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1. In situ preparation of protein- 'Smart' polymer conjugates with retention of bioactivity

Author

Heredia, Karina L., Bontempo, Debora, Ly, Tiffany, Byers, Joshua T., Halstenberg, Sven, and Maynard, Heather D.

Subjects
Proteins -- Chemical properties, Proteins -- Structure, Polymerization -- Analysis, Mass spectrometry -- Usage, Serum albumin -- Chemical properties, Serum albumin -- Structure, Chemistry
Abstract

A study demonstrates that bioactive 'smart' polymer conjugates could be synthesized by polymerizing from defined initiation sites on proteins, thus preparing the polymer conjugates in situ. Protein-polymer conjugates are widely used in biotechnology and medicine, and new methods to prepare the bioconjugates would be advantageous for these applications.

Published
2005

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