1. CircPUM1 promotes hepatocellular carcinoma progression through the miR-1208/MAP3K2 axis.
- Author
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Zhang Y, Wang D, Zhu T, Yu J, Wu X, Lin W, Zhu M, Dai Y, and Zhu J
- Subjects
- Animals, Blotting, Western, Carcinoma, Hepatocellular genetics, Gene Expression Regulation, Neoplastic genetics, Gene Expression Regulation, Neoplastic physiology, Liver Neoplasms genetics, MAP Kinase Kinase Kinase 2 genetics, Mice, Inbred BALB C, Mice, Nude, MicroRNAs genetics, RNA-Binding Proteins genetics, Mice, Carcinoma, Hepatocellular metabolism, Liver Neoplasms metabolism, MAP Kinase Kinase Kinase 2 metabolism, MicroRNAs metabolism, RNA-Binding Proteins metabolism
- Abstract
Hepatocellular carcinoma (HCC) is a common disease with a significant mortality, and there is no effective treatment for advanced patients. Growing evidence indicates that circRNAs are closely related to HCC progression, may be used as biomarkers and targets for the diagnosis and treatment of HCC. Recent researches have shown that circPUM1 may play an oncogene role in a variety of human cancers, but its role in HCC development has not been reported. Our study found that circPUM1 could promote the proliferation, migration and invasion of HCC cells in vitro. In addition, in vivo studies showed that circPUM1 could increase the development of HCC tumours and regulate the expression of EMT-related proteins. Furthermore, we demonstrated that circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208. Our study suggested that circPUM1 may be a potential therapeutic target for HCC., (© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
- Published
- 2021
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