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Introduction: Patients with severe mental illnesses (SMI) are often exposed to polymedication. Additionally, the risk of somatic diseases is twice as high in patients with SMI as in individuals without a psychiatric disorder. Furthermore, drug–drug interactions (DDI) between psychiatric drugs and somatic medications are a well-known cause of adverse drug reactions (ADR). Objectives: The aim of this study was to analyse whether already known DDI related to psychiatric drugs and somatic medication still occur in everyday clinical practice. Methods: Therefore we identified all spontaneous ADR reports contained in the European ADR database EudraVigilance from Germany received between 01/2017 and 12/2021 reported for patients older than 17 years in which antidepressants, antipsychotics and mood stabilizers were reported as suspected/interacting (n= 9,665). ADR reports referring to intentional overdoses and suicide attempts were excluded (n= 9,276 left). We used the ABDATA drug information system in order to identify all potential DDI (pDDI). The identified reports with pDDI were then assessed individually to determine whether the respective DDI occurred. Results: 1,271 reports with 728 potentially interacting drugs pairs related to psychiatric drugs and somatic medications with 2,655 pDDI were found. Restricted to potentially interacting drug pairs with more than 10 reports, (i) hyponatremias related to antidepressants and diuretics (n= 362, 32.6%), (ii) bleeding events related to selective serotonin reuptake inhibitors (SSRI) and platelet aggregation inhibitors, anticoagulants or non-steroidal antiinflammatory drugs (NSAID) (n= 295, 17.5%), and (iii) increased beta-blocker effects related to SSRIs and beta-blockers (n= 126, 11.3%) were the most frequently identified pDDI. After individual case assessment, in 33.3% (14/42), 23.7% (45/190) and 17.4% (8/46) of the reports bleeding events related to SSRIs and anticoagulants, SSRIs and platelet aggregation inhibitors and SSRIs and NSAIDs were reported. Hyponatremia was reported in 7.6% (22/289) of the reports related to antidepressants and diuretics and increased beta-blocker effects in 6.9% (8/116) of the reports related to SSRIs and beta-blockers. Conclusions: According to our analysis, well-known DDI still occur in the treatment of psychiatric patients with psychiatric drugs and somatic medication. Whenever possible, alternative drug combinations with a lower potential of DDIs may be considered or appropriate monitoring measures should be conducted. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

There is a lack of knowledge about the composition of Saccharomyces cerevisiae strains in spontaneous fermentations of Pinot Noir and Chardonnay cultivars. The objectives were to determine the relative abundance of indigenous and commercial S. cerevisiae strains in spontaneous fermentations at three wineries from the two cultivars and to compare the composition of the S. cerevisiae strains between cultivars and wineries. Three fermentation vessels were sampled at three stages of fermentation for each cultivar at each winery. Isolates were identified to the strain level using seven microsatellite loci. Commercial S. cerevisiae strains were isolated at a frequency higher than that of the indigenous strains at each winery for both cultivars. The composition of S. cerevisiae strains was different for each cultivar and at each winery. Our results illustrate the clear influence of inoculated commercial active dry yeast strains on the composition of S. cerevisiae strains in spontaneous fermentations at wineries conducting both inoculated and spontaneous fermentations. [ABSTRACT FROM AUTHOR]

European Radiation Dosimetry Group e.V. (EURADOS) survey on individual monitoring data and dose assessment has been carried out for 550 foreigners returning home after being exposed in Japan to intakes of radionuclides (mainly 131I, 132I, 132Te, 134Cs and 137Cs) as a consequence of the Fukushima Daiichi NPP accident. In vivo and in vitro measurements were performed in their respective countries at an early stage after that accident. Intakes of radionuclides were detected in 208 persons from Europe and Canada, but the committed effective dose E(50) was below the annual dose limit for the public (<1 mSv) in all the cases. Lessons learned from this EURADOS survey are presented here regarding not only internal dosimetry issues, but also the management of the emergency situation, the perception of the risk of health effects due to radiation and the communication with exposed persons who showed anxiety and lack of trust in monitoring data and dose assessments. [ABSTRACT FROM AUTHOR]

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Animals often express behavioral preferences for different types of food or other resources, and these preferences can evolve or shift following association with novel food types. Shifts in preference can involve at least two phenomena: a change in rank preference or a change in specificity. The former corresponds to a change in the order in which hosts are preferred, while a shift in specificity can be an increase in the tendency to utilize multiple hosts. These possibilities have been examined in relatively few systems that include extensive population-level replication. The Melissa blue butterfly, Lycaeides melissa, has colonized exotic alfalfa, Medicago sativa, throughout western North America. We assayed the host preferences of 229 females from ten populations associated with novel and native hosts. In four out of five native-associated populations, a native host was preferred over the exotic host, while preference for a native host characterized only two out of five of the alfalfa-associated populations. Across all individuals from alfalfa-associated populations, there appears to have been a decrease in specificity: females from these populations lay fewer eggs on the native host and more eggs on the exotic relative to females from native-host populations. However, females from alfalfa-associated populations did not lay more eggs on a third plant species, which suggests that preferences for specific hosts in this system can potentially be gained and lost independently. Geographic variation in oviposition preference in L. melissa highlights the value of surveying a large number of populations when studying the evolution of a complex behavioral trait. [ABSTRACT FROM AUTHOR]

In the doubly magic nucleus 208Pb , five states are observed at 5648, 5658, 5686, 5694, 5836keV by 208Pb ( p, p′) via isobaric analog resonances in 209Bi . The 5686, 5694, 5836 states with spins 6-, 7-, 8- are shown to contain almost the full strength of the particle-hole configuration g9/2 f7/2 . The 5658 5- state contains a major g9/2 f7/2 fragment with admixtures of d5/2 f5/2 , d5/2 f7/2 . The 5648, 5649keV states observed in a quintuplet at Ex = 5.63 - 5.65 MeV are preliminarily identified to have spins (4)- and 6+ to 9+. The 5648keV (4)- state contains almost half of the g9/2 f7/2 strength and half of the h9/2 d5/2 strength with admixtures of d5/2 f5/2 , d5/2 p3/2 , d5/2 f7/2 . [ABSTRACT FROM AUTHOR]

Excited states in the deformed nucleus 168Er have been studied with high energy resolution in the ( p, t) reaction, with the Munich Q3D spectrograph. A large number of excited 0+ states (25) and 2+ states (64) have been assigned up to 4.0-MeV excitation energy. This allows detailed investigations along two directions of current interest: first, an extension of microscopic model interpretations into the region of medium level density above the pairing gap; second, a first analysis of the statistical fluctuation (order/chaos) properties of pure sequences of levels, in one deformed nucleus. Predictions of two models (the quasiparticle-phonon model and the projected shell model) are compared to the data, and it is concluded that, in both cases, mixing of more configurations is required in the wave functions. [ABSTRACT FROM AUTHOR]

Surgery on the lateral skull base puts delicate structures at risk. To support the surgeon in identifying and protecting the risk structures the principle of Navigated Control (NC) can be used for preventing iatrogenic injuries. In this paper the application of Navigated Control for surgery on the lateral skull base was investigated for the first time in clinical use. There was no risk structure damage with NC. Navigated Control in lateral skull base surgery seems to have a great potential for safe risk structure protection, a morbidity reduction and in a relief of strain for the surgeon. [ABSTRACT FROM AUTHOR]

A strong rise of E0 transition strengths between the first excited 0+ state and the ground state is predicted in shape transitional regions within the Interacting Boson Model (IBM). This rise matches well existing data and is not connected to a large mixing amplitude between both states. Moreover, a coherence of amplitudes in the wave functions causes the strong transition, without a requirement of explicit mixing of normal and intruder configurations. [ABSTRACT FROM AUTHOR]

We show that the cubic shape invariant K3, which provides a measure for triaxiality for β-rigid nuclei, can be obtained from a small number of observables. This affords approximations which have been tested to hold within a few percent in the rigid triaxial rotor model and the interacting boson model. [ABSTRACT FROM AUTHOR]