1. Risk of dementia and death in community-dwelling older men with bipolar disorder.
- Author
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Almeida OP, McCaul K, Hankey GJ, Yeap BB, Golledge J, and Flicker L
- Subjects
- Aged, Aged, 80 and over, Bipolar Disorder mortality, Comorbidity, Dementia mortality, Humans, Independent Living, Male, Bipolar Disorder epidemiology, Dementia epidemiology
- Abstract
Background: Bipolar disorder has been associated with cognitive decline, but confirmatory evidence from a community-derived sample of older people is lacking., Aims: To investigate the 13-year risk of dementia and death in older adults with bipolar disorder., Method: Cohort study of 37 768 men aged 65-85 years. Dementia (primary) and death (secondary), as recorded by electronic record linkage, were the outcomes of interest., Results: Bipolar disorder was associated with increased adjusted hazard ratio (HR) of dementia (HR = 2.30, 95% CI 1.80-2.94). The risk of dementia was greatest among those with <5 years of history of bipolar disorder or who had had illness onset after 70 years of age. Bipolar disorder was also associated with increased mortality (HR = 1.51, 95% CI 1.28-1.77). Competing risk regression showed that bipolar disorder was associated with increased hazard of death by suicide, accidents, pneumonia or influenza, and diseases of the liver and digestive system., Conclusions: Bipolar disorder in later life is associated with increased risk of dementia and premature death., (© The Royal College of Psychiatrists 2016.)
- Published
- 2016
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