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Herein, we report a new visible-light-promoted strategy to access radical trifluoromethylthiolation reactions by combining halide and photoredox catalysis. This approach allows for the synthesis of vinyl-SCF3 compounds of relevance in pharmaceutical chemistry directly from alkenes under mild conditions with irradiation from household light sources. Furthermore, alkyl-SCF3-containing cyclic ketone and oxindole derivatives can be accessed by radical-polar crossover semi-pinacol and cyclization processes. Inexpensive halide salts play a crucial role in activating the trifluoromethylthiolating reagent towards photoredox catalysis and aid the formation of the SCF3 radical. [ABSTRACT FROM AUTHOR]

A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N-heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups. [ABSTRACT FROM AUTHOR]

[Re]ad all about it: The first examples of the rhenium‐catalyzed dehydrogenative formation of amides and esters with the highly active ReH5(triphos) complex are demonstrated. The addition of a tertiary amine additive improves the selectivity and the stability of the catalyst in the formation of esters from primary alcohols. [ABSTRACT FROM AUTHOR]

Symmetrical diarylalkenes such as (I), the unsymmetrical analogue (IVc) and a series of styrenes are subjected to conditions A) to produce pharmaceutically important vinyl-S-CF3 compounds. [ABSTRACT FROM AUTHOR]

The article presents chemical equations for the article "Transition-Metal-Free Trifluoromethylthiolation of N-Heteroarenes" by J.B. Ernst and colleagues, which appeared in a 2015 issue of the periodical "Chemistry-A European Journal."

A series of (un-)charged NHC derivatives bearing two pentadecyl chains in the backbone was studied in detail to find cooperative effects between the membrane and the NHC derivative. The tendency to show lipid-like behavior is dependent on the properties of the NHC derivative headgroup, which can be modified on demand. The surface activity was investigated by film balance measurements, epifluorescence microscopy, and differential scanning calorimetry. Additionally the cytotoxicity was evaluated against different cell lines such as eukaryotic tumor cell lines. These novel lipid-like NHC derivatives offer a broad spectrum for biological applications. [ABSTRACT FROM AUTHOR]

Use the head of differently (un‐)charged NHC derivatives with long alkyl chains in the backbone to modify their lipid‐like behavior. The inside cover picture illustrates the incorporation of the NHC derivatives into a membrane, leading to different effects according to the headgroup size. Small headgroups enable an integration and membrane rigidification, whereas bigger headgroups disrupt the membrane. Detailed studies provided insight into the lipid‐like behavior, which offers a broad spectrum of biological applications. More information can be found in the Communication by H.‐J. Galla, F. Glorius et al. on page 5920 ff. [ABSTRACT FROM AUTHOR]