1. The Caspofungin Paradoxical Effect is a Tolerant 'Eagle Effect' in the Filamentous Fungal Pathogen Aspergillus fumigatus
- Author
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Clara Valero, Ana Cristina Colabardini, Patrícia Alves de Castro, Jorge Amich, Michael J. Bromley, and Gustavo H. Goldman
- Subjects
Aspergillus fumigatus ,caspofungin ,tolerance ,Eagle effect ,drug heterogeneity ,Microbiology ,QR1-502 - Abstract
ABSTRACT Cell responses against antifungals other than resistance have rarely been studied in filamentous fungi, while terms such as tolerance and persistence are well-described for bacteria and increasingly examined in yeast-like organisms. Aspergillus fumigatus is a filamentous fungal pathogen that causes a disease named aspergillosis, for which caspofungin (CAS), a fungistatic drug, is used as a second-line therapy. Some A. fumigatus clinical isolates can survive and grow in CAS concentrations above the minimum effective concentration (MEC), a phenomenon known as “caspofungin paradoxical effect” (CPE). Here, we evaluated the CPE in 67 A. fumigatus clinical isolates by calculating recovery rate (RR) values, where isolates with an RR of ≥0.1 were considered CPE+ while isolates with an RR of
- Published
- 2022
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