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1. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo

Author

Madhani, Hiten, Madhani, Hiten, Butts, A, Koselny, K, Chabrier-Roselló, Y, Semighini, CP, Brown, JCS, Wang, X, Annadurai, S, DiDone, L, Tabroff, J, Childers, WE, Madhani, Hiten, Madhani, Hiten, Butts, A, Koselny, K, Chabrier-Roselló, Y, Semighini, CP, Brown, JCS, Wang, X, Annadurai, S, DiDone, L, Tabroff, J, and Childers, WE

Abstract

Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we characterized the ant

Published
2014

2. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo

Author

Madhani, Hiten, Madhani, Hiten, Butts, A, Koselny, K, Chabrier-Roselló, Y, Semighini, CP, Brown, JCS, Wang, X, Annadurai, S, DiDone, L, Tabroff, J, Childers, WE, Madhani, Hiten, Madhani, Hiten, Butts, A, Koselny, K, Chabrier-Roselló, Y, Semighini, CP, Brown, JCS, Wang, X, Annadurai, S, DiDone, L, Tabroff, J, and Childers, WE

Abstract

Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we characterized the ant

Published
2014

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