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The article discusses the evaluation of participation and recruitment bias in a real-world data (RWD) study called REALYSA, which focuses on newly diagnosed lymphoma patients. The study found that 54% of patients were included in the program, and factors such as age, gender, lymphoma subtype, performance status, and comorbidities were analyzed. The findings provide insights into patient participation in RWD programs and contribute to the understanding of lymphoma treatment strategies. The study also found that certain factors, such as disease aggressiveness and management approach, influenced the inclusion rate in the program. However, the study had limitations and further research is needed to better understand selection bias in real-world lymphoma cohorts. [Extracted from the article]

We retrospectively reviewed for 72 relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) patients ineligible for autologous stem-cell transplantation (ASCT) treated between 2004 and 2017, efficacy and safety profile of rituximab (375 mg/m2) in combination with etoposide (300 mg/m2) and ifosfamide (1500 mg/m2) at 2, 3, or 4-week intervals. Median age was 79 years (range, 64–92). The median number of previous line was 1 (range 1–8). Patients received a median of six cycles (1–12). Fourteen patients (19%) presented partial and 14 complete responses (19%). Among the 369 cycles, nine patients developed febrile neutropenia (13%), 14 a grade 3–4 neutropenia (19%), 7 a grade 3–4 thrombocytopenia (10%) without grade 3–4 non-hematological toxicity. With a median follow up of 7.8 months, the median progression-free survival, overall survival, and duration of response were 4.4 months, 9.4 months, and 12 months, respectively. This regimen represents a therapeutic option in R/R DLBCL patients ineligible to ASCT. [ABSTRACT FROM AUTHOR]