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1. Extended thiopurine metabolite assessment during 6-thioguanine therapy for immunomodulation in Crohn's disease

Author

de Boer, N.K.H., Derijks, L.J.J., Keizer-Garritsen, J.J., Lambooy, L.H.J., Ruitenbeek, W., Hooymans, P.M., van Bodegraven, A.A., and de Jong, D.J.

Subjects
Drug therapy, Research, Dosage and administration, Crohn's disease -- Drug therapy -- Research, Azathioprine -- Dosage and administration -- Research, Combination drug therapy -- Research, Drug metabolism -- Research, Thioguanine -- Dosage and administration -- Research, Drug therapy, Combination -- Research
Abstract

The proposed metabolic advantage of 6-thioguanine (6-TG) is the direct conversion into the pharmacologically active 6-thioguaninenucleotides (6-TGN). The authors assessed metabolic characteristics of 6-TG treatment in patients with Crohn's disease [...]

Published
2007

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