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As an important and universal petrophysics of heavy oil reservoirs, the two‐phase flow ability inside porous medium is vital for heavy oil development. Utilizing the laminar flow theory and an ideal pore structure, especially cylinder model, the function of the relative permeability of heavy oil–water with water saturation is derived by incorporating the principles of momentum conservation and the characteristics of Bingham fluids, which was modified by validated experiment. Two‐phase relative permeability, considering heavy oil as non‐Newtonian fluid, is the function of water saturation, pore size, oil–water viscosity ratio, and yield stress. The results of the validated experiment show that the theoretical values calculated employing the modified equation exhibit better agreement with the experimental values, particularly when the viscosities of two‐phase fluid are great. The results of the modified two‐phase relative permeability show a decrease in water saturation interval corresponding to the two‐phase flow area and a smaller value of permeability at equal two‐phase relative permeability. The oil–water viscosity ratio in the hydrophobic pores affects the water‐phase relative permeability, although the magnitude of its influence diminishes as the viscosity ratio increases. The behavior of relative permeability in hydrophilic pores is the opposite of that in hydrophobic pores. This work can afford good application prospects for mobility control in multilayered reservoirs through the heterogeneous‐phase‐composite fluid. The saturations of the remaining oil and irreducible water also play a vital role in the prediction of permeability. The work can afford good application prospects for the flow behavior of Bingham heavy oil in pores with different types of wettability. [ABSTRACT FROM AUTHOR]

Fracture identification and evaluation requires data from various resources, such as image logs, core samples, seismic data, and conventional well logs for a meaningful interpretation. However, several wells have some missing data; for instance, expensive cost run for image logs, cost concern for core samples, and occasionally unsuccessful core retrieving process. Thus, a majority of the current research is focused on predicting fracture based on conventional well log data. Interpreting fractures information is very important especially to develop reservoir model and to plan for drilling and field development. This study employed statistical methods such as multiple linear regression (MLR), principal component analysis (PCA), and gene expression programming (GEP) to predict fracture density from conventional well log data. This study explored three wells from a basement metamorphic rock with ten conventional logs of gamma rays, thorium, potassium, uranium, deep resistivity, flushed zone resistivity, bulk density, neutron porosity, sonic porosity, and photoelectric effect. Four different methods were used to predict the fracture density, and the results show that predicting fracture density is possible using MLR, PCA, and GEP. However, GEP predicted the best fracture density with R2 > 0.86 for all investigated wells, although it had limited use in predicting fracture density. All methods used highlighted that flushed zone resistivity and uranium content are the two most significant well log parameters to predict fracture density. GEP was efficient for use in metamorphic rocks as it works well for conventional well log data as the data is nonlinear, and GEP uses nonlinear algorithms. [ABSTRACT FROM AUTHOR]

Background: In ischemic stroke, cerebral autoregulation and neurovascular coupling may become impaired. The cerebral blood flow (CBF) response to spreading depolarization (SD) is governed by neurovascular coupling. SDs recur in the ischemic penumbra and reduce neuronal viability by the insufficiency of the CBF response. Autoregulatory failure and SD may coexist in acute brain injury. Here, we set out to explore the interplay between the impairment of cerebrovascular autoregulation, SD occurrence, and the evolution of the SD-coupled CBF response. Methods: Incomplete global forebrain ischemia was created by bilateral common carotid artery occlusion in isoflurane-anesthetized rats, which induced ischemic SD (iSD). A subsequent SD was initiated 20–40 min later by transient anoxia SD (aSD), achieved by the withdrawal of oxygen from the anesthetic gas mixture for 4–5 min. SD occurrence was confirmed by the recording of direct current potential together with extracellular K+ concentration by intracortical microelectrodes. Changes in local CBF were acquired with laser Doppler flowmetry. Mean arterial blood pressure (MABP) was continuously measured via a catheter inserted into the left femoral artery. CBF and MABP were used to calculate an index of cerebrovascular autoregulation (rCBFx). In a representative imaging experiment, variation in transmembrane potential was visualized with a voltage-sensitive dye in the exposed parietal cortex, and CBF maps were generated with laser speckle contrast analysis. Results: Ischemia induction and anoxia onset gave rise to iSD and aSD, respectively, albeit aSD occurred at a longer latency, and was superimposed on a gradual elevation of K+ concentration. iSD and aSD were accompanied by a transient drop of CBF (down to 11.9 ± 2.9 and 7.4 ± 3.6%, iSD and aSD), but distinctive features set the hypoperfusion transients apart. During iSD, rCBFx indicated intact autoregulation (rCBFx < 0.3). In contrast, aSD was superimposed on autoregulatory failure (rCBFx > 0.3) because CBF followed the decreasing MABP. CBF dropped 15–20 s after iSD, but the onset of hypoperfusion preceded aSD by almost 3 min. Taken together, the CBF response to iSD displayed typical features of spreading ischemia, whereas the transient CBF reduction with aSD appeared to be a passive decrease of CBF following the anoxia-related hypotension, leading to aSD. Conclusions: We propose that the dysfunction of cerebrovascular autoregulation that occurs simultaneously with hypotension transients poses a substantial risk of SD occurrence and is not a consequence of SD. Under such circumstances, the evolving SD is not accompanied by any recognizable CBF response, which indicates a severely damaged neurovascular coupling. [ABSTRACT FROM AUTHOR]

The fracture network modelling and hydrogeological assessment were performed in an 845 m deep borehole of the potential high-level waste repository formation and its caprock. The geometry of the fracture network was simulated using the discrete fracture network (DFN) modelling method, which is based on the geometric characteristics of the individual fractures. The hydrogeological evaluation was based on changes in porosity and permeability along the borehole using flow zone indicator (FZI) values that denote hydraulic flow units (HFU) within the rock body. Fracture network characteristics and hydrogeological features are mainly determined by the wellbore lithology, which can be divided into three zones. The sandstone body was intersected in the upper 300 m of the borehole, which forms a single HFU. The second zone was developed along with the transition zone between the sandstone and the underlying claystone bodies. Here the predominant rock type is claystone, but the characteristics of the fracture network are distinctly different from the deeper parts of this rock body. Below 400 m is the third zone, where distinct and extensive HFU-s could not form, probably due to different water–rock interaction processes that could have changed the porosity and permeability from point to point in the claystone. [ABSTRACT FROM AUTHOR]

The Algyő High (AH) is an elevated crystalline block in southeastern Hungary covered by thick Neogene sediments. Although productive hydrocarbon reservoirs are found in these Neogene sequences, numerous fractured reservoirs also occur in the pre-Neogene basement of the Pannonian Basin. Based on these analogies, the rock body of the AH might also play a key role in fluid storage and migration; however, its structure and therefore the reservoir potential is little known. Based on a comprehensive petrologic study in conjunction with analysis of the spatial position of the major lithologies, the AH is considered to have been assembled from blocks with different petrographic features and metamorphic history. The most common lithologies of garnet-kyanite gneiss and mica schist associated with garnetiferous amphibolite are dominant in the northwestern and southeastern parts of the AH. The first regional amphibolite facies metamorphism of the gneiss and mica schist was overprinted by a contact metamorphic (metasomatic) event during decompression in the stability field of kyanite. Garnet-bearing amphibolite experienced amphibolite facies peak conditions comparable with the host gneiss. Regarding the similarities in petrologic features, the northwestern and southeastern parts of the area represent disaggregated blocks of the same rock body. The central part of the AH area is characterized by an epidote gneiss-dominated block metamorphosed along with a greenschist-facies retrograde pathway as well as a chlorite schist-dominated block formed by greenschist-facies progressive metamorphism. The independent evolution of these two blocks is further confirmed by the presence of a propylitic overprint in the chlorite schists. The different metamorphic blocks of the northwestern, southeastern and central parts of the AH probably became juxtaposed along post-metamorphic normal faults developed due to extensional processes. The supposed brittle structural boundaries between the blocks could have provided hydrocarbon migration pathways from the adjacent over-pressured sub-basins, or could even represent suitable reservoirs. [ABSTRACT FROM AUTHOR]

This study demonstrates that LIBS mapping and spatially resolved local analysis is an efficient and practical approach for the classification of mineral grains (quartz, feldspar, biotite, amphibole) and for prospecting of technologically relevant, low-Z elements (e.g. Be and Li) in granitoid rock samples. We tested three statistical approaches (classification tree (CT) based on indicator elements, linear discriminant analysis (LDA) and random forest (RF)) for the classification of the mineral grains and found that each of the three methods provides fairly similar, very good classification accuracies. RF and LDA provided better than 92% accuracy for all minerals, whereas CT showed a somewhat poorer (around 80%) accuracy for quartz in particular. Our results also demonstrate that using multiple analytical locations within each grain and resting the classification on the majority vote of these individual analysis gives more reliable discrimination (grain-based accuracy is better than location-based accuracy). We also demonstrated that LIBS elemental mapping can provide valuable information about the distribution of chemical elements among the minerals, especially if it is combined with matrix-matched calibration of emission intensity data. We illustrated this by the successful assessment of ng to μg amounts of Be and Li in the studied mineral grains. Our results suggest that mining for Be and Li in granitoid rocks should be aiming for biotite and amphibole grains. [ABSTRACT FROM AUTHOR]

Numerous fractured hydrocarbon reservoirs exist in the metamorphic basement of the Pannonian Basin in Hungary. Many decades of experience in production have proven that these reservoirs are highly compartmentalised, resulting in a complex mosaic of permeable and impermeable domains situated next to each other. Consequently, in most fields, only a small amount of the total hydrocarbon reserve can be extracted. This paper aims to locate the potential migration pathways inside the most productive basement reservoir of the Pannonian Basin, using a multiscale approach. To achieve this, evaluation well-log data, DFN modelling and a composition analysis of fluid trapped in a vein-filling zeolite phase are combined. Data on a single well are presented as an example. The results of the three approaches indicate the presence of two highly fractured intervals separated by a barely fractured amphibolite. The two zones are probably part of the communicating fracture system inside the single metamorphic mass. The gas analysis further specifies the migrated fluids and indicates hydrocarbons of a composition similar to that of the recently produced oil. Consequently, we conclude that the two zones do not only form an ancient migration pathway but are also members of a more recent hydrocarbon system. [ABSTRACT FROM AUTHOR]

Featured Application: Red mud usually contains a significant amount of rare elements. Exact knowledge about their accumulation tendencies as well as identification of those minerals, which store these elements, would help planning better extraction technologies. Detailed mineralogical and geochemical study of red mud samples from Hungary suggests geological and geochemical processes that determine the spatial distribution of certain elements inside the red mud pitfalls. The major processes are the following: (1) Heavy mineral grains (anatase, rutile, titanomagnetite, etc.) tend to subside due to gravitational differentiation and at present accumulate in the deepest horizons of the pitfalls. (2) Kaolinite reacts to cancrinite under hyperalkaline conditions. (3) Due to diagenetic processes, goethite-cancrinite aggregates form in situ. (4) Light mineral grains (e.g., cancrinite) move upward. (5) Cancrinite transforms to calcite at the shallowest horizons, due probably to the reaction with atmospheric CO2. All these processes have a significant role in accumulation tendencies of different groups of elements inside the pitfalls. The behaviour of chalcophile elements and the HFSE elements follow common geochemical rules and remind features of the host bauxite or even its precursor igneous or metamorphic lithologies. The REEs and Sc are possibly adsorbed on goethite and in the channels of cancrinite. Based on linear mixing model calculations, the major container of these elements is cancrinite. The proportion of the REEs and Sc in the Ti-phases, carbonates, phosphates, zircon, etc. is subordinate relative to the amount accumulated by goethite and cancrinite. [ABSTRACT FROM AUTHOR]

Background and Purpose: A new class of dihydropyridine derivatives, which act as co-inducers of heat shock protein but are devoid of calcium channel antagonist and vasodilator effects, has recently been developed with the purpose of selectively targeting neurodegeneration. Here, we evaluated the action of one of these novel compounds LA1011 on neurovascular coupling in the ischaemic rat cerebral cortex. As a reference, we applied nimodipine, a vasodilator dihydropyridine and well-known calcium channel antagonist.Experimental Approach: Rats were treated with LA1011 or nimodipine, either by chronic, systemic (LA1011), or acute, local administration (LA1011 and nimodipine). In the latter treatment group, global forebrain ischaemia was induced in half of the animals by bilateral common carotid artery occlusion under isoflurane anaesthesia. Functional hyperaemia in the somatosensory cortex was created by mechanical stimulation of the contralateral whisker pad under α-chloralose anaesthesia. Spreading depolarization (SD) events were elicited subsequently by 1 M KCl. Local field potential and cerebral blood flow (CBF) in the parietal somatosensory cortex were monitored by electrophysiology and laser Doppler flowmetry.Key Results: LA1011 did not alter CBF, but intensified SD, presumably indicating the co-induction of heat shock proteins, and, perhaps an anti-inflammatory effect. Nimodipine attenuated evoked potentials and SD. In addition to the elevation of baseline CBF, nimodipine augmented hyperaemia in response to both somatosensory stimulation and SD, particularly under ischaemia.Conclusions and Implications: In contrast to the CBF improvement achieved with nimodipine, LA1011 seems not to have discernible cerebrovascular effects but may up-regulate the stress response. [ABSTRACT FROM AUTHOR]

Quartz is among the most common minerals in the Earth's crust and is stable within a wide range of temperature and pressure conditions. As its microstructure is sensitive to different deformation mechanisms, quartz may present information about the structural evolution of many different rock types. The Szentlőrinc-1 well with its drill cuttings brought to the surface from approximately 2 km depth provides an exclusive chance to investigate the shear zone beneath. The drill cutting collection includes only a few small rock grains, and more than 80 % of the material consists of tiny (<1 mm) single quartz grains. In this study, three microstructurally extreme quartz grain types were separated during microscopic analysis: grains with undulose extinction ( U), grains with subgrains ( S), and grains with recrystallized grains ( R). Moreover, numerous microstructurally transitional grains were measured, which represent combinations of the above extremes. The characterisation of single quartz grain microstructures along the whole well enables identification and localisation of the ductile shear zones inside the crystalline complex. This information was combined with well-log data, which could provide information about the brittle deformation. Using these logs, brittle shear zones can be localised along the well. When comparing depths and extensions of the deformed horizons, a coincidence of the brittle and ductile zones becomes clear. This behaviour may suggest two different evolution schemes: it could be caused by primarily evolved softened regions, or it could be described by a detachment fault model. [ABSTRACT FROM AUTHOR]

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The presence of anomalous terrestrial radioisotopes must be suspected in black shale-hosted manganese ore deposits, based on high organic matter content, which is useful tool in genetic, among them paleoenvironmental investigations. Our work aims at the characterization of the paleoredox conditions of the Úrkút Manganese Formation based on comparison of terrestrial radioisotopes and selected element ratios. Paleoredox indicators were estimated on U/Th, δU, Ni/Co, V/Cr, V/(V + Ni) and Ce*. The results of paleoredox indicator element ratios show, that these methods must be used with caution (microbial selective element enrichments, mobilizations), and the complex interpretation using mineralogy and microtexture can be recommended. [ABSTRACT FROM AUTHOR]

Modeling fractured rocks with numerical methods requires some derived parameters, among which the fracture network connectivity and the size of the representative elementary volume (REV) are both of crucial importance. Percolation and REV analyses were made by the RepSim code. The program uses input parameters such as fractal dimension of the fracture midpoints ( D), length exponent ( E) and relative dip ( α) data. For percolation analysis, the relative sizes of the largest percolation clusters have been calculated by stochastic realizations of the simulated fracture networks with different parameter triplets. Furthermore, fracture networks can be classified into three major types on the basis of their ( E, D, α) parameters. For the REV calculations, the porosity of the generated fracture network was calculated. The derived REV size of a fracture network depends essentially on input parameters and shows a decreasing tendency with increasing D and E and vice versa. The method mentioned above was tested on both metamorphic samples of the Pannonian Basin and Variscan granitoid rocks of the Mórágy Complex. Percolation values predicted for the Mórágy granite are highly sensitive to alterations in the input parameters. The amphibolite bodies displayed a modeled fracture network with 80 to 90% of all fractures being interconnected, while the largest achievable percolation cluster size of gneiss is less than 10%. The REV size of the amphibolite is about 20 m as a result of connected fractures filling the whole body, while gneiss has lower porosity and higher REV (approximately 70 m). [ABSTRACT FROM AUTHOR]

Kutnohorite with moderate and bright orange-red cathodoluminescence (CL) was studied by CL microscopy and spectroscopy. This mineral was found in fossiliferous concretions composed mainly of rhodochrosite from the Mn-carbonate mineralization at Úrkút, Hungary. The CL microscopy reveals that kutnohorite occurs as impregnations, layers and veinlets. X-ray diffraction, infrared spectroscopy and electron microprobe studies indicate that the luminescent kutnohorite has excess Ca (72.9–80.0 mol.% CaCO3, 16.3–20.5 mol.% MnCO3, 3.3–5.6 mol.% MgCO3 and 0.0–0.5 mol.% FeCO3). Transmission electron microscopy shows that the luminescent carbonate has a dolomite-type structure, with modulated and mosaic microstructures. The CL spectra of this Ca-rich kutnohorite have a single emission band at 630 nm that is characteristic of Mn2+ substitution in the structure. Our results provide evidence for moderate-to-bright cathodoluminescence of Mn-rich natural carbonates even at 8–10 wt.% Mn and up to 2400 ppm Fe. The self-quenching of Mn appears incomplete in the case of Ca-rich kutnohorite from Úrkút. [ABSTRACT FROM AUTHOR]

Simple Summary: Ischemic stroke is caused by the blockade of a blood vessel in the brain. Consequently, the brain region supplied by the blocked vessel suffers brain damage and becomes acidic. Here we provide a summary of the causes and consequences of acid accumulation in the brain tissue. Ischemic stroke requires immediate medical attention to minimize the damage of brain tissue, and to save function. It would be desirable for the medical treatment to target the site of injury selectively, to enrich the site of ongoing injury with the protective agent, and to avoid undesirable side effects at the same time. We propose that acid accumulation at the sight of brain tissue injury can be used to delineate the region that would benefit most from medical treatment. Tiny drug carriers known as nanoparticles may be loaded with drugs that protect the brain tissue. These nanoparticles may be designed to release their drug cargo in response to an acidic environment. This would ensure that the therapeutic agent is directed selectively to the site where it is needed. Ultimately, this approach may offer a new way to treat stroke patients with the hope of more effective therapy, and better stroke outcome. Ischemic stroke is a leading cause of death and disability worldwide. Yet, the effective therapy of focal cerebral ischemia has been an unresolved challenge. We propose here that ischemic tissue acidosis, a sensitive metabolic indicator of injury progression in cerebral ischemia, can be harnessed for the targeted delivery of neuroprotective agents. Ischemic tissue acidosis, which represents the accumulation of lactic acid in malperfused brain tissue is significantly exacerbated by the recurrence of spreading depolarizations. Deepening acidosis itself activates specific ion channels to cause neurotoxic cellular Ca2+ accumulation and cytotoxic edema. These processes are thought to contribute to the loss of the ischemic penumbra. The unique metabolic status of the ischemic penumbra has been exploited to identify the penumbra zone with imaging tools. Importantly, acidosis in the ischemic penumbra may also be used to guide therapeutic intervention. Agents with neuroprotective promise are suggested here to be delivered selectively to the ischemic penumbra with pH-responsive smart nanosystems. The administered nanoparticels release their cargo in acidic tissue environment, which reliably delineates sites at risk of injury. Therefore, tissue pH-targeted drug delivery is expected to enrich sites of ongoing injury with the therapeutical agent, without the risk of unfavorable off-target effects. [ABSTRACT FROM AUTHOR]