1. Bioactive neolignan, iridoid and flavonoid glycosides from the leaves of Vaccinium bracteatum.
- Author
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Wang, Yin-Yin, Li, Jun-Jiang, Wei, Quan-Hao, Wang, Xin-Xin, Zhang, Jun-Sheng, Yan, Jun-Jie, and Zhang, Hua
- Subjects
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BILBERRY , *HETEROCYCLIC compounds , *VITAMIN C , *MACROPHAGES , *FLAVONOIDS , *SPECTROPHOTOMETERS , *PHYTOCHEMICALS , *PLANT extracts , *REACTIVE oxygen species , *LIGNANS , *GLYCOSIDES , *MOLECULAR structure , *LIPOPOLYSACCHARIDES , *LEAVES , *CHROMATOGRAPHIC analysis - Abstract
Two neolignan glycosides including a new one (1), along with seven iridoid glycosides (3 − 9) and nine flavonoid glycosides (10 − 18), were isolated from the leaves of Vaccinium bracteatum. Their structures were established mainly on the basis of 1D/2D NMR and ESIMS analyses, as well as comparison to known compounds in the literature. The structure of 1 with absolute stereochemistry was also confirmed by chemical degradation and ECD calculation. Selective compounds showed antiradical activity against ABTS and/or DPPH. Moreover, several isolates also suppressed the production of ROS in RAW264.7 cells and exerted neuroprotective effect toward PC12 cells. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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