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1. PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models.

Author

Tosi, Umberto, Kommidi, Harikrishna, Adeuyan, Oluwaseyi, Hua Guo, Maachani, Uday Bhanu, Chen, Nandi, Taojunfeng Su, Guoan Zhang, Pisapia, David J., Dahmane, Nadia, Ting, Richard, and Souweidane, Mark M.

Subjects
*BLOOD-brain barrier, *GLIOMAS, *PHARMACOKINETICS, *GLIAL fibrillary acidic protein, CENTRAL nervous system tumors
Abstract

In this article the author the author talks about the study of positron emission tomography (PET) image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models. It mentions that the PET data reveal that CED has significant mouse-to-mouse variability; imaging is used to modulate CED infusions to maximize tumor saturation; and the use of PET-guide convection-enhanced delivery results in survival prolongation in mouse models.

Published
2020
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