1. Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis.
- Author
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Teruhide Koyama, Laura, Ochoa-Callejero, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Arai, Takahiro Yoshizawa, Yasuhiro Iesato, Yang Lei, Ryuichi Uetake, Ayano Okimura, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Toriyama, Hisaka Kawate, Adams, Ralf H., Hayato Kawakami, and Naoki Mochizuki
- Subjects
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VASCULAR endothelial cells , *ADRENOMEDULLIN , *TAMOXIFEN , *RECOMBINASES , *HOMEOSTASIS , *KNOCKOUT mice - Abstract
The article presents a study which investigates the function of the vascular endothelial adrenomedullin (AM)-receptor activity-modifying protein 2 (RAMP2) in the organ homeostasis and vascular integrity. It states that RAMP2 mice were crossed breed with mice expressing tamoxifen-inducible Cre-recombinase (Cre-ERT2) to create RAMP2 conditional knockout (KO) mice. Results shows that the AM-RAMP2 system is the key factor of homeostasis and vascular integrity from prenatal levels through adulthood.
- Published
- 2013
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