195 results on '"Spring, David R."'
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2. Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
3. CK2 Inhibitors Targeting Inside and Outside the Catalytic Box.
4. Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules.
5. Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules.
6. Site-selective peptide functionalisation mediated via vinyl-triazine linchpins.
7. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
8. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
9. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation.
10. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation.
11. Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
12. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
13. Identification of macrocyclic peptides which activate bacterial cylindrical proteases.
14. Peroxide-cleavable linkers for antibody–drug conjugates.
15. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance.
16. Non-internalising antibody–drug conjugates.
17. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
18. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
19. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
20. Development of small cyclic peptides targeting the CK2α/β interface.
21. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability.
22. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent.
23. Rapid and robust cysteine bioconjugation with vinylheteroarenes.
24. The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
25. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes.
26. Chemical probes targeting the kinase CK2: a journey outside the catalytic box.
27. A dual-enzyme cleavable linker for antibody–drug conjugates.
28. The role of chemical synthesis in developing RiPP antibiotics.
29. Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs).
30. Site-selective modification strategies in antibody–drug conjugates.
31. Photocatalytic methods for amino acid modification.
32. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics.
33. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics.
34. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
35. Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA).
36. C(sp3)–H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection.
37. Efficient and selective antibody modification with functionalised divinyltriazines.
38. An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds.
39. General dual functionalisation of biomacromolecules via a cysteine bridging strategy.
40. Sulfatase-cleavable linkers for antibody-drug conjugates.
41. Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.
42. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
43. Direct Synthesis of N -Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling.
44. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
45. Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery.
46. Cleavable linkers in antibody–drug conjugates.
47. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.
48. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
49. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction.
50. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates.
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