug safety in the two groups was observed. Results: After treatment, SBP, DBP and 24hUP in the study group were lower than those in the control group (P<0.05). After treatment, endothelin-1 (ET-1) in the study group was lower than that in the control group, while nitric oxide (NO) was higher than that in the control group (P<0.05). After treatment, malondialdehyde (MDA) in the study group was lower than that in the control group, and superoxide dismutase(SOD) in the study group was higher than that in the control group (P<0.05). After treatment, the fibrinogen (Fg) and D-dimer (D-D) in the study group were lower than those in the control group, and the prothrombin time (PT) and thrombin time (APTT) in the study group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions in the two groups (P>0.05). Conclusion: Labelolol combined with magnesium sulfate in the treatment of patients with severe preeclampsia can reduce 24hUP, effectively reduce blood pressure, improve coagulation function and vascular endothelial function, and alleviate oxidative stress damage. [ABSTRACT FROM AUTHOR]

BACKGROUND: Autologous nerve transplantation is widely used clinically to achieve the purpose of nerve repair, but the application effect is not good. The application of polyethylene glycol ranges from cell fusion agents to hydrogel bioadhesives to new materials for promoting axon fusion nerve repair. Therefore, if it can be combined with polyethylene glycol to explore ways to speed up the reconstruction of nerve function, it can be better applied to the clinic, and it w ill also have important significance for nerve regeneration and functional reconstruction. OBJECTIVE: To describe the application and progress of polyethylene glycol in the field of neurological reconstruction. METHODS: PubMed and CNKI were used to retrieve articles about polyethylene glycol promoting cell fusion and polyethylene glycol acting o n nerve repair. The search time was from October 2020 to March 2021. The English search terms were "PEG, polyethylene glycol, cell-fusion, nerve function reconstruction, nerve repair". The Chinese search terms were "polyethylene glycol, cell fusion, function reconstruction, nerve repair". All articles were initially screened according to the inclusion and exclusion criteria, and 61 articles with higher relevance were retained for review. RESULTS AND CONCLUSION: (1) Under certain conditions, 70% polyethylene glycol was added with a small amount of adenosine 5'-triphosphate, which can accelerate the rapid growth of injured nerve axons, effectively promote membrane fusion, and realize the reconstruction of nerve cell structure and function. (2) The main factor affecting the efficiency of cell fusion is the concentration of polyethylene glycol it self. When it s concentration is 35%, the relative molecular mass is 4000, or when the concentration is 50%, the relative molecular mass is 1000, greatest impact on cell fusion efficiency is found. The other minor influencing factors are the number of fused cells, the reaction temperature, and time. (3) In further research on different mechanisms of promoting nerve repair, polyethylene glycol can promote axon fusion, which is manifested in the restoration of the continuity of axon morphology and its electrophysiological function. However, further research is needed to prove whether the effective connection of axons can be realized before Wallerian degeneration. (4) Polyethylene glycol has a broad application prospect. In the future, it can be considered in the research and development of new bioadhesives, nerve repair stent improvement, and composite hydrogel research. However, the application of polyethylene glycol in the field of nerve function reconstruction still has many unresolved problems, such as the long-term effects of polyethylene glycol-induced neuronal fusion on the human body, and the maximum delay in treatment time, which need to be continuously improved by follow-up research. [ABSTRACT FROM AUTHOR]