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Abstract Recently, natural photosensitizers, such as berberine, curcumin, riboflavin, and emodin, have received more and more attention in photodynamic therapy. Tanshinone I (TanI) is extracted from a traditional Chinese herb Danshen, and exhibits many physiological functions including antitumor. TanI is a photoactive phytocompounds, but no work was tried to investigate its potential photodynamic effect. This study evaluated the cytotoxicity induced by the photodynamic effect of TanI. The photochemical reactions of TanI were firstly investigated by laser flash photolysis. Then breast cancer cell line MDA-MB-231 was chosen as a model and the photodynamic effect of TanI on cancer cell was evaluated by MTT assay and flow cytometry. The results showed that TanI could be photoexcited by its UV–Vis absorption light to produce 3TanI* which was quickly quenched by O2. MTT assay showed that the photodynamic effect of TanI resulted in more obvious inhibitive effect on cell survival and cell migration. Besides, the photodynamic effect of TanI could induce cell apoptosis and necrosis, lead to cell cycle arrest in G2, increase intracellular ROS, and decrease the cellular Δψm. It can be concluded that the photodynamic effect of TanI can obviously enhance the cytotoxicity of TanI on MDA-MB-231 cells in vitro, which indicated that TanI might serve as a natural photosensitizer.

Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation(LPO) and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.

Recently, mounting evidences have suggested the therapeutic potential of Nrf2/ARE activators for treating Ischemic stroke. Moreover, several Nrf2 activators attenuate ischemic stroke-induced brain injury in several transient focal cerebral ischemia (tMCAO) in experimental animal models.

Based on the characteristics and laws of coal spontaneous combustion in Yanzhou Mining Area, this paper studies the construction of accurate prevention and control system of coal spontaneous combustion, including the research on accurate fire prevention and control of coal spontaneous combustion prediction, monitoring and early warning and advanced disposal. Through the establishment of a 15 t large-scale coal spontaneous combustion testbed to study the characteristics of coal spontaneous combustion, the research and development of infrared thermal imaging technology to determine hidden fire sources, and the development of a series of new fire-fighting materials, technologies and equipment, the three leaps of forward development of “effective management, early prediction and early control, and ahead of time prevention” of coal fire disasters has been realized, and a scientific coal spontaneous combustion technology and management system has been formed in terms of management, equipment and technology; the research results promote the three major changes of coal seam fire from “passive control to advanced prevention and control, from traditional technology to high-tech, and from decentralized practical technology to complete set of applicable technologies”, and build three lines of defense for natural fire disaster “advanced prediction, early prevention, and rapid emergency control”, so as to achieve accurate prevention and control of coal spontaneous combustion in Yanzhou Mining Area.

As a special application of image completion technology,face image completion has an irreplaceable role in the occlusion of face recognition,portrait restoration and other issues.The existing face completion algorithm only aims at complementing the authenticity of the image without considering its identity consistency after completion.A face complement algorithm based on improved generative confrontation network was designed.By introducing SN-GAN algorithm,the stability of model training was improved.At the same time,the identity recognition constraint was added to the generated image using the face recognition model.Experiments have shown that the proposed method can effectively maintain the identity of the complementary image when generating high-authenticity images.