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[Objective]The objective of this study is to identify the genes(TaENO2s)encoding the enolase family member ENO2 in the important crop plant of wheat(Triticum aestivum L.)and to determine the alternative translation feature and protein enolase activity of TaENO2s.[Method]Wheat TaENO2s were identified by bioinformatics. One of the identified TaENO2s was selected as a representative for protoplast-based exogenous expression and characterization of alternative translation products. This selected TaENO2 was also subjected to prokaryotic expression for purification of recombinant protein. The enolase activity of the purified recombinant protein was determined with in vitro assays.[Result]The hexaploid wheat genome had three homeologous TaENO2s which sequences encoded a conserved enolase catalytic center and had a putative alternative translation start site at the internal ATG codon encoding the residue M94(ATGM94) of the enolase sequence. When exogenously expressed in protoplasts, the representative TaENO2 encoded two proteins, one full-length form of cytoplasmic and nuclear enolase protein and one N-terminal truncated form of nuclear transcriptional repressor TaMBP-1, while the variant of the same gene containing mutated ATGM94 only encoded the full-length form of enolase protein. Soluble recombinant GST-TaENO2 protein expressed in Escherichia coli was successfully purified and verified to have an in vitro enzymatic activity to catalyze the conversion from 2-phosphoglycerate (2-PGA)to phosphoenolpyruvate(PEP)[Conclusion]The wheat genome has three TaENO2 genes encoding the enolase protein ENO2. Under the condition of exogenous expression, TaENO2 encodes two protein products via mRNA alternative translation, one enolase protein translated from the first start codon and one TaMBP-1 protein translated from the internal start codon(2-PGA)to phosphoenolpyruvate(PEP).[Conclusion[The wheat genome has three TaENO2 genes encoding the enolase protein ENO2. Under the condition of exogenous expression, TaENO2 encodes two protein products via mRNA alternative translation, one enolase protein translated from the first start codon and one TaMBP-1 protein translated from the internal start codon ATGM94. The prokaryotically expressed recombinant protein GST-TaENO2 possesses in vitro enolase activity.. The prokaryotically expressed recombinant protein GST-TaENO2 possesses in vitro enolase activity. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical characteristics and influencing factors of early postoperative vestibular symptoms in patients with acoustic neuroma by collecting preoperative vestibular function examination, clinical data, and early postoperative vestibular symptom data. Methods The study included 64 patients who had undergone surgery for acoustic neuroma between February 2021 and February 2022. Vestibular symptom types were recorded postoperative 1 day, 3 days, 7 days, 30 days respectively, and the severity of vestibular symptoms were assessed using visual analogue scale for vestibular symptoms (VAS-V). Patients were divided into the vestibular symptom relief group (VAS-V≤ 2) and the vestibular symptom persistence group (VAS-V＞2) based on the median VAS-V score at 30 days postoperatively (VAS-V median score=2). Differences in demographic information, Koos grade, and preoperative vestibular examination results were compared between the two groups. A binary logistic regression model was constructed to explore the influencing factors for the persistence of early postoperative vestibular symptoms. Results Vestibular symptoms were most pronounced on postoperative day 3, and there was no significant change in vestibular symptoms from postoperative day 7 to day 30. The most common vestibular symptoms 30 days after the surgery were dizziness and postural symptoms, in 33 cases (51.6%) and 31 cases (48.4%), respectively. Binary logistic regression analysis showed that normal video-head impulse test (vHIT) gain (OR=4.06, P=0.039), cold calorics test unilateral weekness (UW) <75% (OR=12.45, P=0.001), and gender (OR=0.22, P=0.038) were independent risk factors for the persistence of vestibular symptoms at 30 days postoperatively. Conclusions Preoperative vestibular function and gender are important factors in predicting postoperative vestibular symptoms in patients with acoustic neuroma, and the degree of preoperative vestibular function injury is negatively correlated with the duration of postoperative vestibular symptoms, which is helpful to providing references for early postoperative vestibular function recovery in patients with acoustic neuroma. [ABSTRACT FROM AUTHOR]

Hepatic alveolar echinococcosis (HAE) is a common zoonotic endemic parasitic disease in western China. It lacks of typical clinical manifestations in the early stage, and symptoms become prominent during the end stage, with an alarmingly high mortality rate. Among the treatment of end-stage HAE (es-HAE), orthotopic liver transplantation is almost the only radical treatment due to insufficient remnant liver volume, uncontrollable bleeding and difficulty in vascular reconstruction in vivo. However, the shortage of donor liver and long-term postoperative use of immunosuppressants limit its application. The introduction of ex vivo liver resection and autotransplantation (ELRA) resolves this dilemma and significantly broadens the indications of es-HAE. In addition, multiple centers in China have optimized and modified ELRA to further improve the treatment system of es-HAE. At present, liver transplantation (including ELRA) of es-HAE remains a hot topic for clinicians. In this article, orthotopic liver transplantation, ELRA, auxiliary ELRA and other surgical treatment of es-HAE were reviewed, aiming to further enhance the diagnosis and treatment of es-HAE and improve clinical prognosis of the patients. [ABSTRACT FROM AUTHOR]

前降支起源异常伴钙化在临床上较为罕见, 本文分析了 1 例前降支开口于右冠状窦 伴重度钙化病变的急性心肌梗死患者的诊疗过程, 通过讨论其介入手术策略的选择及血管内 超声对钙化病变的诊断价值, 旨在提高介入医师对此类冠状动脉畸形的认识, 强调在重度钙 化冠状动脉病变中, 血管内超声对介入方案选择的指导价值及棘突球囊对改善不良预后的重 要意义。 [ABSTRACT FROM AUTHOR]

目的　分析 2020 年 6 月—2023 年 4 月临沂地区儿童流感流行病学及甲型流感临床特征。方法　收集 2020年6月—2023年4月临沂市妇幼保健院儿科急诊及发热门诊就诊的流感样症状儿童鼻咽拭子标本6 651份，采 用多重实时荧光PCR方法进行流感病毒检测与分型鉴定；同时记录患儿性别、年龄、发病时间、症状，并后续于电子 病历系统中调取患儿实验室与影像学检查等临床资料。结果 6 651 份儿童咽拭子标本中，流感阳性 1 298 例 （19. 52%），其中甲型流感 1 015例（78. 20%）、乙型流感 283例（21. 80%）。2020年 6月—2021年 5月、2021年 6月— 2022年5月、2022年6月—2023年4月流感阳性例数分别为24例（2. 96%）、275例（10. 50%）、999例（31. 03%），各年 度比较，P均<0. 05。男性及女性流感阳性例数分别为785例（19. 91%）、513例（18. 94%），两性别比较，P>0. 05。≥1 岁者、1～3岁者、4～6岁者、7～14岁者流感阳性例数分别为172例（7. 08%）、469例（22. 04%）、466例（31. 96%）、191 例（30. 08%），4～6岁、7～14岁者与其他年龄段比较，P均<0. 05。2020年6月—2023年4月临沂地区儿童流感出现 了3次流行高发季节，其中2次甲型流感高发［2022年7月—10月（夏季）、2023年2月—4月（春季）］，1次乙型流感 高发（2021年 12月—2022年 3月）。高发季节 2022年夏季甲型流感阳性率低于 2023年春季，2022年 8月最高峰甲 型流感阳性率低于 2023年 3月最高峰，2022夏季 H1N1型、未分型甲型流感病毒低于 2023年春季，H3N2型甲型流 感病毒高于 2023 年春季，P 均<0. 05。2022 年夏季 1～3 岁者甲型流感发生例数高于 2023 年春季，7～14 岁者低于 2023年春季，P均<0. 05；2022年夏季高热、咳嗽发生例数低于 2023年春季，呕吐、腹泻、肌痛发生例数高于 2023年 春季；2022年夏季支气管炎发生例数低于2023年春季，肌炎发生例数高于2023年春季，P均<0. 05。2022年夏季甲 型流感患儿白细胞计数4～12×109 /L者高于2023年春季，≤4×109 /L者低于2023年春季，P均<0. 05。结论 2020年 6月—2023年 4月临沂地区儿童流感出现逐年增高趋势，2021年冬季到 2022年春季为乙型流感流行，而 2022年流 感高发季节为2022年7月—10月（夏季），高峰期为8月份，均为甲型流感H3N2亚型，2023年流感高发季节为2023 年 2月—4月（春季），高峰期为 3月份，以甲型流感 H1N1亚型为主；4～6岁、7～14岁流感阳性率高于其他年龄段。 高发季节夏季甲型流感儿童呕吐、腹泻等胃肠道症状较春季高发，更易引起肌炎、惊厥等并发症，而高发季节春季甲 型流感儿童易出现高热、咳嗽，更易引起支气管炎，且易发展为重症。 [ABSTRACT FROM AUTHOR]

Objective To investigate the molecular mechanism of serum complement C1q/tumor necrosis factor-related protein 13 (CTRP13) involvement in high glucose-induced filtration dysfunction in human hepatic sinusoidal endothelial cells (HLSEC). Methods HLSEC were cultured in vitro, lentiviral CTRP13 overexpression vector (LV-CTRP13) was constructed and infected with HLSEC, and the cells were divided into normal control (5.5 mmol/L glucose, NC), high glucose (25 mmol/L, HG), NC+LV-CTRP13, HG+LV-CTRP13, NC+empty control (LV-CON) group, HG+ LV-CON group, HG+LV-CTRP13+salt-inducible kinase 1 (SIK1) inhibitor (HG-9-91-01) group, HG+ LV-CON+HG-9-91-01 group, HG+LV-CTRP13+cyclic adenosine monophosphate-regulated transcriptional co-activator 2 (CRTC2) inhibitor (GW4064) group, and HG+LV-CON+GW4064 group. The mRNA and protein expression levels of CTRP13, SIK1, CRTC2, P130 Crk-related substrate (P130Cas) were detected by quantitative real-time fluorescence PCR (qRT-PCR) and Western blotting. One-way analysis of variance (ANOVA) was used for comparison between groups. Results Compared with the NC group, mRNA and protein expression of CTRP13, SIK1, and P130Cas were decreased in the HG group, and mRNA and protein expression of CRTC2 were increased (P<0.05). Compared with the HG+LV-CON group, the mRNA and protein expression of CTRP13, SIK1, and P130Cas were elevated in the HG+LV-CTRP13 group, and the mRNA and protein expression of CRTC2 were decreased (P<0.05). Compared with the HG+LV-CTRP13 group, the mRNA and protein expression of CRTC2 was elevated in the HG+LV-CTRP13+HG-9-91-01 group, while the mRNA and protein expression of SIK1 and P130 Crk-associated substrate were decreased (P<0.05). Compared with the HG+LV-CTRP13 group, the mRNA and protein expression of CRTC2 was decreased in the HG+LV-CTRP13+GW4064 group, and the mRNA and protein expression of P130Cas was increased (P<0.05). Conclusion CTRP13, SIK1, CRTC2, and P130Cas are involved in high-glucose-induced HLSEC filtration dysfunction, and CTRP13 overexpression inhibits high-glucose-induced HLSEC filtration dysfunction through a mechanism mediated through the SIK1/CRTC2 pathway. [ABSTRACT FROM AUTHOR]

With the rapid development of urbanization, the vast rural areas of our country are facing the problem of "hollowing". In the context of new urbanization, how to achieve rural revitalization requires further research in the field of rural settlements. The visual analysis tool Citespace is used to quantitatively analyze the literature in the field of rural settlements in domestic and foreign in this paper, drawing research hotspots and development trends through keyword co-occurrence and mutation analysis, and combining domestic articles with geography, landscape ecology, etc. The development status of the field in various disciplines was analyzed. The results are as follows. 1) The current researches have pay more attention on the endogenous growth mechanism of rural settlement development and the problem of disorderly development in rural construction. 2) The development trend of domestic rural settlements focuses on the spatial pattern, influencing factors, and rural revitalization. 3) This field has more research perspectives abroad, and its development momentum in China is stronger. 4) The research of geography in this field is more comprehensive. Landscape ecology is the future research trend of this field. Architecture and urban and rural planning have a certain degree of research, but there are fewer keywords related to them. They have not been sufficiently developed from the perspective of humanities. The research results can provide a certain reference significance for tracking current research hotspots and development trends at home and abroad, conduciving more research and sustainable development of rural settlements. [ABSTRACT FROM AUTHOR]

Mitika is an important representative plateau wetland in China. In order to study the spatial distribution characteristics and pollution status of heavy metals in the surface soil of the wetland, 25 surface soils were collected. The pollution of heavy metals (Cu, Zn, Cr, Ni, Pb, Cd, As and Hg) in wetland soil was evaluated by geo-accumulation index method and potential ecological risk index (RI). The results showed that the average concentrations of Cu, Cr, Ni and Pb in wetland soil in the study area were lower than the background value of Tibet soil, while the average concentrations of Zn, Cd, As and Hg are 1.11, 1.75, 1.15 and 1.53 times of the background value respectively, which was far lower than the risk screening value of GB 15618-2018 soil environmental quality standard, standard for soil pollution risk control of agricultural land (Trial); Except that the accumulation index of Cd element was 0.08, which was slightly polluted, other elements were at the pollution-free level; The potential ecological risk in the study area was moderate, which was mainly related to the accumulation of Hg in the environment and the local low background value; Cu, Zn, Cr, Ni, Pb, Cd and As were mainly from natural sources. Hg was greatly affected by human activities, which brought certain risks to the ecological environment and need to attention. However, the overall environmental quality of wetlands was better than that of other wetlands in China. [ABSTRACT FROM AUTHOR]

Objective To explore the mechanism of microRNA （miRNA）-365a-3p affecting the function of vascular endothelial cells involved in the pathogenesis of preeclampsia （PE）. Methods Primary human umbilical vein endothelial cells （HUVECs） were set as a NC group （transfected miR-365a-3p NC）， a mimics group （trans-fected miR-365a-3p mimics） and a inhibitor group （transfected miR-365a-3p inhibitor）. Logarithmic HUVECs cells were set as the blank group. The cell proliferation， migration and angiogenesis in each group were detected. Dual luciferin assay verified the targeting relationship between miR-365a-3p and downstream gene. The protein expressions of TGF-β1， Smad4 and Smad7 in each group were detected. Results Compared with the blank group and the NC group， the absorbance value and mobility of 24， 48 and 72 h were decreased （P < 0.05）， the number of tubular structures per field were decreased in the mimics group （P < 0.05）， the absorbance value and mobility of 24， 48 and 72 h were increased （P < 0.05）， and the number of tubular structures per field were increased in the inhibitor group （P < 0.05）. Dual luciferin assay showed that Smad7 was a target gene of miR-365a-3p. Compared with the blank group and the NC group， the protein expressions of TGF-β1 and Smad4 in the mimics group were increased （P < 0.05）， while the protein expression of Smad7 was decreased （P < 0.05）. The protein expression levels of TGF-β1 and Smad4 in the inhibitor group were decreased （P < 0.05）， while the protein expression levels of Smad7 were increased （P < 0.05）. Conclusion miR-365a-3p may affect the function of vascular endothelial cells by regulating the downstream TGF-β signaling pathway， and thus participate in the pathogenesis of PE. [ABSTRACT FROM AUTHOR]

Aiming at the problem of multi-sensor data fusion, an adaptive weighted data fusion algorithm based on batch estimation is proposed in this paper. The algorithm uses time series and space series to calculate the variance of the collected data in batches, and uses the data consistency detection to eliminate noise points, and then obtain the adaptive factor. Then, the data is fused by adaptive weighting method to obtain the predicted value. In this paper, simulation experiments are carried out to simulate the data of the Internet of Things. The results show that the adaptive weighted multi-sensor data fusion technology of batch estimation can improve the accuracy of sensor measurement and the reliability of the system when processing data. The weighted average method reduces the root mean square error by 10% and improves the accuracy by 2.3% compared with the traditional adaptive method. [ABSTRACT FROM AUTHOR]

In the process of educational modernization, school reform has become a normal state. Only when teachers become the active supporters and driving force of school reform, can schools embark on the track of sustainable reform with growth. The most important way to support teachers to become the driving force of reform is teachers’ learning. Teachers’ learning has the functions of transmitting experience, promoting the integration among school members and creating new knowledge. It is necessary to design teachers’ learning activities according to the needs of school reform, to guide the resistance to reform in teachers’ learning activities, to advocate teachers’ learning activities oriented towards teaching research, and to create a cooperative organizational culture by cultivating small teachers’ learning teams. [ABSTRACT FROM AUTHOR]

Objective To summarize and analysis the clinical manifestations, pathological types and Testiment of pediatric lung tumors in a single center. Methods The data, including age, gender, operation time and intraoperative blood loss, of 170 children with pulmonary tumor undergoing surgical treatment from November 1989 to October 2021 was retrospectively analyzed. In descriptive analysis, counting data were described by frequency and composition ratio, while measurement data were described by median. Results Among the included 170 children with lung tumors, there were 99 males and 71 females with the median age at diagnosis of 62 months (0.8-211 months). 163 cases received lung tumors resection (100 cases of thoracotomy,63 cases of laparoscopic surgery), including 5 cases of pneumonectomy (1 case on the left side, 4 cases on the right side) with the median operation time of 73 minutes (15-300 minutes), and median intraoperative blood loss of 10ml. (2-500mL.). In the resection group, there were 57 cases (57/170,33.5%) of pleural pulmonary blastoma (PPB), 36 cases (36/170,21. 2%) of inflammatory myofibroblastoma (IMT),47 cases (47/170. 27.6%) of pulmonary metastasis, and 30 cases (30/170, 17.6%) of other tumors. Conclusion The clinical symptoms of pediatric lung tumors are not typical, imaging findings are not specific, and clinical diagnosis is difficult, and most of the tumors are malignant lesions, so early diagnosis and treatment are extremely important for prognosis. [ABSTRACT FROM AUTHOR]

UiO-66-NH2 grafted pyridineimine ligand was prepared by post synthetic modification with metal organic frameworks (MOFs) UiO-66-NH2 and 2-pyridinecarboxaldehyde as raw materials, and then a novel UiO-66-NH2 grafted pyridineimine cobalt catalyst was synthesized by complexation reaction with UiO-66-NH2 grafted pyridineimine ligand and CoCl2·6H2O as raw materials. The structure of the products was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscope, inductively coupled plasma mass spectrometry and nitrogen adsorption-desorption, and the catalytic performance of the UiO-66-NH2 grafted pyridineimine cobalt catalyst in ethylene oligomerization was investigated. The results show that the reaction temperature, Al/Co molar ratio and ethylene pressure have a significant effect on the catalytic activity and products selectivity. The catalytic activity of 1.23×105g/ (molCo·h) and 88.96% selectivity of butene are obtained under the condition of the reaction temperature 25℃, Al/Co molar ratio of 1000 and ethylene pressure of 1.0 MPa. [ABSTRACT FROM AUTHOR]

MgCl2/2-Ethylhexanol/TiCl4system was used to synthesize spherical Ziegler-Natta catalyst for ethylene polymerization, and the composite internal electron donor was added in the synthesis process:nhexyl acetate/diisobutyl phthalate was compared with tetraethoxysilane, ethyl acetate and diisobutyl phthalate as electron donors, respectively.The catalysts and polymers containing different internal electron donors were analyzed by means of X-ray diffraction (XRD), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and the catalytic performance of the catalysts was evaluated by ethylene polymerization.The results showed that under the conditions of temperature 80℃, pressure0.5 MPa and time 2 h, the catalytic activity of the catalyst containing complex internal electron donornhexyl acetate/diisobutyl phthalate was higher than that of other single internal electron donor catalysts, and the catalytic activity was 1.24×105g PE/(molTi·h). [ABSTRACT FROM AUTHOR]

嗜碱性粒细胞可能在人体适应性免疫应答中发挥重要作用。嗜碱性粒细胞在活化后才能发挥其生物学 功能。通过IgE的介导与外源抗原形成免疫复合物，B细胞分化早期所产生免疫球蛋白IgD，细胞因子（如IL-3、IL- 18及IL-33等），模式识别受体TLR等多个途径均可介导嗜碱性粒细胞的活化。活化的嗜碱性粒细胞可能通过促进 Th2型应答、增强体液免疫应答等途径，参与适应性免疫应答及免疫调节。嗜碱性粒细胞的活化可作为过敏反应的 主要效应细胞，通过降低自身免疫细胞表面FcεRI受体活性，抑制体内IgE水平，抑制B细胞的分化，参与SLE的发 生发展。嗜碱性粒细胞活化后可通过细胞表面IgE受体FcεRI，与抗原特异交联，促进Th2型细胞因子的表达水平， 进一步促进Th2细胞分化，导致Th1／Th2细胞失衡，参与RA的发病过程。 [ABSTRACT FROM AUTHOR]

Objective·To analyze the clinical characteristics and prognosis of pediatric acute leukemia (AL) patients with positive mixed linage leukemia (MLL) gene rearrangement (MLL-r). Methods·Forty-five children with MLL-r AL admitted to Shanghai Children′s Hospital, Shanghai Jiao Tong University from January 1, 2009 to December 31, 2019 were retrospectively analyzed. Fluorescence in situ hybridization and/or fluorescent real-time PCR were used to detect the MLL-r. Kaplan-Meier method was used to evaluate the survival of children. Log-rank test was used to compare the difference of survival rate. Univariate analysis and multivariate analysis were performed on the factors influencing survival, such as gender, age and the number of white blood cells. Results·The incidence rate of MLL-r in children with AL in our center was 7.1%, and the incidence rate of MLL-r in children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were 5.4% and 13.3%, respectively. The difference between the two groups was statistically significant (P=0.002). The age of the two groups of children (>1 year and ≤1 year) and the number of white blood cells at the time of onset (≥50×109/L and <50×109/L) were compared. The differences were statistically significant (P=0.032 and 0.021). The main immunophenotype of children with MLL-r ALL was early precursor B-ALL, accounting for 79.2%. The main immunophenotype of children with MLL-r AML was M5, accounting for 77.8%. MLL partner gene analysis showed that MLL/AF4 accounted for 59.2% (16/27) of MLL-r ALL children, of which 68.7% (11/16) were children younger than 1 year old. Compared with the children younger than 1 year old in the non-MLL/AF4 group, the difference was statistically significant (P= 0.034). The majority of children with MLL-r AML were MLL/AF9, accounting for 33.3%. Of the 45 patients, 42 cases were included for the prognosis analysis. The complete remission rate was 97.6% (41/42), and the median follow-up time was 26 (2‒138) months. The median event-free survival (EFS) and overall survival (OS) time were 21 months and 24.5 months, respectively. The 3-year EFS and OS rates were (41.8±9.4) % and (60.9±9.3) %, respectively. The median duration of EFS and OS in children with MLL-r ALL were 21.5 months and 28 months, respectively, and the 3-year EFS and OS rates were (44.3±11.7) % and (58.2±12.1) %, respectively. The median EFS and OS time in children with MLL-r AML were 16 months and 23 months, respectively. The 2-year EFS and OS rates were (36.5±15.8) % and (64.7±14.5) %, respectively. Eight cases of ALL children relapsed, with a median recurrence time of 20 (2 ‒ 36) months; 7 cases of AML children relapsed, with a median recurrence time of 16 (5 ‒ 38) months, and the cumulative recurrence rates were 48.4% and 63.9%, respectively. There was no statistically significant difference between them (P=0.398). Univariate analysis showed that between the groups of MLL-r ALL children >1 year and ≤1 year, white blood cell count ≥50×109/L and <50×109/L, platelet count ≥30×109/L and <30×109/L, there were statistically significant differences in the EFS rate. The P values were 0.028, 0.024 and 0.027 respectively. Multivariate analysis showed that the number of white blood cells at onset was an independent prognostic factor affecting EFS in children with MLL-r ALL (RR=6.113, 95% CI 0.017 ‒ 1.050, P=0.013). Conclusion·The incidence of MLL-r in children with AML is higher than that in children with ALL. The main immunophenotype of MLL-r ALL is early precursor B-ALL. The main immunophenotype of MLL-r AML is M5. Conventional chemotherapy produces a high response rate, which is likely to relapse. The number of white blood cells at the onset ≥50×109/L is a poor prognostic factor for children with MLL-r ALL. [ABSTRACT FROM AUTHOR]

Based on the correlation between time slices of range-gated imaging， a distributed compressed sensing 3D imaging method was proposed， which solved the conflict between a large amount of data and hardware storage performance in 3D imaging. According to the correlation， a distributed compression model based on the joint sparse model was constructed to assist the reconstruction of partial time slices. An adaptive range-gated method was designed， and the gated time was adaptively adjusted according to the set threshold， without distance prior information， which increases system flexibility. The results show that when the average sampling rate is 0.15， the imaging quality of this method is 11.124dB higher than that of the traditional method， and the average error of imaging distance is reduced by 6.240. The distributed imaging method can effectively reduce the collection of time slice redundant information， providing a new idea for range-gated 3D imaging. [ABSTRACT FROM AUTHOR]

The boom of the network short video poses a series of practical challenges to the ideological and political education of college students: the tendency of pan entertainment will impact their ideological conscious- ness, the prevalence of hedonism will dispel their value system, and the supremacy of individualism will weaken their social responsibility. For this reason, we should not only strengthen ideological guidance, build a solid ideo- logical and political education position, but also integrate network resources, improve the mechanism of collaborative education, but also improve the corresponding legal provisions, strengthen network supervision, and create a clean network environment. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of serum homocysteine (Hcy), folic acid and vitamin B12 levels with the severity of coronary artery disease. Methods: 220 patients with stable coronary heart disease diagnosed by coronary angiography were selected as the study group, and 100 healthy volunteers were selected as the control group. Serum levels of Hcy, folic acid, vitamin B12 and N-terminal brain natriuretic peptide precursor (NT-proBNP) were measured and compared between the two groups. The study group was evaluated by SYNTAX score based on coronary angiography, and left ventricular ejection fraction (LVEF) was detected by echocardiography to determine the severity of coronary artery disease. The above indexes of SYNTAX patients with low score (1~22 points), middle score (23~32 points) and high score (≥ 33 points) in the study group were compared. The relationship between serum Hcy, folic acid, vitamin B12 levels with serum NT-proBNP level, SYNTAX score and LVEF in the study group was analyzed. Results: Compared with those of the control group, the serum levels of Hcy and NT-proBNP level of the study group increased while the serum levels of folic acid and vitamin B12 level in the study group decreased (P<0.05). The average SYNTAX score and LVEF in the study group were (28.76±6.58) and (47.33±8.66) % respectively. The serum levels of Hcy and NT-proBNP in patients with middle and high SYNTAX score were higher than those in patients with low SYNTAX score, while serum levels of folic acid, vitamin B12 and LVEF in patients with middle and high SYNTAX score were lower than those in patients with low SYNTAX score; The serum levels of Hcy and NT-proBNP in patients with high SYNTAX score were higher than those in patients with middle SYNTAX score, while serum levels of folic acid, vitamin B12 and LVEF in patients with high SYNTAX score were lower than those in patients with middle SYNTAX score P<0.05). Pearson linear correlation analysis showed that serum Hcy level was positively correlated with serum NT-proBNP level and SYNTAX score (r=0.881, 0.793, P<0.05), negatively correlated with LVEF (r=-0.876, P<0.05), while serum folic acid and vitamin B12 levels were negatively correlated with serum NT-proBNP level and SYNTAX score (folic acid: r=-0.786, -0.825; 12: r=-0.884, -0.818, P<0.05), which was positively correlated with the LVEF (r = 0.893, 0.859, P<0.05). Conclusion: Serum Hcy is an important risk factor for coronary heart disease and its level increases with the aggravation of coronary artery lesions. In contrast, serum folic acid and vitamin B12 are protective factors and their levels decrease with the aggravation of coronary artery lesions. [ABSTRACT FROM AUTHOR]

Objective To explore the epidemic trend and spatio-temporal characteristics of colorectal cancer in Jiading District of Shanghai，China，and to provide evidence for prevention and control of colorectal cancer and rational allocation of health resources. Methods The data of colorectal cancer in Jiading District of Shanghai from 1996 to 2016 was collected.The incidence rate was calculated，and spatial and temporal scanning was used to analyze the spatial aggregation of colorectal cancer. Results From 1996 to 2016，a total of 4 279 cases of colorectal cancer were reported in Jiading District of Shanghai，with a crude incidence of 36.2/100 000 and a standardized incidence of 16.4/100 000.Colon cancer accounted for 58.0%，the standardized incidence of colon cancer was on the rise with fluctuation. The number and incidence of rectal cancer were lower than that of colon cancer，accounting for 42.0%. The standardized incidence of colon and rectal cancers were generally higher in male than in female，and the standardized incidence of colon and rectal cancer by town had significant differences.In addition，a cluster was detected by spatial scanning statistics. We also found that the age distribution of 2 clusters of colon cancer and 1 cluster of rectal cancer were statistically different from that of the remaining areas outside the circle. Conclusion The incidence of colorectal cancer in Jiading District of Shanghai showed an upward trend， and the incidence of colorectal cancer may have a tendency of spatial aggregation.The results of this study can provide reference for the prevention and resource allocation of colorectal cancer. [ABSTRACT FROM AUTHOR]

Objective: To investigate of the clinical effect of dexmedetomidine on the elderly mental illness patients without electroconvulsive therapy. Methods: 60 elderly mental illness patients who underwent with electroconvulsive therapy in our hospital from September 2015 to February 2019 were enrolled in this study. They were divided into divided into the dexmedetomidine group and control group accorded to the random number table method, 30 cases in each group. The two groups were given intravenous anesthesia with propofol, and the dexmedetomidine group was given a short bolus injection with dexmedetomidine 0.2µg/kg (20 mL) 10 min before electroconvulsive therapy, and the control group was bolused with 20 mL of normal saline. Record and compare the anesthetic effect of the two groups and the vital signs fluctuations. Results: The amount of propofol, recovery time and recovery time of the dexmedetomidine group were significantly lower or shorter than in the control group (P<0.05). The systolic blood pressure, diastolic blood pressure and heart rate of the two groups before anesthesia and without electroconvulsive shock for 20 min were within the normal range. There was no significant difference between the two groups (P>0.05). There were no significant differences in serum IgA and IgM between the two groups before and after treatment (P>0.05). The incidence of adverse reactions such as irritability, panic attacks, delayed recovery, headache, nausea and vomiting during the dexmedetomidine group were 6.7%, which was significantly lower than of the control group (36.7%, P<0.05). Conclusions: Dexmedetomidine for the treatment of elderly mental illness patients without convulsion electroconvulsive therapy will not have a negative impact on the vital signs and immune function of the body, can reduce the amount of propofol, improve the anesthetic effect, and have higher safety. [ABSTRACT FROM AUTHOR]

Objectives: To investigate pathological subtypes, clinical characteristics and prognosis of patients with breast hemato-logical malignancies. Methods: We conducted a retrospective review of Xijing Hospital of Air Force Medical University for hematological malignancies diagnosed in breast tissue form Jan.2014 to Jan.2019). Pathological subtypes, clinical characteristics, and patient outcomes were analyzed. Results: We identified 33 cases, 32 of them were female, with a mean age of 45.5 years (12-78 years). By pathological diagnosis of 30 cases were lymphomas which included 29 (29/33, 87 .9 %) Non-Hodgkin lymphoma (NHL) and 1(1133, 3.0%) Hodgkin lymphoma and 3 (3/33, 9.1 %) were recurrence of acute leukemias. The 29 NHL cases included 18 (18/29, 62.1%) diffuse large B-cell lymphomas (DLBCLs), 3 (3/29, 10.3%) NK/T cell lymphomas, 2 (2/29, 6.8%) B lymphoblastic leukemia/lymphomas (B-ALLILBLs), 1 (1129, 3.4%) each of follicular lymphoma (FL), Burkitt lymphoma, primary cutaneous anaplastic large cell lymphoma (C-ALCL) and 3 (3/29, 10.3%) lymphomas-not otherwise specified. In total, 9 (57.6%) cases were primary, which were all lymphomas, and 14 (42.4%) cases were secondary to the breast. Our study sh owed the lesions were mainly involved in the right breast (18/33, 54.5%), followed by the left breast (1 0/33, 30. 3%), and were rarely involved in both sides(5/33, 15.2 %) . 19 primary cases had high er platelet count (P=O .004), significantly lower β2-MG (P=0.0 49), less B symptoms(P=0.017)and bone marrow involvement(P< 0 .01), more were Ann Arbor stage I-II (P< 0.01) than secondary ones. Significant statistical difference in OS is shown between primary cases and secondary ones (HR=9.846, P=0.002). Patients with marrow involvement had worse overall survival (OS) than those without marrow involvement (HR=6.434, P< 0.01). Conclusions: The majority of breast hematological malignancies patients are middle-aged females. Primary hematological malignancies of the breast are more common than secondary ones: 57.5% versus 42.5%. Our study showed that the most common hemato-logical malignancy was DLBCL, with the right breast mass as the main clinical manifestation. Primary cases had significant higher platelet count, lower β2-MG, less B symptoms and bone marrow involvement, more were Ann Arbor stage I-II than secondary ones. Moreover, primary cases had better OS than secondary ones. Patients with marrow involvement was associated with an inferior outcome. [ABSTRACT FROM AUTHOR]

Personnel training is the foundation of Healthy Chin逅 and the new era has put fonvard high-quality requirements for the training of high-level applied public health personneL This study aims to construct the path and measures of domestic high-level applied public health personnel, in order to provide reference for the talent training in China. Through literature research on public health education in China and the United States, this study summarizes the background, current situation, and connotation of the training of high-level applied public health talents in China, draws on the experience and inspirations of the United States, and raises suggestions on the development of China's training of high-level applied public health personneL China can carry out the training of high-level applied public health talents from the perspective of macro-social ecology and micro-path. For the specific micro-path, we can start with educational concept, training plan, teaching staffs training mode, and evaluation mechanism to improve the quality of public health education. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical characteristics and risk factors of mixed connective tissue disease associated with pulmonary arterial hypertension (MCTD-PAH). Methods Twelve MCTD-PAH patients diagnosed by right heart catheterization (RHC) at Tianjin Medical University General Hospital were retrospectively included, and 36 MCTD patients without pulmonary arterial hypertension (MCTD-non-PAH) were randomly selected from the same period of hospitalization based on gender and age. The clinical features and auxiliary examination of the two groups were compared, and the survival status of the two groups was compared. Results The proportion of dyspnea after activity, myositis and pericardial effusion were higher in the MCTD-PAH group than those of the control group. Serum sedimentation rate and immunoglobulin G (IgG) levels were higher in the MCTD-PAH group. Multivariate Logistic regression analysis showed that dyspnea after activity and high level of IgG were risk factors for predicting the occurrence of PAH in MCTD. Three patients (16.7%) died in the MCTD-PAH group, and no patients died in the control group. Conclusion Pulmonary arterial hypertension is one of the serious complications of MCTD. MCTD patients have shortness of breath after activity and high level of IgG should be wary of concomitant PAH. [ABSTRACT FROM AUTHOR]

Idiopathic inflammatory myopathy (IIM) is a heterogeneous autoimmune disease of unknown etiology characterized by proximal limb muscle involvement and chronic inflammation. Multiple systems may be involved, with interstitial lung disease (ILD) being the most common manifestation of respiratory system involvement in IIM. This article summarizes the current methods of myositis animal models and myositis-associated ILD model construction methods, so as to provide reference for the subsequent construction and research of IIM-ILD models. [ABSTRACT FROM AUTHOR]

Objective To explore the correlation between simulated defecography and TCM patterns. Methods Patients with chronic constipation (几=80) were diagnosed as the following patterns: liver-qi stagnation, spleen-lung qi deficiency, spleen-kidney yang deficiency and liver-kidney yin deficiency. PACS system was used to examine patients and collect imaging data. Their correlation was analyzed. Results Through the interpretation of corresponding TCM patterns and defecographical findings, different TCM patterns and related defecography manifestations were distinguished in different quadrants. Specificity analysis showed that there was a strong correlation between spleen-lung qi deficiency and spleen-kidney yang deficiency, while there were significant differences between liver-kidney yin deficiency and liver-qi stagnation. There was no significant difference between the symptoms and signs of perineal descent and mucosal intussusception. Puborectalis syndrome was more specific. Liver-qi stagnation was strongly correlated with puborec talis syndrome, while liver-kidney yin deficiency was strongly correlated with mucosal prolapse and rectocele. Spleen-lung qi deficiency and spleen-kidney yang deficiency were more likely to lead to perineal descent, mucosal intussusception, sacrum-rectal separae, small intestinal hernia and sigmoid hernia. Conclusion The study found that there was a certain correlation between defecographic findings and TCM patterns. It may provide the basis for clinical treatment based on pattern diagnosis and may promote the development of dialectical and objective differentiation of traditional Chinese medicine. [ABSTRACT FROM AUTHOR]

Objective To study the clinical value of bevacizumab combined with cisplatin in the treatment of malignant pleural effusion of lung adenocarcinoma. Methods 68 patients with malignant pleural effusion of lung adenocarcinoma admitted to our hospital from August 2015 to August 2017 were included in the study and divided into study group and control group according to computer table method. The control group was given cisplatin, and the study group was given cisplatin and bevacizumab. Then the short- term effects were compared in the two groups after 1 week of treatment. The results of vascular endothelial growth factor （VEGF） measurement and adverse reactions in the pleural effusion after 4 weeks of treatment were observed. Results The total effective rate （85.29%） in the study group was significantly higher than that in the control group （61.76%） . There was a statistically significant difference between the two groups. The incidence of adverse reactions in the study group was 23.53% （2 cases of I° myelosuppression， 6 cases） of gastrointestinal reaction，）， 32.35% in the control group （3 cases of I° myelosuppression， 8 cases of digestive tract reaction）；the VEGF level of the study group decreased significantly after treatment， and there was no statistically significant change in the control group. Conclusion Bevacizumab combined with cisplatin infusion for the treatment of malignant pleural effusion of lung adenocarcinoma is effective, which can effectively improve the short- term efficacy of patients. In addition, pleural VEGF may also be used as a curative effect ofmalignant pleural effusion of lung adenocarcinoma. [ABSTRACT FROM AUTHOR]

Ｏｂｊｅｃｔｉｖｅ　Ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｖａｌｕｅ ｏｆ ｃｏｍｐｕｔｅｄ ｔｏｍｏｇｒａｐｈｙ （ＣＴ） ｔｅｘｔｕｒｅ ａｎａｌｙｓｉｓ ｉｎ ｄｉｆｆｅｒｅｎｔｉａｌ ｄｉａｇｎｏｓｉｓ ｏｆ ｉｎｆｌａｍｍａｔｏｒｙ ａｎｄ ｍａｌｉｇｎａｎｔ ｐｕｌｍｏｎａｒｙ ｎｏｄｕｌｅｓ． Ｍｅｔｈｏｄｓ　Ｔｈｅ ｉｍａｇｅ ｄａｔａ ｏｆ ５４ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｌｕｎｇ ｃａｎｃｅｒ ａｎｄ ３６ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｐｕｌｍｏｎａｒｙ ｉｎｆｌａｍｍａｔｏｒｙ ｎｏｄｕｌｅｓ ｗｅｒｅ ｒｅｔｒｏｓｐｅｃｔｉｖｅｌｙ ｃｏｌｌｅｃｔｅｄ ｉｎ ｏｕｒ ｈｏｓｐｉｔａｌ． Ａｌｌ ｔｈｅ ｐａｔｉｅｎｔｓ ｒｅｃｅｉｖｅｄ ｃｈｅｓｔ ＣＴ ｓｃａｎ． ＣＴ ｔｅｘｔｕｒｅ ａｎａｌｙｓｉｓ ｏｆ ｅｎｔｒｏｐｙ， ｃｏｒｒｅｌａｔｉｏｎ ｄｅｇｒｅｅ ａｎｄ ｃｏｎｔｒａｓｔ ｒａｔｉｏ ｗｅｒｅ ｐｅｒｆｏｒｍｅｄ ｂｙ ｔｈｅ ＭａＺｄａ ｓｏｆｔｗａｒｅ． Ｔｈｅ ｒｅｃｅｉｖｅｒ ｏｐｅｒａｔｉｎｇ ｃｈａｒａｃｔｅｒｉｓｔｉｃ ｃｕｒｖｅ （ＲＯＣ） ｗａｓ ｅｓｔａｂｌｉｓｈｅｄ ａｎｄ ｔｈｅ ａｒｅａ ｕｎｄｅｒ ｔｈｅ ｃｕｒｖｅ （ＡＵＣ） ｗａｓ ｃａｌｃｕｌａｔｅｄ ｔｏ ｅｖａｌｕａｔｅ ｔｈｅ ｖａｌｕｅ ｏｆ ＣＴ ｔｅｘｔｕｒｅ ａｎａｌｙｓｉｓ ｉｎ ｄｉｆｆｅｒｅｎｔｉａｌ ｄｉａｇｎｏｓｉｓ ｏｆ ｉｎｆｌａｍｍａｔｏｒｙ ａｎｄ ｍａｌｉｇｎａｎｔ ｐｕｌｍｏｎａｒｙ ｎｏｄｕｌｅｓ． Ｒｅｓｕｌｔｓ　Ｉｎ ｔｈｅ ｌｕｎｇ ｃａｎｃｅｒ ｇｒｏｕｐ， ｔｈｅ ｖａｌｕｅ ｏｆ ｅｎｔｒｏｐｙ， ｃｏｒｒｅｌａｔｉｏｎ ｄｅｇｒｅｅ ａｎｄ ｃｏｎｔｒａｓｔ ｒａｔｉｏ ｗｅｒｅ １．５８±０．０７， ０．０２±０．１７ ａｎｄ ８．７９±２．５９， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｉｎ ｔｈｅ ｉｎｆｌａｍｍａｔｏｒｙ ｎｏｄｕｌｅｓ ｇｒｏｕｐ， ｔｈｅ ｖａｌｕｅ ｏｆ ｅｎｔｒｏｐｙ， ｃｏｒｒｅｌａｔｉｏｎ ｄｅｇｒｅｅ ａｎｄ ｃｏｎｔｒａｓｔ ｒａｔｉｏ ｗｅｒｅ １． ５１ ± ０． ０４， ０． ２２ ± ０． １６ ａｎｄ １２． ５３ ± ２． ２４， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｔｈｅ ｄｉｆｆｅｒｅｎｃｅｓ ｗｅｒｅ ａｌｌ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ （Ｐ ｖａｌｕｅｓ ｗｅｒｅ ０．００８， ０．０２７， ａｎｄ ０．００６， ｒｅｓｐｅｃｔｉｖｅｌｙ） ｂｅｔｗｅｅｎ ｔｗｏ ｇｒｏｕｐｓ． Ｔｈｅｒｅ ｗａｓ ｎｏｔ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ （Ｐ＞０．０５） ｉｎ ｔｈｅ ＣＴ ｖａｌｕｅｓ ｂｅｔｗｅｅｎ ｔｈｅ ｌｕｎｇ ｃａｎｃｅｒ ｇｒｏｕｐ ａｎｄ ｔｈｅ ｉｎｆｌａｍｍａｔｏｒｙ ｎｏｄｕｌｅ ｇｒｏｕｐ ｂａｓｅｄ ｏｎ ｔｈｅ ｎｏｎ⁃ｃｏｎｔｒａｓｔ ｅｎｈａｎｃｅｄ ＣＴ ｓｃａｎ． Ｍｅａｎｗｈｉｌｅ， ｔｈｅｒｅ ｗａｓ ｎｏ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ （Ｐ ＞ ０．０５） ｉｎ ｔｈｅ ｖａｌｕｅ ｏｆ ｅｎｔｒｏｐｙ， ｃｏｒｒｅｌａｔｉｏｎ ｄｅｇｒｅｅ ｏｒ ｃｏｎｔｒａｓｔ ｒａｔｉｏ ｂｅｔｗｅｅｎ ｔｗｏ ｇｒｏｕｐｓ ｂａｓｅｄ ｏｎ ａｒｔｅｒｉａｌ ｐｈａｓｅ ｏｒ ｖｅｎｏｕｓ ｐｈａｓｅ ｏｆ ｃｏｎｔｒａｓｔ ｅｎｈａｎｃｅｄ ＣＴ． Ｔｈｅ ＲＯＣ ａｎａｌｙｓｉｓ ｓｈｏｗｅｄ ｔｈａｔ ｔｈｅ ＡＵＣ ｉｎ ｄｉｆｆｅｒｅｎｔｉａｔｉｎｇ ｔｈｅ ｌｕｎｇ ｃａｎｃｅｒ ａｎｄ ｉｎｆｌａｍｍａｔｏｒｙ ｎｏｄｕｌｅｓ ｗａｓ ０．８２１， ０．７７８ ａｎｄ ０．８７５， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｔｈｅ ＡＵＣ ｏｆ ｃｏｍｂｉｎａｔｉｏｎ ｏｆ ｔｈｒｅｅ ｐｈａｓｅｓ ｗａｓ ０．９３１， ｗｈｉｃｈ ｗａｓ ｈｉｇｈｅｒ ｔｈａｎ ｔｈｅ ＡＵＣ ｏｆ ｅｎｔｒｏｐｙ， ｃｏｒｒｅｌａｔｉｏｎ ｄｅｇｒｅｅ ａｎｄ ｃｏｎｔｒａｓｔ ｒａｔｉｏ ｒｅｓｐｅｃｔｉｖｅｌｙ （Ｐ＜０．０１）． Ｔｈｅ ｓｅｎｓｉｔｉｖｉｔｙ ｗａｓ ８８．９％， ａｎｄ ｔｈｅ ｓｐｅｃｉｆｉｃｉｔｙ ｗａｓ ８７．５％． Ｃｏｎｃｌｕｓｉｏｎ　ＣＴ ｔｅｘｔｕｒｅ ａｎａｌｙｓｉｓ ｉｓ ａ ｈｉｇｈ⁃ｐｏｔｅｎｔｉａｌ ｉｍａｇｅ ａｎａｌｙｓｉｓ ｍｅｔｈｏｄ， ｗｈｉｃｈ ｃａｎ ｐｒｏｖｉｄｅ ｍｏｒｅ ｉｎｆｏｒｍａｔｉｏｎ ｆｏｒ ｔｈｅ ｄｉｆｆｅｒｅｎｔｉａｌ ｄｉａｇｎｏｓｉｓ ｏｆ ｂｅｎｉｇｎ ａｎｄ ｍａｌｉｇｎａｎｔ ｐｕｌｍｏｎａｒｙ ｎｏｄｕｌｅｓ． [ABSTRACT FROM AUTHOR]

目的观察体外受精－ 胚胎移植( IVF-ET) 周期中扳机后12 ~ 13h 患者血清人绒毛膜促性腺激索 ( HCG)水平对周期结局的影响。方法回顾性分析 645 例不孕患者的临床资料，共行人工助孕656 个质期，其中 IVF 周期 480 个、卵质内单精子注射 (ICSI) 周期 176 个。根据扳机后12 ~ 13 h 血清 HCG 水平将患者分为低、中、高 水平，分别为A、B、C 三组。比较三组获卵率、M II 卵率、受精率、优胚率、卵裂率、重度卵巢过度剌激综合征( OHSS) 发生率、着床率、临床妊娠率及活产率差异， 并分析HCG 水平与获卵率、M II 卵率及受精率的相关性。结果在 IVF/ICSI 周期中， A 组获卵率低于B 组和C 组( P 均<0.05), B 组、C 组获卵率差异无统计学意义；三组获卵率与血 清HCG 水平呈正相关(r = 0.082, P < 0.05) ， 三组优胚率、卵裂率、重度 OHSS 发生率、着床率、临床妊娠率和活产 率差异均无统计学慈义。在IVF 周期中， A 组受精率均低于B 组、C 组( P 均<0.05), B 组、C 组受精率差异无统计 学意义，三组受精率与血清 HCG 水平无明显相关性(r = - 0.058, P>0.05)。在ICSI 周期中， A 组M II 卵率低于C 组(P < 0.05) ，三组M II 卵率与血清 HCG 水平呈正相关(r = 0.183,P < 0.05) ; A 组受精率低于C 组(P < 0.05) ， 三 组受精率与血清HCG 水平无明显相关性(r = 0.033, P > 0.05) 。结论在 IVF/ICSI 周期中， 扳机后12 ~ 13 h 血清 HCG 水平越低，其获卵率、成熟率及受精率会越低。 [ABSTRACT FROM AUTHOR]

Objective：To evaluate the cryopreservation effects of the programmed freezing and the vitrification freezing on human ovarian tissue. Methods: Human ovarian tissue specimens of 19 endometrial carcinoma cases were collected. The tissue specimen was divided into two parts: one was cryopreserved with the programmed freezing (the group A), and another with the vitrification freezing （ｔhe group B）． 38 SCID nude mice （transplanted host）were equally divided into two groups，and the thawed human ovarian tissues from the two groups were transplanted to jugular subcutaeous. The day of transplanted host received ovariectomy was defined as D0, while the day of human ovarian tissue transplanted defined as D21. The vaginal cytology examination of transplanted host was performed daily for observation of estrous cycle until D63. The levels of serum AMH on D0, D21, D42 and D63 were measured using ELISA. Results: The estrous cycle of the ovariectomy mice disappeared. A total of 14 transplanted hosts in two groups recovered the estrous cycle up to D63，and there was no significant difference between the two groupｓ （８ in the group A and 6 in the group B, P＞0.0５）． However, the recovering time of the estrous cycle in the group A was significantly shorter than that in the group B [(16.38±1.60) d vs. (18.33 ±1.21)d, P＜0.05]． There were no significant differences in the AMH levels on D0, D21, D42 and D63 between the two groupｓ （Ｐ＞0.05）． The AMH level on D21 was significantly lower than that on D0 in the group A or B (all P<0.05). The AMH level in those transplanted hosts who had recovered estrous cycle on D42 and D63 was recovered but did not return to the level on D0, while the AMH level in the transplanted hosts who had not recovered their estrous cycle on D42 and D63 did not rebound and was still significantly lower than that on D0. Conclusions: Both the programmed freezing and the vitrification freezing can effectively preserve ovarian tissue. [ABSTRACT FROM AUTHOR]

： Bismuth ferrite (BiFeO3) powders were prepared by chemical co-precipitation method. The BFO precursors were prepared by using Bi(NO3)3 • 5H2 O and Fe(NO3)3 • 9H2O as raw materials，dilute nitric acid as solvent and sodium hydroxide as precipitant. Then the BiFeO3 powders were obtained after calcination. The effect of pH value and calcining process on structure and photocatalysis of BFO was discussed. The powders were characterized by XRD and SEM. The results showed that when the pH value of the precipitation system was within the range of 8-11，the pure phase BFO powders were acquired by calcining for 2 h at 600 °C. The pure phase BFO powders showed excellent visible light photocatalytic activity. The photocatalytic degradation rate was increased with the increase of crystal size of BFO. [ABSTRACT FROM AUTHOR]

目的对比分析慢速冷冻法、玻璃化冷冻法保存小鼠卵巢组织的效果。方法将BALB/C雌性小 鼠随机均分为慢速冷冻组、玻璃化冷冻组，取卵巢组织后分别进行慢速冷冻、玻璃化冷冻。冷冻21天结束 时，取卵巢组织进行病理学观察，比较两组各级卵泡正常率；采用免疫组化法检测卵巢组织中血管生成素2 (Ang-2)及其受体酪氨酸激酶受体2 (Tie-2)表达。结果慢速冷冻组始基卵泡正常率高于玻璃化冷冻组 (P<0.05 )，初级卵泡、次级卵泡正常率比较差异均无统计学意义（P均>0.05)。两组颗粒细胞冷冻前 Ang-2( + + + )、Tie-2( + + + )阳性表达率均高于冷冻后，慢速冷冻组解冻后颗粒细胞Ang-2( + + + )、 Tie-2( + + + )阳性表达率均高于玻璃化冷冻组；两组卵泡膜细胞冷冻前Ang-2、Tie-2阳性表达率均高于冷冻 后，慢速冷冻组解冻后卵泡膜细胞Ang-2、Tie-2阳性表达率均高于玻璃化冷冻组；组间及组内比较/^均< 0.05(结论慢速冷冻法、玻璃化冷冻法均会损伤卵巢组织内各级卵泡，并导致Ang-2、Tie-2表达变化，但慢 速冷冻法对卵巢组织的损伤更小。 [ABSTRACT FROM AUTHOR]

Objective: To explore the association between the two single nucleotide polymorphisms(SNPs) of LKB1(Live kinase B1) gene rs741765(380 C>T) and rs6510599(459 G>A) with type 2 diabetes mellitus(T2DM) and clinical and metabolic traits in Han people from Shanxi, China. Methods: A single allele specific prime polymerase chain reaction(SASP-PCR) was used to screen the SNP of LKB1 gene rs741765(380 C>T) and rs6510599(459 G>A) in 130 cases of T2DM and 100 cases of normal control group, and sequenced the PCR products. A nalyzed the single nucleotide polymorphisms with related clinical and metabolic traits. Results: LKB1 gene rs741765(380 C>T) mutation: TT genotype frequencies were higher in T2DM group than in normal control group(P=0.023). The level of HbA1c and LDL-c were higher in TT genotype than in other genotype in T2DM group(P=0.030; P=0.002). The level of FPG was higher in TT genotype than in other genotype in normal control group(P=0.011). rs6510599(459 G>A) mutation: There were no significant differences in AA genotye frequencies between T2DM group and normal control group(P>0.05). rs6510599(459 G>A) was not correlated with clinical traits(P>0.05). Conclusion: There were SNPs in rs741765(380 C>T) and rs6510599(459 G>A) in the population of Shanxi province. LKB1 gene rs741765(380 C>T) was significantly correlated with T2DM in the population of Shanxi province; rs6510599(459 G>A) SNP was not correlated with T2DM in the population of Shanxi province. [ABSTRACT FROM AUTHOR]

Objective: To study the curative efficacy of oxiracetam combined with maixuekang capsule in the treatment of acute cerebral infarction and its effects on the serum vascular cell adhesion molecule-1 (VCAM-l).cell adhesion molecule-1 (ICAM-1),Matrix metalloproteinase -9 (MMP-9) levels. Methods: 90 patients with acute cerebral infarction who were treated from March 2014 to March 2015 in our hospital were selected as the research objects. According to the draw method, those patients were divided into the experimental group (n=45) and the control group (n=45). Both groups were treated with conventional therapy, such as lipid regulation, anti-platelet, blood circulation activation and removment of blood stasis, maintainance of electrolyte balance, nerve protection and reduction of intracranial pressure, oxygen therapy if necessary. The control group was treated with oxiracetam injection additionally, each time 4G. added in 250 mL saline for intravenous drip, 1 times a day. While the observation group was treated with maixuekang capsule based on the control group, 3 tablets each time, 3 times a day. Two groups were treated for a period of 3 weeks. Then the clinical efficacy, changes of NIHSS score, serum VCAM-1, ICAM-1. MMP-9, MMSE. ADL score before and after treatment as well as the incidence of adverse reaction were compared between two groups. Results: The total effective rate of experimental group was significantly higher than that of the control group (P<0.05): the NIHSS score was significantly lower than that of the control group (P<0.05): the VCAM-1, ICAM-1. MMP-9 levels were significantly lower than those of the control group (P<0.05); the MMSE. ADL score were significantly higher than those of the control group (P<0.05); the incidence of adverse reactions was significantly lower than that of the control group (P<0.05). Conclusion: Oxiracetam combined with maixuekang capsule could enhance the efficacy of acute cerebral infarction, it could promote the recovery of nerve function, which might be related to regulate the levels of serum VCAM-1. ICAM-1 and MMP-9 levels and further improve the function of vascular endothelium. [ABSTRACT FROM AUTHOR]

Objective：To investigate the effect of enhanced recovery after surgery (ERAS) program used in patients undergoing laparoscopic hysterectomy. Methods：A retrospective analysis of 87 cases of laparoscopic total hysterectomy in China PLA General Hospital from January 2016 to January 2017 was selected. All patients were divided into two groups according to the recovery management. The observation group (42 cases) received the enhanced recovery after surgery program during the anesthesia period, and the control group (45 cases) received routine recovery management. There was no significant difference between the two groups in age, body mass index (BMI), history of abdominal surgery, operation time, intraoperative blood loss and disease constitution (P＞0.05). The indexes of postoperative recovery and the medical satisfaction between the two groups were observed and recorded. Results：The postoperative exhaust time, indwelling catheter time, mobilization time, average length of stay and average hospitalization expenses of the observation group were less than those of the control group, the difference was statistically significant (P＜0.05). There were no significant differences in the incidence of complications between the two groups(P＞0.05). The medical satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (90.5% vs. 73.3%, χ2=4.254, P=0.039). Conclusions：For patients undergoing laparoscopic hysterectomy, enhanced recovery program can accelerate postoperative recovery and improve medical satisfaction. 【Keywords】 Perioperative nursing；Laparoscopes；Gynecologic surgical procedures；Hysterectomy；Enhanced recovery after surgery；Recovery management [ABSTRACT FROM AUTHOR]

报道1例在合肥市第一人民医院（安徽医科大学第三附属医院）内分泌科诊治的新诊断 合并代谢综合征的2型糖尿病（T2DM）患者, 应用胰岛素强化降糖治疗后转换为德谷胰岛素利拉鲁肽 注射液联合口服药物治疗的诊治过程。患者为59岁男性, 主因口干、多饮、多尿半年余就诊。患者体 重指数（BMI）28.1 kg/m2, 腰围92 cm, 糖化血红蛋白（HbA1c）9.9%, 甘油三酯3.09 mmol/L, 高密度脂蛋 白胆固醇0.71 mmol/L, 主要诊断为T2DM、高血压病、代谢综合征。入院后予皮下胰岛素泵强化降糖 治疗, 根据血糖监测情况调整胰岛素泵剂量, 治疗5 d后患者血糖较前明显改善, 停用胰岛素泵, 改为 德谷胰岛素利拉鲁肽注射液16剂量单位（1次/早）皮下注射, 联合二甲双胍缓释片0.5 g（2次/d）+达格 列净10 mg（1次/d）, 用药过程中患者无胃肠道不良反应和低血糖, 血糖控制良好出院。出院1、3个月 后门诊复查随访, 患者血糖均控制达标。3个月后患者HbA1c为6.9%, 体重82.2 kg, BMI 26.5 kg/m2, 腰 围89 cm, 葡萄糖在目标范围内时间为93.7%. [ABSTRACT FROM AUTHOR]

Objective: To study the curative efficacy of decitabine combine with CAG regimen in the treatment of acute myeloid leukemia and its effects on the serum Interferon-γ (IFN-γ). alpha hvdroxybutyrate dehydrogenase (HBDH) and lactate dehydrogenase (LDH) levels. Methods: 70 cases of patients with acute myeloid leukemia who were treated from February 2013 to October 2016 in our hospital were selected as research objects. According to the random number table, the patients were divided into the observation group (n=35) and the control group (n=35). Both groups of patients were treated conventional treatment. The control group was treated with CAG scheme, intravenous injection of aclambicin. 20 mg each time, granulocyte colony stimulating factor. 300 p.g each time, subcutaneous intravenous cytarabiiie, 10-15 mg/m2 each time, while the observation group was treated with intravenous drip of decitabine on the basis of control group. 15 mg/m2 each time. Then the therapeutic effect, serum interferon-γ (IFN-γ). alpha hvdroxybutyrate dehydrogenase (HBDH). lactate dehydrogenase (LDH ) levels before and after treatment, incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective of observation group was significantly higher than that of the control group [91.42%(32/35)vs68.57%(24/35)](P< 0.05); the serum IFN-γ. HBDH. LDH levels were significantly higher than those of the control group[(3.21 ± 1.01)pg/ml vs. (5.13 ± 1.90)μg/mL. (103.62± 26.39)U/L vs. (118.S0± 28.60)U/L. (101.36± 27.32)U/L vs. (123.08± 30.59)U/L](P< 0.05); the incidence rate of adverse reactions was significantly lower than that of the control group [20.00%(7/35) vs. 42.85%(15/35)(P< 0.05)]. Conclusion: Decitabine combined with CAG regimen was more effective for acute myeloid leukemia than CAG regimen alone, which might be related to reduce the serum levels of IFN-γ. HBDH and LDH. [ABSTRACT FROM AUTHOR]

To solve the blocking artifacts of prior block segment compressive sensing， a new reconstruction algorithm was proposed which could reduce the blocking artifacts at low complexity. When sparse representing， discrete wavelet transform (DWT) method was utilized instead of discrete cosine transform (DCT) to improve detail component of image. When measuring， the measurement matrix of each block was reweighted to improve the quality of image according to the difference frequency between each block. When reconstructing， the orthogonal matching pursuit (OMP) algorithm was used to speed up reconstruction rather than the matching pursuit (MP) algorithm. Simulation results demonstrated that the blocking artifacts could be effectively eliminated by the proposed algorithm without making any effects on reconstruction speed and memory requirement. [ABSTRACT FROM AUTHOR]

The study attempts to explore the mechanism of teachers’ agency in professional development.With 522 teachers being interviewed, it is carried on by questionnaires in an individual-centered perspective.Through examining the external factors and internal factors that influence the different-level agency teacher groups, the result indicates that the teachers in the high-level agency group have two more influence paths than the teachers in the low-level agency group in the influence mechanism of teachers’ agency in professional development, one is that the environment of professional development influences their perceived self-efficacy by the degree of satisfaction on professional development, and further influences their individual agency, the other is that the general individual agency influences their perceived self-efficacy by the values of professional development, and further influences their individual agency. Compared with the teachers in the low-level agency group in the influence mechanism of environmental agency in professional development, the teachers in the high-level agency group also have two more influence paths that influence their environmental agency, one is that the general environmental agency first influences teachers’ perceived self-efficacy, and further influences their environmental agency, the other is that the general environmental agency directly influences teachers’ environmental agency. [ABSTRACT FROM AUTHOR]

心肌再灌注损伤在体表心电图上可表现为ＳＴ段抬高或压低，有时还伴有心律失常。本文报道一例心肌再灌注损伤后的心电图改变及其临床诊疗过程。患者初步诊断为劳力型心绞痛，冠状动脉造影示多支血管病变，择期行冠状动脉搭桥术后出现心肌再灌注损伤。 [ABSTRACT FROM AUTHOR]

Based on SAR investigation, two series of abamectin analogues containing urea and acyl thiourea groups were designed according to analog synthesis and sub-structure. Their structures were confirmed by 1H NMR, MS and elemental analysis. Their insecticidal activity was tested against Tetranychus cinnabarinus and Brevicoryne brassicae. All the tested compounds showed significant inhibitory activity against the above two insect species. Notably, the majority of those compounds exhibited high selectivity against B. brassicae, some of which were much better in comparison to abamectin. Especially, compound 9h displayed more potent activity than abamectin against the above two insect species, namely, T. cinnabarinus (LC50 = 0.100 μmol/L) and B. brassicae (LC50 = 1.71 μmol/L). Moreover, compound 9o showed superior activity against B. brassicae, with LC50 value of 1.13 μmol/L. [ABSTRACT FROM AUTHOR]

目的探讨支气管肺炎的临床路径教学法在儿科住院医师规范化培训中的应用效果。方法选取2016年7月至2017年7月在该院儿科轮转的48名规范化培训医师,随机分为对照组和试验组,每组24名。对照组采用传统教学法,试验组在传统教学的基础上引入临床路径教学法。比较2组住院医师临床理论知识和临床实践等方面能力的提高情况及教学满意度。结果试验组在理论知识掌握、病例分析、病史采集、体格检查、医患沟通、病历书写方面的成绩均高于对照组,但在个体化诊治方面不及对照组,差异均有统计学意义(P<0.05)。试验组在掌握诊治要点、规范诊疗行为、提高临床思维、教学启发性和提高自学能力方面的满意度显著高于对照组,差异均有统计学意义(P<0.05),但2组在教学的生动性和个体化诊治方面的满意度比较差异无统计学意义(P>0.05)。结论临床路径教学法对规范儿科住院医师,提高其疾病诊治能力、临床工作综合能力和教学满意度方面有重要意义。 [ABSTRACT FROM AUTHOR]

Objective This study aimed to investigate the health-related quality of life and health utility value of hospitalized osteoporosis patients and to analyze the factors that influence them. Methods The study collected general data of osteoporosis patients hospitalized in Gansu Provincial Hospital, detected bone metabolism indexes, measured bone mineral density of the lumbar spine and hip, assessed fall risk, predicted fractures, evaluated quality of life, and calculated health utility values. The Mann-Whitney test and the Kluscal-Wallis test were used for univariate analysis. The Tobit regression model was used to analyze the factors affecting the quality of life of participants. Results A total of 241 hospitalized osteoporosis patients were enrolled as study subjects. Their health utility value was 0.876 (0.728-0.942). Univariate analysis showed that age, education, risk of falls, place of residence, smoking, previous use of anti-osteoporosis drugs, low-invasive fracture history, FRAX score, left hip T-value, and calcium were associated with health utility values in patients with osteoporosis (P＜0.05). The result of the Tobit regression model showed that a high literacy rate (primary school: β=0.119, P=0.043; junior high school: β=0.113,P=0.044; high school or college or technical school β=0.171, P=0.002) was a protective factor for quality of life. High risk of fall (intermediate risk β=-0.138, P＜0.001; high-risk β=-0.316, P＜0.001), low-invasive fracture history (β=-0.190, P＜0.001), and FRAX score of high risk (β=-0.088,P=0.027) were risk factors for quality of life. Conclusion The health utility value of hospitalized osteoporosis patients is lower than that of the general population, indicating poor health-related quality of life. Patients with low literacy rate, high risk of fall, fractures, and high risk of FRAX score have poorer quality of life. Improving the quality of life of patients, promoting health, preventing falls, and active intervening are necessary. [ABSTRACT FROM AUTHOR]

Objective To investigates the death tnnid of HIV/AIDS patients in Shandong Province from 2013 to 2022, aiidto (\xpl()m the ndat(xl infhumcing factors. Methods A total of 25 181 HIV/AIDS patients living in Shandong Province from 2013 to 2022 更etc as the study objects, d(miographi(* (*hara(*t(risti(*s, antintnmnd therapy and (*aus(s of death wem collected Study ol)j(x*ts w(te dividcxl into three groups: surviial, AIDS 一 ndat(xl death and non 一 AIDS 一 related ckath. Kruskal - Wallis test andf2 test wctc conductc(l for inter group (comparison, Joinpoint ngnssion model was ns(xl to analyzes the tnmd change of mortality, and nnord(T(xl multicatcgorical logistic tegtession was ns(xl to analyze HIV/AIDS death and its influencing factors. Results From 2013 to 2022, a total of 1 187 HIV/AIDS paticnits deaths were reported in Shandong Pt()yin(:(打 among which AIDS 一 ndatcxl dcaths a(*(*ount(xl for 34. 63% and non - AIDS 一 ndatcxl dcaths a(*(*ount(xl for 65. 37%. The mortality raters show(xl a (Iccmasing tnncl (APC was 一 13. 58, - 20. 29, and 一 9. 67, mspcctiv(』y, all P < 0. 05). Unor(l(r(xl multicatcgorical logistic regression analysis show(xl that the time from diagnosis to ART initiation gMatcr than 30 days, WHO clinical stages U, HI, and IV were the risk factors for AIDS 一 ndat(xl denth of HIV/AIDS patients, and the OR (95% CI) values were 1. 74(1.41 一 2. 16), 1.93 (1.38 - 2, 70) 3 2. 61 (1.87 一 3. 63) and 4. 81 (3. 71 - 6. 23); the time from diagnosis to ART initiation gmatcr than 30 days3 male, farmer and heterosexual transmission 賀ere the risk factors for non -AIDS - related death of HIV/AIDS patients, with OR (95% CI) valuer of 2. 10(1.79 -2.46), 1. 75(1.38 - 2. 20), 1.60 (1.28 -2. 01), and 1.75(1.48 - 2. 08). Conclusion From 2013 to 2022, the ease fatality mtc of HIV/AIDS patients in Shandong Pnrvincc has shown a downwanl tnmd after the start of ART, the 3gc of ckath incmascd, and the ease fatality nite of non 一 AIDS 一 ndat(xl ckaths is generally high(江 than that of AIDS 一 related ckaths. Them an (liffcmnccs in the influencing factors for AIDS 一 ndatcxl and non 一 AIDS 一 ndat(xl dcaths, and targeted interventions should he(lc¥(:l()pc(L. [ABSTRACT FROM AUTHOR]

【Objective】Explore the effects of different irrigation periods and amounts on the growth and photosynthetic characteristics of quinoa in the northern foothills of the Yinshan Mountains, to determine the reasonable irrigation system for quinoa in the area.【Methods】In Wuchuan Dry Farming Experiment Station in Inner Mongolia, 6 drip irrigation treatments, W1 (irrigation in the seedling stage + branching stage), W2 (irrigation in the seedling stage + heading stage), W3 (irrigation in the seedling stage + filling stage), W4 (irrigation in the seedling stage + branching stage + heading stage), W5 (irrigation in the seedling stage + branching stage + filling stage), and W6 (irrigation in the seedling stage + heading stage + filling stage) were set up. The plant dry matter accumulation dynamics, leaf area index, changes in photosynthetic characteristics and crop yield effects of quinoa during the growth period were monitored.【Results】During the entire growth period of quinoa, dry matter accumulation and leaf area index showed upward trends with the increase of drip irrigation amount. The leaf area index of W5 treatment increased by 45.00% compared with W1 treatment in the filling stage. During the flowering stage of quinoa, the leaf photosynthetic rate, transpiration rate and stomatal conductance had downward trends as the drip irrigation amount increased, but some levels of deficit irrigation could significantly improve leaf water use efficiency. The leaf water use efficiency of W5 treatment significantly increased (P<0.05) by 39.04% compared to W1 treatment. There were significant differences in the yield of quinoa under different drip irrigation treatments. W5 treatment had the highest yield of 2 245.60 kg/hm², which was significantly increased (P<0.05) by 78.68% compared to W1 treatment.【Conclusion】In the northern foothills of Yinshan Mountains, irrigation with a total volume of 1 350 m³/hm² during the seedling, branching, and filling stages of quinoa improved water use efficiency and achieved high yield. [ABSTRACT FROM AUTHOR]

The fertility preservation is suitable for those patients with primary ovarian insufficiency, tumor, autoimmune disease, and those people who want to postpone parenthood. Young women with tumor will be the main population of fertility preservation because radiotherapy and chemotherapy always impaire their fertility and living quality. There are three kinds of fertility preservation technology: embryo freezing, oocyte freezing and ovarian tissue cryopreservation. The technology of embryo freezing has been successfully used in clinical practice. The technology of oocyte freezing is getting mature. However, the technology of ovarian tissue cryopreservation is still at the early stage of research. Both of slow-freezing method and virtification method can be applied in fertility preservation techniques, with own advantages and disadvantages. The paper mainly introduces the methods of fertility preservation and the problems needed to be solved. [ABSTRACT FROM AUTHOR]

More and more young women are diagnosed with cancer. Radiotherapies and chemotherapies increase the survival rate of cancer patients, while their reproductive ability could be damaged by those anti-tumor treatments. At present, there are some reports about the fertility preservation in patients suffering from breast cancer and haematological malignances. According to the tumor types and other situations, the embryo cryopreservation, oocyte cryopreservation and ovarian tissue cryopreservation can be recommended as a personalized program of fertility preservation. Three kinds of freezing methods have their advantages and disadvantages. The embryo freezing and egg freezing need to extend the waiting time before anti-tumor treatment, but these technologies are relatively mature. Compared with them, the ovarian tissue cryopreservation do not delay the anti-tumor treatment, but the technology is not yet mature. The success rate of fertility preservation program is also affected by many factors, such as the age of patient, the type of tumor, and the specific treatment. In this paper, we reviewed in the research progress of fertility preservation of tumor women. [ABSTRACT FROM AUTHOR]

Traditional Chinese Medicine(TCM) is characterized by holism concept. Through Inner Canon of Huangdi, the theory of "yin-yang of four seasons and five zang-organs"is one of the academic thoughts which presents wholism concept of "correspondence between nature and human". Siwu Tang has been appraised as the "saint prescription of gynecology", directed at various blood troubles. This article tries to study the mechanism of Siwu Tang against blood troubles from the view of the wholism concept of"yin-yang of four seasons and five zang-organs". [ABSTRACT FROM AUTHOR]

Across China, the standardized training of residents will be carried out in 2015, and the educational reform about it attracts the wide concern. With the rapid development of modern information technology, the micro-lecture plays a role in the teaching activities is becoming more and more outstanding. The short and efficient teaching content of micro-lecture can be downloaded rapidly, expediently, and repeatedly, which improve the learning efficiency and quality. Application of micro-lecture in the standardized training of residents in the practicing base is feasible. Micro-lecture introduces the contents about disease and operation intuitively by micro-video,cartoon, and 3D model. Active participation in the whole process of micro-lecture can gradually improve efficiency of the standardized training, alleviate medicine trouble contradiction, and increase medical data. Here, we share some thoughts on micro-lecture in the standardized training of residents with our counterparts. [ABSTRACT FROM AUTHOR]

目的探讨超声引导下经皮肺穿刺活检术在肺周围型病变中的应用价值。方法收集2014 年1 月至 2017 年10 月兰州大学第二医院呼吸内科胸部CT 主要表现为肺周围型病变的患者212 例，均行超声引导下经皮肺穿 刺活检术及支气管镜检查，并对其进行相关性分析。结果超声引导下经皮肺穿刺活检术诊断肺周围型病变的阳性率 为68.40%（145/212），而支气管镜检查诊断肺周围型病变的阳性率为3.77%（8/212），二者比较，差异有统计学意义（P< 0.01）。总体而言，肺周围型病变以右肺下叶居多，占33.49%（71/212）；腺癌患病率最高，占38.21%（81/212）；男性以鳞癌 为主，占28.15%（38/135），比例显著高于女性[7.79%（6/77）]，差异有统计学意义（χ2=12.353，P<0.01）；女性以腺癌为主， 占64.94%（50/77），比例明显高于男性[22.96%（31/135）]，差异有统计学意义（χ2=12.353，P<0.01）。病灶直径的大小、病 灶距胸壁的距离对诊断肺癌的阳性率未见明显影响（P>0.05）。结论超声引导下经皮肺穿刺活检术对肺周围型病变 具有较好的诊断价值，可以提高肺周围型病变的早期诊断率。 [ABSTRACT FROM AUTHOR]