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A review with 636 references. The literature on saturated amino sulfonic acids with primary/secondary amino group and their derivatives from XIX century to 2016 is surveyed, focusing mainly on results published in the last two decades. Synthesis of saturated amino sulfonic acids and their derivatives, their occurrence among natural products, as well as their use for design of peptidomimetics, conjugates with various molecules of practical significance, applications as building blocks for drug discovery and for other reasons are discussed. [ABSTRACT FROM AUTHOR]

A range of 5H-pyrrolo[3,4-b]pyrazine-based peptidomimetics were designed, and their efficient synthesis starting from 5-imino-5H-pyrrolo[3,4-b]pyrazin-7-amine by subsequent interaction with Nprotected amino acid hydrazides and amino acid esters with N,N-carbonyldiimidazole as the coupling agent was elaborated. [ABSTRACT FROM AUTHOR]

A variety of 1 H-isoindole-based peptides was designed as potential mimics, and their efficient synthesis starting from 1-imino-1 H-isoindol-3-amine by subsequent interaction with N-Boc-amino acid hydrazides and amino acid ester isocyanates generated in situ, followed by chain elongation using conventional peptide chemistry, was elaborated. [ABSTRACT FROM AUTHOR]

by cyclization of electron-rich anilines with heterocyclic CF3-containing amines [ABSTRACT FROM AUTHOR]

A highly efficient multigram synthesis of spirocyclic and fused isoxazoline building blocks is described. Isoxazoline‐3‐carboxylates were synthesized via a regioselective 1,3‐dipolar cycloaddition reaction of 2‐chloro‐2‐(hydroxyimino)acetate and carbo‐ or heterocyclic alkenes bearing endo‐ or exocyclic C=C double bonds, resulting in fused or spirocyclic isoxazolines, respectively. The preparation of up to 300 g of these compounds was achieved in a single run. The ester group of isoxazolines was then subjected to common synthetic transformations for the synthesis of corresponding building blocks, including alcohols, chlorides, azides, amines, aldehydes, carboxylic acids, amino acids and their derivatives, difluoromethyl‐substituted compounds, and bicyclic γ‐lactones. Additionally, a direct cycloaddition‐based approach to the synthesis of aminoalkyl‐ and chloromethyl‐substituted isoxazolines was proposed to improve their preparation. The described isoxazoline building blocks are expected to be valuable tools for drug discovery. [ABSTRACT FROM AUTHOR]

Abstract: N′,N″-1H-Isoindole-1,3-diylidenedialkyl(aryl,heteroaryl)carbohydrazides were prepared in good yields via 1,1,3-trichloro-1H-isoindole, which was shown to be a versatile reagent for their synthesis. Tautomeric structure and conformational behaviour of dicarbohydrazides in solid state as well as in solution have been studied by X-ray crystallography, NMR spectroscopy and quantum calculations. The dependence of Z/E amide-type isomerism upon steric effects and solvent polarity is discussed. [Copyright &y& Elsevier]

• The synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives is developed. • The proposed mechanism depicted is in agreement with the experimental data. • The structure of all compounds obtained was confirmed by spectroscopic methods. The synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delépine reaction is reported. The substrate substituents' influence on the reaction course was studied, and a possible reaction mechanism proposed. The structure of 2-(methoxymethyl)isoindolin-1-imine was confirmed by X-ray diffraction analysis. [ABSTRACT FROM AUTHOR]

Novel approach to CF 3 -/CHF 2 -oxazoles was developed. The key reaction was oxidation of fluoroalkyl enamides with PhI(RCO 2 ) 2 . [ABSTRACT FROM AUTHOR]

A library of cyclopropyl- and cyclobutylpiperidine derivatives were synthesized from commonly available starting materials through Wittig reactions. [ABSTRACT FROM AUTHOR]

A library of the title piperidines is obtained by Wittig reactions starting from readily available materials. [ABSTRACT FROM AUTHOR]

The article presents chemical equations related to the article "Facile Synthesis of Hydrazine Derivatives of 5H-Pyrrolo[3,4-b]pyrazine and 1H-Pyrrolo[3,4-b]quinoxaline" by I. V. Rudenko and others, published in the "Synthesis" in 2013.