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The size grading during fish farming benefits growth management and feed control, improving aquaculture efficiency. A guided live fish grading device was designed to solve the problem of high labor intensity and low efficiency in domestic live fish grading. The structural composition and working principle of the grading device were introduced, and the mechanical analysis and parameter design of the fish conveying mechanism were carried out. Based on the relationship between fish body mass and body shape parameters, the morphological data of experimental crucian carp were measured. Meanwhile, the power function fitting method was used to obtain the equation of the relationship between crucian body thickness and body weight, which serves as the basis for setting the distance between grading channels. When grading, the spacing between the guide plates on both sides of the grading channel is adjusted, and the grading channel is set to meet the fish specification requirements so that fish's body through the grading channel. Live fish grading performance experiment was carried out, with fish weight range of 0. 14-0. 33 kg and thickness range of 30-39 mm. Grading tests and effect analysis were conducted under three conditions of fish conveying speeds of 0. 15 m/ s, 0. 20 m/ s, and 0. 25 m/ s. The experimental results show that the grading accuracy can reach over 90% under normal conditions, and the appropriate grading speed and grading channel setting have higher efficiency. This guided grading device can quickly and accurately grade live fish, improving the efficiency of mechanized operations in the breeding process. [ABSTRACT FROM AUTHOR]

With the improvement of people's living standards, the aquatic leisure food market represented by shrimp has shown a vibrant scene. Shrimp leisure food is a fast moving consumer product made from high protein and low fat shrimp such as seawater shrimp and freshwater shrimp. The development of the nutritional, functional and healthy snack foods of shrimp through storage technology, pretreatment technology, steaming technology, drying technology, preservation technology, by product utilization, processing technology and other technologies, have broad development prospects. The shrimp snack food industry needs to seek development in basic research and technological innovation, production processes and equipment, market innovation, and demand orientation, and branding, lifestyle, convenience, and personalization are the key to the survival and development of shrimp snack foods. [ABSTRACT FROM AUTHOR]

Reasonable support form and support parameters are the key to ensuring the stability of the roadway surrounding rock. The joint support effect of bolt + metal mesh + shot grouting in the Grade IV surrounding rock area of the drainage roadway of Julong Copper Mine in Xizang is poor. In this paper, for the problems of support in the Grade IV surrounding rock area of the drainage roadway of Julong Copper Mine, bolt and steel arch support, as well as the thickness of shot grouting, is introduced on the basis of the existing support. Different bolt support parameters are designed and optimized using finite element numerical simulation software. The results show that there is an obvious stress addition phenomenon at the roadway surrounding rock roof. With the increase of bolt support parameters, the maximum stress value at the roadway roof increases. With the increase of row spacing between bolts, the maximum displacement of the roadway roof increases, the bolt spacing increases from 1.2 m to 2.0 m, and the displacement of the roadway roof is 4 mm, 4.38 mm, and 4.82 mm, respectively. The optimal support parameter of the bolts is 1.6 m x 2.4 m. The results of the study provide theoretical references for the selection of the support parameters of the bolts of similar roadways. [ABSTRACT FROM AUTHOR]

Objective: To construct the regulatory network of competitive endogenous RNA (ceRNA) and explore the molecular mechanism of ischemic stroke (IS) by using bioinformatic analysis to screen the differentially-expressed genes . Method: The expression profiles of miRNA, mRNA and lncRNA in IS were downloaded from the NCBI GEO database. Differentially-expressed miRNAs, lncRNAs, and mRNAs were identified by the limma package in R software. The prediction of the relationship of lncRNAmiRNA and miRNAmRNA were performed by starBase, miRDB and miRwalk databases. The results of prediction and differential analysis were taken to intersect and screened out differentiallyexpressed target mRNA (DETmRNAs), Kyoto Encyclopedia of Genes and Genomes (KEGG)and gene ontology (GO) enrichment analysis was performed by using the DAVID database. The protein-protein interaction (PPI) network was constructed by using the STRING database and the core target genes in the network were identified by Cytoscape software. Result: A total of 20 differentially-expressed miRNAs, 1512 lncRNAs, and 278 mRNAs were identified, and a ceRNA network was successfully constructed with the interactions of 5 lncRNAs-6 miRNAs-102 mRNAs in IS. The 285 DETmRNAs functions are mostly involved in the biological process such as chromatin organization, negative regulation of phosphoprotein phosphatase activity, or cell cycle. KEGG mainly enriched the signaling pathway including leukocyte transendothelial migration and platelet activation. The top 10 core genes were CREB1, MAPK1, GSK3B, SP1, PIK3R1, NR3C1, NCOR1, NFATC1, SETD2, and NSD1. Conclusion: The construction of the ceRNA network can help to further understand the molecular mechanism of IS and screen potential biomarkers, providing clues to further define rehabilitation targets and develop rehabilitation strategies. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation of peripheral blood lymphocyte, T-cell, Th-cell, and Ts-cell counts with the development of checkpoint-inhibitor-related pneumonitis in NSCLC. Methods The clinical data of 85 patients with NSCLC treated with immune checkpoint inhibitors (ICIs) were retrospectively analyzed. Paired t-test was used to analyze lymphocyte changes. ROC curves were utilized to analyze predictive performance. The Spearman correlation coefficient test was conducted to analyze the linear relationship between lymphocyte changes and CIP grade. Results A statistically significant decrease in lymphocyte, T-cell, Th-cell, and Ts-cell counts from the baseline was observed in patients at the onset of CIP (P<0.05), whereas no such change was observed in the control group. ROC curve analysis revealed AUCs of 0.867, 0.843, 0.865, and 0.843 for lymphocyte, T-cell, Th-cell, and Ts-cell counts, respectively. A linear relationship was found between the percentage decrease in lymphocyte, T-cell, and Ts-cell counts from the baseline and the severity of CIP (P<0.05). Conclusion Decreased lymphocyte, T-cell, Th-cell, and Ts-cell counts have a predictive value for the development of CIP, and the lymphocyte count change has the greatest predictive value. The percentage decrease in lymphocyte, T-cell, and Ts-cell counts from the baseline is correlated with the severity of CIP. [ABSTRACT FROM AUTHOR]

Electrochemistry is an important tertiary subject in physical chemistry, and the classical content of electrochemistry has become an indispensable part of physical chemistry textbooks. This paper presents a comparative study of the contents of electrochemistry sections in 13 representative physical chemistry textbooks at home and abroad, and analyzes them from several perspectives, including their teaching concepts, organization of teaching contents, selection of teaching contents, and introduction of new knowledge, which are of certain reference value for the preparation and teaching of electrochemistry sections in physical chemistry textbooks. [ABSTRACT FROM AUTHOR]

To solve the need for automatic counting of fishery breeding and transportation, a fish identification algorithm design and programming based on machine vision is proposed. Using digital image recognition and classification technology, proved that Scale Invariant Feature Transform SIFT and Speed Up Robust Feature SURF algorithm can effectively detect and label fish image feature points. A Fast Library for Approximate Nearest Neighbors FLANN matching algorithm is designed to test rotation and generalized fish target finding based on image features proving that the SURF feature is good for individual detection and SIFT feature is good for generalization target detection. In view of the fragmentation characteristics of FLANN image feature matching, combined with the actual situation of image information area aggregation, and using the template detection method for reference, a template detection algorithm for image segmentation scanning and feature matching is designed; using Maximally Stable Extremal Regions MSER method to eliminate the redundancy of the recognition results, test result proved that the algorithm can correctly identify the multi-fish target. This study found that the algorithm and software could successfully identify multiple fish targets in the images, with good test results and strong practical implications. [ABSTRACT FROM AUTHOR]

目的 探讨富血小板血浆（platelet-rich plasma, PRP）在治疗老年慢性难愈创面中的临床效果。方法 自 2020 年 4 月至 2021 年 12 月，泰兴市人民医院烧伤整形科收治 58 例老年慢性难愈创面患者，按照治疗方法分为 PRP 组（27 例）和对照 组（31 例），PRP 组创面行 PRP 治疗，对照组行碱性成纤维细胞生长因子治疗。1 周后测定创面内肉芽组织内皮细胞生长因子 （vascular endothelial cell growth factor, VEGF）和表皮生长因子（epidermal growth factor, EGF）的含量，观察一个月后的创面愈合率， 比较两种方法的疗效。结果 治疗 1 周后两组患者创面内肉芽组织 VEGF、EGF 含量较治疗前均有提高，且 PRP 组升高更 明显，差异具有统计学意义（P＜0.05）。治疗 1 个月后，PRP 组的创面愈合率明显高于对照组，差异具有统计学意义（P＜ 0.05）。结论 相对于外源性碱性成纤维细胞生长因子，PRP 能显著提高老年慢性难愈创面组织相关生长因子的含量，有效地促 进创面愈合。 [ABSTRACT FROM AUTHOR]

To investigate the efficacy of 3D laparoscopic radical gastrectomy for advanced gastric cancer and its effect on serum exosome Dicer and Phosphatase and tensin homolog deleted on chromosome ten (PTEN). A total of 60 patients with advanced gastric cancer treated in our hospital from July 2018 to May 2021 were selected as the research subjects. According to 1:1 random envelope lottery, the patients were divided into 3D group and laparotomy group, with 30 patients in each group. The open group was treated with open surgery, and the 3D group was treated with 3D laparoscopic radical gastrectomy. The surgical indications, complications, visual analog scales (VAS) score and Dicer and PTEN expressions of the two groups were compared and analyzed. There were no difference in the operation time and the number of lymph node dissections compared between the two groups(P>0.05). The postoperative exhaust time, postoperative gastric tube removal time, surgical incision length, the amount of bleeding, postoperative hospital stay, and surgery in the 3D group were less than that of the open group (P<0.05). The incidence of complications such as anastomotic bleeding, anastomotic leakage, gastroparesis, incision infection, and venous thrombosis in the 3D group at 14 days after operation were lower than the open group (P<0.05). The VAS scores of the 3D group at 1 d, 7 d and 14 d after operation were lower than those of the open group (P<0.05). The relative expression levels of serum exosomes Dicer and PTEN at 14 d after operation in the two groups were higher than that at 1d before operation (P<0.05), the 3D group were higher than the open group (P<0.05). All patients were followed up until November 1, 2021. The average follow-up time were (17.92± 0.22) months. The recurrence rate of the 3D group were 3.33 %, which were lower than the 20.00 % of the open group (P<0.05). 3D laparoscopic radical gastrectomy for patients with advanced gastric cancer can promote the secretion of serum exosome Dicer and PTEN without increasing the complexity of surgery, and can also promote the recovery of patients, reduce complications, relieve patients' pain, and reduce the recurrence rate during follow-up. [ABSTRACT FROM AUTHOR]

Objective: To analyze the short-term efficacy of the anterior middle approach for laparoscopic rectal cancer and the group 253 lymph node dissection. Methods: A total of 80 cases of rectal cancer, who were diagnosed and treated in Jiangsu Provincial Hospital of Traditional Chinese Medicine from June 2017 to June 2020, were selected and were divided into middle group(n=42) and lateral group (n=38) according to the different surgical approaches. Results: All the patients were treated with laparoscopic rectal cancer resection, the middle group was received the anterior approach and the lateral group, received the lateral approach. The short-term efficacy and the group 253 lymph nodes dissection effects were recorded and followed up. All the patients underwent smooth operation, and there was no tension in the mesentery and intestine after anastomosis. The group 253 lymph node dissection time in the middle group was less than that in the lateral group (P<0.05), and there was no statistical difference in the number of group 253 lymph node dissection between the two groups (P>0.05). There was no significant difference in the operation time and intraoperative blood loss between the two groups (P>0.05). The postoperative anal first exhaust time, postoperative drainage tube removal time, and postoperative hospital stay in the middle group were significantly less than those in the lateral group (P<0.05). The postoperative 9 months of incidences of complications such as intestinal obstruction, anastomotic leakage, anastomotic bleeding, and wound infection in the middle group was 4.8 %, which was significantly lower than that(23.7 %) in the lateral group (P<0.05). All the patients were followed up for 9 months, and the recurrence rate of the middle group was 2.4 %, which was significantly lower than that (15.8 %) of the lateral group (P<0.05). Conclusion: The application of the anterior middle approach in patients with laparoscopic rectal cancer can improve the cleaning efficiency of the group 253 lymph node, promote the recovery of patients, reduce the incidence of postoperative complications, and reduce the short-term recurrence rate. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) is a common chronic orthopedic disease in modern clinic. It is believed in traditional Chinese medicine (TCM) that the disease is caused by deficiency of the kidney, the spleen, and the liver. At present, with the rapid development of molecular biology, the relationship between intestinal microecology and osteoporosis has become a hot clinical research. However, the treatment of OP from the visceral organs in TCM is only supported by its theory. In this paper, based on the research result of modern molecular biology, the authors explain the scientology of TCM in the treatment of OP from the spleen, in order to provide a strong scientific basis for TCM clinical treatment of OP from the spleen, and provide new ideas for TCM in the prevention and treatment of OP. [ABSTRACT FROM AUTHOR]

Sea ice thickness is one of the most important and inaccessible parameters of sea ice, which is of great significance to marine disaster warning and climate change. In this paper, 10 multi-source ( Sentinel-2, Landsat-8, Landsat-7) medium and high-resolution images from January to March 2018 are selected to monitor the sea ice in Liaodong Bay of the Bohai Sea. The sea and land segmentation is based on the normalized water body index. By analyzing the spectral characteristics of sea water and sea ice, the sea ice region is extracted by the maximum likelihood method, and the sea ice thickness is inverted by the exponential albedo model. The inversion results are compared with the ice thickness calculated by Zubov empirical model. The correlation coefficient is 0. 884, which proves the feasibility of medium high resolution optical remote sensing data in sea ice thickness inversion. At the same time, taking advantage of the medium and high resolution remote sensing data, using ice thickness information to extract sea ice types and estimate sea ice resources, it can provide reference for the prevention and mitigation of sea ice disaster and the utilization of sea ice resources in the Bohai Sea. [ABSTRACT FROM AUTHOR]

[Objective] The morphological structure of flower and leaf organs of 17 Lespedeza materials were studied in order to provide scientific basis for the identification of the germplasm resources. [Method] The morphological structure of flower and leaf organs such as inflorescence type, flower color and size, lobes, petiole length and leaf size about 17 Lespedeza materials were measured in the peak anthesis period. Cluster analysis was used. [Result] The 17 materials were firstly divided to Sect. Macrolespedeza Maxim and Sect. U:spedeza. according to the presence or absence of cleistogamous flower. The length of inflorescences and leaves could further distinguish L. fornwsa (Vog.) Koehne and L. bicolorTurcz. The leaf shape and size, ratio of calyx to corolla could distinguish the materials of Sect. Lespedeza. All materials of U:spedeza were divided into 4 categories by cluster analysis. Hl was a self-contained class because of having the super inflorescence. The second type of H3, H8, H16 and H18 had bigger inflorescence and belonged to having no cleistogamous flower. The third group of H14, H20, H21 and H26 had no pedicels, but had the slender leavers. Although there were many kinds of materials in the fourth group, they were all Sect. Lespedeza. [Conclusion] As a supplement of germplasm morphological classification, quantitative classification was feasible in practice. [ABSTRACT FROM AUTHOR]

MgO-Al2O3-SiO2, glass-ceramics were prepared by a melt-quenching method. The effects of CaO content on crystallization, micro-morphology, flexural strength, thermal expansion coefficient, and dielectric properties were investigated. The activation energy for sintering was calculated based on the Arrhenius model of a constant heating rate. The results showed that since Ca atoms entered into the glass network, CaO addition reduced the softening point and the crystallization temperature of glass effectively and changed the crystallization tendency. Also, CaO doping reduced the sintering activation energy and promoted the sintering process of glass ceramics. The increase of secondary crystal phase (MgAl2Si3O18)0.6 leaded to an increase o f thermal expansion coefficient of the glass-ceramic. Mean while, an increase of flexural strength was related to the increase of bulk density and the internal stress generated by high thermal expansion phase. When the amount of CaO was 3 wt %, the glass-ceramic sintered at 950 °C showed best performances: flexural strength of 152 MPa, thermal expansion coefficient of 3.52 X 10-6 /°C, dielectric constant of 5.89, and dielectric loss of 1.85 X 10-3 . [ABSTRACT FROM AUTHOR]

Objective: To determine the urine levels of bladder cancer specific antigen- 1/-4 (BLCA- 1/-4) in the patients with bladder cancer and its clinical value. Methods: 38 cases of bladder cancer, and 40 healthy control cases were selected as the research subject. Urine samples were collected from all patients. A competitive enzyme-linked immunosorbent assay was used to determine the BLCA-1 and BLCA-4 levels in urine. The cut-off value is determined by ROC curve. Results: Urine BLCA-1 and BLCA-4 levels in BC patients were significantly higher than those in the healthy controls (P<0.001); ROC curve showed that the sensitivity and specificity of BLCA-1 in the urine for the diagnosis of bladder cancer were 71% (27/38) and 90% (36/40) with a cut-off value of 0.859 ng/mL. BLCA-1 levels in the urine of MIBC (T2-T4) were significantly higher than those patients without muscular coat invasion (Ta-Tl, P0.05). The level of BLCA-4 was higher in the high grade of bladder cancer (P<0.05), but there was no significant difference in the level of BLCA-4 in patients with different stages of bladder cancer (P>0.05). ROC curve showed that the sensitivity and specificity of the urinary BLCA-1 for the diagnosis of bladder cancer were 71 % (27/38) and 90% (36/40) with a cut-off value of 0.859 ng/mL, and the sensitivity and specificity of the urinary BLCA-1 for the diagnosis of bladder cancer were 76.3% (29/38) and 97.5% (39/40) with a cut-off value of 0.620 ng/mL. The sensitivity and specificity of combined detection of BLCA-1 and BLCA-4 in the diagnosis of bladder cancer were 84.2% (32/38) and 100%( 40/40), respectively, with accuracy of 0. 923 (77/78), positive predictive value of 100%(32/32), negative predictive value of 86 .9%(40/46) and YOUDEN index of 0.842 . Conclusion: The levels of BLCA-1 and BLCA-4 in urine of patients with bladder cancer were significantly increased, and it showed a high level of sensitivity and specificity in diagnosing the bladder cancer. Combined detection of urine BLCA-1 and BLCA-4 in diagnosing bladder cancer showed more valuable than single marker. [ABSTRACT FROM AUTHOR]

Objective· To reveal the effect of denatured collagen type I on the endothelial cell proliferation, migration, and angiogenesis-related proteins. Methods· Human umbilical vein endothelial cells were cultured on the plates coated with normal collagen (normal collagen group), half concentration normal collagen (half collagen group) or denatured collagen (denatured collagen group). CCK-8 assay was performed to test cell proliferation ability two days later. The effect of collagen on cell migration was measuredscratch test. The s of membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth factor (VEGF) were detectedWestern blotting. The s of angiopoietin 1 (Ang-1) and Ang-2 were measuredELISA. Results· CCK-8 results showed that the proliferation activity of denatured collagen group was significantly higher than that of normal collagen group and half collagen group (PPPConclusion· Denatured collagen type I can promote proliferation, migration and MT1-MMP, VEGF, and Ang-2 s in endothelial cells, suggesting that collagen denaturation may play an active role in the process of angiogenesis during wound healing. [ABSTRACT FROM AUTHOR]

By means of the self-defined artificial neural network (ANN) and its excellent function fitting function, aimed at aggregate-mortar matrix 2-phase concrete, the analytical solutions of the highly nonlinear coupling differential equation of the differential method in the indirect homogenization theory were given, the functional relations between the volume modulus and the shear modulus of concrete and the volume fractions of aggregate were obtained respectively, and the results were compared with those of numerical simulation. The results show that, the method based on the ANN is fast and has higher precision. In addition, the method of deconstructing ANN provides the formula of calculating the elastic modulus of aggregate-mortar matrix-pore 3-phase concrete directly from aggregate volume fractions and initial porosities under constant meso-mechanical parameters. For concrete samples with different aggregate volume fractions and initial porosities, the formula has higher calculation accuracy, and avoids the complex analysis and many assumptions of the traditional homogenization method. The work provides a new idea of homogenization method for composite materials. [ABSTRACT FROM AUTHOR]

Trawl winch is the most important equipment of trawler fishing. In order to ensure safe dragging operations of fishing vessel equipment under the complex sea conditions as well as to realize the quick response and precise control of trawl winch, and keep net shape good, in this study, the trawl tension automatic control system was designed based on electro-hydraulic control technology. The system mainly consisted of proportional directional valve, balance valve, overflow valve, pilot valve, oil pressure sensor, and electric control system. Through measured input and output pressure of motor, we calculated warp tension as the feedback signal and used PLC (programmable logic controller) to control the pressure of pilot relief valve, which was used to adjust the left and right warp tension and position, to maintain the dynamic balance of system as well as to keep the net shape good. The man-machine interface and operation mode of automatic tension control was developed based on LabVIEW, of which its main function consisted of parameter set, information management, system monitor and data inquire. The system facilitated operator monitoring the running state of the various equipment, and management equipment operation. In order to verify the characteristic and practicability of tension control of the system, application test was carried on the East China Sea area in 2015. The experiment continued about 4.5 hours, including three stages: shooting net, dragging net, and heaving net, which tested speed control and tension control performance of the system under the corresponding operating conditions, and measured relevant data such as shoot depth, shoot length, shoot speed, heave speed, warp tension and winch working pressure. The test result showed that dragging stage was the longest, and in this process, the left warp and right warp were kept balance, warp tension was mainly affected by hydrodynamic, warp weight, and water resistance of fishing gear. Warp shoot length range was 350-490 m, warp tension range was 118 -148 kN, corresponding to the system pressure of 2.3-2.7 MPa, and the average trawling speed of fishing vessel was 5.6 kN. Although warp tension various with the shoot length and shoot depth change, the winch was in constant tension state at the most. Data showed that the system could adjust the warp tension well to ensure trawl warp tension maintained in a certain range through adjusting the speed of receiving or releasing net, which suppressed effectively the interference of the warp tension variation on the nets. In addition, experiment also recorded the chart of net shape by netsonde, calculated the net expansion parameter. It could be known that net mouth perimeter was equal before and after using the tension automatic control system by comparison data. The net mouth height and net mouth roundness increased and the net mouth area was expanded by 9.5% after using tension control system, which effectively adjusted the net mouth expansion and improving the fishing efficiency. During the different stage of experiment, the set pressure of overflow valve should be different correspondingly. At the beginning of shooting, the pressure value was small, which can maintain good net mouth shape and position. Due to net speed increased relative to water flow, warp tension was increased and the maximum value reached 208 kN. The set pressure of overflow valve should be large so that it could be used to effectively protect warp and net safety, provided a guarantee for the safe production of fishing vessel. The experiment process was basically consistent with the actual fishing conditions. We concluded that in the tension automatic control mode, the trawl winch can automatically adjust speed of heave and shoot according to the fishing vessel speed and water flow. Though the system could generate heat and result in power loss during uses, the warp tension control system still cab meet the requirements of warp speed and tension control in the different trawl condition. [ABSTRACT FROM AUTHOR]

After years of construction,laboratory and experimental course for major of economics and management hold large scales, but there are still many shortcomings. How to further develop laboratory construction, improve laboratory status is a problem. This paper presents a platform for integration and the development of strategies to improve economic and management laboratory construction and management levels. The platform can promote innovation laboratories to coordinatedly and sustainably develop. [ABSTRACT FROM AUTHOR]

【Objective】 The present paper aimed to study the effects of Pandanus amaryllifolius Roxb. intercropping with Areca catechu L. on the structure and diversity of soil bacterial communities, to clarify the key environmental factors affecting soil bacterial community in the intercropping mode, so as to provide a theoretical basis for optimizing the betel nut intercropping mode and the development of tropical farmland economy. 【Method】 Through the method of field experiment, the experimental plots including A. catechu monocropping （control'), P. amaryllifolius monocropping （control） and P. amaryllifolius intercropping with A. catechu were established in Xinglong area to measure soil physical and chemical properties, nutrient content, soil bacterial abundance, and diversity to explore the effect of intercropping model on soil bacterial community structure and diversity. 【Result】 The results showed that the ACE index, Chao1 index and Shannon index of the bacterial community under the A. catechu intercropping P. amaryllifolius model were significantly reduced than control（P<0.05,the same as below）. In intercropping mode, pH, electrical conductivity, total phosphorus, and bulk density were the main environmental factors that affected the changes of soil bacterial communities. In the three planting modes, the dominant bacteria phyla of bacteria were Proteobacteria, Actin bacteria, Actin bacteria, and Chloroflexi. The relative abundance of Proteobacteria, Acid bacteria and Acidobacteria was decreased, and the relative abundance of Chloroflexi was increased. Among them, Acid bacteria was significantly positively correlated with soil bulk density; Chloroflexi was extremely significantly positively correlated with conductivity and organic matter （P<0.01,the same as below）, extremely significantly negatively correlated with total phosphorus, and significantly negatively correlated with total potassium. 【Conclusion】 P. amaryllifolius intercropping with A. catechu does not affect the total number of bacterial OTU, but significantly reduces the diversity index of soil bacterial community by reducing pH and increasing electrical conductivity. Intercropping mode reduces the contents of total phosphorus, total potassium and organic matter by increasing soil bulk density, while reducing the abundance of Proteobacteria, Actinomycetes and Acid bacteria, but increasing the abundance of Chloroflexi. It can be seen that although the betel nut intercropping system significantly reduces the content of soil nutrients, it can improve the abundance and diversity of in-situ soil bacterial flora of betel nut forest, which is of positive significance to maintain the soil health of betel nut forest and promote the development of related industries of betel nut and betel nut. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis (RA) is an autoimmune disease that causes joint inflammation and pain, impairs joint function, and causes deformity. To date, there is no complete cure for RA. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway has been identified as an important pathway for the prevention and treatment of RA. The PI3K/Akt signaling pathway is involved in a number of biological processes, including cell survival, proliferation, and inflammatory responses. It plays a key role in the development of RA by regulating the production of inflammatory mediators, influencing cellular autophagy and osteoclast differentiation, regulating apoptosis, mediating cell migration and infiltration, and regulating angiogenesis and permeability. Modulation of this signaling pathway may help to control inflammation, to slow down joint damage, and to promote tissue repair, thus improving patients' quality of life. Drug development targeting to PI3K/Akt signaling pathway is an important way to explore effective prevention and treatment of RA. By reviewing a large number of literature reports, this paper describes the research progress of the role of PI3K/Akt signaling pathway in the development of RA, with the aim of providing insight into the pathogenesis of RA and the development of new drugs and treatments in the future, and even more, to provide reference for future clinical practice and research. [ABSTRACT FROM AUTHOR]

Objective To understand the infection route and infection factors of elderly human immunodeficiency virus (HIV)/AIDS (PLWHA) patients(PLWHA), and to propose prevention and treatment measures. Methods A total of 60 patients over 50 years old with PLWHA were selected and interviewed for their demographic characteristics, social activities, high risk behaviors, condom use and AIDS awareness. Results Among the 60 patients, 35 were male and 25 were female. Primary school education and below, accounting for 50.00% (30/60). Marriage was dominated by marriage/cohabitation, accounting for 55. 00% (33/60). The main transmission route was heterosexual transmission, accounting for 80. 00% (48/60). The proportion of infection path ways of different genders was compared, and the difference was statistically significant (X² = 37. 592, P <0. 01). The proportion of men having commercial heterosexual sex was 71. 43 % (25/35). Among the 26 patients with commercial heterosexual sexual history, 25 never used condoms. The places where men bought sexual services were mainly low end hair salons, roadside shops and anonymous places. Among the 60 cases, 70.00% (42/60) were found through medical institutions, 78.33% (47/60) were unaware of A IDS before HIV infection was detected. After knowing the infection, 60.00% (36/60) had varying degrees of depression, anxiety and shame. Conclusion Elderly PLWHA lacks knowledge of AIDS prevention, and is prone to unsafe sex, mainly transmitted by commercial sex in males and by fixed sex in females. It suggests that the next work should focus on the sexual health and safe sex of the elderly and expand the testing, strengthen the intervention of sex workers in entertainment places, and promote the use of condoms. [ABSTRACT FROM AUTHOR]

High quality textbooks are the important foundation for high level teaching. This paper made a comparative study of 15 typical physical chemistry textbooks at home and abroad. The comparison is made on 16 aspects including compilation idea, teaching content, acknowledge framework, teaching objectives and the composition and publication of textbooks. The advantages and disadvantages of Chinese physical chemistry textbooks are summarized. Seven suggestions of the important directions and key points for the future construction of physical chemistry textbooks during the 14th Five-Year Plan period was proposed. It has certain reference value for the compilation and publication of physical chemistry textbooks. [ABSTRACT FROM AUTHOR]

马蹄肾主要在胚胎发育时，双侧输尿管芽的内侧支互相融合，诱导两侧肾下极或上极融合在一起 而形成。尽管存在解剖变异，但大部分马蹄肾具有良好的功能。马蹄肾可作为扩大标准供肾，为解决供肾不足提 供一种选择。本文就马蹄肾作为肾移植供肾的特点、国内外现状以及手术经验做一综述。 [ABSTRACT FROM AUTHOR]

Generally, the macro-scopic mechanical properties of heterogeneous composites depend on meso-components’ distribution and mechanical properties, but it is extremely difficult to establish a clear macro-meso relationship expression. To cope with this challenge, for concrete, a strategy based on deep learning was proposed to obtain the stress-strain curves through meso-model image information. First, the GoogLeNet model based on convolutional neural networks was used for image information recognition and extraction. According to the complexity of the stress-strain curve, data preprocessing operations were performed and the corresponding multi-task loss function was designed. The meso-model images in the data set were generated with the random aggregate model based on the Monte Carlo method, and numerical simulation experiments were conducted to obtain the uniaxial compressive stress-strain curve of the corresponding meso-model. Finally, the feasibility of the proposed method was evaluated through training and testing. The training efficiency and prediction accuracy of the GoogLeNet model are better than the AlexNet and ResNet models, and have good generalization ability and robustness. [ABSTRACT FROM AUTHOR]

目的 观察 2 型糖尿病 (T2DM) 患者血浆 miR-320b 的表达变化, 并分析其与糖代谢指标的相关性。 方法 T2DM 患者 (T2DM 组) 30 例、T2DM 前期患者 (T2DM 前期组) 29 例和体检健康者 (健康对照组) 30 例, 采用 qRT-PCR法检测三组受检者血浆中miR-320b。取三组受检者清晨空腹静脉血浆, 采用葡萄糖氧化酶法检测空腹血 糖 (FPG), 采用高效液相离子交换色谱法检测糖化血红蛋白 (HbA1c), 采用化学发光方法检测空腹胰岛素 (FINS), 并计算胰岛素抵抗指数 (HOMA-IR)、胰岛β细胞功能指数 (HOMA-β)。结果 T2DM组、T2DM 前期组、健康对照组 血浆中 miR-320b 相对表达量分别为 0. 148 (0. 076, 0. 394)、0. 447 (0. 080, 0. 926)、3. 820 (1. 894, 6. 720), 两两比 较, P均<0. 05。T2DM组、T2DM 前期组受检者血浆中 FPG、HbA1c 水平及 HOMA-IR 均高于健康对照组 (P均<0. 05), FINS 水平及 HOMA-β 均低于健康对照组 (P均<0. 05)；且 T2DM 组受检者血浆中FPG、HbA1c水平均高于T2DM前期 组 (P均<0. 05), FINS水平低于T2DM前期组 (P<0. 05)。三组受检者血浆中miR-320b相对表达量与 HOMA-IR 负相 关 (r=-0. 263, 95% CI为-0. 448～-0. 056 7, P=0. 013 3), 与 HOMA-β 正相关 (r=0. 494, 95%CI为0. 317～0. 638, P<0. 01), 与 FPG、HbA1c、FINS 均 无 关 (P 均 >0. 05)。结 论 与 体 检 健 康 者 和 T2DM 前 期 患 者 相 比, T2DM 患 者 血 浆 中 miR-320b 相对表达量降低；血浆中 miR-320b 相对表达量与糖代谢指标 HOMA-IR、HOMA-β 相关。 [ABSTRACT FROM AUTHOR]

The hydration mechanism of fiber-reinforced MgO/SiO2 cement was discussed, and the effect of MgO/SiO2 mixture ratio on the hydration process of the system was studied. The influence of MgO/SiO mixing ratio and aging time on the mechanical properties of the material was studied through the tensile/bending strength test. The change rule of the material properties with the MgO/SiO2 mixing ratio was determined and the optimal formula was obtained. The morphology and composition of hydration products of MgO/SiO2 composite were characterized by SEM and FT-TR. The hyd ration process of MgO/SiO2 cement was studied by pH value and ion concentration characterization. The results showed that the hyd ration products of the MgO/SiO2 mixed system were MgO/SiO2 and hydrated magnesium silicate gel. The mechanical properties of MgO/SiO2 cement were affected by the interaction of MgO/SiO2 and magnesium silicate hyd rate. The 60% MgO/SiO2 % Si02 mixing ratio was the best formulation of the cement composite material. The flexural strength of the MgO/SiO2 sample added with lignocellulose fiber was about 9.2 MPa on the first day of aging，which was 26% higher than that of the ordinary cement(7.3 MPa), and the flexural strength was still higher than that of the ordinary cement after 10 days of accelerated aging. Tt could be seen that the addition of lignocellulosic fiber to MgO/SiO2 could significantly enhance the flexural strength and improve the mechanical properties of MgO/SiO2 cement. [ABSTRACT FROM AUTHOR]

According to the meso-structure of concrete, a high-efficiency stepwise overlap checking method was proposed based on traditional 2 D modeling. Voids were introduced directly into the models and different concrete meso-structures were generated. The method involves various models containing circular, elliptical or polygonal aggregates and circular or elliptical voids. Meanwhile, several modeling examples based on different area fractions and different shapes of aggregates and voids were given to prove the computation efficiency of the proposed algorithm. At last, the mechanical behaviors of standard concrete specimens under uniaxial compression were simulated. The effects of internal voids on the main paths of crack propagation, concrete failure modes and macroscopic mechanical performances were analyzed. [ABSTRACT FROM AUTHOR]

Linear elastic fracture mechanics(LEFM) has become an enormously successful theory framework in characterizing the crack propagation in a wide range of solid materials. For linear elastic rock fracture mechanics, rocks is generally simplified to brittle materials, in which the fracture process zone(FPZ), i. e. the region ahead of the crack tip where micro-cracks initiate and coalesce, is small enough to be ignored compared to the size of the crack and the size of the specimen. On the other hand, coals usually exhibit quasi-brittle failure behaviors, char-acterized by a strain softening regime after the peak stress. For the ductile material, the size of FPZ is considerably large and has strong impact on the fracture behavior, and thus the theory of LEFM is no longer suitable for characterizing the crack propagation in coals. The cohesive zone model(CZM) has proven a useful theoretical tool to describe the fracture behavior in the FPZ of ductile materials. In the theory of CZM, the FPZ in front of the real crack tip is lumped hypothetically into a discrete line or plane corresponding to two-dimensional or three-dimensional cases, respectively, and the nonlinear behavior occurrence in the FPZ is represented by a con-stitutive equation that relates the cohesive stresses to the displacement jump across this line or plane. The consti-tutive relationships of CZMs for the different rank coals, including weakly caking coals, gas coals, fat coals, meager-lean coals and anthracite, have been determined by the disk-shaped compact tension(DC(T)) tests. The results show that the initial stiffness and peak loads increase with the coal rank increase. As the coal rank increases, the critical crack separation displacement reduces, and meanwhile the shape of the postpeak softening curves tends to be linear and the failure mode becomes more brittle. To arrive at a general form of constitutive relationships of CZMs in coals, the Karihaloo’s polynomial cohesion-separation law is applied to fit the softening curves of the five different rank coals. By considering the mechanical properties and the ductile failure of coals, the authors establish the multi-physics coupling equations for the hydraulic fracturing in coals, including the deformation equation of porous media, fluid flow equation in the pores, fluid flow equation in the fractures and Karihaloo’s polynomial constitutive equation, and simulate it with cohesive interface elements. Combined with a large-scale hydraulic fracturing experiment, the obtained mathematical model of hydraulic fracturing in coals is verified, and the effect of coal properties and the fracture process zone on hydraulic fracturing is discussed. [ABSTRACT FROM AUTHOR]

目的：探讨后腹腔镜保留肾单位手术治疗肾肿瘤的临床疗效。方法选择16例肾肿瘤患者，肿瘤直径平均2．4 cm。均采用后腹腔镜行保留肾单位手术，术中采用冰屑水肾蒂周围降温，三明治法缝合肾脏创面。观察手术时间、术中出血量、肾脏缺血时间、术后并发症等。结果16例手术顺利完成，无中转行开放手术者。肾动脉阻断时间18～22 min、平均20 min，手术时间96～168 min、平均118 min，术中出血量40～400 mL、平均120 mL。术后无出血、漏尿等并发症。术后随访6～30个月，患者肾功能及GFR均正常，肿瘤无局部复发。结论后腹腔镜保留肾单位术切除肾肿瘤疗效满意，可缩短手术时间，减少肾热缺血时间，并可有效保护肾功能。 [ABSTRACT FROM AUTHOR]