7 results on '"Wang, Kai‐Xin"'
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2. IRMOF‐8‐encapsulated curcumin as a biocompatible, sustained‐release nano‐preparation.
- Author
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Wang, Kai‐Xin, Cai, Meng‐Ru, Yin, Dong‐Ge, Hu, Xue‐Ling, Peng, Hulin‐Yue, Zhu, Rong‐Yue, Liu, Man‐Ting, Xu, Yu‐Chen, Qu, Chang‐Hai, Ni, Jian, and Yin, Xing‐Bin
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CONTROLLED release preparations , *COORDINATION polymers , *CURCUMIN , *DRUG solubility , *POROUS polymers , *REACTIVE oxygen species , *POROSITY , *MITOCHONDRIAL membranes - Abstract
Metal‐organic frameworks (MOFs) are porous coordination polymers formed by metal ions and organic ligands through coordination bonds. In drug delivery applications, MOFs can impart sustained release, targeting, protection of easily degradable drugs, and improved drug solubility. Isoreticular metal‐organic framework‐8 (IRMOF‐8) is a mesoporous MOF with a network topology bridged in the form of an octahedral cluster. Compared with other materials, it has the remarkable advantages of high porosity and a regular pore structure. Curcumin (CUR) is a diketone compound with potent antitumor effects. Due to its poor solubility and stability, its clinical application is limited. Therefore, we used IRMOF‐8 as a carrier for the encapsulation of CUR to overcome the shortcomings of CUR itself and expand its clinical application. In this study, IRMOF‐8 was synthesized through direct mixing of triethylamine (TEA). In vitro cell experiments demonstrated the biocompatibility of IRMOF‐8. Using the solvent adsorption method, CUR was encapsulated by IRMOF‐8 with a drug loading content of 58.86 ± 0.98 wt%. In vitro drug release experiments performed at pH levels of 7.2 and 5.5 showed that the preparation had a sustained‐release effect over 7 days. Through cytotoxicity experiments after drug loading, it was found that CUR@IRMOF‐8 had a strong cytotoxic effect on HepG2 cells, promoted cell apoptosis and intracellular uptake, decreased mitochondrial membrane potential, and increased reactive oxygen species. Hence, CUR@IRMOF‐8 is expected to become an excellent sustained‐release preparation for potential applications in tumor treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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- View/download PDF
3. Antitumour properties based on the self‐assembly of camptothecin and carbamoylmannose conjugates.
- Author
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Wang, Jia‐Li, Wang, Kai‐Xin, Han, Tian‐Lei, Li, Jin‐Mei, He, Xu, Rong, Rui‐Xue, Cao, Zhi‐Ran, Li, Xiao‐Liu, and Wang, Ke‐Rang
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APOPTOSIS , *CANCER cells , *ALKALOIDS , *DRUG side effects , *CAMPTOTHECIN - Abstract
Camptothecin (CPT) and its analogues show potent antitumour activity. However, poor water solubility and severe side effects have restricted their applications in clinical practice. In this paper, a novel self‐assembly based on camptothecin and carbamoylmannose conjugates (CPT‐Man) was constructed. The self‐assembly increased the water solubility of camptothecin to 0.64 mg/ml and antitumour activity. Moreover, CPT‐Man could induce obvious cancer cell apoptosis. This work provides a new approach for exploring carbohydrate‐modified antitumour properties by self‐assembled CPT drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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4. Image style migration based on cycle generative adversarial networks.
- Author
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PENG Yan-fei, Wang Kai-xin, Mei Jin-ye, SANG Yu, and ZI Ling-ling
- Abstract
Image style migration refers to learning the style of oil painting pictures and applying the learned style to other pictures to make the pictures have the style of oil painting. The current methods based on generative adversarial networks have been widely used in image style migration. Aiming at the problem that Cycle Generative Adversarial Networks (CycleGAN) do not have high texture definition when processing images, a method of adding a Local Binary Pattern (LBP) algorithm is proposed. The LBP algorithm is added into the generation model of CycleGAN to enhance the extraction of image texture features by CycleGAN. Aiming at the problem of noise in the generated images, Total Variation Loss is added into the loss function to constrain the noise. The experimental results show that the quality of the generated images can be improved by adding LBP algorithm and Total Variation Loss, and the generated images have better visual effects. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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5. Melatonin Alleviates High Temperature-Induced Pollen Abortion in Solanum lycopersicum.
- Author
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Qi, Zhen-Yu, Wang, Kai-Xin, Yan, Meng-Yu, Kanwar, Mukesh Kumar, Li, Dao-Yi, Wijaya, Leonard, Alyemeni, Mohammed Nasser, Ahmad, Parvaiz, and Zhou, Jie
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MELATONIN , *PLANT growth , *PLANT development , *POLLEN , *TOMATOES , *HEAT shock proteins - Abstract
Melatonin is a pleiotropic signal molecule that plays critical roles in regulating plant growth and development, as well as providing physiological protections against various environmental stresses. Nonetheless, the mechanisms for melatonin-mediated pollen thermotolerance remain largely unknown. In this study, we report that irrigation treatment with melatonin (20 µM) effectively ameliorated high temperature-induced inactivation of pollen and inhibition of pollen germination in tomato (Solanum lycopersicum) plants. Melatonin alleviated reactive oxygen species production in tomato anthers under high temperature by the up-regulation of the transcription and activities of several antioxidant enzymes. Transmission electron micrograph results showed that high temperature-induced pollen abortion is associated with a premature degeneration of the tapetum cells and the formation of defective pollen grains with degenerated nuclei at the early uninuclear microspore stage, whilst melatonin protected degradation of organelles by enhancing the expression of heat shock protein genes to refold unfolded proteins and the expression of autophagy-related genes and formation of autophagosomes to degrade denatured proteins. These findings suggest a novel function of melatonin to protect pollen activity under high temperature and support the potential effects of melatonin on reproductive development of plants. [ABSTRACT FROM AUTHOR]
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- 2018
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6. Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato.
- Author
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Hasan, Md. Kamrul, Xing, Qu‐Fan, Zhou, Can‐Yu, Wang, Kai‐Xin, Xu, Tong, Yang, Ping, Qi, Zhen‐Yu, Shao, Shu‐Jun, Ahammed, Golam Jalal, and Zhou, Jie
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SOLANUM , *PEPPERS , *ATMOSPHERIC carbon dioxide , *TOMATOES , *HEAT shock proteins , *MELATONIN , *PHOTOSYSTEMS - Abstract
Increasing carbon dioxide (CO2) promotes photosynthesis and mitigates heat stress‐induced deleterious effects on plants, but the regulatory mechanisms remain largely unknown. Here, we found that tomato (Solanum lycopersicum L.) plants treated with high atmospheric CO2 concentrations (600, 800, and 1000 µmol mol−1) accumulated increased levels of melatonin (N‐acetyl‐5‐methoxy tryptamine) in their leaves and this response is conserved across many plant species, including Arabidopsis, rice, wheat, mustard, cucumber, watermelon, melon, and hot pepper. Elevated CO2 (eCO2; 800 µmol mol−1) caused a 6.8‐fold increase in leaf melatonin content, and eCO2‐induced melatonin biosynthesis preferentially occurred through chloroplast biosynthetic pathways in tomato plants. Crucially, manipulation of endogenous melatonin levels by genetic means affected the eCO2‐induced accumulation of sugar and starch in tomato leaves. Furthermore, net photosynthetic rate, maximum photochemical efficiency of photosystem II, and transcript levels of chloroplast‐ and nuclear‐encoded photosynthetic genes, such as rbcL, rbcS, rbcA, psaD, petB, and atpA, significantly increased in COMT1 overexpressing (COMT1‐OE) tomato plants, but not in melatonin‐deficient comt1 mutants at eCO2 conditions. While eCO2 enhanced plant tolerance to heat stress (42°C) in wild‐type and COMT1‐OE, melatonin deficiency compromised eCO2‐induced thermotolerance in comt1 plants. The expression of heat shock proteins genes increased in COMT1‐OE but not in comt1 plants in response to eCO2 under heat stress. Further analysis revealed that eCO2‐induced thermotolerance was closely linked to the melatonin‐dependent regulation of reactive oxygen species, redox homeostasis, cellular protein protection, and phytohormone metabolism. This study unveiled a crucial mechanism of elevated CO2‐induced thermotolerance in which melatonin acts as an essential endogenous signaling molecule in tomato plants. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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7. Fluorescent enhancement sensing of cadmium (II) ion based on a perylene bisimide derivative.
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Xiong, Jiu-Kai, Wang, Ke-Rang, Wang, Kai-Xin, Han, Tian-Lei, Zhu, Hong-Yu, Rong, Rui-Xue, Cao, Zhi-Ran, and Li, Xiao-Liu
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PERYLENE , *BISIMIDES , *CADMIUM , *BINDING constant , *IONS , *DETECTION limit , *AQUEOUS solutions - Abstract
• Fluorescence turn-on sensing of Cd2+ ion based on perylene bisimide derivative was developed. • The sensor showed high selective for Cd2+ ion in aqueous solution. • The sensor exhibited fluorescence enhancement upon complexing with Cd2+ ion in living cells. A perylene bisimide derivative (PBI-Lac-DPA) with lactose and DPA moiety conjugates was synthesized, and this compound exhibited fluorescence turn-on sensing for Cd2+ ions in an aqueous solution with a binding constant of (6.0 ± 0.3) × 104 M−1, and detection limit of 5.2 × 10-7 M. PBI-Lac-DPA exhibited high selectivity for the Cd2+ ion with a 2:1 binding stoichiometry between PBI-Lac-DPA and Cd2+ ions due to the additional coordinating sites in the self-assembly process of PBI-Lac-DPA itself. Furthermore, PBI-Lac-DPA exhibited fluorescence enhancement upon complexation with the Cd2+ ion in living cells. This work explored a new method for increasing the selectivity for Cd2+ ions via the enhanced additional complex sites of the DPA moiety from self-assembly process. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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