1. Improved medication adherence in COPD patients using tiotropium or tiotropium olodaterol with the HealthPrize digital behavior change program.
- Author
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Firlik KS, Anupindi VR, Hayes V, DeKoven M, Shaikh A, and Franchino-Elder J
- Subjects
- Humans, Male, Retrospective Studies, Female, Middle Aged, Aged, Cohort Studies, Benzoxazines administration & dosage, Benzoxazines economics, Health Care Costs statistics & numerical data, Drug Combinations, Administration, Inhalation, Follow-Up Studies, Pulmonary Disease, Chronic Obstructive drug therapy, Pulmonary Disease, Chronic Obstructive economics, Tiotropium Bromide administration & dosage, Medication Adherence statistics & numerical data, Bronchodilator Agents administration & dosage, Bronchodilator Agents economics, Bronchodilator Agents therapeutic use
- Abstract
Objective: To assess the impact of the HealthPrize RespiPoints™ program on treatment adherence and persistence in adults with chronic obstructive pulmonary disease (COPD)., Methods: In this retrospective cohort study, program participants and nonparticipants receiving tiotropium bromide (TIO) or TIO and olodaterol between 1 January 2015-31 March 2020 were propensity score matched (PSM), from the linked database of the HealthPrize patient list and IQVIA PharMetrics® Plus. Treatment adherence, persistence, healthcare resource utilization, and costs were compared. Multivariable logistic regression models assessed the odds of adherence (≥80% proportion of days covered [PDC]), adjusted risk of discontinuation, and adjusted total healthcare costs., Results: Program participants ( n = 262) demonstrated a 44% greater adherence during followup than nonparticipants ( n = 262) (mean [standard deviation] PDC: 0.72 [0.27] vs 0.50 [0.36], p < 0.0001). Participants had higher odds of adherence vs nonparticipants (adjusted odds ratio: 2.51; 95% confidence interval: 1.72-3.66, p < 0.0001) and a lower percentage of participants discontinued their index medication (19.85% vs 33.59%, p = 0.0004). Fewer participants were hospitalized during follow-up (13.74% vs 17.56%, p = 0.23); adjusted total medical costs were 24% lower ( p = 0.08). Higher pharmacy costs partially offset lower healthcare costs., Conclusions: Program participants showed improved COPD medication adherence and persistence compared to nonparticipants.
- Published
- 2024
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