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Clear cell renal cell carcinoma (ccRCC) and ischemic stroke are critical global health challenges with a notable association. This study explores the correlation between tumor-related factors and ischemic stroke risk, aiming to construct a predictive nomogram model for ischemic stroke in ccRCC patients. We retrospectively analyzed data from ccRCC patients who underwent nephrectomy at the First Hospital of Shanxi Medical University between January 1, 2013, and May 31, 2022. The data were randomly divided into a training cohort (70%) and a validation cohort (30%). Predictive factors were identified using univariate logistic regression, least absolute shrinkage and selection operator regression, and multivariate logistic regression. A nomogram and a Shiny local calculator were developed using these predictors. We identified six predictors for the nomogram: WHO/ISUP grade, diabetes, hypertension, LDL-C, age, and D-dimer. The nomogram showed good discrimination, with an area under the ROC curve of 0.816 in the training cohort and 0.775 in the validation cohort. The optimal cutoff value was 53.7%. The model demonstrated excellent calibration and clinical applicability. WHO/ISUP grade correlates with ischemic stroke risk, offering insights into cancer-related ischemic stroke mechanisms. This nomogram aids in identifying high-risk individuals among ccRCC patients, facilitating early management and improved outcomes. [ABSTRACT FROM AUTHOR]

As a critical metabolite, the standardization of lactate quantification is increasingly crucial. Therefore, we developed LaconicSF, a lactate-responsive biosensor exhibiting exceptional specificity in lactate detection. LaconicSF enables efficient lactate quantification in CHO cell culture medium and holds potential as a user-friendly detection tool for lactate quantification in vitro. [ABSTRACT FROM AUTHOR]

A comprehensive investigation has been carried out on a series of complexes of the type (N^N)Pt(–C≡C–Ar)2, where N^N represents diarylamino-substituted 2,2′-bipyridine (bpy) ligands and –C≡C–Ar refers to the substituted arylacetylide ligands. The introduction of trifluoromethyl and methoxy substituents to the phenylacetylide unit results in color tuning of the phosphorescence energy in these complexes. The bulky diarylamino substituents on the bipyridine ligand showed distinctive electronic properties, resulting in improved hole-transporting characteristics. Solution-processed phosphorescent organic light-emitting devices (PHOLEDs) were fabricated using these PtII emissive dopants with poly(9-vinylcarbazole) (PVK) as the host. All the devices exhibit promising performances with the best luminance efficiency being up to 20 cd A−1 and the external quantum efficiency reaching 7%. [ABSTRACT FROM AUTHOR]

Understanding the mechanisms of invasion and metastasis in head and neck squamous cell carcinoma (HNSCC) is crucial for effective treatment, particularly in metastatic cases. In this study, we analyzed multicenter bulk sequencing and comprehensive single-cell data from 702,446 cells, leading to the identification of a novel subtype of cancer-associated fibroblasts (CAFs), termed Secreted Frizzled-Related Protein2 CAFs (SFRP2_CAFs). These cells, originating from smooth muscle cells, display unique characteristics resembling both myofibroblastic CAFs and inflammatory CAFs, and are linked to poorer survival outcomes in HNSCC patients. Our findings reveal significant interactions between SFRP2_CAFs and SPP1 tumor-associated macrophages, which facilitate tumor invasion and metastasis. Moreover, our research identifies Nuclear factor I/X (NFIX) as a key transcription factor regulating SFRP2_CAFs behavior, confirmed through gene regulatory network analysis and simulation perturbation. [ABSTRACT FROM AUTHOR]

A series of new cyclometalated iridium(III) complexes containing a methyl or a trifluoromethyl substituted 2-(4-benzylphenyl)pyridine molecular framework have been synthesized and characterized. All these complexes are amorphous and possess excellent thermal stabilities. Arising from the propensity of the tetrahedral geometry of the CH2 moiety in the benzyl group, this could make the metal complexes less crystalline, attain more morphologically stable thin-film formation and reduce the triplet–triplet annihilation process, especially in the solid state. The optical, electrochemical, and photo- and electrophosphorescence traits of these iridium(III) phosphors have been studied in terms of the electronic nature of the pyridyl ring substituents. Electrophosphorescent organic light-emitting diodes (OLEDs) with attractive device performance can be fabricated based on these materials. The best electroluminescent (EL) performance can be obtained with a maximum current efficiency (ηL) of 76.3 cd A−1, a maximum power efficiency (ηP) of 51.1 lm W−1, a maximum external quantum efficiency (ηext) of 21.4% and a pure green CIE color coordinates of (0.27, 0.64). The present work provides a simple way to enhance the OLED performance by simply modifying the molecular design of the benchmark emitters, which show great potential for application in multicolor displays. [ABSTRACT FROM AUTHOR]

Background: The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) and gastric cancers (GC) with deficiency of mismatch repair (dMMR) or microsatellite instability-high (MSI-H). Methods: This retrospective study enrolled patients with dMMR/MSI-H CRC and GC who received at least one dose of neoadjuvant ICIs (neoadjuvant cohort, NAC) or adjuvant ICIs (adjuvant cohort, AC) at 17 centers in China. Patients with stage IV disease were also eligible if all tumor lesions were radically resectable. Results: In NAC (n = 124), objective response rates were 75.7% and 55.4%, respectively, in CRC and GC, and pathological complete response rates were 73.4% and 47.7%, respectively. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 96% (95%CI 90–100%) and 100% for CRC (median follow-up [mFU] 29.4 months), respectively, and were 84% (72–96%) and 93% (85–100%) for GC (mFU 33.0 months), respectively. In AC (n = 48), the 3-year DFS and OS rates were 94% (84–100%) and 100% for CRC (mFU 35.5 months), respectively, and were 92% (82–100%) and 96% (88–100%) for GC (mFU 40.4 months), respectively. Among the seven patients with distant relapse, four received dual blockade of PD1 and CTLA4 combined with or without chemo- and targeted drugs, with three partial response and one progressive disease. Conclusion: With a relatively long follow-up, this study demonstrated that neoadjuvant and adjuvant ICIs might be both associated with promising DFS and OS in dMMR/MSI-H CRC and GC, which should be confirmed in further randomized clinical trials. [ABSTRACT FROM AUTHOR]

In this study, ZnCo2O4/Ag3PO4 composite catalyst was prepared by the precipitation method, and their performance in the photocatalytic degradation of methyl orange (MO) was studied. The catalysts were characterized by scanning electron microscopy, high‐resolution transmission electron microscopy, X‐ray diffraction, energy‐dispersive X‐ray spectroscopy, selected area electron diffraction, X‐ray photoelectron spectroscopy, and UV‐Vis diffuse reflectance spectroscopy. The results indicate that the 0.1 ZnCo2O4/Ag3PO4 composite system has good photocatalytic activity in the degradation of methyl orange. Under simulated sunlight conditions, the degradation rate can reach 94% after 30 min. The maximum reaction rate constant of 0.1 ZnCo2O4/Ag3PO4 was 0.05301 min−1, which is 3 times and 52 times the rate constant of pure Ag3PO4 and pure ZnCo2O4, respectively. In catalyst recycling experiments, 0.1 ZnCo2O4/Ag3PO4 still degraded methyl orange at a rate of 84.4% after three cycles. Trapping experiments showed that holes and superoxide radicals mostly contributed to the photocatalytic degradation of methyl orange by the catalyst, while hydroxyl radicals played a partial role. The energy level structure of ZnCo2O4/Ag3PO4 is conducive to the effective separation of photogenerated electrons and holes, improving the lifespan of photogenerated charges. In the investigated catalyst series, 0.1 ZnCo2O4/Ag3PO4 demonstrated the best photocatalytic performance. [ABSTRACT FROM AUTHOR]

Despite extensive works have been devoted to study the scale inhibition behavior, the performance of inhibitors is still not fully understood. In this paper, we present a laboratory study to elucidate the impact of water composition on the performance of some commonly used phosphonate and polymeric calcium carbonate scale inhibitors, in highly supersaturated brines at high temperature. Calcium tolerance inhibitor chemicals with various molecular structures are studied using dynamic scale loop test method at 150 °C. Brine composition is varied by changing the non-stoichiometry of scaling lattice ions, e.g., ( Ca 2 + ) / ( CO 3 2 − ) ratio, over a wide range. Test results indicate that the effectiveness of inhibitors can be significantly changed by the scaling ion ratio. In general, the efficacy of inhibitors decreases significantly with calcium concentration in the test brine even at constant supersaturation state and temperature, and also the performance ranking of the different inhibitor chemistries can be changed with brine composition. This could be caused by the alternations of interactions between inhibitor molecules and the surface of calcium carbonate scale crystals. Findings from this study suggest that the effect of scaling ion ratio must be considered in scaling risk assessment and for the optimization of inhibitor treatment programs. [ABSTRACT FROM AUTHOR]

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe and fatal acute respiratory disease in humans. High fatality rates and continued infectiousness remain a pressing concern for global health preparedness. Antibodies targeted at the receptor-binding domain (RBD) are major countermeasures against human viral infection. Here, we report four potent nanobodies against MERS-CoV, which are isolated from alpaca, and especially the potency of Nb14 is highest in the pseudotyped virus assay. Structural studies show that Nb14 framework regions (FRs) are mainly involved in interactions targeting a novel epitope, which is entirely distinct from all previously reported antibodies, and disrupt the protein-carbohydrate interaction between residue W535 of RBD and hDPP4 N229-linked carbohydrate moiety (hDPP4-N229-glycan). Different from Nb14, Nb9 targets the cryptic face of RBD, which is distinctive from the hDPP4 binding site and the Nb14 epitope, and it induces the β5-β6 loop to inflect towards a shallow groove of the RBD and dampens the accommodation of a short helix of hDPP4. The particularly striking epitopes endow the two Nbs administrate synergistically in the pseudotyped MERS-CoV assays. These results not only character unprecedented epitopes for antibody recognition but also provide promising agents for prophylaxis and therapy of MERS-CoV infection. Author summary: MERS-CoV is one of the most prevalent zoonotic virus that has spread through 27 countries and infected more than 2,605 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate and its persistent wide spread infectiousness in animal reservoirs have generated tremendous global public health concern. However, no licensed therapeutic agents or vaccines against MERS-CoV are currently available. To address the risk of MERS-CoV and its variants re-emergence, we developed four highly effective Nbs from alpaca and solved two crystal complexes of Nb9 and Nb14 with RBD. Remarkably, the neutralizing activity of Nb14 represents the highest of MERS-CoV antibodies reported to date. The novel epitopes of Nb14 and Nb9 locate outside the RBD and hDPP4 interface, and the unique different epitopes and mechanisms of Nb14 and Nb9 provide a better neutralizing for synergistically against MERS-CoV infection. Our findings provide insights into the cryptic epitopes on RBD and the development of antibodies against MERS-CoV infection. [ABSTRACT FROM AUTHOR]

SnSb2Te4 (SST), a ternary van der Waals (vdW) material, has been widely investigated during last decades for potential applications in superconductivity, thermoelectricity, and optoelectronics. Recently, atomically thin SST has been predicted to show abnormal electronic band structure evolutions, high carrier mobility, and strong light–matter interaction. However, controllable synthesis of such SST crystals has been a huge challenge. Herein, atomically thin SST flakes are prepared via a chemical vapor deposition (CVD) method by using SbCl3, SnCl4·5H2O, and Te as the precursors. Multiple structural characterizations reveal that the SST flakes are single crystals with high crystallinity. Due to the narrow bandgap of 0.42 eV, SST‐based photodetectors have a broadband spectrum detection range from visible light through communication bands (480–1550 nm). More importantly, benefiting from a high room‐temperature carrier mobility over 300 cm2 V−1 s−1, the SST photodetectors demonstrate a response/recovery time of tens of tens of microseconds, which exceeds most typical transition metal dichalcogenide (TMDC) flakes. In addition, the photodetector maintains high performance after being exposed to the air for 2 months, suggesting good environmental stability. These excellent performances suggest that the SST flakes are promising for next‐generation optoelectronics. [ABSTRACT FROM AUTHOR]

Background: This retrospective cohort study explores a practical approach to acquiring pathogenic microorganisms in patients with bone and joint infections. Methods: From Aug 2018 to Mar 2022, 68 consecutive patients (87 cultures) with bone and joint infection were recruited in this study. All cultures followed the Peking University First Hospital Procedure of Culturing Pathogenic microorganisms for bone and joint infection. Tissue samples were obtained through fluoroscopy-guided biopsy or open debridement. Tissue samples were divided into manual homogenization (MH), manual mixture (MM), and pathological examination. The baseline, antibiotic exposure, laboratory, surgical, and microbial data were reviewed. Independent sample T-test, Mann–Whitney U-test, and Chi-square test were used to detect the difference between patients who received different processing measures. Results: The average age was 55.8± 2.4 years old. Thirty-nine patients were male. The total positive culture rate of the manual homogenization group was 80.5% (70/87). Thirty-five patients had mixed infections with more than one microorganism cultured. Staphylococci accounted for 60.23% of all microorganisms. Staphylococcus aureus (18.2%) and Staphylococcus epidermidis (15.9%) were the two most common bacteria cultured in this study. Patients with positive culture in the manual mixture group had significantly higher WBC (p = 0.006), NE% (p = 0.024), ESR (p = 0.003), CRP (p = 0.020) and IL6 (0.050) compared to patients with negative culture. After tissue homogenization, only ESR is still statistically different. Patients without SIRS had a low positive culture rate (59.4%). Tissue homogenization could significantly increase the positive culture rate of patients without SIRS. Pre-culture antibiotic exposure was not an independent risk factor for culture results. Conclusion: Peking University First Hospital Procedure for Culturing Pathogenic microorganisms for Bone and Joint Infections was a practical approach for obtaining pathogenic microorganisms. [ABSTRACT FROM AUTHOR]

Six cationic iridium(III) complexes bearing different bulky N,N′-chelating ligands were successfully synthesized and characterized by spectroscopic, electrochemical, thermal and photophysical methods. Because the molecular quenching and self-aggregation within molecules would deteriorate the device efficiency, the bulky molecules can suppress these problems and improve the device performance. The best doped organic light-emitting diodes based on these charged Ir(III) complex E1 exhibited Lmax of 26,800 cd/m2, ηL, max of 35.0 cd/A and ηP, max of 18.5 lm/W, which also showed a small efficiency roll-off in the range of 100 to 1000 cd/m2. [ABSTRACT FROM AUTHOR]

Pyrazoline and pyrazole compounds are important building blocks in the development of photofunctional compounds. Two new solution-processable platinum-containing polyynes functionalized with these chromophores in the main chain (P1 and P2) were synthesized and characterized by spectroscopic, thermal and optical methods. By changing the spacer from 2-pyrazoline to the electron-rich pyrazole in the main chain, the photophysical properties including energy levels, absorption wavelength and bandgap of the polymers were finely tuned. The photovoltaic properties of P1 with better absorption features were also studied. [ABSTRACT FROM AUTHOR]

Four new solution-processable platinum-containing polyynes functionalized with triphenylamine backbone and different acceptor fragment in the side chain were synthesized and characterized by spectroscopic, thermal and optical methods. The main- and side-chains show different absorption features in the solar spectrum, resulting in broad absorption coverage of the whole visible region. By changing the acceptor group in the side chain, the photophysical properties including energy levels, absorption wavelength and bandgap of the polymers were finely tuned. As the strength of electron acceptor is increased, the power conversion efficiency (PCE) of organic polymer solar cells fabricated with these polymers as electron donor and (6,6)-phenyl-C61-butyric acid methyl ester (PCBM) as electron acceptor was increased. PCE of 1.35% can be obtained from solar cell based on the polyplatinayne with the dicyanovinyl side group under illumination of an AM 1.5 solar cell simulator in a 1:4 (polymer:PCBM) blend ratio. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has significantly impacted global society and economies, prompting a shift in online consumer purchasing behavior (OCPB). This study aims to explore the evolving typologies of OCPB in the context of post-pandemic retail transformations. Utilizing data from a leading Chinese e-commerce platform, this study employed data mining techniques and the Bidirectional Encoder Representations from Transformers (BERT) model to analyze OCPB typologies. The BERT model, known for its advanced multi-task capabilities, demonstrated high reliability in classifying OCPB into three distinct types, as evidenced by robust performance metrics including accuracy, precision, recall, and F1-score. However, the BERT model alone did not fully capture the nuanced concept of OCPB typology. To address this, this study integrated grounded theory to further delineate OCPB typologies, identifying key dimensions such as social and economic adaptation, product attributes, and user experience. Our findings offer a comprehensive understanding of OCPB typologies and provide valuable insights for retailers navigating the post-COVID-19 landscape. This research not only contributes to the academic discourse on consumer behavior but also offers practical guidance for enhancing retail strategies in a rapidly changing environment. Plain language summary: Online consumer purchasing behavior typology The COVID-19 pandemic has changed the way people shop online. This study looks at how online shopping habits have evolved since the pandemic started, focusing on different types of shopping behaviors. We used information from a big online shopping site in China and special computer programs to study these behaviors. Our research found three main types of online shopping behaviors. However, to get a deeper understanding, we also looked at why people shop the way they do, considering factors like how they adapt socially and economically, what they think about the products, and their shopping experience. Our findings help us better understand online shopping habits and offer advice to stores on how to improve their online selling strategies in the new normal after the pandemic. This study is useful for both researchers interested in consumer behavior and for businesses looking to adapt to changes in how people shop. [ABSTRACT FROM AUTHOR]

The classification of coal bursting liability is of great significance for the prevention and control of rock burst. To address the shortcomings in existing bursting liability classification methods, a comprehensive evaluation model for bursting liability based on a combination of weighted-fuzzy set theory and three influencing factor analyses is proposed. The model selects four evaluation indicators: dynamic failure time (DT), elastic energy index (WET), bursting energy index (KE), and uniaxial compressive strength (RC). Two types of membership functions, trapezoidal fuzzy numbers (TFN) and Gaussian fuzzy numbers (GFN), are used to quantitatively describe the fuzziness between indicator levels. The Delphi method and a random forest feature identification method are combined to obtain a subjective and objective combined weighting, determining the optimal combination weight of the four indicators. Based on Zadeh operator (ZO), maximum-minimum operator (MMO), weightedaverage operator (WAO), and all-around restrictive operator (ARO), calculations are carried out for the synthesis of indicator weights and memberships. Maximal membership principle (MMP) and Credible identification principle (CIP) are utilized as evaluation principle to assess the bursting liability level, constructing 16 fuzzy comprehensive evaluation models. The impact of membership functions, fuzzy operators, and evaluation principle on evaluation results are systematically analyzed based on the discrimination results of 127 sample sets. The results show that the optimal fuzzy comprehensive evaluation model is constructed using the trapezoidal fuzzy numbers, weighted average operator, and maximal membership principle (TFN-WAO-MMP), with a classification accuracy of 97.64%. Finally, the optimal model is applied to 10 engineering instances, and the evaluation results are consistent with the actual situation, verifying the reliability and effectiveness of the model. Overall, these findings contribute to the development of a more sophisticated and accurate method for assessing the rock burst tendency of coal specimens. By leveraging the theory of fuzzy sets, this approach provides a more nuanced and nuanced evaluation of rock burst tendency, and thus offers the potential to improve workplace safety and efficiency in the coal mining industry. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to analyse the difference between arthroscopic fixation and open reduction internal fixation (ORIF) of posterior cruciate ligament (PCL) tibial avulsion fractures. Methods: This retrospective study analysed patients with an acute PCL tibial avulsion fracture who underwent surgical treatment at our hospital and follow-up for at least 24 months. Variables based on sex, age, Meyers–McKeever type, surgical method, meniscus tear, external fixation, labour or sports, Lysholm knee score, IKDC score, and KT-1000 value were also recorded. Multifactor unconditional logistic regression and Student's t test with 1:1 propensity score matching (PSM) to remove confounding factors were used for analysis. Results: Sixty-five cases achieved knee function graded as "good" or better, and 9 cases not. Single-factor analysis indicated that Meyers–McKeever type (χ2 = 4.669, P = 0.031) and surgical approach (χ2 = 9.428, P = 0.002) are related to functional outcomes. Multifactorial logistic regression analysis further confirmed that Meyers–McKeever typing (OR = 10.763, P = 0.036, [95% CI 1.174–98.693]) and surgical approach (OR = 9.274, P = 0.008, [95% CI 1.794–47.934]) are independent risk factors affecting prognosis. In addition, PSM verified significant differences in the Lysholm score (t = 3.195, P = 0.006), IKDC score (t = 4.703, P = 0.000) and A-KT/H-KT (t = 2.859, P = 0.012). However, the affected-side KT-1000 value (A-KT, mm, t = 1.225, P = 0.239) and healthy-side KT-1000 value (H-KT, mm, t = 1.436, P = 0.172) did not significantly differ between the two groups. The proportions of cases in which the Lysholm score, IKDC and A-KT/H-KT exceeded the minimal clinically important difference (MCID) were 62.5% (20/32), 62.5% (20/32) and 93.75% (30/32), respectively. Conclusion: Compared with ORIF, an arthroscopic approach for PCL tibial avulsion fractures achieves better results. Level of evidence: Retrospective cohort study; Level II. [ABSTRACT FROM AUTHOR]

Background: Ischemic stroke (IS) and malignant tumor (MT) have high morbidity and mortality rates worldwide, and several associations exist between them. This study aimed to determine the effect of MT on hospital mortality in patients with IS. Methods: Based on their MT status, participants with IS in the Medical Information Mart for Intensive Care IV (MIMIC-IV) were divided into two groups. The primary outcome was in-hospital all causes mortality. Kaplan-Meier survival analysis was performed to evaluate the intergroup in-hospital mortality, and three Cox regression models were used to determine the association between MT and in-hospital mortality. Results: A total of 1605 participants (749 males and 856 females) were included in the study. The mean age was 72.030 ± 15.463 years. Of these, 257 (16%) patients died in the hospital. Kaplan-Meier analysis showed that the MT group had a significantly lower possibility of in-hospital survival than the non-MT group. In the unadjusted model, in-hospital mortality among MT patients had a higher odds ratio (OR) of 1.905 (95% CI, 1.320–2.748; P < 0.001) than the non-MT group. After adjusting for basic information, vital signs, and laboratory data, MT was also associated with increased in-hospital mortality (OR = 1.844, 95% CI: 1.255–2.708; P = 0.002). Conclusions: Among the patients with IS, the risk of all causes in-hospital mortality was higher for MT than for patients non-MT. This finding can assist clinicians in more accurately assessing prognosis and making informed treatment decisions. [ABSTRACT FROM AUTHOR]

The molecular categorization of colon cancer patients remains elusive. Gene set enrichment analysis (GSEA), which investigates the dysregulated genes among tumor and normal samples, has revealed the pivotal role of epithelial-to-mesenchymal transition (EMT) in colon cancer pathogenesis. In this study, we employed multi-clustering method for grouping data, resulting in the identification of two clusters characterized by varying prognostic outcomes. These two subgroups not only displayed disparities in overall survival (OS) but also manifested variations in clinical variables, genetic mutation, and gene expression profiles. Using the nearest template prediction (NTP) method, we were able to replicate the molecular classification effectively within the original dataset and validated it across multiple independent datasets, underscoring its robust repeatability. Furthermore, we constructed two prognostic signatures tailored to each of these subgroups. Our molecular classification, centered on EMT, hold promise in offering fresh insights into the therapy strategies and prognosis assessment for colon cancer. [ABSTRACT FROM AUTHOR]

Under the background of green and low‐carbon transformation of industrial high‐energy‐consuming parks, in order to realize the coordinated development planning of energy and transportation under different peaking capacity requirements, this paper proposes a collaborative optimization model of industrial high‐energy‐consuming parks under green and low‐carbon. Firstly, by studying the energy balance mechanism between industrial load and new energy, an energy topology prior model of energy interaction in the next generation of industrial new energy power grid is constructed. Then, based on the probability characteristics of the equilibrium state of different regions in the high‐energy‐consuming industrial zone, combined with the prior knowledge of industrial load and low‐carbon power system, a collaborative development planning model of high‐energy‐consuming industrial parks is constructed. Finally, the proposed model is simulated. From the simulation results the authors can see the dynamic division model and solution algorithm of energy balance region established in this paper can effectively improve the energy balance ability of power grid, reduce peak shaving demand and use more renewable energy. [ABSTRACT FROM AUTHOR]

Background: Observational studies have suggested an association between birth weight and type 2 diabetes mellitus, but the causality between them has not been established. We aimed to obtain the causal relationship between birth weight with T2DM and quantify the mediating effects of potential modifiable risk factors. Methods: Two-step, two-sample Mendelian randomization (MR) techniques were applied using SNPs as genetic instruments for exposure and mediators. Summary data from genome-wide association studies (GWAS) for birth weight, T2DM, and a series of fatty acids traits and their ratios were leveraged. The inverse variance weighted (IVW) method was the main analysis approach. In addition, the heterogeneity test, horizontal pleiotropy test, Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test, and leave-one-out analysis were carried out to assess the robustness. Results: The IVW method showed that lower birth weight raised the risk of T2DM (β: −1.113, 95% CI: −1.573 ∼ −0.652). Two-step MR identified 4 of 17 candidate mediators partially mediating the effect of lower birth weight on T2DM, including ratio of polyunsaturated fatty acids to monounsaturated fatty acids (proportion mediated: 7.9%), ratio of polyunsaturated fatty acids to total fatty acids (7.2%), ratio of omega-6 fatty acids to total fatty acids (8.1%) and ratio of linoleic acid to total fatty acids ratio (6.0%). Conclusions: Our findings supported a potentially causal effect of birth weight against T2DM with considerable mediation by modifiable risk factors. Interventions that target these factors have the potential to reduce the burden of T2DM attributable to low birth weight. [ABSTRACT FROM AUTHOR]

Microplastics (MPs) are contaminants ubiquitously found in the global biosphere that enter the body through inhalation or ingestion, posing significant risks to human health. Recent studies emerge that MPs are present in the bone marrow and damage the hematopoietic system. However, it remains largely elusive about the specific mechanisms by which MPs affect hematopoietic stem cells (HSCs) and their clinical relevance in HSC transplantation (HSCT). Here, we established a long-term MPs intake mouse model and found that MPs caused severe damage to the hematopoietic system. Oral gavage administration of MPs or fecal transplantation of microbiota from MPs-treated mice markedly undermined the self-renewal and reconstitution capacities of HSCs. Mechanistically, MPs did not directly kill HSCs but disrupted gut structure and permeability, which eventually ameliorated the abundance of Rikenellaceae and hypoxanthine in the intestine and inactivated the HPRT-Wnt signaling in bone marrow HSCs. Furthermore, administration of Rikenellaceae or hypoxanthine in mice as well as treatment of WNT10A in the culture system substantially rescued the MPs-induced HSC defects. Finally, we validated in a cohort of human patients receiving allogenic HSCT from healthy donors, and revealed that the survival time of patients was negatively correlated with levels of MPs, while positively with the abundance of Rikenellaceae, and hypoxanthine in the HSC donors' feces and blood. Overall, our study unleashes the detrimental roles and mechanisms of MPs in HSCs, which provides potential strategies to prevent hematopoietic damage from MPs and serves as a fundamental critique for selecting suitable donors for HSCT in clinical practice. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to study the effect of current-carrying condition on the electrochemical process and atmospheric corrosion behavior of the commercial aluminum alloys. Design/methodology/approach: Potentiodynamic polarization tests were performed to study the electrochemical process of the aluminum alloys. Salt spray tests and weight loss tests were carried out to study the atmospheric corrosion behavior. The corrosion morphology of the alloys was observed, and the products were analyzed. Findings: The corrosion process of four aluminum alloys was accelerated in the current-carrying condition. Moreover, the acceleration effect on A2024 and A7075 was much stronger than that on A1050 and A5052. The main factors would be the differences in microstructure and corrosion resistance between these alloys. As the carried current increased, the corrosion rate and corrosion current density of the aluminum alloys gradually increased, with the protection of the corrosion product film decreasing linearly. Originality/value: This is a recent study on the corrosion behavior of conductors under current-carrying condition, which truly understands the corrosion status of power grid materials. Relevant results provide support for the corrosion protection and safe service of aluminum alloy in power systems. [ABSTRACT FROM AUTHOR]

Aroma is an indispensable factor that substantially impacts the quality assessment of black tea. This study aims to uncover the dynamic alterations in the sweet and floral aroma black tea (SFABT) throughout various manufacturing stages using a comprehensive analytical approach integrating gas chromatography electronic nose, gas chromatography–ion mobility spectrometry (GC-IMS), and gas chromatography–mass spectrometry (GC-MS). Notable alterations in volatile components were discerned during processing, predominantly during the rolling stage. A total of 59 typical volatile compounds were identified through GC-IMS, whereas 106 volatile components were recognized via GC-MS throughout the entire manufacturing process. Among them, 14 volatile compounds, such as linalool, β-ionone, dimethyl sulfide, and 1-octen-3-ol, stood out as characteristic components responsible for SFABT with relative odor activity values exceeding one. This study serves as an invaluable theoretical platform for strategic controllable processing of superior-quality black tea. [ABSTRACT FROM AUTHOR]

Energy conservation, emission reduction and vigorous development of new energy are inevitable trends in the development of the power industry, but factors such as energy storage loss, solar energy loss and line loss in real power situations have led the problem to a complex direction. To address these intricacies, we use a more precise modeling approach of power loss and propose a collaborative optimization method integrating the Deep-Q-Network (DQN) algorithm with the multi-head attention mechanism. This algorithm calculates weighted features of the system's states to compute the Q-values and priorities for determining the next operational directives of the energy system. Through extensive simulations that replicate real world microgrid (MG) scenarios, our investigation substantiates that the optimization methodology presented here effectively governs the distribution of energy resources. It accomplishes this while accommodating uncertainty-induced losses, ultimately achieving the economic optimization of MG. This research provides a new approach to deal with problems such as energy loss, which is expected to improve economic efficiency and sustainability in areas such as microgrids. [ABSTRACT FROM AUTHOR]

The objective of this research was to explore the impacts of heightened CO2 concentrations on human health and wellness in an underground confined space. A total of 180 participants were subjected to CO2 concentrations ranging from 1000 to 10000 ppm within a confined underground environment. The study assessed not only subjective perceptions and physiological responses but also cognitive performance, integrating novel measures such as emotion, skin conductance (SC), and heart rate variability (HRV). The findings demonstrated a notable variation in thermal sensation votes (TSV) and perceived air quality acceptability with the change in CO2 concentration. A significant increase in total mood disturbance (TMD) of 1.5 units was observed at a CO2 concentration of 8500 ppm, compared to 1000 ppm. Cognitive performance remained consistent for concentrations below 8500 ppm; however, a substantial alteration was noted at 10000 ppm. In terms of task difficulty, numerical calculations were perceived to require 0.74 units more effort than letter searches. As CO2 concentration exceeded 7500 ppm, significant variances were noted in physiological parameters such as diastolic blood pressure (DBP), heart rate (HR), LF/HF, MF/HF ratios, PNN 50, and frequency domains of HRV (LF, MF, and HF) in comparison to the parameters at 1000 ppm. At 8500 ppm, the LF and HF parameters were found to be 780 and 452.3 units, respectively, higher than at 7000 ppm. These findings suggest that high humidity, low temperature, and elevated CO2 concentrations collectively contribute to the significant human stress responses. This study is of interest as there are limited reported researches on the air quality in underground confined space. [ABSTRACT FROM AUTHOR]

Objective: The surgical treatment of patients with ankylosing spondylitis and severe thoracolumbar kyphosis combined with hip flexion contracture is very difficult for all the surgeons. The femoral neck osteotomy (FNO) is the first step to break the ice. The evaluation of a new modified FNO method is very important to improve the curative effect. Methods: Five male patients with nine bone‐fused hips who underwent the new femoral neck osteotomy were included from October 2021 to March 2022. The FNO was designed that the saw blade was manipulated from the lateral femoral neck base to the inferior part of the femoral head, keeping Pauwels' angle less than 30° on the coronal plane. On the transverse plane, the angle between the saw blade and the coronal plane was more than 15°. On the sagittal plane, the saw blade cut through the femoral neck. They accepted pedicle subtraction osteotomy (PSO) after FNO according to the patient' recovery. Then, 2 weeks later, the patients underwent total hip arthroplasty (THA). The visual analogue scale (VAS), Harris hip score (HHS) and passive hip flexion‐extension range of motion (ROM) were used to evaluate hip function. The data were analyzed by paired t‐test. Results: The average operation time and blood loss of FNO, the average interval between FNO and THA were collected. The average angle of the trunk and lower limb (ATL) was 36.33° ± 16.36° pre‐FNO, 82.89° ± 13.51° post‐FNO and 175.22° ± 3.42° post‐THA. The average VAS scores were 0 pre‐FNO, 5 ± 1.58 post‐FNO and 2.6 ± 0.55 post‐THA. The average HHS was 43.56 ± 1.59 preoperatively and 83.89 ± 2.21 postoperatively. The average hip extension ROM was 23.89° ± 12.69° pre‐FNO, −22.67° ± 14.18° post‐FNO and − 3.33° ± 2.50 post‐THA°. The average hip flexion ROM was 23.89° ± 12.69° pre‐FNO, 35.56° ± 12.11° post‐FNO and 104.44° ± 5.27° post‐THA. The differences among them were significant (p < 0.05). Only one hip (11.11%) displaced completely after FNO. Conclusion: A new modified FNO was developed, which can provide osteotomy with a certain degree of stability and greater ease for performing PSO and THA. [ABSTRACT FROM AUTHOR]

Aims: To analyse spatial and temporal changes in the global burden of diabetes mellitus (DM) attributable to dietary factors from 1990 to 2019. Materials and Methods: The burden of DM was analysed in terms of age‐standardized disability‐adjusted life‐year (DALY) rates and age‐standardized death rates (ASDRs), which were obtained from the Global Burden of Disease Study 2019, and their corresponding estimated annual percentage changes (EAPCs). Results: The ASDR exhibited a decreasing trend (EAPC = −0.02), while the age‐standardized DALY rate exhibited an increasing trend (EAPC = 0.65). Forty‐four percent of the burden of DM was attributable to dietary factors, with the three largest contributors being high intake of red meat, high intake of processed meat, and low intake of fruit. Residence in a region with a high sociodemographic index (SDI) was associated with a diet low in whole grains and high in red meat and processed meat, while residence in a low‐SDI region was associated with a diet low in whole grains and fruits, and high in red meat. Conclusions: The age‐standardized DALYs of DM attributable to dietary factors increased between 1990 and 2019 but differed among areas. The three largest dietary contributors to the burden of DM were high intake of red meat, high intake of processed meat, and low intake of fruit. [ABSTRACT FROM AUTHOR]

Multiple input multiple output (MIMO) technology necessitates detection methods with high performance and low complexity; however, the detection problem becomes severe when high-order constellations are employed. Variational approximation-based algorithms prove to deal with this problem efficiently, especially for high-order MIMO systems. Two typical algorithms named Gaussian tree approximation (GTA) and expectation consistency (EC) attempt to approximate the true likelihood function under discrete finite-set constraints with a new distribution by minimizing the Kullback–Leibler (KL) divergence. As the KL divergence is not a true distance measure, 'exclusive' and 'inclusive' KL divergences are utilized by GTA and EC, respctively, demonstrating different performances. In this paper, we further combine the two asymmetric KL divergences in a nested way by proposing a generic algorithm framework named nested variational chain. Acting as an initial application, a MIMO detection algorithm named Gaussian tree approximation expectation consistency (GTA-EC) can thus be presented along with its alternative version for better understanding. With less computational burden compared to its counterparts, GTA-EC is able to provide better detection performance and diversity gain, especially for large-scale high-order MIMO systems. [ABSTRACT FROM AUTHOR]

Background: Cranio-lenticulo-sutural dysplasia (CLSD) is a rare dysmorphic syndrome characterized by skeletal dysmorphism, late-closing fontanels, and cataracts. CLSD is caused by mutations in the SEC23A gene (OMIM# 607812) and can be inherited in either an autosomal dominant or autosomal recessive pattern. To date, only four mutations have been reported to cause CLSD. This study aims to identify the disease-causing variants in a large cohort of congenital cataract patients, to expand the genotypic and phenotypic spectrum of CLSD, and to confirm the association between SEC23A and autosomal recessive CLSD (ARCLSD). Methods: We collected detailed medical records and performed comprehensive ocular examinations and whole-exome sequencing (WES) on 115 patients with congenital cataracts. After suspecting that a patient may have CLSD based on the sequencing results, we proceeded to conduct transmission electron microscopy (TEM) on the cultured skin fibroblasts. The clinical validity of the reported gene-disease relationships for the gene and the disease was evaluated using the ClinGen gene curation framework. Results: Two novel compound heterozygous variants (c.710A > C p.Asp237Ala, c.1946T > C p.Leu649Pro) of the SEC23A gene, classified as variant of uncertain significance, were identified in the proband with skeletal, cardiac, ocular, and hearing defects. The observation of typical distended endoplasmic reticulum cisternae further supported the diagnosis of CLSD. Application of the ClinGen gene curation framework confirmed the association between SEC23A and ARCLSD. Conclusion: This study expands the genotypic and phenotypic spectrum of CLSD, proposes TEM as a supplemental diagnostic method, and indicates that congenital cataracts are a typical sign of ARCLSD. [ABSTRACT FROM AUTHOR]

TA15 titanium alloy holds great significance as a crucial material in the aerospace industry. In order to gain deeper insights into the influence of hot isostatic pressing (HIP) temperature on the tensile characteristics of materials formed through laser powder bed fusion (L-PBF), a comparative heat treatment experiment was crafted, aligning with the HIP treatment temperature settings. Specifically, the temperatures selected for this investigation were 900 °C, 940 °C, 980 °C, and 1020 °C, while the duration of the holding time was set at 2 h. Notably, the microstructure within the β phase region demonstrated distinct disparities between the HIP-treated specimens and those subjected to heat treatment. The heat-treated specimens exhibited the formation of Widmanstatten structure at 980 °C, while the metallographic structure of the HIP-treated specimens consisted of the lath α phase. In heat-treated specimens, an upward trend in temperature from 900 °C to 1020 °C led to a gradual decrease in UTS (995 MPa, 947 MPa, 886 MPa, and 892 MPa), YS (921 MPa, 865 MPa, 799 MPa, and 784 MPa). The elongation (15.7%,14.6%, and 13.3%) diminished as the temperature increased from 900 °C to 980 °C. At 1020 °C, the elongation slightly increased to 13.9%. The HIP-treated specimens showcased a declining trend in UTS (1008.5 MPa, 947 MPa, 886 MPa, and 892 MPa) and YS (939 MPa, 897.5 MPa, 839.5 MPa, and 844.5 MPa) with an increase in HIP treatment temperature from 900 °C to 980 °C, after which they experienced a slight increment upon further elevation to 1020 °C. The elongation (16%,18.3%, and 20.5%) demonstrated a remarkable improvement from 900 °C to 980 °C. At 1020 °C, the elongation decreased to 17.5%. [ABSTRACT FROM AUTHOR]

Finally, -sulfoximine esters with alkyl substituents ( I tert i -butyl, cyclohexyl, butyl) were investigated under the standard reaction conditions and afforded the corresponding sulfoximine B 4h b - B j b in moderate yields (42-56%). Keywords: sulfoximines; S-alkylation; sulfinamides; sulfoximine esters EN sulfoximines S-alkylation sulfinamides sulfoximine esters 1829 1833 5 08/29/23 20230915 NES 230915 Graph The development of modern synthetic chemistry not only facilitates the construction of compound libraries, studies on structure-activity relationships, and developments of the synthesis process, but also considerably improves the rate of generation of small-molecule drugs and provides efficient support for the discovery of candidate drug compounds. Synthesis of Sulfoximines through Selective Sulfur Alkylation of Sulfinamides Generated In Situ from -Sulfoximine Esters The reaction then proceeds smoothly through a selective S-alkylation, rather than an N-alkylation, with readily available alkyl bromides to give the corresponding sulfoximines in reasonable yields (Scheme 1c). [Extracted from the article]

In the fields of environment and transportation, the aerodynamic noise emissions emitted from heavy-duty diesel engine turbocharger compressors are of great harm to the environment and human health, which needs to be addressed urgently. However, for the study of compressor aerodynamic noise, particularly at the full operating range, experimental or numerical simulation methods are costly or long-period, which do not match engineering requirements. To fill this gap, a method based on ensemble learning is proposed to predict aerodynamic noise. In this study, 10,773 datasets were collected to establish and normalize an aerodynamic noise dataset. Four ensemble learning algorithms (random forest, extreme gradient boosting, categorical boosting (CatBoost) and light gradient boosting machine) were applied to establish the mapping functions between the total sound pressure level (SPL) of the aerodynamic noise and the speed, mass flow rate, pressure ratio and frequency of the compressor. The results showed that, among the four models, the CatBoost model had the best prediction performance with a correlation coefficient and root mean square error of 0.984798 and 0.000628, respectively. In addition, the error between the predicted total SPL and the observed value was the smallest, at only 0.37%. Therefore, the method based on the CatBoost algorithm to predict aerodynamic noise is proposed. For different operating points of the compressor, the CatBoost model had high prediction accuracy. The noise contour cloud in the predicted MAP from the CatBoost model was better at characterizing the variation in the total SPL. The maximum and minimum total SPLs were 122.53 dB and 115.42 dB, respectively. To further interpret the model, an analysis conducted by applying the Shapley Additive Explanation algorithm showed that frequency significantly affected the SPL, while the speed, mass flow rate and pressure ratio had little effect on the SPL. Therefore, the proposed method based on the CatBoost algorithm could well predict aerodynamic noise emissions from a turbocharger compressor. [ABSTRACT FROM AUTHOR]

Background: The sedative dexmedetomidine has been shown to reduce mortality in adult patients with severe sepsis, but it is not known whether children benefit. This study explored the effects of dexmedetomidine on the outcomes of children with severe sepsis with mechanical ventilation. Methods: In this retrospective cohort study, children with severe sepsis requiring mechanical ventilation from 2016 to 2020 were categorized as dexmedetomidine and non-dexmedetomidine group. The propensity score matching was performed to match cases in both groups. The primary outcome was 28-day mortality, and the secondary outcomes were acute kidney injury, ventilator-free days, lengths of PICU and hospital stays. The Kaplan-Meier method and was the log-rank test used to estimate the 28-day mortality rate and assess between-group differences. Results: In total, 250 patients were eligible patients: 138 in the dexmedetomidine group and 112 in the non-dexmedetomidine group. After 1:1 propensity score matching, 61 children in each group. dexmedetomidine group showed more lower 28-day mortality (9.84% vs. 26.23%, P = 0.008). During the 7-day observation period after PICU admission, the dexmedetomidine group showed significantly lower neurological and renal sub-scores at day 7 and serum creatinine level at day 3 and day 7. There were no statistical differences in the incidence of acute kidney injury, ventilator-free days, lengths of PICU and hospital stays between the two groups. Conclusions: dexmedetomidine treatment in children with severe sepsis is associated with better outcomes and should therefore be considered for the sedation strategy. [ABSTRACT FROM AUTHOR]

In this work, we have developed a successful Sonogashira coupling reaction utilizing IPrCl-Cl as the activation reagent to couple carboxylic acids with terminal alkynes. The reaction employs CuI/Pd(PPh3)2Cl2 as the co-catalyst and Et3N as the solvent, resulting in excellent yields (up to 88%) of ynones. The use of carboxylic acids as a starting material makes this method a valuable contribution to organic synthesis. [ABSTRACT FROM AUTHOR]

Due to green development in recent years, water-borne epoxy resins (WBE) have become increasingly popular since they generate the lowest level of volatile organic compounds (VOC) during curing. However, because of the large surface tension of water, it is easy to produce voids and cracks during the curing process of the coating. An electrochemical strategy was used in this study to assess the impact of different SiO2 content on the corrosion performance of a WBE coating, in which micron spherical SiO2 particles were synthesized in a liquid phase reduction. The results showed that the synthesized micron spherical SiO2 particles were about 800 ± 50 nm in diameter and in an amorphous state. By hydrophilizing the surfaces of these SiO2 particles, uniform dispersion in an aqueous solvent and a WBE can be achieved. It is important to note that adding a small or excessive amount of SiO2 to a coating will not improve corrosion resistance and may even reduce corrosion resistance. With the appropriate modification of SiO2, corrosion resistance of composite coatings is greatly enhanced, as is the adhesion between the coatings and the metallic substrates. Because the appropriately modified SiO2 can effectively fill the pores that are formed during the curing process, a corrosive medium is less likely to react with the matrix when the medium comes into contact with the matrix. Based on their incorporation content of 3 wt.%, their corrosion resistance is the best after 16 cycles of AC-DC-AC accelerated corrosion tests. [ABSTRACT FROM AUTHOR]

Purpose: A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) have been reported potentially involved in bone metabolism and related to bone mineral density. This Mendelian Randomization (MR) analysis was performed to determine whether there are causal associations of serum ADAM/ADAMTS with BMD in rid of confounders. Methods: The genome-wide summary statistics of four site-specific BMD measurements were obtained from studies in individuals of European ancestry, including forearm (n = 8,143), femoral neck (n = 32,735), lumbar spine (n = 28,498) and heel (n = 426,824). The genetic instrumental variables for circulating levels of ADAM12, ADAM19, ADAM23, ADAMTS5 and ADAMTS6 were retrieved from the latest genome-wide association study of European ancestry (n = 5336 ~ 5367). The estimated causal effect was given by the Wald ratio for each variant, the inverse-variance weighted model was used as the primary approach to combine estimates from multiple instruments, and sensitivity analyses were conducted to assess the robustness of MR results. The Bonferroni-corrected significance was set at P < 0.0025 to account for multiple testing, and a lenient threshold P < 0.05 was considered to suggest a causal relationship. Results: The causal effects of genetically predicted serum ADAM/ADAMTS levels on BMD measurements at forearm, femoral neck and lumbar spine were not statistically supported by MR analyses. Although causal effect of ADAMTS5 on heel BMD given by the primary MR analysis (β = -0.006, -0.010 to 0.002, P = 0.004) failed to reach Bonferroni-corrected significance, additional MR approaches and sensitivity analyses indicated a robust causal relationship. Conclusion: Our study provided suggestive evidence for the causal effect of higher serum levels of ADAMTS5 on decreased heel BMD, while there was no supportive evidence for the associations of ADAM12, ADAM19, ADAM23, and ADAMTS6 with BMD at forearm, femoral neck and lumbar spine in Europeans. [ABSTRACT FROM AUTHOR]

Heavy-duty diesel engines equipped with turbochargers is an effective way to alleviate energy shortage and reduce gas emissions, but their compressor aerodynamic noise emissions have become an important issue that needs to be addressed urgently. Therefore, to study the aerodynamic noise emission characteristics of a compressor during the full operating range, experimental and numerical simulation methods were used to analyze the aerodynamic noise emissions. The results showed that aerodynamic noise's total sound pressure level (SPL) increased with increased speed under the test conditions. At low speeds, the total SPL of aerodynamic noise was affected by the mass flow of the compressor more obviously. The maximum difference of aerodynamic noise total SPL was 1.55 dB at 60,000 r/min under different mass flows. At the same speed, the compressor could achieve lower aerodynamic noise emissions by operating in the high-efficiency region (middle mass flows). In the compressor aerodynamic noises, the blade passing frequency (BPF) noise played a dominant role. The transient acoustic-vibration spectral characteristics and fluctuation pressure analysis indicated that BPF and its harmonic frequency noises were mainly caused by the unsteady fluctuation pressure. As the speed increased, the BPF noise contributed more to the total SPL of the aerodynamic noise, and its percentage was up to 75.35%. The novelty of this study was the analysis of the relationship between compressor aerodynamic noise and internal flow characteristics at full operating conditions. It provided a theoretical basis for reducing the heavy-duty diesel engine turbocharger compressor aerodynamic noise emissions. [ABSTRACT FROM AUTHOR]

In response to the problem of mismatch between new energy output and multi-energy load requirement in multi-energy power systems, this article proposes a dynamic optimization model for new energy output in multiple time intervals based on multi-energy storage coordination. First, considering the energy conversion characteristics of multi-energy storage, the dynamic optimization method of new energy output based on the discrete division of subinterval of scheduling time is studied. Then, considering the cost of adjusting various resources comprehensively, the optimization objective of new energy output is studied, and a model-solving method based on a directed graph topology distributed algorithm is proposed. Finally, simulation verification was conducted, and the simulation results showed that the method proposed in this paper can effectively suppress the new energy fluctuation and reduce peak-shaving costs. [ABSTRACT FROM AUTHOR]

Hematologic malignancies (HMs) pose a serious threat to patients' health and life, and the five-year overall survival of HMs remains low. The lack of understanding of the pathogenesis and the complex clinical symptoms brings immense challenges to the diagnosis and treatment of HMs. Traditional therapeutic strategies for HMs include radiotherapy, chemotherapy, targeted therapy and hematopoietic stem cell transplantation. Although immunotherapy and cell therapy have made considerable progress in the last decade, nearly half of patients still relapse or suffer from drug resistance. Recently, studies have emerged that nanomaterials, nanotechnology and nanomedicine show great promise in cancer therapy by enhancing drug targeting, reducing toxicity and side effects and boosting the immune response to promote durable immunological memory. In this review, we summarized the strategies of recently developed nanomaterials, nanotechnology and nanomedicines against HMs and then proposed emerging strategies for the future designment of nanomedicines to treat HMs based on urgent clinical needs and technological progress. [ABSTRACT FROM AUTHOR]