1. Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N , N '-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus .
- Author
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Wang Z, Zhao L, Jing H, Song G, and Li J
- Subjects
- Ligands, Coordination Complexes pharmacology, Coordination Complexes chemistry, Coordination Complexes chemical synthesis, Molecular Structure, Heterocyclic Compounds chemistry, Heterocyclic Compounds pharmacology, Heterocyclic Compounds chemical synthesis, Models, Molecular, Crystallography, X-Ray, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents chemical synthesis, Staphylococcus aureus drug effects, Polymers chemistry, Polymers pharmacology, Polymers chemical synthesis, Microbial Sensitivity Tests
- Abstract
As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd
2 (L)2 (bibp)2 ]n (1) and [Ni(L)(bib)]n (2), where H2 L = N , N '-bis(4-carbozvlbenzvl)-4-aminotoluene, bibp = 4,4'-bis(imidazol-1-yl)biphenyl, and bib = 1,3-bis(1-imidazoly)benzene, have been synthesized under solvothermal and hydrothermal condition. Structural clarification was performed through infrared spectrum and single-crystal X-ray diffraction analysis, while thermal analysis and XRD technology were used for the performance assessment of compounds 1 and 2 . In addition, antibacterial performance experiments showed that compounds 1 and 2 have certain selectivity in their antibacterial properties and have good antibacterial properties against S. aureus . As the concentration of the compound increases, the inhibitory effect gradually strengthens, and when the concentration of the compound reaches 500 μg/mL and 400 μg/mL, the concentration of the S. aureus solution no longer increases and has been completely inhibited.- Published
- 2024
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