1. Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.
- Author
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Ostrakhovitch EA, Song ES, Macedo JKA, Gentry MS, Quintero JE, van Horne C, and Yamasaki TR
- Subjects
- Aged, Biomarkers blood, Biomarkers cerebrospinal fluid, Diagnosis, Differential, Essential Tremor cerebrospinal fluid, Essential Tremor diagnosis, Female, Humans, Male, Middle Aged, NAD blood, Nicotinamide Phosphoribosyltransferase blood, Parkinson Disease cerebrospinal fluid, Parkinson Disease diagnosis, Pentose Phosphate Pathway, alpha-Synuclein cerebrospinal fluid, Essential Tremor blood, Parkinson Disease blood, alpha-Synuclein blood
- Abstract
Parkinson's disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiology. We sought to determine whether an underlying metabolic pattern may differentiate ET from PD. Circulating metabolites in plasma and cerebrospinal fluid (CSF) were analyzed using gas chromatography-mass spectroscopy. There were several disrupted pathways in PD compared to ET plasma including glycolysis, tyrosine, phenylalanine, tyrosine biosynthesis, purine and glutathione metabolism. Elevated α-synuclein levels in plasma and CSF distinguished PD from ET. The perturbed metabolic state in PD was associated with imbalance in the pentose phosphate pathway, deficits in energy production, and change in NADPH, NADH and nicotinamide phosphoribosyltransferase levels. This work demonstrates significant metabolic differences in plasma and CSF of PD and ET patients., (Published by Elsevier B.V.)
- Published
- 2022
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