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Your search keyword '"somatic hypermutation (SHM)"' showing total 27 results

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27 results on '"somatic hypermutation (SHM)"'

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1. Unfolding the Role of Splicing Factors and RNA Debranching in AID Mediated Antibody Diversification.

2. SRSF1-3, a splicing and somatic hypermutation regulator, controls transcription of IgV genes via chromatin regulators SATB2, UBN1 and histone variant H3.3.

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3. Splicing regulator SRSF1-3 that controls somatic hypermutation of IgV genes interacts with topoisomerase 1 and AID.

4. AID preferentially targets the top strand in nucleosome sequences.

5. Prospects for modulating the CD40/CD40L pathway in the therapy of the hyper-IgM syndrome.

6. AID Biology: A pathological and clinical perspective.

7. The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.

8. Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.

9. Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.

10. DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

11. A novel activation-induced cytidine deaminase (AID) mutation in Brazilian patients with hyper-IgM type 2 syndrome.

12. Regulation of Aicda expression and AID activity.

13. Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.

14. The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination.

15. Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination.

16. Mechanism of somatic hypermutation: Critical analysis of strand biased mutation signatures at A:T and G:C base pairs

17. Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: A large-scale simulation study

18. Regulation of IgA synthesis at mucosal surfaces

19. The regulation of somatic hypermutation

20. Transcriptional control of B cell development and function

21. Translocations into human chromosome 14 JH region: factors influencing downstream abortive immunoglobulin class switching

22. Imitating the humoral immune response

23. B cells as effectors

24. Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments

25. DNA Double Strand Breaks Occur Independent of AID in Hypermutating Ig Genes.

26. Class-switch recombination: after the dawn of AID