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Urbanization and industrialization have increased dependence on the fast-depleting non-renewable energy sources, such as fossil fuels. To mitigate this challenge, it is imperative to source an alternative, through the conversion of agricultural waste to other usable forms of energy. This study focuses on the production of alkali-pretreated solid biofuel from cabbage waste using cassava waste as binder. Proximate analysis, ultimate analysis, calorific value, and physicochemical parameters of treated cabbage briquette (TCB) and untreated cabbage briquette (UCB) were assessed before and after delignification. Eco-friendliness and the presence of potential toxic elements (PTEs) in both UCB and TCB were evaluated using energy dispersive X-ray fluorescence (EDXRF). While surface modification and bond orientation of TCB and UCB samples were monitored using scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectrophotometer, respectively, ultimate analysis recorded a mean carbon value of 47.98 ± 0.13 wt% (UCB) and 49.48 ± 0.06 wt% (TCB). The recorded mean density values of 0.58 ± 0.10 and 0.64 ± 0.22 g/cm3 were noted for UCB and TCB, respectively, with compressive strength of 0.62 ± 0.03 (UCB) and 0.69 ± 0.20 N/mm2 (TCB) at p < 0.05, while the calorific values were 10.20 ± 0.12 and 13.41 ± 0.02 MJ/kg for UCB and TCB, respectively, at p < 0.05. EDXRF results ascertained a reduction in PTEs concentration which aligns with the recorded low mean TCB ash content value of 1.94 ± 0.22% at carbon counts of 1000. The FTIR recorded a shift in C-O stretch of TCB and UCB with recorded values of 1006 and 1002 cm−1, respectively, signifying surface modification, while the SEM micrographs show a surface disruption and modification with flakes-like morphology. The finding of this study shows that delignification improves the combustion properties of the treated solid biofuel when compared to the untreated briquette samples. [ABSTRACT FROM AUTHOR]

Antimicrobial resistance and oxidative stress are increasing and researchers are being encouraged to search the natural plant products, due to their popular usage in ethno-medicine, for alternative source of antimicrobial and antioxidant compounds. Gmelina arborea used in West-Africa and Ayurveda folkloric medicine to cure several diseases was therefore investigated for phytochemical, antioxidant and antimicrobial activities. Extracts and chromatographic fractions of the root-bark tested for antibacterial activity with the MIC determined on seven selected bacteria using agar dilution method. The antioxidant capacity of the crude extracts was determined by six (6) methods: total flavonoid content, total phenolic content, ferric reducing power, total antioxidant capacity, Trolox equivalent antioxidant capacity and DPPH (2,2-diphenyl-1-picryhydrazyl) properties. Phytochemical screening indicated the presence of saponins, tannins, flavonoids, terpenoids anthraquinones, phenols and alkaloids. The methanol and ethyl acetate extracts of the plant showed good antibacterial activities (18 mm inhibitory zones and MIC and MBC 12.5-100 mg/mL) against P. aeruginosa ATCC 27853 and S. aureus ATCC 6571. Antioxidant study of the extracts revealed that both ethyl acetate and methanol extracts have good antioxidant capacity comparable to that of ascorbic acid standard. Therefore, Gmelina arborea could prove a valuable source of developing new antimicrobial and antioxidant compounds for therapeutic uses. [ABSTRACT FROM AUTHOR]

Introduction: In endemic malarial nations, repeated use of antimalarial drugs has increased due to resistance, misuse, and unrestricted availability, which could contribute to infertility rates. Therefore, we investigated the effects of long-term repeated treatment with two commonly prescribed artemisinin-based combination therapies, artemether/lumefantrine (A/L) and artesunate-amodiaquine (A/A), on reproductive potential in mice. Methods: Sixty male mice were divided into three groups: control, A/L, and A/A treatment. Mice underwent treatment for three consecutive days per week, and this regimen was repeated every two weeks for a total of six cycles. Sperm parameters were evaluated after the 1st, 2nd, 3rd, and 6th exposure cycles, after which treated male mice were paired with female mice for mating. Results: Sperm viability was significantly reduced by 21% (P<0.001) following the 6th exposure to A/L, whereas the 2nd, 3rd, and 6th exposures to A/A resulted in significant decreases in sperm viability of 26% (P<0.001), 12% (P<0.01), and 31% (P<0.001), respectively, compared to the control group. Treatment with A/A during the 3rd and 6th periods led to a significant decline (P<0.001) in sperm mass activity by 20% and 28%, respectively, compared to the control group. However, long-term therapeutic exposure to A/L or A/A did not affect testosterone levels, epididymal content, or the ability to impregnate female mice. Conclusion: Long-term treatment with A/L or A/A did not affect testosterone levels or epididymal content. However, a decrease in sperm viability was observed, even though the mice remained fertile. [ABSTRACT FROM AUTHOR]

This study assessed the factors militating against the effective implementation of electronic health records (EHR) in Nigeria, the computerization of patients' health records with a lot of benefits including improved patients' satisfaction, improved care processes, reduction of patients' waiting time, and medication errors. Despite these benefits, healthcare organizations are slow to adopt the EHR system. Therefore, the study assessed the factors militating against the effective implementation of the EHR system, the level of awareness of EHR, and the utilization of electronic health records; it also investigated the factors militating against the effective implementation of EHR. This is a descriptive cross-sectional study conducted among members of staff of the University of Medical Sciences Teaching Hospital (UNIMEDTH). Purposive sampling was adopted to select the study participants, and a structured questionnaire was used for data collection. Statistical Product and Service Solutions (SPSS) version 27 was used for data analysis, R and Microsoft Excel were used for data visualization. Findings revealed that the respondents had a high level of awareness of EHR with an average mean of 1.29. The study revealed a low utilization rate for EHR (mean 3.01, SD 0.115) and data storage (mean 3.00, SD 0.231), indicating major problems with EHR implementation. Financial limitations (mean 2.63, SD 0.486) and insufficient ICT resources (mean 2.62, SD 0.516) are the main challenges. The regression analysis revealed that EHR utilization is highly impacted by awareness (F = 4.26, p < 0.008), accounting for 15.1% of the variance. Governmental assistance and financial constraints showed a statistically significant negative correlation (r=−0.04, p < 0.05), while inadequate internet connectivity and epileptic power supply showed a statistically significant positive association (r = 0.1, p < 0.05). The results show that, more government support is needed to alleviate financial constraints, and a stable power supply may enhance internet accessibility. The study concluded that epileptic power supply, poor internet connectivity, financial constraints, and other factors mentioned in the study militate against the effective implementation of electronic health records. It was recommended that the management should implement electronic health records effectively for efficient and effective health care delivery. [ABSTRACT FROM AUTHOR]

The global shift toward renewable energy raises concerns that the legacy of energy injustice—historical imbalances in the distribution of benefits and burdens from fossil fuels—may persist within renewable systems intended to address climate change. Current research highlights that energy injustice could threaten the success of this transition, yet limited focus has been placed on understanding public responses to these emerging injustices. Existing frameworks often reduce public opinion to simplistic binaries (for example, "supporters vs. opponents"), which fail to capture the nuanced and diverse perspectives necessary for a comprehensive understanding of public sentiment on energy issues. To address this, we introduce the "PARO framework," a novel tool that categorizes public responses to energy injustice within the renewable energy context. The PARO framework broadens the analytical lens on public opinion, offering insights that can guide more targeted and effective solutions for promoting equitable energy transitions. [ABSTRACT FROM AUTHOR]

Background: Bone fractures remain a significant global public health issue despite preventive measures, leading to substantial health and economic consequences. Effective treatment options are difficult to access in most sub-Saharan African countries, leading to reliance on unqualified practitioners and resulting in serious complications that worsen poverty. In Nigeria, the main challenge is the need for out-of-pocket payment for healthcare, which is the primary method of health financing. However, anecdotal evidence suggests that some patients find it easier to finance their fracture care than others. This study aimed to identify the factors that predict difficult fracture-care financing among patients treated operatively for long-bone fractures (LBFs) in southwestern Nigeria. Methods: The study collected socio-demographic and clinical data on 690 consecutive adult patients with LBFs treated with SIGN nails between July 2014 and June 2024 at a mission teaching hospital in southwestern Nigeria. A literature review and preliminary interviews were conducted with patients, caregivers, and hospital staff to understand potential risk factors for difficult fracture-care financing. The patients were divided into two cohorts – easy fracture-care financing (EF) and difficult fracture-care financing (DF) – based on their promptness in paying the in-patient care bills. Potential risk factors for DF identified in the initial univariate analysis were entered as covariates into a binary logistic regression to determine the significant predictors of DF. Results: The mean age of the patients was 45.1 years (SD = 17.52). The DF cohort comprised 321 (46.5%) patients. Significant predictors of DF included younger age (p = 0.018), male gender (p = 0.002), lack of formal education or low level of education (p < 0.001), residence in the hospital city (p < 0.001), absence of health insurance (p = 0.013), lack of extended family support (p < 0.001), previous traditional bone setting treatment (p = 0.005), concomitant injury (p = 0.017), and a post-operative hospital stay longer than one week (p = 0.036). Conclusions: The findings suggest that improving people's socioeconomic status through job creation, women's empowerment, reduction of gender inequality, higher education, comprehensive health insurance coverage, and stronger family bonds, as well as preventive strategies to reduce the occurrence and severity of injuries, can improve fracture-care financing in low-resource settings. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability. [ABSTRACT FROM AUTHOR]

The progressive development of resistance in Neisseria gonorrhoeae to almost all available antibiotics has made it crucial to develop novel approaches to tackling multi-drug resistance (MDR). One of the primary causes of antibiotic resistance is the over-expression of the MtrCDE efflux pump protein, making this protein a vital target for fighting against antimicrobial resistance (AMR) in N. gonorrhoeae. This study was aimed at evaluating the potential MtrCDE efflux pump inhibitors (EPIs) and their stability in treating gonorrhoea infection. This is significant because finding novel EPIs would allow for the longer maintenance of antibiotics at therapeutic levels, thereby prolonging the susceptibility of currently available antibiotics. A virtual screening of the selected Helichrysum populifolium compounds (4,5-dicaffeoylquinic acid, apigeninin-7-glucoside, and carvacrol) was conducted to evaluate their potential EPI activity. An integrated computational framework consisting of molecular docking (MD), molecular mechanics generalized born, and surface area solvation (MMGBSA) analysis, molecular dynamics simulations (MDS), and absorption, distribution, metabolism, and excretion (ADME) properties calculations were conducted. Of the tested compounds, 4,5-dicaffeoylquinic acid revealed the highest molecular docking binding energies (−8.8 kcal/mol), equivalent MMGBSA binding free energy (−54.82 kcal/mol), indicative of consistent binding affinity with the MtrD protein, reduced deviations and flexibility (root mean square deviation (RMSD) of 5.65 Å) and, given by root mean square fluctuation (RMSF) of 1.877 Å. Carvacrol revealed a docking score of −6.0 kcal/mol and a MMGBSA computed BFE of −16.69 kcal/mol, demonstrating the lowest binding affinity to the MtrD efflux pump compared to the remaining test compounds. However, the average RMSD (4.45 Å) and RMSF (1.638 Å) of carvacrol-bound MtrD protein showed no significant difference from the unbound MtrD protein, except for the reference compounds, implying consistent MtrD conformation throughout simulations and indicates a desirable feature during drug design. Additionally, carvacrol obeyed the Lipinski rule of five which confirmed the compound's drug-likeness properties making it the most promising EPI candidate based on its combined attributes of a reasonable binding affinity, sustained stability during MDS, its obedience to the Lipinski rule of five and compliance with drug-likeness criteria. An in vitro validation of the potential EPI activities of H. populifolium compounds confirmed that 4,5-dicaffeoylquinic acid reduced the expulsion of the bis-benzimide dye by MtrCDE pump, while carvacrol showed low accumulation compared to other compounds. While 4,5-dicaffeoylquinic acid demonstrated the highest binding affinity in computational analysis and an EPI activity in vitro, it showed lower stability compared to the other compounds, as indicated in MDS. This leaves carvacrol, as a better EPI candidate for the management of gonorrhoea infection. [ABSTRACT FROM AUTHOR]

Background: Mesenchymal stem cells (MSCs) derived from gestational tissues offer a promising avenue for prenatal intervention in congenital malformations although their application is hampered by concerns related to cellular plasticity and the need for invasive, high-risk surgical procedures. Here, we present naturally occurring exosomes (EXOs) isolated from amniotic fluid-derived MSCs (AF-MSCs) and their mimetic analogs (MIMs) as viable, reproducible, and stable alternatives. These nanovesicles present a minimally invasive therapeutic option, addressing the limitations of MSC-based treatments while retaining therapeutic efficacy. Methods: MIMs were generated from AF-MSCs by combining sequential filtration steps through filter membranes with different porosity and size exclusion chromatography columns. A physicochemical, structural, and molecular comparison was conducted with exosomes (EXOs) released from the same batch of cells. Additionally, their distribution patterns in female mice were evaluated following in vivo administration, along with an assessment of their safety profile throughout gestation in a mouse strain predisposed to neural tube defects (NTDs). The possibility to exploit both formulations as mRNA-therapeutics was explored by evaluating cell uptake in two different cell types(fibroblasts, and macrophages) and mRNA functionality overtime in an in vitro experimental setting as well as in an ex vivo, whole embryo culture using pregnant C57BL6 dams. Results: Molecular and physiochemical characterization showed no differences between EXOs and MIMs, with MIMs determining a threefold greater yield. Biodistribution patterns following intraperitoneal administration were comparable between the two particle types, with the uterus being among targeted organs. No toxic effects were observed in the dams during gestation, nor were there any malformations or significant differences in the number of viable versus dead fetuses detected. MIMs delivered a more intense and prolonged expression of mRNA encoding for green fluorescent protein in macrophages and fibroblasts. An ex-vivo whole embryo culture demonstrated that MIMs mainly accumulate at the level of the yolk sac, while EXOs reach the embryo. Conclusions: The present data confirms the potential application of EXOs and MIMs as suitable tools for prevention and treatment of NTDs and proposes MIMs as prospective vehicles to prevent congenital malformations caused by in utero exposure to drugs. [ABSTRACT FROM AUTHOR]

This systematic literature review investigates the fairness of machine learning algorithms in educational settings, focusing on recent studies and their proposed solutions to address biases. Applications analyzed include student dropout prediction, performance prediction, forum post classification, and recommender systems. We identify common strategies, such as adjusting sample weights, bias attenuation methods, fairness through un/awareness, and adversarial learning. Commonly used metrics for fairness assessment include ABROCA, group difference in performance, and disparity metrics. The review underscores the need for context-specific approaches to ensure equitable treatment and reveals that most studies found no strict tradeoff between fairness and accuracy. We recommend evaluating fairness of data and features before algorithmic fairness to prevent algorithms from receiving discriminatory inputs, expanding the scope of education fairness studies beyond gender and race to include other demographic attributes, and assessing the impact of fair algorithms on end users, as human perceptions may not align with algorithmic fairness measures. [ABSTRACT FROM AUTHOR]

Human hair is characterised by variability, determined by genetic and macromolecular factors. Whilst the European hair type has been a focus of extensive research, Afro-textured hair care faces challenges created by insufficient knowledge of its properties. Applications of hair care products that are incompatible with Afro-textured hair frequently have detrimental effects on the scalp. This highlights the need for partnerships to bridge the gap between research and hair care practices and address challenges related to Afro-textured hair. In this review, we performed data mining of the existing literature and in silico network analysis of the biomarkers relevant to Afro-textured hair. The approaches to hair maintenance are highlighted in the context of hair anatomy and growth cycles, organisation of keratins, surface lipids, and chemical bonds. We discuss a range of biomarkers affecting hair fibre's shape and mechanical strength, with the gene interactive network pointing to the hierarchical organisation of important traits, notably hair shaft diameter, keratinization, and hair follicle patterning, which likely contribute to the increased sensitivity of hair to extrinsic factors. We propose that a better understanding of the genetic traits, molecular structure, and biomechanics of Afro-textured hair is required to initiate more effective hair care solutions that would benefit the wider population. [ABSTRACT FROM AUTHOR]

Feeding embryos with exogenous feed components prior to hatching has been reported to positively improved the growth and immune response in poultry. This study investigated the effects of in ovo administration of aqueous extracts of garlic, oyster mushroom and their combination on hatching traits and post-hatch performance of broiler chickens. A total of 230 broiler hatching eggs were sorted and incubated. On candling, 200 (85.11 % fertility) fertile eggs were obtained and distributed into five treatments: control, in ovo injection of garlic, oyster mushroom, combination of garlic and oyster mushroom, and de-ionized water (SHAM) at 0.1 ml.egg-1 in each treatment. In ovo injection was done on 18th day of incubation. Data collected were subjected to One-Way Analysis of Variance. Chick weight was the highest (P < 0.05) in birds hatched from eggs injected with aqueous extracts of garlic (50.91 g per chick). The highest proportions (P < 0.05) of heart (0.65 %) and spleen (0.18 %) were observed in birds from eggs injected with oyster mushroom and the combination of garlic and oyster mushroom, respectively. Significantly highest lymphocyte counts (P < 0.05) were found in birds from eggs injected with aqueous extracts of garlic, and the combination of garlic and oyster mushroom. The best (P < 0.05) feed conversion rate (FCR) (1.82) was recorded in birds from eggs on in ovo injection of aqueous extract of oyster mushroom. The study suggests that in ovo injection of aqueous extracts of garlic and oyster mushroom at 0.1 ml per egg can enhance chick weight, heart, spleen functions and overall growth performance in broiler chickens. [ABSTRACT FROM AUTHOR]

Arid and semiarid regions cover more than one‐third of the land surface, where the interplay between water, land use, and management strongly influences carbon (C) sequestration. Yet, information on the C management practices and how local biophysical conditions affect the C sequestration potential is limited. We explored the opportunities, research gaps, and future directions of land C sequestration in arid and semiarid regions, using New Mexico as an example. We also identified the major land use types and their potential for C storage and sequestration. Our results showed that innovations in cropland and rangeland management, protection of existing forests, and restoration of degraded forest lands after drought and wildfire enhanced C sequestration in arid and semiarid lands. Landscape‐scale C balance studies with fine‐scale mapping, improving water and nutrient use efficiency, and policy incentives to support farms will unlock the full potential of C sequestration in croplands, rangelands, and forest lands. Future research should focus on the response of land management practices to climate anomalies and their potential to sequester C and offset greenhouse gas emissions as a natural climate solution in arid and semiarid regions. Core Ideas: We reviewed C sequestration through sustainable land management practices in arid and semiarid regions.Regenerative cropland and rangeland management can enhance C sequestration in dry areas.Restoration of degraded forest lands after drought and wildfire is critical for forest C sequestration.Incentivizing farmers to adopt regenerative practices is necessary to maximize C sequestration in arid lands. [ABSTRACT FROM AUTHOR]

Diabetes cardiomyopathy (DCM) refers to heart muscle damage. Inflammatory cytokines have been implicated in the development of DCM. These cytokines can cause inflammation and oxidative stress in the heart, leading to structural and functional changes contributing to heart dysfunction. This present study investigated the cardioprotective property of co-administration of hesperidin (HSP) and acarbose (ACA) with/without exercise (EX) on tumor necrosis factor (TNF-ɑ), interleukin 10 (IL-10), anti-cardiomyopathic markers in diabetic rat. Induction of diabetes was via intraperitoneal injection of STZ at 50 mg/kg body weight to rats of 9 groups (n = 8), and confirmed via fasting blood glucose level (FBGL) and glycated hemoglobin. In the aftermath subjection to hesperidin and acarbose (25 mg/mL and 25 mg/mL dosing at 2 mL/kg/b. w respectively) with/without exercise for 14 days, the diastolic and systolic blood pressure was also conducted. At the end of the experiment, the heart tissues were extracted and homogenized, and used for biochemical assays such as; TNF-ɑ, IL-10, ACE, PDE-5, AChE, Arginase, LDH, 5′ Nucleotidase, ATPDase, ROS, TBARS, and GSH. The results revealed that there was a reduction in FBGL, blood pressure, ACE, PDE-5, AChE, Arginase, LDH, 5′ Nucleotidase, ATPDase enzyme activities, ROS, and TBARS levels while GSH level was increased in tissue homogenate of DCM rat treated ACA and HSP with/without EX. Interestingly, significant observation was in exercised rats co-administered with HSP and ACA compared to hesperidin or acarbose treated alone without exercise. Conclusively, co-administration of HSP and ACA to exercised DM rats had the most effective and promising effect in the management of DCM, therefore, recommends exercise coupled with HSP in combination with ACA as an effective therapy in the management of diabetes and cardiac complications. [ABSTRACT FROM AUTHOR]

Bioactive peptides (BPs) derived from agri-food side-streams display great potential as functional ingredients and nutraceuticals. However, BPs can be susceptible to environmental stressors and food processing conditions and typically exist as an aqueous mixture of various peptides, making their storage and use in foods very challenging. Microencapsulation offers a solution, utilizing suitable wall materials to create a protective matrix and transform them into powders for improved stability and application versatility. Here, we investigated the possibility of creating freeze-dried microencapsulated BP powders from bread waste using maltodextrin as the wall material to maintain their antifungal properties against Penicillum albocoremium, Eurotium herbariorum and Penicillium roqueforti fungi. The results were compared to those obtained from galactoglucomannans (GGM) and glucuronoxylans (GX) sourced from forest industry side-streams, aiming to explore their potential suitability as innovative materials for microencapsulating BPs. Maltodextrin microcapsules exhibited the highest inhibition rate on the tested fungi (10 − 44%), followed by GX (26 − 39%) and then GGM (9 − 14%) counterparts. Interactions between wall materials and BPs, as illustrated by FTIR analyses, were found to be the cause of variations in antifungal activities among BP microcapsules. The use of wall materials, especially wood hemicelluloses, facilitated freeze drying of BPs. However, their application in food products is restricted by the decline in the BP bioactivity resulting from the freeze drying process. For this reason, additional research on alternative drying methods is needed. The results of this study are expected to open new ways of production of stable functional ingredients from side-streams of the forest and food industries. [ABSTRACT FROM AUTHOR]

Background: Sphingosine-1 phosphate (S1P) is a bioactive lipid molecule that modulates inflammation and hepatic lipid metabolism in MASLD, which affects 1 in 3 people and increases the risk of liver fibrosis and hepatic cancer. S1P can be generated by 2 isoforms of sphingosine kinase (SphK). SphK1 is well-studied in metabolic diseases. In contrast, SphK2 function is not well characterized. Both sphingolipid and redox metabolism dysregulation contribute to MASLD pathologic progression. While SphK2 localizes to both the nucleus and mitochondria, its specific role in early MASH is not well defined. Methods: This study examined SphK2 depletion effects on hepatic redox metabolism, mitochondrial function, and inflammation in a 16-week western diet plus sugar water (WDSW)-induced mouse model of early MASH. Results: WDSW- SphK2 −/− mice exhibit increased hepatic lipid accumulation and hepatic redox dysregulation. In addition, mitochondria-localized cholesterol and S1P precursors were increased. We traced SphK2 −/− -mediated mitochondrial electron transport chain impairment to respiratory complex-IV and found that decreased mitochondrial redox metabolism coincided with increased oxidase gene expression and oxylipin production. Consistent with this relationship, we observed pronounced increases in hepatic inflammatory gene expression, prostaglandin accumulation, and innate immune homing in WDSW- SphK2 −/− mice compared to WDSW-wild-type mice. Conclusions: These studies suggest SphK2-derived S1P maintains hepatic redox metabolism and describe the potential consequences of SphK2 depletion on proinflammatory gene expression, lipid mediator production, and immune infiltration in MASH progression. [ABSTRACT FROM AUTHOR]

The monkeypox outbreak has grown beyond the regions in which it was considered endemic. It has spread from central and west Africa to non-endemic regions like Europe, America, and other parts of the world. It has recently been classified as a public health emergency of international concern. This study evaluated the challenges faced globally and equitable access to monkeypox vaccines. Global competition has been observed in the race to obtain vaccines, with low- and middle-income countries being disadvantaged. Great inequity exists in the distribution of vaccines globally through advance purchase agreements, vaccine stockpiling, vaccine nationalism, the inequitable distribution of existing resources, and insufficient surveillance and reporting mechanisms. To address some of these challenges, there is a need for strengthening the global vaccine manufacturing capacity, targeting countries with elevated risk profiles and limited resources, strengthening surveillance systems, and addressing vaccine hesitancy. [ABSTRACT FROM AUTHOR]

Purpose: Chorea is a clinical sign characterized by involuntary, rapid, unpredictable, and irregular muscle movements that can affect various parts of the body. It can be seen in various medical conditions, both neurological and systemic, of genetic and acquired etiology. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has been used to treat various types of chorea. The aim of this study was to evaluate the efficacy of GPi DBS for chorea in pediatric patients. Methods: The authors undertook a single-center retrospective study of all pediatric patients who underwent DBS in the period from July 2017 to April 2024 to identify those presenting with chorea. Results: Three patients with chorea underwent bilateral posteroventral GPi DBS without surgical complications. The mean age at operation was 14.2 years (range: 1.5 years), and the mean follow-up was 49 months (range: 15 months). Two of the 3 patients experienced a positive effect on chorea with an improvement in functional status. In one patient, the pre- and postop Gross Motor Function Classification System (GMFCS) score was 4, while his Burke-Fahn-Marsden Dystonia Scale (BFMDS) score improved from 102/20 pre- to 53.5/20 postop. In the other patient the GMFCS score improved from 4 preop to 3 postop. His preop BFMDS score was not available, postop it was 83/120. In the patient who did not experience a positive effect on chorea the pre- and postop GMFCS score was 4, her BFMDS score was 84.5/120 pre- and 100/120 postop. Conclusion: Bilateral GPi DBS can be safely administered to pediatric patients with choreiform movement disorders, and it could be an effective treatment option for managing chorea in certain patients. [ABSTRACT FROM AUTHOR]

Erectile dysfunction (ED) is a multifactorial social problem affecting men worldwide. While phosphodiesterase type 5 inhibitors (PDE5) like sildenafil are commonly used, they often present side effects, underscoring the need for alternative therapies. Therefore, this study investigated the potential of phytochemicals from Detarium senegalense in the management of ED. A library of phytochemicals from Detarium senegalense was generated, prepared, and interacted with six key enzymes implicated in ED, including PDE5, using the Schrödinger Maestro suite. The results identified catechin, epicatechin, and gallic acid as the leading compounds with significant binding affinities for the targeted enzymes. Catechin and epicatechin (−9.877 and −11.408 kcal/mol, respectively) exhibited comparable binding affinities to sildenafil (−11.926 kcal/mol) on PDE5. The MD simulation results also revealed superior stability and ability to maintain interaction with key amino acids at the active site of PDE5 over the entire simulation period for these compounds. These compounds also demonstrated favorable ADMET profiles over sildenafil, including high gastrointestinal absorption and no violation of Lipinski's rule, indicating good bioavailability and drug likeness. These findings suggest that flavonoids from Detarium senegalense, especially catechin and epicatechin, have potential in the management of ED by interacting with multiple targets involved in its pathogenesis. [ABSTRACT FROM AUTHOR]

Global higher education aims to develop students' intellectual capacities, foster personal growth, and mold behaviors, thoughts, and creativity for a fulfilling life. Within this framework, university residential spaces play a vital role in advancing these objectives. A well-designed hostel, tailored to students' needs and comfort, promotes shared interests and positive educational outcomes. Therefore, the importance of satisfactory residential facilities in improving students' performance should not be underestimated. This research examined the satisfaction levels of current residents of the College of Agriculture and Environmental Science hostel at Kaduna State University (KASU) regarding their accommodation. It also explored variations in satisfaction among groups with different socio-demographic characteristics. The study focused on two performance requirements for the evaluation of students' satisfaction, namely, the technical performance requirement (thermal comfort, acoustical comfort, visual comfort, indoor air quality, and fire safety) and the functional performance requirement (interior and exterior finish systems, room layout, support services, efficiency of circulation, and proximity to other facilities on campus). A total of forty-eight (48) performance indicators from the two performance requirement were evaluated through a survey questionnaire. The findings indicated that students generally expressed dissatisfaction across all performance elements, except thermal comfort and indoor air quality, room layout and size, efficiency of circulation, and proximity to facilities. The significance of this study lies in its potential to inform targeted improvements and interventions that enhance student satisfaction, comfort, and overall experience within university hostel accommodations. Findings from this study will contribute to creating a more supportive, enjoyable and conducive living environment for students, ultimately promoting their well-being and academic success. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability. [ABSTRACT FROM AUTHOR]

Background: Celiac disease (CD) affects the small intestine and can hinder nutrient absorption. It is found worldwide and common in certain groups of people including individuals with Type 1 Diabetes Mellitus (T1DM). However, the prevalence of CD in the West African region is not documented. This study aimed to investigate the prevalence and pattern of CD autoimmunity in Nigerian children and adolescents diagnosed with T1DM. Methods: This was a cross-sectional descriptive study of children and adolescents with T1DM at the Paediatric Endocrinology Clinic of seven selected tertiary health facilities in Nigeria. Information was collected on socio-demographics, clinical characteristics and anthropometrics. The subjects were screened for markers of CD autoimmunity using anti-tissue transglutaminase antibody (tTG) and anti-endomysial antibody (EMA). Endoscopy and duodenal biopsy were recommended for participants with elevated CD-specific antibodies. Results: The study recruited a total of 104 children and adolescents with TIDM, out of which six participants (5.8%) had CD autoimmunity. All six participants were females, aged between 3 and 12 years, with a mean age of 9.2 ± 3.7 years. Participants with CD autoimmunity were more likely to have DM diagnosed before the age of 10 years compared to those without CD autoimmunity (83.3% vs. 37.7%, p = 0.149). Except for two participants, all individuals with CD autoimmunity experienced gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and bloating. Conclusion: This study highlights the occurrence of CD autoimmunity in Nigerian children and adolescents with TIDM. Healthcare providers should consider screening for celiac disease in children and adolescents with T1DM, particularly in females and when gastrointestinal symptoms are present. Additionally, the findings from this study suggest that there is a high probability of a significant burden of CD, even within the general population in Nigeria. Therefore, it's important to maintain a high level of suspicion and to actively screen at-risk groups in clinical settings to ensure early diagnosis of CD. [ABSTRACT FROM AUTHOR]

The effectiveness of frequent compost application in improving soil health is well‐documented. Less is known on the long‐term effects of infrequent compost application to semiarid soils. Compost made of dairy manure and straw bedding was applied once in a dryland organic hard red winter wheat (Triticum aestivum L. emend. Thell.)–fallow system at 50 Mg ha−1 dry wt. in 1994 in a randomized complete block design with three replicates. Twenty‐eight years later, yields in composted plots (1.4 Mg ha−1) remained higher (p < 0.1) than in control plots (0.79 Mg ha−1). Plant‐available P, acid phosphatase activity (ACP), and total N were higher in composted plots by 143%, 37%, and 29%. Soil organic carbon (SOC) and dehydrogenase enzyme activity were greater by 25% and 20% with compost compared to the control, as were aggregate stability determined using SLAKES method, autoclave‐extractable protein, and CO2‐96 h by 143%, 22%, and 16%. Soil extractable K and Zn also increased with compost application. The interaction of ACP and estimated evapotranspiration (ET) emerged as a pivotal factor in explaining the variation in yield. These findings suggest that growers may see some yield improvements from periodic compost applications to dryland organic winter wheat–fallow systems. This strategy could help rebuild SOC and partially counter the challenges of low and variable precipitation. Core Ideas: Twenty‐six years after compost application, soil health indicators were over 140% higher than without compost.Potential acid phosphatase activity strongly predicted yield variation based on path analysis.A large compost application provided lasting benefits to soil health and improved yield. [ABSTRACT FROM AUTHOR]

Introduction: Atrial high‐rate episodes (AHRE) have been linked to increased thromboembolic risk and all‐cause mortality in patients with cardiac implantable electronic devices (CIEDs). Various predictors of AHRE development have been identified, emphasizing the need for close monitoring and the potential transition to clinical atrial fibrillation (AF). However, the predictive value of P wave characteristics on AHRE development remains conflicting. This meta‐analysis aims to summarize existing data to investigate this association. Method: We examined studies from MEDLINE and EMBASE databases up to May 2024 to investigate the association of baseline P‐wave duration (PWD), P‐wave dispersion (PWDIS), and interatrial block (IAB) with the risk of developing AHRE. We extracted the mean and standard deviations of PWD and PWDIS to calculate the pooled mean difference (MD). Risk ratios (RR) and 95% confidence intervals (CIs) were used to assess the association between IAB and AHRE risk, using the generic inverse variance method for combination. Results: The meta‐analysis included nine studies. Patients with AHRE had longer PWD and PWDIS compared to those without AHRE, with a pooled MD for PWD of 9.17 ms (95% CI: 4.74–13.60; I2 = 47%, p < 0.001) and a pooled MD for PWDIS of 20.56 ms (95% CI: 11.57–29.56; I2 = 57%, p < 0.001). Additionally, patients with IAB had a higher risk of developing AHRE, with a pooled RR of 3.33 (95% CI: 2.53–4.38; I2 = 0%, p < 0.001), compared to those without IAB. Conclusions: Our meta‐analysis found that patients with AHRE had higher PWD and PWDIS than those without AHRE. Additionally, IAB was associated with a higher risk of developing AHRE. These findings emphasize the importance of close monitoring and risk stratification, particularly for patients with P wave abnormalities. [ABSTRACT FROM AUTHOR]

A quantitative understanding of the migration of munitions and canonical objects in the nearshore is needed for the effective management of contaminated sites. Migrations of munitions with a density range of 2000 kg/m3 to 5720 kg/m3 were quantified in a large-scale wave flume. The forcing consisted of six cases of varying wave heights, periods, still water depths, and durations. The cross-shore profile, typical of natural sandy beaches, was sub-divided into swash, surf, and offshore zones. Overall, 2228 migration measurements were recorded with 16% and 84% of the migration observations classified as "motion" (net distance > 0.5 m) and "no motion" (net distance ≤ 0.5 m), respectively. The probability of munitions migration increased with proximity to the shoreline. There was a nearly equal probability of onshore or offshore migration in the swash zone. Migration in the surf zone tended to be offshore-directed (65%), while migration was onshore-dominant (65%) in the offshore zone. Migration in the offshore zone was preferentially onshore due to skewed waves over flat bathymetry. Less dense munitions in the offshore zone may have migrated offshore likely still related to the skewed nature of the wave profile causing transport in both directions through the majority of the wave phase. The largest migration distances occurred in the surf zone likely due to downslope gravity. Migration in the surf and swash zones is a balance between skewed/asymmetric forcing and downslope gravity, with downslope gravity tending to be pronounced provided the forcing is sufficient to initiate motion. An exception was sometimes observed in the swash zone where onshore forcing was sufficient to transport munitions to the seaward side of the berm where they became trapped in a bathymetric depression between the dune and berm. Relating overall migration (Lagrangian) to fixed hydrodynamic measurements (Eulerian) was ineffective. Parameters such as the Shields number, wave skewness, and wave asymmetry estimated from the closest measurement location were insufficient to predict migration. Large scatter in the migration data resulting from competing hydrodynamic, morphodynamic, and munitions response processes makes robust deterministic predictions with flow statistics and dimensionless numbers difficult. [ABSTRACT FROM AUTHOR]

Nutritional modifications to improve meat quality is targeted by farmers. Bird eye pepper (BEP) contains bio-compounds of physiological significance. The potency of BEP of varying inclusion level and sieve size on meat quality [fatty acid (FA), lipid profile and oxidative stability] of broiler chickens was investigated. A total of 246 birds fed diet-containing BEP [inclusion level (0, 0.15 and 0.3%), sieve size (0.05 and 0.1 mm)] were randomized to six treatments replicated 4 times in a 2 by 3 factorial layout. After feeding (31 days), forty-eight birds (two per replicate) were slaughtered and breast muscles harvested. Meat lipid profile and 2-thiobarbituric acid reactive substance (TBARs) were determined on day (d) 0, while TBARs was further assessed on d 3 and 5, but FA on d 10 of refrigeration storage. BEP diet (0.15%) increased (p < 0.05) total monounsaturated FA (MUFA), unsaturated FA (UFA) and n-3 FA, while 0.05 mm BEP lowered (p < 0.05) meat index of thrombogenicity (TI) but increased meat hypocholesteromic: hypercholesteromic (HH) value. Dietary 0.15% (0.05 mm) BEP yielded low (p < 0.05) SFA but high MUFA: SFA, UFA: SFA and NVI, while 0.15% (0.1 mm) BEP diet resulted in high total MUFA and higher (p < 0.05) UFA, n-3 and n-3: n-6 FA. Control, 0.15% and 0.05 mm BEP diets reduced (p < 0.05) meat cholesterol value. This study has shown that 0.15% (0.05 mm) BEP diet had no deleterious effect on the growth of broiler chickens but improved the NVI, IA, TI, HH, TBARs and cholesterol of the meat – a significance to health-conscious consumers. [ABSTRACT FROM AUTHOR]

Background: Mannose‐binding lectin (MBL) is a key component of the innate immune system that plays a crucial role in binding to the microbial sugar surface to recognize and eliminate pathogens by activating the complement system. Objective: To detect and quantify the MBL protein concentration and chicken MBL expression in selected chicken breeds in South Africa. Methods: Forty‐five blood samples from three indigenous chicken breeds, Ovambo (OV = 9), Venda (VD = 9) and Potchefstroom Koekoek (PK = 9), and two exotic chicken breeds, Rhode Island Red (RIR = 9) and Lohmann Brown (LB = 9), were used for MBL protein concentration using enzyme‐linked immunosorbent assay (ELISA) techniques. Also 20 liver samples from symptomatic two indigenous chicken breeds, OV (5) and PK (5), and two exotic chicken breeds, RIR (5) and LB (5), were used for MBL expression using quantitative polymerase chain reaction (qPCR) techniques. A general linear model was done using Tukey's multiple comparison post hoc test. Results: The findings revealed MBL protein concentration from 5.26 to 18.56 µg/mL. The LB breed had the lowest mean 6.40 ± 0.80 µg/mL, whereas the PK breed had the highest mean MBL concentration of 17.70 ± 0.24 µg/mL of MBL protein concentration. At 12, 25 and 35 weeks, the MBL proteins of OV, VD, PK, RIR and LB varied significantly at p ≤ 0.05. The mRNA MBL expression of OV and LB breeds showed a 1‐fold decrease in MBL expression, while RIR showed a 2‐fold increase in MBL expression, and the PK showed more than a 3‐fold increase in MBL expression relative to the control. The least‐squares means for OV, LB, PK and RIR mRNA MBL expression were 0.54 ± 0.19, 0.68 ± 0.30, 4.46 ± 2.76 and 2.89 ± 0.19 µg/mL, respectively. Conclusion: MBL protein was detected and quantified with distinct differences in concentration and expression levels at the presence of mycoplasma gallisepticum among the sampled South African chicken breeds. This highlights the genetic diversity of MBL as a tool for disease prevention in South African chicken breeds. [ABSTRACT FROM AUTHOR]

Background: Early detection of chronic obstructive pulmonary disease (COPD) is a strategy to address the increasing human and economic costs of this condition. This study aimed to inform pharmacists' case-finding strategies by providing an overview of case-finding approaches by health care practitioners. Methods: A scoping review was conducted based on the Joanna Briggs Institute and the PRISMA Extension for Scoping Reviews (PRISMA ScR) guidelines. Included studies were analyzed under the following themes: population characteristics, inclusion and exclusion criteria, setting, case-finding strategies and yield, health care practitioners involved, interprofessional collaboration and the provision of preventive services. Studies were then characterized by highest yields (the weighted average of each approach expressed as a percentage of the total number of new COPD cases divided by the total number of patients screened using the same approach). Results: The screening process produced 170 eligible studies. Twenty case-finding approaches with average yields of new COPD cases ranging from 3.8% to 29% were identified. The approach with the highest yield involved the use of a questionnaire, peak flow meter and pre–post spirometry. In 14 of these approaches, the process was initiated with the use of questionnaires. In many of the studies, case-finding was targeted at high-risk and/or symptomatic patients. Characteristics of studies with the highest case-finding yields included provider education/training, patient education, active screening, multistep approaches to case-finding, provider engagement, diagnostic criteria by guidelines and engagement of other health care practitioners. Conclusion: In our scoping review of case-finding methods for patients with COPD, we found the greatest yield from pre–post spirometry following initial screening with a peak flow meter and questionnaire. Pharmacists and health researchers can use these approaches to identify high-risk patients for interventions. [ABSTRACT FROM AUTHOR]

Currently, there is no known cure for diabetes. Different pharmaceutical therapies have been approved for the management of type 2 diabetes mellitus (T2DM), some are in clinical trials and they have been classified according to their route or mechanism of action. Insulin types, sulfonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones, meglitinides, sodium–glucose cotransporter type 2 inhibitors, and incretin-dependent therapies (glucagon-like peptide-1 receptor agonists: GLP-1R, and dipeptidyl peptidase 4 inhibitors: DPP-4). Although some of the currently available drugs are effective in the management of T2DM, the side effects resulting from prolonged use of these drugs remain a serious challenge. GLP-1R agonists are currently the preferred medications to include when oral metformin alone is insufficient to manage T2DM. Medicinal plants now play prominent roles in the management of various diseases globally because they are readily available and affordable as well as having limited and transient side effects. Recently, studies have reported the ability of phytochemicals to activate glucagon-like peptide-1 receptor (GLP-1R), acting as an agonist just like the GLP-1R agonist with beneficial effects in the management of T2DM. Consequently, we propose that careful exploration of phytochemicals for the development of novel therapeutic candidates as GLP-1R agonists will be a welcome breakthrough in the management of T2DM and the co-morbidities associated with T2DM. [ABSTRACT FROM AUTHOR]

The burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome in recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, a drug known to be effective against all Schistosoma species, due to reports of reduced efficacy and resistance. Therefore, this study seeks to investigate the antischistosomal potential of phytochemicals from Azadirachta indica against proteins that have been implicated as druggable targets for the treatment of schistosomiasis using computational techniques. In this study, sixty-three (63) previously isolated and characterized phytochemicals from A. indica were identified from the literature and retrieved from the PubChem database. In silico screening was conducted to assess the inhibitory potential of these phytochemicals against three receptors (Schistosoma mansoni Thioredoxin glutathione reductase, dihydroorotate dehydrogenase, and Arginase) that may serve as therapeutic targets for schistosomiasis treatment. Molecular docking, ADMET prediction, ligand interaction, MMGBSA, and molecular dynamics simulation of the hit compounds were conducted using the Schrodinger molecular drug discovery suite. The results show that Andrographolide possesses a satisfactory pharmacokinetic profile, does not violate the Lipinski rule of five, binds with favourable affinity with the receptors, and interacts with key amino acids at the active site. Importantly, its interaction with dihydroorotate dehydrogenase, an enzyme responsible for the catalysis of the de novo pyrimidine nucleotide biosynthetic pathway rate-limiting step, shows a glide score and MMGBSA of −10.19 and −45.75 Kcal/mol, respectively. In addition, the MD simulation shows its stability at the active site of the receptor. Overall, this study revealed that Andrographolide from Azadirachta indica could serve as a potential lead compound for the development of an anti-schistosomal drug. [ABSTRACT FROM AUTHOR]

The export flow bottlenecks impact the extensiveness and intensiveness of Africa’s exports to its trade partners. These bottlenecks are influenced by supply chain disruptions, administrative inefficiencies, quality infrastructure deficiencies, customs procedures’ inefficacies, a proliferation of trade documentation, etc. The preponderance of these bottlenecks brought to the fore the need to improve exports through trade facilitation policies. Several trade facilitation measures have been implemented with different export outcomes. Nevertheless, the opportunities characterising the implementation of trade facilitation measures have provided the necessary impetus for many African countries to embark on export promotion. This study investigates the determinants of the implemented trade facilitation measures in Africa from the perspective of extensive and intensive margins of exports. An augmented gravity model derived from Helpman, Melitz and Rubenstein’s framework is adopted in this study to a panel of 54 African countries between 2005 and 2018. The findings indicate that export-facilitating quality infrastructure such as telephone, internet services and time to import and export determine the improvement in export facilitation at the extensive and intensive export margins. An improved implementation of these quality infrastructures, except for the exporting time, propels the probability of export; while they enhance the trade intensity, except for internet service usage. Although the robustness checks also suggest somewhat similar outputs, the logistics performance index indicates that though there are challenges in Africa’s quest for improved trade facilitation, the implemented export-facilitating quality infrastructures are export-enhancing. [ABSTRACT FROM AUTHOR]

Cutaneous wound healing is a complex multi-step process that is highly controlled, ensuring efficient repair to damaged tissue and restoring tissue architecture. Multiple cell types play a critical role in wound healing, and perturbations in this can lead to non-healing wounds or scarring and fibrosis. Thus, the process is tightly regulated and controlled. Cellular senescence is defined as irreversible cell cycle arrest and is associated with various phenotypic changes and metabolic alterations and coupled to a secretory program. Its role in wound healing, at least in the acute setting, appears to help promote appropriate mechanisms leading to the complete restoration of tissue architecture. Opposing this is the role of senescence in chronic wounds where it can lead to either chronic non-healing wounds or fibrosis. Given the two opposing outcomes of wound healing in either acute or chronic settings, this has led to disparate views on the role of senescence in wound healing. This review aims to consolidate knowledge on the role of senescence and aging in wound healing, examining the nuances of the roles in the acute or chronic settings, and attempts to evaluate the modulation of this to promote efficient wound healing. [ABSTRACT FROM AUTHOR]

Background: Tumours that metastasize to the ovary can occur in conjunction with other ovarian lesions, including benign sex cord stroma tumours like fibroma or fibrothecoma. This case report presents a unique instance of metastatic signet ring carcinoma involving the ovary in a background of fibroma in a Black African woman. Patient presentation: A 46-year-old gravida 3, para 0 (2 alive), patient was referred from the general outpatient clinic to the gynecology clinic due to progressive abdominal swelling over the past eight months. Abdominal examination revealed marked distension with massive ascites. Physical examination of the chest demonstrated dullness to percussion over both lung bases, with increased dullness noted on the right. Auscultation revealed decreased air entry in the right middle and lower lung zones, with normal to increased air entry in the remaining lung fields. Abdominopelvic ultrasound revealed a large irregularly marginated homogeneous solid mass in the right adnexa measuring 16.4 × 11.7 × 12.7 cm. An abdominal CT scan revealed bilateral pleural effusion, which was more pronounced on the right, ascites, and evidence of pulmonary and hepatic metastasis. Serum chemistry revealed abnormal levels of several analytes, including elevated CA 125 at 1,108.8 (normal range 0–35) U/L and CA 19–9 at 63.8 (normal range 0–35) U/L. She subsequently underwent staging laparotomy with total abdominal hysterectomy and bilateral salpingo-oophorectomy, without any postoperative complications. The histologic sections of the right and left ovaries revealed a moderately cellular lesion composed of intersecting bundles of spindle cells in a fascicular and storiform pattern. Additionally, pockets of small round to oval-shaped cells with intracytoplasmic clear vacuoles pushing the nucleus to the periphery (signet ring cells) were identified in a few foci. These cells were initially thought to be ovarian stroma or theca cells. Microscopic examination revealed signet ring cells with cytoplasmic positivity for periodic acid-Schiff (PAS) staining. The histopathological diagnosis was metastatic signet ring cell carcinoma involving the ovary, with an underlying ovarian fibroma. Conclusions: Ovarian metastatic signet ring carcinoma in a background of fibroma can pose a significant diagnostic challenge, as signet ring cells can mimic the ovarian stroma or theca cells, especially if they are only observed in a few foci of the sections. [ABSTRACT FROM AUTHOR]

Introduction: Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate possible molecular targets of oritavancin in human and microbes in relevance to its mechanism of action and model its pharmacokinetics for optimal dose selection in clinical practice. Methods: Computational methods were used in this study which include target prediction, molecular docking, molecular dynamics simulation, pharmacokinetics prediction, and physiological-based pharmacokinetics (PBPK) modeling. Results: Oritavancin was moderately soluble in water and did not permeate the blood-brain barrier. Seven molecular targets were identified in humans. Molecular docking results showed highest binding affinity of oritavancin with PI3-kinase p110-gamma subunit (−10.34 kcal/mol), followed by Acyl-CoA desaturase (−10.07 kcal/mol) and Cytochrome P450 2C19 (−8.384 kcal/mol). Oritavancin PBPK modelling in adult human showed that infusion has lower peak concentrations (Cmax) compared to bolus administration, with 1200 mg dose yielded Cmax of 16.559 mg/L, 800 mg dose yielded Cmax of 11.258 mg/L, and 200 mg over 3 days dose yielded Cmax of 7.526 mg/L. Notably, infusion gave extended half-life (t1/2) for all doses and slightly higher clearance rates compared to bolus, particularly for the 1200 mg and 800 mg doses. The results corroborated existing clinical pharmacokinetic data, and confirmed the model's accuracy and predictive capability. Conclusion: This comprehensive computational study has provided invaluable insights into the pharmacological profile of Oritavancin, aiding its further development and optimization for clinical use. [ABSTRACT FROM AUTHOR]

This research investigates the sustainable design features of selected female university hostels in Kaduna state, Nigeria, with a focus on identifying strengths and weaknesses in their current sustainability practices. The objectives are to analyse selected existing female hostels in Kaduna, Nigeria, and develop design recommendations to improve their sustainability. The study employs a case study research design, collecting data through field observations and architectural assessments. Findings reveal that while the buildings are strategically oriented along the north-south axis to optimize natural light and energy efficiency, there is significant untapped potential for renewable energy integration. Additionally, Waste management practices are inadequate, with improper disposal observed on or near the sites. Although natural ventilation and daylighting strategies, such as window openings and courtyards, were successfully implemented, the hostels lack appropriate landscaping. Thermal comfort is generally wellmanaged, but noise control measures are absent. The construction relied solely on concrete blocks, which offer high thermal mass, yet no recycled materials were utilized, and water management practices were not implemented. While most building materials were locally sourced, the absence of modular coordination indicates inefficiencies in design. The study underscores the need for a more integrated approach to sustainable design in university hostels, offering targeted recommendations that prioritize environmental responsibility while addressing the specific needs of female students in Kaduna state, Nigeria. [ABSTRACT FROM AUTHOR]

Sub-Saharan Africa having remained economically poor throughout its more than sixty years of independence and relying on the finding that the acquisition of a high level of digital and entrepreneurship skills tends to create wealth for nations in modern times, this study investigates the extent to which sub-Saharan Africa’s higher education institutions may leverage the facilitation of the learning of digital technologies and entrepreneurship for Africa’s economic emancipation through lifelong learning. The work carried out at the level of eight (8) lifelong learning outfits of eight (8) premier universities drawn from the four (4) regions of sub-Saharan Africa is scrutinized through the administration of a six (6)-item questionnaire with a view to establish whether or not Africa’s higher education institutions are currently facilitating the learning of digital technologies and entrepreneurship through lifelong learning to a level that may promote Africa’s economic emancipation. The findings of the current study are that sub-Saharan Africa (i). possesses very few higher education institutions in comparison to the global average, (ii). is yet to prioritize lifelong learning both nationally and at the higher education level, and (iii). is incapable to produce the needed population of digital and entrepreneurship graduates that may propel its economic emancipation as a result of its current level of neglect of lifelong learning. [ABSTRACT FROM AUTHOR]

A total of 288-day-old chicks were used to investigate the effect of processed bovine blood rumen digesta mixture (BBRDM) as partial replacement for soyabeans on performance of broiler chickens. Considerable quantities of fresh bovine blood and rumen digesta were collected on weight/weight basis using the 1:2 ratio, processed via heat treatment for 2 hours 30 minutes and thereafter sun-dried for five days until it was dried. The BBRDM was used to formulate four dietary treatments consisting of 0 %, 20 %, 40 % and 60 % as partial replacement for soyabeans. The experimental birds were balanced for weight and divided into four (4) treatment groups of seventy-two (72) birds each. Each group was further divided into 4 subgroups comprising of 18 birds each serving as replicate. Data collected on the response variables (growth performance indices, haematological parameters and carcass traits) were subjected to One-way Analysis of Variance. Results revealed non-significant variations in all the growth, haematological indices (at starter and finishing phases) as well as carcass traits measured. In conclusion, partial substitution of soya beans meal with 60 % BBRDM in the diet is recommended for broiler chicken production for enhanced growth, better blood function, health status as well as carcass yield with probable reduction in the production cost. [ABSTRACT FROM AUTHOR]

Laying hen farming is an important sub-sector of the Nigerian livestock industry as it provides significant proportion of the needed animal protein to the populace as well as creating employment opportunities. Despite the significance of the laying hen industry to the national economy, farmers are usually faced with a lot of risks and uncertainties such as heat stress, flood, fire outbreaks, theft and unpredicted damages. They pose serious threat to the success of the laying hen farming enterprise in Nigeria. A multi-stage sampling technique was employed in selecting Laying Hen Farmers (LHF) in Lagos and Oyo States. The first stage was the purposive selection of Lagos and Oyo states in South-west (SW) being the highest poultry production areas in the SW, Nigeria. The second stage involved the selection of six Local Government Areas (LGAs) from Lagos state and eight Local Governments from Oyo state. The third stage was the random selection of one hundred and ninety-eight (198) and three hundred and nine (309) laying hen farmers selected from Lagos and Oyo State, respectively, giving a total of five hundred and seven (507) laying hen farmers selected for the study. Majority have access to credit facilities (87.1 %) and extension services (84.7 %), while there was poor access to insurance across the locations. The most prevalent production risks among the LHF were attack of predators, pest and disease infestation. Age, education and livestock insurance reduced the probability of exposure to production risks, while household size, access to extension and distance to residence increased the probability of LHF exposure to production risks. Educational status, flock size, access to livestock insurance and access to credit significantly increased TFP, while farming experience, feed quantity, hired labour and extension access reduced TFP. The probit results show that age, household size, education, access to resources and insurance significantly affect production risks. [ABSTRACT FROM AUTHOR]

The present study involves the development of a new method, a range-dependent multivariate adaptive regression splines–genetic algorithm (RD-MARS-GA), for monthly streamflow prediction. The results of the RD-MARS-GA model are compared with standard MARS, Gaussian process regression, principal component regression, M5 model tree and random forest. The input data utilized in the study combine satellite and ground-based datasets. Monthly data from the Treene, Schaale, and Wandse rivers in Northern Germany were used as case studies. The satellite datasets used were sourced from Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), Integrated Multi-Satellite Retrievals for Global Precipitation Measurement (IMERG GPM) and Moderate Resolution Imaging Spectroradiometer Evapotranspiration (MODIS). A comparison of the results reveals that the RD-MARS-GA can improve the forecasting accuracy of the MARS model across all watersheds at different temporal scales. The RD-MARS-GA model surpassed the other regression models and improved the root mean square accuracy of the MARS model by 12.8%, 26.7% and 18.5% in predicting one-month-ahead streamflow of the rivers Treene, Schaale, and Wandse, respectively. [ABSTRACT FROM AUTHOR]

The influence of participative budgeting, organizational commitment, and interaction of participative budgeting and organizational commitment on managerial performance in budgeting activities is an area in management accounting that is continuously receiving research attention. Earlier studies were conducted in developed countries and focused on large firms, excluding small and medium-size firms and reported conflicting findings. This serves as the motivation for the study. The study population consisted of all Sachet and Table Water producing firms registered with the Delta State Ministry of Commerce and Trade, Nigeria. A sample of 150 firms was selected based on purposive sampling technique. Data were obtained through the administration of questionnaires by research assistants of the sampled firms. Multiple regression analysis was deployed to estimate the influence of participative budgeting, organizational commitment and the interaction of participative budgeting, and organizational commitment on managerial performance of budgeting activities. Findings show that participating budgeting, organizational commitment and the interaction of participative budgeting and organizational commitment have a positive and significant influence on managerial performance. The findings have policy implications for organizational control design, the budgeting system, strategies for involving managers in budgeting, instilling their organizational commitment, and improving their performance. [ABSTRACT FROM AUTHOR]

Microplastics (MPs) are emerging and ubiquitous contaminants, known to accumulate in river sediments. In many developing nations, the absence of policies for managing plastic waste puts the inland river ecosystems at risk of excessive abundance of plastics and MPs. However, only limited studies have reported MPs in river environments in these countries. The current study therefore examined the abundance and nature of MPs and potentially toxic elements (PTEs) in the sediments of the Odo-Ona and Ogun Rivers in Southwest Nigeria. MPs were extracted from the sediments using the density separation method and categorized according to their size, colour and shapes. The range of MP abundances found in the Ogun River sediments was 66.6 ± 12.2 to 311 ± 20.8 particles/kg, while that of the Odo-Ona River ranged from 133 ± 50 to 433 ± 100 particles/kg. The MPs polymer analyses revealed the presence of polyethylene (PE), polypropylene (PP) and polyamide (PA) particles in the sediments. PE was most abundant in the two rivers, constituting 72.8% and 59.7% of MPs (with 0.5 – 5 mm size), recovered from the Odo-Ona and Ogun Rivers, respectively. High concentrations of Cr and Pb with ranges of 10.3 – 48.3 and 10.1 – 211 mg/kg, respectively, were detected in the sediments and were associated with anthropogenic effects. This study reveals the impact of indiscriminate waste dumping on the water bodies, and calls for strict enforcement of environmental laws in the country. [ABSTRACT FROM AUTHOR]

Plastic pollution is a major driver of climate change that is associated with biodiversity loss, greenhouse gas emissions, and negative soil, plant, animal, and human health. One of the solutions that has been proposed and is currently reducing the adverse effects of plastic on the planet is the replacement of synthetic plastics with biopolymers. The biodegradable polymers have been adapted for most of the applications of synthetic plastic. However, their use and disposal present some sustainability challenges. Recycling emerges as an effective way of promoting the sustainability of biopolymer use. In this article, we review recycling as a viable solution to improve the sustainability of biopolymers, emphasizing the current types and technologies employed in biopolymer recycling and the challenges faced in their adoption. Our exploration of the future directions in the conversion of biopolymers into new polymers for reuse establishes a connection between established continuous technological innovation, integration into circular economy models, and the establishment and strengthening of collaborations among key stakeholders in relevant industries as necessary steps for the adoption, full utilization, and improvement of recycling technologies for biopolymers. By connecting these factors, this study lays a foundation for the establishment of a roadmap for improved biopolymer recycling technologies and processes that promote the sustainability of synthetic plastic alternatives. [ABSTRACT FROM AUTHOR]

Monosodium glutamate (MSG) is a silent excitotoxin used as a flavour enhancer but exerts serious health hazards to consumers. MSG plays a role in neuronal function as the dominant excitatory neurotransmitter. It is transferred into the blood and ultimately increases brain glutamate levels, causing functional disruptions notably via oxidative stress. The study evaluated the toxic effect of high consumption of MSG and the modulatory role of vitamin C on ATPase activities in the striatum and cerebellum of male Wistar rats for five weeks. Rats were grouped into four (A-D): group A was fed with rat's show only; Group B was fed with diet containing 15% MSG; Group C was treated with vitamin C (200 mg/kg b.wgt orally in 0.9% saline solution) only for 3 weeks; and group D rats were fed with MSG and vitamin C. The findings show that MSG does not affect body and cerebellum weights but increases striatal weight. MSG increases the malondialdehyde (MDA) level and significantly decreases catalase (CAT) and superoxide dismutase (SOD) activities and glutathione (GSH) levels. MSG significantly impaired striatal and cerebellar ATPases activities (Na+/K+-, Ca2+-, Mg2+- and total ATPases). Vitamin C treatment abolishes MSG-induced oxidative stress and improves ATPase activities. The findings show that vitamin C has beneficial effects in improving the functions of membrane-bound ATPases against MSG toxicity in rat's striatum and cerebellum. [ABSTRACT FROM AUTHOR]