86 results on '"Miyatake, Nobuyuki"'
Search Results
2. Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005).
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Kanaji, Nobuhiro, Ichihara, Eiki, Tanaka, Takaaki, Ninomiya, Takashi, Kozuki, Toshiyuki, Ishikawa, Nobuhisa, Nishii, Kazuya, Shoda, Hiroyasu, Yamaguchi, Kakuhiro, Kawakado, Keita, Toyoda, Yuko, Inoue, Masaaki, Miyatake, Nobuyuki, Watanabe, Naoki, Inoue, Takuya, Mizoguchi, Hitoshi, Komori, Yuta, Kojima, Kazuki, and Kadowaki, Norimitsu
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EPIDERMAL growth factor ,EPIDERMAL growth factor receptors ,KINASE inhibitors - Abstract
Purpose: This study investigated the safety and efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) re-administration after recovery from EGFR-TKI-induced interstitial lung disease (ILD). Methods: This multicenter retrospective study collected data from consecutive advanced NSCLC patients who underwent EGFR-TKI re-administration after recovery from EGFR-TKI-induced ILD. Results: Fifty-eight patients were registered. The grades of initial TKI-induced ILD were grade 1 to 4. TKIs used for re-administration were erlotinib for 15 patients, osimertinib for 15, gefitinib for 14, afatinib for 13 patients, and dacomitinib for 1 patient. ILD recurred in 13 patients (22.4%), comprising 3 patients with grade 1, 6 patients with grade 2, and 4 patients with grade 3. No significant associations were found between ILD recurrence and age, smoking history, performance status, time from initial ILD to TKI re-administration, or concomitant corticosteroid use. However, the incidence of ILD recurrence was high in cases of repeated use of gefitinib or erlotinib or first time use of osimertinib at TKI re-administration. The ILD recurrence rate was lowest in patients treated with first time use of gefitinib (8%) or erlotinib (8%), followed by patients treated with repeated use of osimertinib (9%). The response rate, median progression-free survival by TKI re-administration, and median overall survival were 55%, 9.6 and 84.8 months, respectively. Conclusion: This study showed that EGFR-TKI re-administration is a feasible and effective treatment for patients who recovered from EGFR-TKI-induced ILD. Our results indicate that re-administration of EGFR-TKI is an important option for long-term prognosis after recovery from EGFR-TKI-induced ILD. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Enhancing Driving Ability in Older Adults through Health Exercises and Physical Activity: A Randomized Controlled Trial.
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Katayama, Akihiko, Hase, Ayako, and Miyatake, Nobuyuki
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- 2023
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4. Comparison of Impressions of COVID-19 Vaccination and Influenza Vaccination in Japan by Analyzing Social Media Using Text Mining.
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Mori, Yoshiro, Miyatake, Nobuyuki, Suzuki, Hiromi, Mori, Yuka, Okada, Setsuo, and Tanimoto, Kiyotaka
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INFLUENZA vaccines ,COVID-19 vaccines ,TEXT mining ,SOCIAL media ,MULTIDIMENSIONAL scaling - Abstract
The aim of this study was to compare impressions of COVID-19 vaccination and influenza vaccination in Japan by analyzing social media (Twitter
® ) using a text-mining method. We obtained 10,000 tweets using the keywords "corona vaccine" and "influenza vaccine" on 15 December 2022 and 19 February 2023. We then counted the number of times the words were used and listed frequency of these words by a text-mining method called KH Coder. We also investigated concepts in the data using groups of words that often appeared together or groups of documents that contained the same words using multi-dimensional scaling (MDS). "Death" in relation to corona vaccine and "severe disease" for influenza vaccine were frequently used on 15 December 2022. The number of times the word "death" was used decreased, "after effect" was newly recognized for corona vaccine, and "severe disease" was not used in relation to influenza vaccine. Through this comprehensive analysis of social media data, we observed distinct variations in public perceptions of corona vaccination and influenza vaccination in Japan. These findings provide valuable insights for public health authorities and policymakers to better understand public sentiment and tailor their communication strategies accordingly. [ABSTRACT FROM AUTHOR]- Published
- 2023
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5. Longitudinal trajectory of vascular age indices and cardiovascular risk factors: a repeated-measures analysis.
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Watanabe, Daiki, Gando, Yuko, Murakami, Haruka, Kawano, Hiroshi, Yamamoto, Kenta, Morishita, Akie, Miyatake, Nobuyuki, and Miyachi, Motohiko
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CARDIOVASCULAR diseases risk factors ,CAROTID intima-media thickness ,FACTOR analysis ,AGE ,PHYSICAL fitness ,CARDIOPULMONARY fitness - Abstract
This study aimed to identify the modifiable cardiovascular risk factors associated with longitudinal changes, which are nine functional and structural biological vascular aging indicators (BVAIs), to propose an effective method to prevent biological vascular aging. We conducted a longitudinal study of 697 adults (a maximum of 3636 BVAI measurements) who were, at baseline, aged between 26 and 85 years and whose BVAIs were measured at least twice between 2007 and 2018. The nine BVAIs were measured using vascular testing and an ultrasound device. Covariates were assessed using validated questionnaires and devices. During the mean follow-up period of 6.7 years, the average number of BVAI measurements ranged from 4.3 to 5.3. The longitudinal analysis showed a moderate positive correlation between the common carotid intima-media thickness (IMT) and chronological age in both men (r = 0.53) and women (r = 0.54). In the multivariate analysis, BVAIs were associated with factors such as age, sex, residential area, smoking status, blood clinical chemistry test levels, number of comorbidities, physical fitness, body mass, physical activity, and dietary intake. The IMT is the most useful BVAI. Our findings suggest that modifiable cardiovascular risk factors are associated with longitudinal changes in BVAI as represented by IMT. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Use of Complementary and Alternative Medicine and Its Relationship with Health-Related Quality of Life (HRQOL) in Patients with Type 2 Diabetes Mellitus.
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Mori, Yoshiro, Daikuhara, Hiroyuki, Oshima, Tomie, Suzuki, Hiromi, Okada, Setsuo, and Miyatake, Nobuyuki
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TYPE 2 diabetes ,ALTERNATIVE medicine ,CROSS-sectional method ,OUTPATIENT medical care ,QUALITY of life - Abstract
The present study investigated the use of complementary and alternative medicine (CAM) and its relationship with health-related quality of life (HRQOL) in patients with type 2 diabetes mellitus. A total of 421 patients with type 2 diabetes mellitus who completely met the inclusion criteria, aged 67.3 ± 12.8 years, among 622 outpatients were recruited in this cross-sectional study. We examined the use of CAM, such as supplements, Kampo, acupuncture, and yoga. HRQOL was assessed by EuroQOL. A total of 161 patients (38.2%) with type 2 diabetes mellitus used some type of CAM. The use of supplements and/or health foods was the highest among CAM users (112 subjects, 26.6%). HRQOL was significantly lower in patients who used some CAM (0.829 ± 0.221) than in those without any CAM use (0.881 ± 0.189), even after adjustments for confounding factors [F(1, 414) = 2.530, p = 0.014]. Proper information on CAM is needed for patients with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Factors associated with changes in the objectively measured physical activity among Japanese adults: A longitudinal and dynamic panel data analysis.
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Watanabe, Daiki, Murakami, Haruka, Gando, Yuko, Kawakami, Ryoko, Tanisawa, Kumpei, Ohno, Harumi, Konishi, Kana, Sasaki, Azusa, Morishita, Akie, Miyatake, Nobuyuki, and Miyachi, Motohiko
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JAPANESE people ,PHYSICAL activity ,METABOLIC equivalent ,PENIS curvatures ,DATA analysis ,PHYSICAL fitness ,BODY mass index ,PANEL analysis ,GROWTH curves (Statistics) - Abstract
Factors associated with dynamic changes in the objectively measured physical activity have not been well understood. We aimed to 1) evaluate the longitudinal change in the physical activity trajectory according to sex which is associated with age and to 2) determine the factors associated with the dynamic change in physical activity-related variables across a wide age range among Japanese adults. This longitudinal prospective study included 689 Japanese adults (3914 measurements) aged 26–85 years, whose physical activity data in at least two surveys were available. Physical activity-related variables, such as intensity (inactive, light [LPA; 1.5 to 2.9 metabolic equivalents (METs)], moderate-to-vigorous [MVPA; ≥3.0 METs]), total energy expenditure (TEE), physical activity level (PAL), and step count, were evaluated using a validated triaxial accelerometer. Statistical analysis involved the latent growth curve models and random-effect panel data multivariate regression analysis. During a mean follow-up period of 6.8 years, physical activity was assessed an average of 5.1 times in men and 5.9 times in women. The profiles for the inactive time, LPA (only men), MVPA, step count, PAL, and TEE showed clear curvature, indicating an accelerated rate of change around the age of 70. In contrast, other variables exhibited minimal or no curvature over the age span. The MVPA trajectory was positively associated with alcohol consumption, hand grips, leg power, and trunk flexibility and negatively associated with age, local area, body mass index (BMI), comorbidity score, and heart rate over time. Our results indicated that the physical activity trajectory revealed clear curvature, accelerated rate of change around the age of 70, and determined physical health and fitness and BMI as dynamic factors associated with physical activity changes. These findings may be useful to help support populations to achieve and maintain the recommended level of physical activity. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Problematic internet use and attachment styles among adolescents in Japan.
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Suzuki, Hiromi, Miyatake, Nobuyuki, and Kusaka, Takashi
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ADDICTIONS -- Risk factors ,COMPULSIVE behavior -- Risk factors ,LIFESTYLES ,STATISTICS ,RESEARCH ,ANALYSIS of variance ,MULTIPLE regression analysis ,MENTAL health ,ATTACHMENT behavior ,RISK assessment ,RESEARCH funding ,DESCRIPTIVE statistics ,PARENT-child relationships ,INTERNET addiction ,DATA analysis software ,DATA analysis ,COMPULSIVE behavior ,ADOLESCENCE - Abstract
Background: Problematic Internet use (PIU) remains a significant social concern in Japan and across the globe. Numerous studies have been conducted to examine the prevalence of PIU, and its association with lifestyle habits and mental health status. To the best of our knowledge, few studies have examined the association between parental attachment and PIU in Japan. Furthermore, preventive measures in Japan have primarily targeted adolescents via education. Therefore, in this study we explored the association between PIU and attachment styles among adolescents to seek a new approach for the development of appropriate, effective measures. Methods: A self‐administered survey was conducted at one private (in 2018) and two public junior high schools (in 2020) in Kagawa Prefecture, western Japan. We used the Internet Addiction Test (IAT), the Experiences in Close Relationships–Relationship Structures (ECR–RS) questionnaire, and the Birleson Depression Self‐Rating Scale for Children (DSRS‐C). Multiple regression analysis was performed to examine the association between IAT scores and attachment styles. Results: Of 1,413 participants (grades 7–9; 700 boys and 713 girls), 39% of the students showed possible PIU and 3% showed PIU. Students with PIU tended to sleep for shorter durations, access the Internet for long hours, and have a poor mental health status (p < 0.01). PIU was significantly associated with insecure attachment (p < 0.0001). Conclusions: The findings of our study imply that improving attachment styles and developing secure attachment between the child and parent might help mitigate and/or prevent PIU. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Caffeine Consumption Is Associated With Higher Level of Physical Activity in Japanese Women.
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Tripette, Julien, Murakami, Haruka, Hara, Hidemi, Kawakami, Ryoko, Gando, Yuko, Ohno, Harumi, Miyatake, Nobuyuki, and Miyachi, Motohiko
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CAFFEINE ,JAPANESE people ,LONGITUDINAL method ,NUTRITIONAL assessment ,PHYSICAL fitness ,PROBABILITY theory ,QUESTIONNAIRES ,SEX distribution ,STATISTICAL significance ,OXYGEN consumption ,PHYSICAL activity ,DESCRIPTIVE statistics - Abstract
Caffeine has been described as a sports performance-enhancing substance. However, it is unclear whether it can increase the level of physical activity (PA) in nonathletic individuals. This study investigates the relationship between daily caffeine consumption and (a) daily PA/fitness or (b) intervention-induced changes in PA in women and men. On the basis of responses to a dietary habit questionnaire, which included items on caffeinated beverages, 1,032 Japanese adults, were categorized into lower or higher caffeine consumption groups (relative to the median caffeine consumption). In each group, daily step count; sedentary time; and light, moderate, and vigorous PA outcomes were objectively measured. Physical fitness, including peak oxygen consumption, was also evaluated. The relationship between daily caffeine consumption and the change in the levels of PA was investigated in a subgroup of 202 subjects who participated in a 1-year PA counseling intervention. Women in the higher caffeine consumption group presented higher moderate-to-vigorous PA and step count compared with their counterparts in the lower consumption group (4.0 ± 2.1 vs. 3.3 ± 2.1 MET-hr/day, p <.001; 10,335 ± 3,499 vs. 9,375 ± 3,527 steps/day, p <.001). A significant positive correlation was noted between caffeine consumption and peak oxygen consumption among women (r =.15, p <.001). No caffeine-related effects were noted in men. The lower and higher caffeine consumption groups showed no significant differences in their levels of PA at the end of the 1-year intervention. Therefore, caffeine consumption appears to be associated with higher levels of PA in Japanese women. Further studies are needed to clarify this association. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Supplemental hydroxychloroquine therapy regulates adipokines in patients with systemic lupus erythematosus with stable disease.
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Wakiya, Risa, Ueeda, Kiyo, Shimada, Hiromi, Nakashima, Shusaku, Kameda, Tomohiro, Miyatake, Nobuyuki, Kato, Mikiya, Miyagi, Taichi, Sugihara, Koichi, Mizusaki, Mao, Mino, Rina, Kadowaki, Norimitsu, and Dobashi, Hiroaki
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SYSTEMIC lupus erythematosus ,ADIPOKINES ,HYDROXYCHLOROQUINE ,RESISTIN ,PROGNOSIS - Abstract
Background: In patients with systemic lupus erythematosus (SLE), a higher frequency of atherosclerotic lesions is associated with poor prognosis. Hydroxychloroquine (HCQ) has been reported to improve the lifespan and the prognosis of dyslipidaemia in patients with SLE, but the mechanism is unclear. We investigated the effect of supplemental HCQ treatment on the levels of serum cytokines associated with atherosclerosis in patients with stable SLE. Methods: Patients with SLE who received supplemental HCQ and maintained low disease activity between January 2016 and September 2020 were included in this study. Disease activity was assessed using Safety of Estrogens in Lupus National Assessment-SLE Disease Activity Index, Cutaneous Lupus Erythematous Disease Area and Severity Index, and Lupus Low Disease Activity State. Serum complement titres, anti-dsDNA antibodies, and serum cytokines (adiponectin, resistin, and leptin) were analyzed before and after HCQ treatment. Results: Forty-one patients (4 males and 37 females, mean age 41.3 ± 13.2 years) were included. Serum adiponectin levels were significantly increased after 3 months of HCQ treatment compared to baseline, and serum resistin levels were significantly reduced. The change in serum resistin level after HCQ administration was correlated with a significant reduction in serum TNF-α, interleukin (IL)-6, IL-8, and IL-1RA levels. Conclusions: Supplemental HCQ treatment in patients with SLE improved adipokine levels. HCQ may improve prognosis by controlling disease activity in SLE and reducing risk factors for atherosclerosis. Key Points • Hydroxychloroquine has been reported to improve the prognosis of dyslipidaemia in patients with SLE, but the underlying mechanism is unclear. • In this study, hydroxychloroquine improved adipokine levels in patients with SLE, implicating adipokines as a potential mechanism underlying the benefit of hydroxychloroquine on dyslipidaemia. • Supplemental hydroxychloroquine should be considered in patients with SLE harboring lipid abnormalities and risk factors for atherosclerosis. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Association between skeletal muscle mass or percent body fat and metabolic syndrome development in Japanese women: A 7-year prospective study.
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Yamada, Yosuke, Murakami, Haruka, Kawakami, Ryoko, Gando, Yuko, Nanri, Hinako, Nakagata, Takashi, Watanabe, Daiki, Yoshida, Tsukasa, Hatamoto, Yoichi, Yoshimura, Eiichi, Sanada, Kiyoshi, Miyatake, Nobuyuki, and Miyachi, Motohiko
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ADIPOSE tissues ,JAPANESE women ,MUSCLE mass ,SKELETAL muscle ,LEG muscles ,METABOLIC syndrome - Abstract
Previous cross-sectional studies have indicated that low relative appendicular lean mass (ALM) against body weight (divided by body weight, ALM/Wt, or divided by body mass index, ALM/BMI) was negatively associated with metabolic syndrome (MetS). Conversely, previous cross-sectional studies have indicated that the absolute ALM or ALM divided by squared height (ALM/Ht
2 ) were positively associated with MetS. The aim of this longitudinal study was to investigate the association between low absolute or relative skeletal muscle mass, leg muscle power, or percent body fat and the development of MetS in Japanese women in a 7-y prospective study. The study participants included 346 Japanese women aged 26 to 85 years. The participants were divided into low and high groups based on the median values of ALM/Wt, ALM/BMI, ALM/Ht2 , absolute ALM, or leg power. The longitudinal relationship between ALM indices or leg power and MetS development was examined using Kaplan-Meier curves and Cox regression models (average follow-up duration 7 years, range 1 to 10 years). During follow-up, 24 participants developed MetS. MetS incidence was higher in the low ALM/Wt group than the high ALM/Wt group even after controlling for age, obesity, waist circumference, family history of diabetes, smoking, and physical activity [adjusted hazard ratio = 5.60 (95% CI; 1.04–30.0)]. In contrast, MetS incidence was lower in the low ALM/Ht2 group than the high ALM/Ht2 group [adjusted hazard ratio = 10.6 (95%CI; 1.27–89.1)]. MetS incidence was not significantly different between the low and high ALM/BMI, absolute ALM, and leg power groups. Both ALM/Ht2 and ALM/Wt were not significant predictive variables for MetS development when fat mass or percent body fat was taken into account in the Cox model. At the very least, the results of this study underscore the importance of body composition measurements in that percent body fat, but not ALM, is associated with MetS development. [ABSTRACT FROM AUTHOR]- Published
- 2022
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12. Pre-Impressions of the Third COVID-19 Vaccination among Medical Staff: A Text Mining-Based Survey.
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Mori, Yoshiro, Miyatake, Nobuyuki, Suzuki, Hiromi, Mori, Yuka, Okada, Setsuo, and Tanimoto, Kiyotaka
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MEDICAL personnel ,COVID-19 vaccines ,COVID-19 ,JAPANESE people ,AGE groups - Abstract
The aim of this study was to investigate the pre-impressions of the third Coronavirus disease 2019 (COVID-19) vaccination among Japanese medical staff using quantitative analysis. Among 413 medical staff, 260 (60 men and 200 women) aged 40.4 ± 12.3 years were enrolled in this cross-sectional study. Pre-impressions of the third COVID-19 vaccination were analyzed using the text-mining analysis software, KH coder. Among 260 subjects, 242 (93.1%) agreed to the third vaccination, with the rate being lower among subjects in their 30s (87.3%) than those in the other age groups. The word "side effects" was characteristic of subjects in their 20s and nurses, and "pregnancy" of those in their 30s and administrative staff. Pre-impressions of the third COVID-19 vaccination varied among age groups and different professions. The results obtained provide useful information for promoting the third COVID-19 vaccination to Japanese adults. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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13. Preterm birth is strongly affected by the glucocorticoid dose during pregnancy in women complicated by systemic lupus erythematosus.
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Shimada, Hiromi, Wakiya, Risa, Kanenishi, Kenji, Miyatake, Nobuyuki, Nakashima, Shusaku, Mansour, Mai Mahmoud Fahmy, Kato, Mikiya, Miyagi, Taichi, Sugihara, Koichi, Ushio, Yusuke, Mino, Rina, Mizusaki, Mao, Kameda, Tomohiro, Kadowaki, Norimitsu, and Dobashi, Hiroaki
- Published
- 2022
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14. Reproducibility and prognostic significance of area of residual tumor (ART) in post-neoadjuvant resections of pancreatic ductal adenocarcinoma.
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Kameyama, Ai, Ye, Juanjuan, Shimomura, Ayaka, Yokohira, Masanao, Nakano-Narusawa, Yuko, Yamakawa, Keiko, Mukai, Yuri, Sanomura, Takayuki, Okuyama, Hiroyuki, Miyatake, Nobuyuki, Furihata, Mutsuo, Tanaka, Chiharu, Kitazawa, Riko, Bando, Yoshimi, Suemitsu, Yamato, Kojima, Motohiro, Mino-Kenudson, Mari, Suzuki, Yasuyuki, Okano, Keiichi, and Matsuda, Yoko
- Abstract
The pathologic assessments of tumor response after neoadjuvant chemoradiotherapy (NACRT) are critical to improving the prognostic stratification for patients with pancreatic ductal adenocarcinoma (PDAC). Here we clarified the utility of our new grading system based on the area of residual tumor (ART) as compared to existing systems, such as the College of American Pathologists (CAP) and MD Anderson (MDA) score. Methods : Eight reviewers individually evaluated the tumor regression grade of 30 patients with PDAC based on three types of grading systems. The interobserver concordance and clinicopathological characteristics were compared between the three systems. Results: The interobserver concordance (kappa value) of the ART, CAP, and MDA score were 0.61, 0.48, and 0.53, respectively. Discrepant cases, which were 27% of the cases, exhibited smaller tumor and tumor bed sizes than concordant cases. The reduction in tumor size evaluated by microscopy showed a correlation with the rate of change in carcinoembryonic antigen (CEA) level, CA19-9 level, and tumor size on computed tomography (CT). The ART score was correlated with the tumor size on CT before and after NACRT and disease-free survival. The CAP and MDA scores were not associated with prognosis. Conclusion: The ART grading system may be the most practical system to assess the tumor response in post-NACRT resections of PDAC. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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15. Effect of a 1-year intervention comprising brief counselling sessions and low-dose physical activity recommendations in Japanese adults, and retention of the effect at 2 years: a randomized trial.
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Tripette, Julien, Gando, Yuko, Murakami, Haruka, Kawakami, Ryoko, Tanisawa, Kumpei, Ohno, Harumi, Konishi, Kana, Tanimoto, Michiya, Tanaka, Noriko, Kawano, Hiroshi, Yamamoto, Kenta, Morishita, Akie, Iemitsu, Motoyuki, Sanada, Kiyoshi, Miyatake, Nobuyuki, and Miyachi, Motohiko
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PHYSICAL activity ,ADULTS ,COUNSELING ,OXYGEN consumption ,WAIST circumference - Abstract
Background: In an effort to increase people's adherence to active lifestyles, contemporary physical activity (PA) guidelines now include low-dose PA. Methods: PA was evaluated in 583 participants of the Nutritional and Physical Activity Intervention Study (NEXIS) cohort (30–65 years old); 349 inactive participants (MVPA, 2.7 ± 1.0 MET-h/day) were randomly assigned to the intervention or control groups, and 235 active participants participated in follow-up visits. The intervention aimed to increase MVPA and comprised five brief counseling sessions over 1 year. The 1-year target for the participant was increasing their step-count to 10,000 steps/d or +3000 steps/d, relative to the baseline score. The counseling sessions were designed to stimulate progressive changes in physical behaviors by recommendations promoting small and/or light-intensity bouts of PA. PA was measured at baseline, the end of the intervention, and 1 year after the intervention ended. Additionally, several nutrition, health, and fitness parameters were measured. Results: Participants in the intervention group significantly increased their step-count from 8415 ± 1924 at baseline to 9493 ± 2575 at the end of the 1-year period. During the same period, MVPA significantly increased by 0.9 MET-h. The daily time spent in ≥ 3, ≥ 4 and ≥ 5 MET activities increased by 11, 6, and 3 min, respectively. This increase in PA remained observable 1 year after intervention concluded. The active group maintained higher physical activity levels throughout the two years. The intervention group showed smaller energy intakes at the end of the 2-year period. Significant correlations were noted between the 1-year change in MVPA and the change in resting heart rate (r = − 0.22), and between the 2-year change in MVPA and the change in waist circumference (r = − 0.08) and peak oxygen consumption capacity (r = 0.23) in the intervention group only. Conclusions: A prolonged and progressive PA intervention promoting small bouts of light-to-moderate PA may be used in healthy, not-optimally-active people to increase PA beyond the strict period of the intervention. Further studies are necessary to understand whether low-dose PA messages can be effective in initiating a progressive increase toward larger amounts of PA. Trial registration: Clinical Trials.gov, NCT00926744, retrospectively registered. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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16. Relationship among psychological distress, food dependence, and the time discount rate: a pilot mediation analysis.
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Owari, Yutaka, Miyatake, Nobuyuki, and Suzuki, Hiromi
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PILOT projects ,STRUCTURAL equation modeling ,COMPULSIVE eating ,CONFIDENCE intervals ,DELAY discounting (Psychology) ,QUESTIONNAIRES ,FACTOR analysis ,STATISTICAL correlation ,PSYCHOLOGICAL distress - Abstract
Psychological distress (PD) was shown to be associated with food dependence and higher time discount rate; however, few studies have clarified the relationship among these three variables. To clarify whether time discount rate mediated a relationship between food dependence and PD. In this study, the subjects were 91. We evaluated food dependence scores and time discount rate using self-administered questionnaires as well as PD using K6 questionnaires. Simple correlation and mediation analyses were performed by Structural Equation Modelling (SEM) to clarify relationships among PD, food dependence, and time discount rate. By SEM, a significant relationship was found between food dependence and K6 scores (standardized coefficient (β)=0.341, p=0.001). Moreover, a significant correlation was found between food dependence scores and time discount rate (β=0.345, p=0.001) as well as between time discount rate and K6 scores (β=0.419, p<0.001). By having time discount rate as a parameter, the correlation coefficients between food dependence and K6 scores varied between 0.341 (p=0.001) and 0.197 (p=0.045). After bootstrapping, 0 was not included in the 99% confidence interval [0.013, 0.139]. Time discount rate may mediate the relationship between food dependence and PD. To improve PD, food dependence as well as time discount rate should be reduced. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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17. Health-related quality of life in Japanese low-risk prostate cancer patients choosing active surveillance: 3-year follow-up from PRIAS-JAPAN.
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Hirama, Hiromi, Sugimoto, Mikio, Miyatake, Nobuyuki, Kato, Takuma, Venderbos, Lionne D. F., Remmers, Sebastiaan, Shiga, Kenichiro, Yokomizo, Akira, Mitsuzuka, Koji, Matsumoto, Ryuji, Osawa, Takahiro, Abe, Takashige, Sasaki, Hiroshi, Egawa, Shin, Ninomiya, Iku, Hashine, Katsuyoshi, Roobol, Monique J., and Kakehi, Yoshiyuki
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PROSTATE cancer patients ,QUALITY of life ,JAPANESE people ,PROSTATE cancer ,WATCHFUL waiting - Abstract
Purpose: To evaluate the health-related quality of life (HRQoL) of Japanese men on active surveillance (AS) in the Prostate cancer Research International Active Surveillance study in Japan (PRIAS-JAPAN). Methods: Participants were included in the PRIAS-JAPAN HRQoL study between January 2010 and March 2016. Their general HRQoL was assessed using a validated Japanese version of the Short-Form 8 Health Survey (SF-8) at enrolment and annually thereafter until discontinuation of AS. The SF-8 mental component summary (MCS) and physical component summary (PCS) of men on AS were compared with scores of the general population (norm-based score [NBS]: 50) and MCS and PCS scores for men following AS were analysed over time. We tested whether MCS and PCS scores over time explained discontinuation of AS. Results: Five hundred and twenty-five patients enrolled, and the median age at baseline was 68 years. At enrolment and after 1-, 2-, and 3-year follow-ups, the PCS and MCS scores were significantly higher than the NBS of the general Japanese population except for the median PCS at 3 years. We found that age at diagnosis and time on AS negatively affected the PCS score of men on AS, while every additional year on AS led to a 0.27 point increase in MCS scores. Neither PCS nor MCS were predictors for discontinuation of AS. Conclusion: Japanese men following an AS strategy for 3 years reported better HRQoL compared with the general population, indicating that monitoring Japanese low-risk prostate cancer patients can be an effective treatment strategy. Study registration: Clinical trial registry—UMIN (University Hospital Medical Information Network); UMIN000002874 (2009/12/11) [ABSTRACT FROM AUTHOR]
- Published
- 2021
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18. Prediction of Maximal Oxygen Uptake From a 3-Minute Walk Based on Gender, Age, and Body Composition.
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Cao, Zhen-Bo, Miyatake, Nobuyuki, Aoyama, Tomoko, Higuchi, Mitsuru, and Tabata, Izumi
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AEROBIC capacity ,CARDIOVASCULAR fitness ,PREDICTION models ,RATE of perceived exertion ,WALKING ,BODY composition ,OXYGEN consumption ,PHYSICAL fitness research - Abstract
Background: The purpose was to develop new maximal oxygen uptake (VO
2max ) prediction models using a perceptually regulated 3-minute walk test. Methods: VO2max was measured with a maximal incremental cycle test in 283 Japanese adults. A 3-minute walk test was conducted at a self-regulated intensity corresponding to ratings of perceived exertion (RPE) 13. Results: A 3-minute walk distance (3MWD) was significantly related to VO2max (r = .60, P < .001). Three prediction models were developed by multiple regression to estimate = .78, standard error of estimate (SEE) = 5.26 ml·kg-1 ·min-1 ], waist circumference (WC model, R = .80, SEE = 5.04 ml·kg-1 ·min-1 ), or body fat percentage (%Fat model, R = .84, SEE = 4.57 ml·kg-1 ·min-1 ), suggesting that the %Fat model is the best model [VO2max = 37.501 + 0.463 x Gender (0 = women, 1 = men) - 0.195 x Age - 0.589 x %Fat + 0.053 x 3MWD]. Cross-validation by using the predicted residual sum of squares (PRESS) procedures demonstrated a high level of cross-validity of all prediction models. Conclusions: The new VO2max prediction models are reasonably applicable to estimating VO2max in Japanese adults and represent a quick, low-risk, and convenient means for estimating VO2max in the field. [ABSTRACT FROM AUTHOR]- Published
- 2013
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19. Factors affecting the Apgar score of offsprings born to mothers suffering from systemic lupus erythematosus.
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Hiromi Shimada, Tomohiro Kameda, Kenji Kanenishi, Nobuyuki Miyatake, Shusaku Nakashima, Risa Wakiya, Mikiya Kato, Taichi Miyagi, Fahmry Mansour, Mai Mahmoud, Toshiyuki Hata, Norimitsu Kadowaki, Hiroaki Dobashi, Shimada, Hiromi, Kameda, Tomohiro, Kanenishi, Kenji, Miyatake, Nobuyuki, Nakashima, Shusaku, Wakiya, Risa, Kato, Mikiya, and Miyagi, Taichi
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- 2020
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20. Does physical activity attenuate the association between birth weight and glycated hemoglobin in nondiabetic Japanese women?
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Aoyama, Tomoko, Miyatake, Nobuyuki, Seki, Akiho, Hossaka, Kouji, Takimoto, Hidemi, and Tanaka, Shigeho
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Lower birth weight is associated with a risk of type 2 diabetes in adulthood. However, it is not clear whether this association is modified by physical activity. This study aimed to examine the association between birth weight and glycemic status and whether this association is mediated by moderate- and vigorous-intensity activity (MVPA) in Japanese women. The participants were 103 nondiabetic women (47.4 ± 10.8 years), who underwent health checkups in which data of glycated hemoglobin (HbA1c) were collected. Abdominal circumference (AC) was measured at the umbilical region. Birth weight was obtained from the Maternal and Child Health Handbook records or reported based on the participant's or his/her mother's recall. Time (min/day) spent in MVPA (≥3.0 metabolic equivalents) was objectively measured using a triaxial accelerometer (Actimarker EW4800). Birth weight was inversely correlated with HbA1c (r = −0.32, P < 0.01). Multiple linear regression analyses revealed that lower birth weight was associated with increased HbA1c (β = −0.22, P < 0.05) even after adjusting for age, state of menstruation, AC, and family history of diabetes. This association was little changed when MVPA was introduced as an independent variable in the model (β = −0.23, P < 0.05). These results suggest that lower birth weight may be associated with higher HbA1c levels before the onset of type 2 diabetes, irrespective of adulthood physical activity. Early-life development should be taken into account when considering the risk of diabetes in Japanese women, even if they are physically active. [ABSTRACT FROM AUTHOR]
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- 2020
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21. An exploratory study of relationship between lower-limb muscle mass and diabetic polyneuropathy in patients with type 2 diabetes.
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Kataoka, Hiroaki, Miyatake, Nobuyuki, Kitayama, Naomi, Murao, Satoshi, and Tanaka, Satoshi
- Subjects
MUSCLE mass ,PEOPLE with diabetes ,TYPE 2 diabetes ,MULTIPLE regression analysis ,BIOELECTRIC impedance - Abstract
Purpose: This exploratory study compared the lower-limb muscle mass (thigh muscle mass [TMM] and lower-leg muscle mass [LLMM]) in type 2 diabetic patients with and without diabetic polyneuropathy (DPN). Methods: A total of 130 patients with type 2 diabetes, hospitalized for glycemic control, were enrolled in this cross-sectional study. TMM and LLMM were measured using the bioelectrical impedance method. The muscle mass value was normalized by the bodyweight, and the total muscle mass was calculated by combining the muscle mass on the left and right (%TMM and %LLMM). DPN was evaluated according to the Japanese criteria. Anthropometric parameters, blood pressure, laboratory data, exercise habits, medication, related index of diabetes, and diabetic complications were analyzed. Results: Sixty patients, comprising of 32 males (47.8%) and 28 females (44.4%) with type 2 diabetes (46.2%), had DPN. The %TTM and %LLMM were significantly lower in type 2 diabetic patients with DPN than in those without DPN. Multiple regression analysis identified DPN, age, and hemoglobin A1c (HbA1c) as the determinants of %TMM, and DPN and HbA1c were identified as the determinants of %LLMM in type 2 diabetic patients. Discussion: The %TMM and %LLMM were significantly decreased in type 2 diabetic patients with DPN. DPN was found to be the strongest determinant of %TMM and %LLMM. Preventing and improving DPN, through active physical therapy, may increase the muscle mass of the lower limbs. [ABSTRACT FROM AUTHOR]
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- 2020
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22. Behavior problems and dysfunctional parenting: Cross‐sectional study in Japan.
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Suzuki, Hiromi, Yoda, Takeshi, Kanda, Kanae, Nishimoto, Naoki, Miyatake, Nobuyuki, Konishi, Yukihiko, Nishida, Tomoko, Yokoyama, Katsunori, Kusaka, Takashi, and Hirao, Tomohiro
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COMPETENCY assessment (Law) ,DIAGNOSIS of child development deviations ,BEHAVIOR disorders in children ,PRESCHOOLS ,PARENT-child relationships ,PARENTING ,QUESTIONNAIRES ,MULTIPLE regression analysis ,SOCIOECONOMIC factors ,CROSS-sectional method - Abstract
Background: The Japanese government has established a law encouraging early detection and treatment of developmental disorders in children. Child behavior problems (CBP) tend to be recognized at school as a result of developmental disorders. The aim of this study was to identify factors associated with CBP in Japan. We hypothesized that factors other than developmental disorders are important in explaining CBP. Methods: The study was conducted between February and March 2015. Parents of 3,515 children aged 2–5 years attending one of 34 public nursery schools in Takamatsu, Kagawa, Japan received self‐administered questionnaires addressing parental socioeconomic factors, mental health, parenting style (i.e. hostile, overreactive, or lax), developmental disorders in children, and CBP. A multiple regression analysis was applied to explore associations between CBP and possible factors. Results: Overall, 1,410 mothers were eligible to participate in the study. Children diagnosed with developmental disorders accounted for 7.8% of the sample, while on the Eyberg Child Behavior Inventory 17% of children had behavior problems needing clinical intervention. After adjustment for confounding factors, as well as for the diagnosis of developmental disorders, poor mental status and all three dysfunctional parenting styles had strong associations with CBP, and hostile, overreactive, and lax parenting had standardized β‐values (β) of 0.29, 0.28, and 0.15, respectively (P < 0.01). A problematic relationship between the parents was also significantly associated with CBP (β = −0.29, P < 0.01). Conclusion: When CBP are identified, parenting skills, mental health status and parental relationships should be considered along with the possibility of developmental disorders in the development of interventions. [ABSTRACT FROM AUTHOR]
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- 2019
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23. Effect of biologic disease-modifying anti-rheumatic drugs for patients with rheumatoid arthritis who hope to become mothers.
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Shimada, Hiromi, Kameda, Tomohiro, Kanenishi, Kenji, Miyatake, Nobuyuki, Nakashima, Shusaku, Wakiya, Risa, Kato, Mikiya, Miyagi, Taichi, Mansour, Mai Mahmoud Fahmy, Hata, Toshiyuki, Kadowaki, Norimitsu, and Dobashi, Hiroaki
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PREMATURE rupture of fetal membranes ,HIGH-risk pregnancy ,RHEUMATOID arthritis ,TUMOR necrosis factors ,PREMATURE labor ,SYNTHETIC drugs - Abstract
Objectives: We examined the effect of biologic disease-modifying anti-rheumatic drugs on the time to pregnancy in patients with rheumatoid arthritis who hope to become mothers. Additionally, we evaluated adverse pregnancy outcomes and risk factors of these drugs. Method: We retrospectively investigated 25 pregnancies of 19 patients who were taking disease-modifying anti-rheumatic drugs. In 15 pregnancies, patients continued biologic disease-modifying anti-rheumatic drugs until conception (group A). In 10 pregnancies, patients discontinued biologic disease-modifying anti-rheumatic drugs and conventional synthetic disease-modifying anti-rheumatic drugs at the time of planning to conceive (group B). We used tumor necrosis factor inhibitors (certolizumab pegol and etanercept) for group A patients. Results: The mean time to pregnancy was shorter in group A than in group B (5.9 ± 3.8 vs 11.0 ± 6.5 months, P = 0.04). The mean birth weight of newborns was lighter in group B than in group A (2446.5 ± 352.4 vs 2969.4 ± 459.9 g, P = 0.007). There were no significant differences in the rates of preterm birth, light-for-date, and premature rupture of the membranes between the groups. In patients with preterm birth or light-for-date newborns, the mean dose of corticosteroids during pregnancy was significantly higher compared with that in those with full-term birth or non-light-for-date newborns (P = 0.02, P < 0.01, respectively). Conclusions: In patients with rheumatoid arthritis who hope to conceive, continuing biologic disease-modifying anti-rheumatic drugs at the time of conception could shorten the time to pregnancy. Using biologic disease-modifying anti-rheumatic drugs before pregnancy does not affect abortion, preterm birth, light-for-date, and premature rupture of the membranes. [ABSTRACT FROM AUTHOR]
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- 2019
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24. Sub-analysis of the prevalence of locomotive syndrome and its relationship with health-related quality of life in patients with obstructive sleep apnea syndrome as classified by age and sex.
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Kataoka, Hiroaki, Miyatake, Nobuyuki, Ichikawa, Hirohisa, Arakawa, Yukako, and Mori, Yoshihiro
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QUALITY of life ,SLEEP apnea syndromes ,CONTINUOUS positive airway pressure ,METABOLIC syndrome - Abstract
The purpose of this study was to investigate the prevalence of locomotive syndrome (LS) in patients with obstructive sleep apnea syndrome (OSAS), and to compare the health-related quality of life (HRQOL) among patients with and without LS as classified by age and sex. A total of 1173 patients with OSAS (1013 males and 160 females) who were treated with continuous positive airway pressure (CPAP) therapy were enrolled in this cross-sectional study. Male participants were divided into 6 groups (30-39 years, 40-49 years, 50-59 years, 60-69 years, 70-79 years, and 80-89 years) and female participants were divided into 5 groups (40-49 years, 50-59 years, 60-69 years, 70-79 years, and 80-89 years). LS was evaluated using a "loco-check" established by the Japanese Orthopedic Association. HRQOL was evaluated using the EuroQol 5-dimensional questionnaire (EQ-5D). The prevalence of LS among the different age and sex groups was 19.6-79.4% in males and 27.0-95.5% in females and increased with age. In males aged 30-39 and 70-79 years, and in females aged 50-59 years, the EQ-5D scores were significantly lower in OSAS patients with LS than in OSAS patients without LS, even after adjusting for confounding factors. In OSAS patients, LS was closely linked to HRQOL. Preventing and improving the outcomes of LS would be beneficial for improving the HRQOL in OSAS patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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25. Decrease in toe pinch force in male type 2 diabetic patients with diabetic nephropathy.
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Kataoka, Hiroaki, Miyatake, Nobuyuki, Kitayama, Naomi, Murao, Satoshi, and Tanaka, Satoshi
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PEOPLE with diabetes ,PINCH grip ,TOES ,ALBUMINURIA ,DIABETIC nephropathies ,GRIP strength ,PHYSIOLOGY - Abstract
Background: The purpose of this cross-sectional study was to investigate the toe pinch force (TPF) of type 2 diabetic patients with diabetic nephropathy by disease stage, and to clarify the factors affecting the TPF.Methods: Seventy-four men with diabetic nephropathy (age: 62.7 ± 8.9 years, duration of diabetes: 14.2 ± 8.6 years) were enrolled. According to the staging of diabetic nephropathy, TPF and knee extension force (KEF) were compared among three groups: normoalbuminuria, microalbuminuria, and overt nephropathy. In addition, we investigated factors influencing TPF and KEF by performing multiple regression analysis.Results: Normoalbuminuria group, microalbuminuria group, and overt nephropathy group included 26, 25, and 23 patients, respectively. The TPF of the overt nephropathy group (3.15 ± 0.75 kg) was significantly lower than that of the normoalbuminuria (4.2 ± 0.7 kg, p < 0.001) and microalbuminuria groups (3.65 ± 0.81 kg, p = 0.022). The KEF of the overt nephropathy group (37.1 ± 8.3 kgf) was significantly lower than that of the normoalbuminuria group (44.8 ± 8.3 kgf, p = 0.010). Multiple regression analysis revealed that diabetic polyneuropathy (DPN) and diabetic nephropathy were determinant factors of the TPF; and age, body mass index, and diabetic nephropathy were determinant factors of the KEF.Conclusion: We found in male patients with diabetic nephropathy, the TPF and KEF decreased with progression of diabetic nephropathy. Furthermore, our findings suggest diabetic nephropathy and DPN are critically involved in the reduction of TPF and KEF. [ABSTRACT FROM AUTHOR]
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- 2018
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26. A pilot study of short-term toe resistance training in patients with type 2 diabetes mellitus.
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Kataoka, Hiroaki, Miyatake, Nobuyuki, Kitayama, Naomi, Murao, Satoshi, and Tanaka, Satoshi
- Abstract
Objective: The purpose of this pilot study was to investigate the effect of short-term toe resistance training on toe pinch force and toe muscle quality in patients with type 2 diabetes mellitus. Methods: A total of 12 patients with type 2 diabetes mellitus who were hospitalized to improve glycemic control (8 men and 4 women, duration of diabetes 12.2 ± 9.5 years) were enrolled in this pilot study. Exercise therapy was performed with conventional aerobic exercise and four newly developed toe resistance training exercises for 2 weeks. Changes in anthropometric parameters, blood pressure (BP), heart rate, and muscle parameters, i.e. muscle mass, toe pinch force and toe muscle quality were evaluated after the exercise program. Results: There were no significant differences of body weight, body mass index, BP, heart rate, and upper/lower muscle mass after exercise performance. However, toe pinch force was significantly increased (pre: 2.92 ± 1.19 kg, post: 3.65 ± 1.58 kg, p = 0.007). Toe muscle quality (toe pinch force/lower leg muscle mass) were also significantly increased (pre: 2.15 ± 0.86 kg/kg, post: 2.72 ± 1.26 kg/kg, p = 0.009). Conclusions: Two weeks of toe resistance training significantly increased toe pinch force and toe muscle quality in patients with type 2 diabetes mellitus. Toe resistance training is might be essential for treating patients with diabetes mellitus in clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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27. Prevalence of attention deficit hyperactivity disorder and/or autism spectrum disorder and its relation to lifestyle in female college students.
- Author
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Takahashi, Keizo, Miyatake, Nobuyuki, Kurato, Risa, and Takahashi, Nobuko
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Objective: The aim of this study was to explore the prevalence of attention deficit hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) and its relation to lifestyle in female college students. Subjects and methods: A total of 375 female college students (19.2 ± 1.3 years) among 439 students were enrolled in this cross-sectional study. Using a self-reported questionnaire, we measured the prevalence of ADHD using the ADHD Self-Report Scale-v1.1 (ASRS) and the prevalence of ASD using the Autism-Spectrum Quotient (AQ). In addition, lifestyle choices such as medications, physical activity, cigarette smoking, alcohol drinking and sleeping habits were also evaluated. Results: The suspected prevalence of ADHD was 102 students (27.2 %) and the suspected prevalence of ASD was 4 students (1.1 %). Only one student (0.3 %) was thought to have both ADHD and ASD. Subjects with suspected ADHD had higher AQ scores compared with those without suspected ADHD. There were no unhealthy lifestyle choices in subjects with suspected ADHD and/or ASD. Conclusion: The prevalence of suspected ADHD and/or ASD may be relatively high even among female college students in Japan. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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28. Psychological distress between chronic hemodialysis patients with and without low back pain.
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Hishii, Shuhei, Miyatake, Nobuyuki, Nishi, Hiroyuki, Katayama, Akihiko, Uzike, Kazuhiro, Hashimoto, Hiroo, and Koumoto, Kiichi
- Abstract
Objective: The aim of this study was to compare psychological distress between patients on chronic hemodialysis with and without chronic low back pain (CLBP). Subjects and methods: A total of 72 patients on chronic hemodialysis, aged 72.9 ± 10.8 years, were enrolled in this cross-sectional study. Psychological distress using the K6, questionnaire for CLBP, and physical activity using the tri-accelerometer were evaluated. Results: Twenty-nine patients (40.3 %) were having CLBP. The K6 scores were 4.0 ± 4.6 and physical activity ( n = 55) was 1.0 ± 1.0 METs h/day. K6 scores in patients on chronic hemodialysis with CLBP were significantly higher than those in patients on chronic hemodialysis without CLBP even after adjusting for sex, age, duration of hemodialysis and physical activity. Conclusion: These results suggest that higher psychological distress was a fundamental feature in patients on chronic hemodialysis with CLBP. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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29. A pilot study of the relationship between diet and mental health in female university students enrolled in a training course for registered dietitians.
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Mochimasu, Kazumi, Miyatake, Nobuyuki, and Hase, Ayako
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Objective: The purpose of the present pilot study was to investigate the link between diet and mental health in female university students enrolled in a training course for registered dietitians. Subjects and methods: A total of 62 female university students, with a mean age of 18.79 ± 0.45 years, participated in this cross-sectional study. Diet surveys were performed using the brief-type self-administered diet history questionnaire (BDHQ). Mental health was also evaluated using the general health questionnaire-12 (GHQ-12), which was the shortest form and clinically available. Lifestyles such as physical activity levels were also evaluated. Results: The mean energy intake was 1379 ± 575 kcal and the mean GHQ score was 3.11 ± 2.41. Among nutrients, vegetable fat and sucrose showed a weak positive correlation with the GHQ scores. Among food groups, potatoes, fats and oils, and confectioneries also showed a weak positive correlation with the GHQ scores. A multiple regression analysis showed that the confectioneries were the determining factor for the GHQ scores. Conclusion: Proper education concerning their diets and reducing confectioneries in their daily lives might be beneficial for the mental health of female university students. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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30. Comparison of health-related quality of life between type 2 diabetic patients with and without locomotive syndrome.
- Author
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Asakura, Rie, Miyatake, Nobuyuki, Mochimasu, Kazumi, Kurato, Risa, and Kuwana, Susumu
- Abstract
Objective: The aim of this study was to compare health-related quality of life (HRQOL) between type 2 diabetic patients with and without locomotive syndrome, which is a risk for becoming bedridden because of deteriorating locomotive organs. Subjects and methods: A total of 135 patients with type 2 diabetes mellitus (69.2 ± 10.2 years) were enrolled in this cross-sectional study. HRQOL was evaluated by the Euro-QOL-5 (EQ-5D), and locomotive syndrome was evaluated by 'loco-check,' established the Japanese Orthopedic Association. Clinical data, such as anthropometric parameters, blood and urine examination results, blood pressure (BP), drug usage, and psychological distress, were analyzed. Results: Average HbA1c in all patients was 7.2 ± 1.0 %, and 74 patients (54.8 %) were identified as having the locomotive syndrome. EQ-5D scores were significantly lower in type 2 diabetic patients with locomotive syndrome than in those without locomotive syndrome, even after adjusting for age, sex, body mass index (BMI), and HbA1c. By the multiple regression analysis, locomotive syndrome and age were identified as determinant factors of HRQOL in type 2 diabetic patients. Conclusion: In type 2 diabetic patients, lower HRQOL was a characteristic feature of subjects with locomotive syndrome, even after adjusting for confounding factors. Prevention or management of locomotive syndrome may be beneficial for improving HRQOL in type 2 diabetic patients. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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31. Relationship of toe pinch force to other muscle strength parameters in men with type 2 diabetes.
- Author
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Kataoka, Hiroaki, Miyatake, Nobuyuki, Kitayama, Naomi, Murao, Satoshi, Kohi, Fumikazu, and Tanaka, Satoshi
- Abstract
Objective: The aim of this study was to explore the relations between toe pinch force and other muscle strength parameters in male patients with type 2 diabetes mellitus. Methods: A total of 40 men with type 2 diabetes (age: 53.4 ± 13.1 years, duration of diabetes: 8.5 ± 8.1 years) who needed exercise training were enrolled in this cross-sectional study. We evaluated the clinical parameters and 4 muscle strength parameters, which were toe pinch force, handgrip strength, isometric knee extension force, and isometric ankle dorsiflexion force. Results: The HbA1c, toe pinch force, handgrip strength, isometric knee extension force, and isometric ankle dorsiflexion force were 10.1 ± 2.4 %, 3.2 ± 1.2 kg, 37.3 ± 7.0 kg, 39.6 ± 11.4 kgf, and 17.0 ± 6.3 kgf, respectively. Toe pinch force was significantly correlated with handgrip strength ( r = 0.365, p = 0.0206), isometric knee extension force ( r = 0.668, p < 0.0001), and isometric ankle dorsiflexion force ( r = 0.514, p = 0.0007). All muscle strength parameters were significantly lower in patients with diabetic polyneuropathy than in those without polyneuropathy. Conclusion: Although toe pinch force was significantly correlated with the other muscle strength parameters, the correlation was not so strong. However, evaluation of toe pinch force might be recommended for assessment of distal limb muscle strength in patients with type 2 diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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32. Cardiorespiratory Fitness Suppresses Age-Related Arterial Stiffening in Healthy Adults: A 2-Year Longitudinal Observational Study.
- Author
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Gando, Yuko, Murakami, Haruka, Kawakami, Ryoko, Yamamoto, Kenta, Kawano, Hiroshi, Tanaka, Noriko, Sawada, Susumu S., Miyatake, Nobuyuki, and Miyachi, Motohiko
- Subjects
AGING ,BLOOD pressure ,CARDIOVASCULAR disease diagnosis ,CARDIOVASCULAR system physiology ,COMPARATIVE studies ,EXERCISE tests ,HYPERTENSION ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,TIME ,EVALUATION research ,BRACHIAL artery ,HUMAN research subjects ,ANKLE brachial index ,DISEASE progression - Abstract
Cardiorespiratory fitness is negatively associated with arterial stiffness, although it is unclear whether it is associated with prospective arterial stiffness changes. The authors examined cardiorespiratory fitness and arterial stiffness progression in a 2-year follow-up study of 470 healthy men and women aged 26 to 69 years. Peak oxygen uptake (V˙O2peak) was measured at baseline using a graded cycle exercise test. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV) at baseline and after 2 years. Two-year changes in baPWV were significantly higher in patients in the lowest V˙O2peak tertile (28.8±7.6 cm/s) compared with those in the highest V˙O2peak tertile (-1.4±7.5 cm/s) (P=.024) and were inversely correlated with V˙O2peak (r=-.112, P=.015). Stepwise multiple regression analysis revealed that age, glucose, baPWV, V˙O2peak, and sex were independent correlates of 2-year changes in baPWV, suggesting that higher cardiorespiratory fitness is associated with age-related arterial stiffening suppression. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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33. Evaluation of antireflux surgery using multichannel intraluminal impedance-pH measurement in neurologically impaired patients.
- Author
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Tanaka, Aya, Shimono, Ryuichi, Kubo, Hiroyuki, Fujii, Takayuki, and Miyatake, Nobuyuki
- Subjects
ESOPHAGEAL motility ,NEUROLOGY ,HYDROGEN-ion concentration measurement ,POSTOPERATIVE period ,PEDIATRIC surgery ,BOLUS (Digestion) ,GASTROESOPHAGEAL reflux diagnosis ,SURGICAL complications ,GASTROESOPHAGEAL reflux ,NEUROLOGICAL disorders ,PATIENT monitoring ,PREOPERATIVE care ,DISEASE complications ,DIAGNOSIS - Abstract
Purpose: This study aimed to evaluate esophageal function before and after antireflux surgery (ARS) in neurologically impaired (NI) patients using 24 h multichannel intraluminal impedance (MII)-pH measurement.Methods: Seven NI patients (age, 0-33 years; median, 13 years) were assessed before and after ARS using 24 h MII-pH. We described reflux parameters such as pH reflux index, bolus exposure index, number of acidic and nonacidic reflux episodes, mean acid clearance time and median bolus clearance time, and esophageal motility parameters in dry swallows such as bolus presence time (BPT), total bolus transit time (TBTT), and total propagation velocity (TPV).Results: The postoperative reflux parameters such as pH reflux index, acid clearance time, bolus exposure index, and the number of acidic reflux episodes significantly decreased (P < 0.05) compared with the preoperative ones. The esophageal motility parameters including all sites of BPTs, TBTT, and TPV did not change in the MII-pH measurement after ARS (P = non-significant).Conclusion: ARS effectively reduced gastro-esophageal reflux (GER) in NI patients without the impairment of esophageal motility by MII-pH measurement. MII-pH was useful to detect the subtype of GER before and after ARS and appeared to be appropriate for evaluating esophageal motility. [ABSTRACT FROM AUTHOR]- Published
- 2015
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34. Relationship between cigarette smoking and one leg with eyes closed balance in Japanese men.
- Author
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Saito, Takeshi, Miyatake, Nobuyuki, and Nishii, Kenji
- Abstract
Objective: To investigate the link between cigarette smoking and one leg with eyes closed balance in Japanese men. Subjects and methods: We used data from 4224 Japanese men, aged 43.3 ± 13.9 years, in this cross-sectional study. Balance, such as one leg with eyes closed balance was measured. In addition, cigarette smoking habits were obtained by well-trained medical staff. The effect of cigarette smoking on one leg with eye closed balance was evaluated. Results: A total of 1613 men (38.2 %) had smoking habit and 1471 men (34.8 %) regularly exercised. Age-related changes in one leg with eyes closed balance were noted. One leg with eyes closed balance in subjects with cigarette smoking (30.9 ± 31.8 s) was significantly lower than those in subjects without cigarette smoking (32.4 ± 33.5 s) even after adjusting for confounding factors i.e. age, body weight and exercise habits. Conclusion: Cigarette smoking might be associated with one leg with eyes closed balance in Japanese men. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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35. Evaluation of psychological distress using the K6 in patients on chronic hemodialysis.
- Author
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Katayama, Akihiko, Miyatake, Nobuyuki, Nishi, Hiroyuki, Hashimoto, Hiroo, Uzike, Kazuhiro, Sakano, Noriko, Tanaka, Keiko, and Koumoto, Kiichi
- Abstract
Objective: The aim of this study was to evaluate psychological distress in patients on chronic hemodialysis. Subjects and methods: A total of 72 patients on chronic hemodialysis were enrolled in this study. We evaluated psychological distress by using the K6 questionnaire, health-related quality of life (HRQOL) by using the EQ-5D questionnaire, and clinical parameters. Among the 72 patients, we also evaluated changes in K6 scores in 58 patients at 1-year follow-up. Results: The mean K6 score was 3.7 ± 3.7 and 2 subjects (2.8 %) were defined as having psychological distress. K6 scores were significantly correlated with body fat percentage, albumin level, and EQ-5D scores in total subjects. K6 scores were also significantly and negatively correlated with EQ-5D scores in men and women. In the 1-year follow-up group, changes in K6 scores were weakly and negatively correlated with changes in EQ-5D scores. Conclusion: Psychological distress was closely associated with HRQOL in patients on chronic hemodialysis. Coping strategies for psychological distress might be useful in improving HRQOL in patients on hemodialysis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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36. The linkage among ambulance transports, death and climate parameters in Asahikawa City, Japan.
- Author
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Kataoka, Hiroaki, Mochimasu, Kazumi, Katayama, Akihiko, Kanda, Kanae, Sakano, Noriko, Tanaka, Keiko, and Miyatake, Nobuyuki
- Abstract
Objective: The aim of this study was to investigate the linkage among climate parameters, total ambulance transports and the number of deaths in Asahikawa City in northern Japan. Methods: Monthly data on total ambulance transports and the number of deaths from January 2004 to December 2011 were obtained from Asahikawa City Fire Department and the Asahikawa City official website. Climate parameters for the required period were also obtained from the Japan Meteorological Agency, Japan. To adjust for the population, we also used monthly population data on Asahikawa City. The linkage among climate parameters, total ambulance transports and the number of deaths was evaluated by ecological analysis. Results: The mean air temperature in the Asahikawa area was 7.3 ± 10.1 °C. Total ambulance transports (/a hundred thousand people/day) and the number of deaths (/a hundred thousand people/day) were 10.0 ± 0.6 and 2.6 ± 0.3, respectively. Using quadratic curves, total ambulance transports and the number of deaths were weakly correlated with some climate parameters. The number of deaths was weakly and positively correlated with total ambulance transports. Conclusion: A weak linkage among climate parameters, total ambulance transports and the number of deaths was noted in Asahikawa City, Japan. However, these associations were not as high as expected. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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37. Association of Higher Methotrexate Dose With Lymphoproliferative Disease Onset in Rheumatoid Arthritis Patients.
- Author
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Kameda, Tomohiro, Dobashi, Hiroaki, Miyatake, Nobuyuki, Inoo, Masayuki, Onishi, Ikuko, Kurata, Noriyuki, Mitsunaka, Hiroki, Kawakami, Kimihiro, Fukumoto, Tetsuya, Susaki, Kentaro, Izumikawa, Miharu, Nakashima, Shusaku, Shimada, Hiromi, Takeuchi, Yohei, Haba, Reiji, Mano, Shohei, Onishi, Hiroaki, Imataki, Osamu, and Matsunaga, Takuya
- Published
- 2014
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38. Circulating leptin levels are associated with physical activity or physical fitness in Japanese.
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Miyatake, Nobuyuki, Murakami, Haruka, Kawakami, Ryoko, Tabata, Izumi, and Miyachi, Motohiko
- Abstract
Objective: The aim of this study was to evaluate the link between circulating leptin levels and physical activity and/or physical fitness in apparently healthy Japanese. Methods: A total of 85 men and 111 women who were not taking any medication were enrolled in this cross-sectional study. Circulating leptin levels, physical activity measured by tri-axial accelerometers and peak oxygen uptake were evaluated. We also assessed anthropometric data, blood pressure, blood examinations and energy intake. Results: Circulating leptin levels were 3.2 ± 2.3 ng/mL in men and 5.9 ± 3.8 ng/mL in women. Circulating leptin levels were significantly and positively correlated with body weight, body mass index, abdominal circumference, insulin and the homeostasis model assessment index, and significantly and negatively correlated with peak oxygen uptake in both sexes. Stepwise multiple regression showed that peak oxygen uptake in men and physical activity evaluated by $$\sum {\left[ {{\text{metabolic equivalents }} \times \rm h {\text{ per week}}({\text{METs}}\;\;h/w)} \right]}$$ in women were determinant factors for circulating leptin levels after adjusting for confounding factors. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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39. Lower air temperature is associated with ambulance transports and death in Takamatsu area, Japan.
- Author
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Mochimasu, Kazumi, Miyatake, Nobuyuki, Tanaka, Naoko, and Kinoshita, Hiroshi
- Abstract
Objective: The aim of this study was to investigate the linkage among ambulance transports, the number of death and air temperature in Takamatsu area, Japan. Methods: Monthly data of ambulance transports (total and acute disease) and the number of death from 2004 to 2012 were obtained from Fire Department Service in Takamatsu and Takamatsu city official website, Japan. Climate parameters for required period were also obtained from Japan Meteorological Agency. Population data in Takamatsu area were also used to adjust ambulance transports and the number of death. The linkage among ambulance transports, the number of death and climate parameters was evaluated by ecological analysis. Results: Total ambulance transports (/a hundred thousand people/day) and ambulance transports due to acute disease (/a hundred thousand people/day) were 12.3 ± 0.9 and 6.8 ± 0.7, respectively. The number of death (/a hundred thousand people/day) was 2.5 ± 0.4. By quadratic curve, ambulance transports due to acute disease and the number of death were significantly correlated with the parameters of air temperature. However, the number of death was the highest in January and the lowest in August. Conclusion: Although higher air temperature was only associated with higher ambulance transports, lower air temperature was associated with both higher ambulance transports and the number death in Takamatsu area, Japan. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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40. Circulating adiponectin levels are associated with peak oxygen uptake in Japanese.
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Miyatake, Nobuyuki, Numata, Takeyuki, Murakami, Haruka, Kawakami, Ryoko, Sanada, Kiyoshi, Tabata, Izumi, and Miyachi, Motohiko
- Abstract
Objective: The aim of this study was to investigate the link between circulating adiponectin levels and peak oxygen uptake and/or physical activity in Japanese. Methods: A total of 528 subjects (188 men and 340 women) were enrolled in this cross-sectional study. Circulating adiponectin levels, physical activity measured by tri-axial accelerometers, peak oxygen uptake and metabolic risk parameters were evaluated. We also assessed anthropometric factors, blood pressure, blood examinations and energy intake. Results: Circulating adiponectin levels were 6.7 ± 3.0 μg/mL in men and 11.0 ± 4.9 μg/mL in women. Circulating adiponectin levels were positively correlated with physical fitness after adjusting for age, physical activity evaluated by Σ [metabolic equivalents × h per week (METs h/w)], cigarette smoking habit and energy intake in both sexes. However, these associations were attenuated further after adjusting for body mass index including other confounding factors, especially in men. However, circulating adiponectin levels were not associated with physical activity in either sex. Conclusion: Circulating adiponectin levels were associated with peak oxygen uptake rather than physical activity. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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41. Serum vaspin levels are associated with physical activity or physical fitness in Japanese: a pilot study.
- Author
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Miyatake, Nobuyuki, Wada, Jun, Nakatsuka, Atsuko, Sakano, Noriko, Teshigawara, Sanae, Miyachi, Motohiko, Tabata, Izumi, and Numata, Takeyuki
- Abstract
Aim: To investigate the link between serum vaspin levels and physical activity and/or physical fitness in Japanese. Methods: A total of 156 subjects (81 men and 75 women) was enrolled in this cross-sectional study. Serum vaspin levels, physical activity by uniaxial accelerometers, peak oxygen uptake, and metabolic risk parameters were evaluated. We also assessed anthropometric and body composition parameters. Results: Serum vaspin levels were over the level of 10 ng/mL in 15 subjects (9.6 %: Vaspin High group). In Vaspin Low group (<5 ng/mL: 74 men and 67 women), serum vaspin levels were 0.12 ± 0.18 ng/mL in men and 0.39 ± 0.70 ng/mL in women. Peak oxygen uptake was significantly and positively correlated with serum vaspin levels even after adjusting for age, physical activity evaluated by Σ[metabolic equivalents × h per week (METs⋅h/w)], BMI, and other confounding factors in men. In turn, physical activity was significantly and positively correlated with serum vaspin levels even after adjusting for confounding factors in women. Conclusion: Serum vaspin levels were closely associated with physical fitness in men and physical activity in women independent of body composition in this Japanese cohort. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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- View/download PDF
42. Evaluation of physical activity and its relationship to health-related quality of life in patients on chronic hemodialysis.
- Author
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Katayama, Akihiko, Miyatake, Nobuyuki, Nishi, Hiroyuki, Uzike, Kazuhiro, Sakano, Noriko, Hashimoto, Hiroo, and Koumoto, Kiichi
- Abstract
Objective: The aim of this study was to investigate the relationship between physical activity and health-related quality of life (HRQOL) in patients on chronic hemodialysis. Methods: A total of 31 men (69.0 ± 11.1 years) and 17 women (66.9 ± 10.0 years) among 61 male and 30 female patients on chronic hemodialysis at Innoshima General Hospital, Onomichi, Japan, were enrolled in this cross-sectional study. Physical activity was evaluated using tri-axial accelerometers. HRQOL and psychological distress were also evaluated using the EuroQol questionnaire (EQ-5D) and the K6 questionnaire, respectively. Results: Physical activity evaluated by Σ[metabolic equivalents × h per week (METs·h/w)] was 8.1 ± 6.0 METs·h/w, and EQ-5D score was 0.754 ± 0.177. Among all patients, EQ-5D scores were significantly correlated with physical activity over 4 METs on non-hemodialysis treatment days ( r = 0.426, p = 0.003). In women, EQ-5D scores were also correlated with physical activity over 4 METs on hemodialysis treatment days and non-hemodialysis treatment days. By stepwise multiple regression analysis, physical activity over 4 METs on non-hemodialysis treatment days was a determinant factor of EQ-5D even after adjusting for age and K6 scores. Conclusion: Physical activity over 4 METs on non-hemodialysis treatment days might be associated with EQ-5D in patients on chronic hemodialysis, especially in women. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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43. Serum Interleukin-18 Levels Are Associated with Physical Activity in Japanese Men.
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Oda, Kanae, Miyatake, Nobuyuki, Sakano, Noriko, Saito, Takeshi, Miyachi, Motohiko, Tabata, Izumi, and Numata, Takeyuki
- Subjects
BLOOD serum analysis ,INTERLEUKIN-18 ,PHYSICAL activity ,JAPANESE people ,CROSS-sectional method ,ANTHROPOMETRY ,HUMAN body composition ,AEROBIC capacity ,DISEASES - Abstract
Objective: To investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men. Methods: A total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study. We assessed anthropometric and body composition parameters. Serum IL-18 levels, physical activity by uniaxial accelerometers, peak oxygen uptake and metabolic risk parameters were also evaluated. Results: Serum IL-18 levels were 179.4±84.7 pg/mL. Physical activity evaluated by Σ[metabolic equivalents × h per week (METs⋅h/w)]was significantly and negatively correlated with serum IL-18 levels (r = −0.252, p = 0.0235). These associations remained even after adjusting for age, peak oxygen uptake and other confounding factors. Conclusion: Serum IL-18 levels were closely associated with physical activity independent of peak oxygen uptake in Japanese men. [ABSTRACT FROM AUTHOR]
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- 2013
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- View/download PDF
44. Does Cardiorespiratory Fitness Modify the Association between Birth Weight and Insulin Resistance in Adult Life?
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Aoyama, Tomoko, Tsushita, Kazuyo, Miyatake, Nobuyuki, Numata, Takeyuki, Miyachi, Motohiko, Tabata, Izumi, Cao, Zhen-Bo, Sakamoto, Shizuo, and Higuchi, Mitsuru
- Subjects
CARDIOPULMONARY system ,PHYSICAL fitness ,BIRTH weight ,INSULIN resistance ,DISEASES in adults ,JAPANESE people ,HOMEOSTASIS ,DISEASES - Abstract
Objective: Lower birth weight is associated with higher insulin resistance in later life. The aim of this study was to determine whether cardiorespiratory fitness modifies the association of birth weight with insulin resistance in adults. Methods: The subjects were 379 Japanese individuals (137 males, 242 females) aged 20–64 years born after 1943. Insulin resistance was assessed using a homeostasis model assessment of insulin resistance (HOMA-IR), which is calculated from fasting blood glucose and insulin levels. Cardiorespiratory fitness (maximal oxygen uptake, VO
2 max) was assessed by a maximal graded exercise test on a cycle ergometer. Birth weight was reported according to the Maternal and Child Health Handbook records or the subject’s or his/her mother’s memory. Results: The multiple linear regression analysis revealed that birth weight was inversely associated with HOMA-IR (β = −0.141, p = 0.003), even after adjustment for gender, age, current body mass index, mean blood pressure, triglycerides, HDL cholesterol, and smoking status. Further adjustments for VO2 max made little difference in the relationship between birth weight and HOMA-IR (β = −0.148, p = 0.001), although VO2 max (β = −0.376, p<0.001) was a stronger predictor of HOMA-IR than birth weight. Conclusions: The results showed that the association of lower birth weight with higher insulin resistance was little modified by cardiorespiratory fitness in adult life. However, cardiorespiratory fitness was found to be a stronger predictor of insulin resistance than was birth weight, suggesting that increasing cardiorespiratory fitness may have a much more important role in preventing insulin resistance than an individual’s low birth weight. [ABSTRACT FROM AUTHOR]- Published
- 2013
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45. Protective effect of D-psicose against testicular atrophy induced by di(2-ethylhexyl) phthalate.
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Suna, Shigeru, Tokuda, Masaaki, Hirao, Tomohiro, Yamaguchi, Fuminori, Miyatake, Nobuyuki, Suzue, Takeshi, Asakawa, Fumiyuki, Jitsunari, Fumihiko, and Izumori, Ken
- Subjects
D-Psicose ,DIETHYLHEXYL phthalate ,ATROPHY ,TESTIS injuries ,REPRODUCTIVE toxicology ,SPERMATOGENESIS ,THERAPEUTIC use of antioxidants ,PREVENTION ,PHYSIOLOGY - Abstract
The pollutant di(2-ethylhexyl) phthalate (DEHP) is a suspected reproductive toxicant. To clarify the protective effect of D-psicose on DEHP-induced testicular atrophy, we exposed rats to 1% DEHP via their diet while receiving D-psicose supplementation. A significant negative correlation was found between plasma mono(2-ethylhexyl) phthalate (MEHP) concentrations and relative testicular weight in rats given the 1% DEHP-containing diet for seven days. There was, however, no significant difference in testicular weight compared with control in rats given the 1% DEHP-containing diet plus 2% D-psicose-supplemented water. Rats given the 1% DEHP-containing diet for 14 days showed severe testicular atrophy. Conversely, those given the diet plus 2 or 4% D-psicose-supplemented water did not develop testicular atrophy and exhibited complete spermatogenesis. Testicular weight was also restored almost completely by D-psicose. But, incomplete but significant protection was noted in rats receiving a 2% DEHP-containing diet plus 4% D-psicose-supplemented water for 14 days. The present study shows the almost complete protective effect of D-psicose against DEHP-induced testicular atrophy. Although the reproductive toxicity of DEHP in human beings remains unclear, D-psicose may act as a protective agent against oxidant-mediated testicular injury in mammals, including human beings. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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46. \Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease.
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Kurose, Yuko, Wada, Jun, Kanzaki, Motoko, Teshigawara, Sanae, Nakatsuka, Atsuko, Murakami, Kazutoshi, Inoue, Kentaro, Terami, Takahiro, Katayama, Akihiro, Watanabe, Mayu, Higuchi, Chigusa, Eguchi, Jun, Miyatake, Nobuyuki, and Makino, Hirofumi
- Subjects
GALECTINS ,DIABETES ,T cells ,IMMUNOGLOBULINS ,KIDNEY diseases - Abstract
Background: Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of cyclin dependent kinase inhibitors such as p27Kip1 and p21Cip1. Methods: We investigated the serum levels of Gal-9 in the patients with type 2 diabetes and various stages of chronic kidney disease (CKD) (n=182). Results: Serum Gal-9 levels in the patients with type 2 diabetes were 131.9 ± 105.4 pg/ml and Log10Gal-9 levels significantly and positively correlated with age (r=0.227, p=0.002), creatinine (r=0.175, p=0.018), urea nitrogen (r=0.162, p=0.028) and osmotic pressure (r=0.187, p=0.014) and negatively correlated with estimated glomerular filtration rate (eGFR) (r=-0.188, p=0.011). Log10Gal-9 levels increased along with the progression of GFR categories of G1 to G4, and they were statistically significant by Jonckheere-Terpstra test (p=0.012). Log10Gal-9 levels remained similar levels in albuminuria stages of A1 to A3. Conclusion: The elevation of serum Gal-9 in the patients with type 2 diabetes is closely linked to GFR and they may be related to the alteration of the immune response and inflammation of the patients with type 2 diabetes and CKD. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
47. Relationship between cigarette smoking and muscle strength in Japanese men.
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Saito T, Miyatake N, Sakano N, Oda K, Katayama A, Nishii K, Numata T, Saito, Takeshi, Miyatake, Nobuyuki, Sakano, Noriko, Oda, Kanae, Katayama, Akihiko, Nishii, Kenji, and Numata, Takeyuki
- Published
- 2012
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48. Relationship Between Cigarette Smoking and Muscle Strength in Japanese Men.
- Author
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Saito, Takeshi, Miyatake, Nobuyuki, Sakano, Noriko, Oda, Kanae, Katayama, Akihiko, Nishii, Kenji, and Numata, Takeyuki
- Published
- 2012
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- View/download PDF
49. Changes in Air Temperature and Its Relation to Ambulance Transports Due to Heat Stroke in All 47 Prefectures of Japan.
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Murakami, Shoko, Miyatake, Nobuyuki, and Sakano, Noriko
- Published
- 2012
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50. Reduced Bone Mineral Density in Hypertensive Patients Is Associated with Left Ventricular Diastolic Dysfunction, Not Left Ventricular Hypertrophy.
- Author
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Masugata, Hisashi, Senda, Shoichi, Murao, Koji, Inukai, Michio, Hosomi, Naohisa, Iwado, Yasuyoshi, Noma, Takahisa, Kohno, Masakazu, Miyatake, Nobuyuki, Himoto, Takashi, and Goda, Fuminori
- Subjects
HYPERTENSION ,BONE density ,LEFT heart ventricle ,CARDIAC hypertrophy ,ANTIHYPERTENSIVE agents ,ECHOCARDIOGRAPHY ,HEART failure risk factors - Abstract
Left ventricular (LV) hypertrophy and diastolic dysfunction are commonly observed in hypertensive patients, and have been demonstrated to be risk factors of chronic heart failure due to LV diastolic dysfunction. Recently, reduced bone mineral density has been found in hypertensive patients compared with healthy controls. However, relationships between bone mineral density and LV hypertrophy and diastolic dysfunction have not been fully assessed. We examined relationships between bone mineral density and both LV hypertrophy and diastolic dysfunction in 38 hypertensive patients (23 males, 15 females; mean age 71 ± 8 y) who had been treated with antihypertensive drugs for at least 1 year. The bone mineral density of the calcaneus was measured with a quantitative ultrasound measurement device (A-1000 EXPRESS/InSight, GE Healthcare, Horten, Norway), and the stiffness index was determined as a parameter of bone mineral density. Echocardiography was performed to measure the left ventricular mass index as a parameter of LV hypertrophy. Left ventricular diastolic dysfunction was also assessed by early diastolic mitral annular velocity ( e′), and the ratio of early transmitral flow velocity ( E) to e′ ( E/ e′). The bone mineral density did not correlate with left ventricular mass index, but did correlate with e′ ( r == 0.453, P < .01) and E/ e′ ( r == −0.359, P < .05). Thus, reduced bone mineral density in hypertensive patients is not associated with LV hypertrophy but with LV diastolic dysfunction. Hypertensive patients with reduced bone mineral density may have a high risk of chronic heart failure due to LV diastolic dysfunction as well as bone fractures due to osteoporosis. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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