1. Defective Angiogenesis in Mice Lacking Endoglin.
- Author
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Li, Dean Y., Sorensen, Lise K., Brooke, Benjamin S., Urness, Lise D., Davis, Elaine C., Taylor, Douglas G., Boak, Beth B., and Wendel, Daniel P.
- Subjects
- *
HEMORRHAGIC diseases , *VASCULAR diseases , *GENES , *TRANSFORMING growth factors-beta , *ANALYTICAL chemistry - Abstract
Reports that loss-of-function mutations in the human endoglin gene ENG causes hereditary hemorrhagic telangiectasis (HHT1), a disease characterized by vascular malformations. Shows that by gestational day 11.5 mice lacking endoglin die from defective vascular development; Vasculogenesis unaffected in mice lacking transforming growth factor-beta (TGF-beta); Results of loss of endoglin; Need for endoglin for angiogenesis.
- Published
- 1999