1. Apelin signalling: a promising pathway from cloning to pharmacology
- Author
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Masri, B., Knibiehler, B., and Audigier, Y.
- Subjects
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CARDIOVASCULAR system , *MICROBIAL genetics , *CENTRAL nervous system , *LENTIVIRUS diseases - Abstract
Abstract: The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality. [Copyright &y& Elsevier]
- Published
- 2005
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