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Evidence for prognosis and treatment of elderly patient with primary central nervous system is limited. High-dose methotrexate should be applied whenever possible, especially combination with oral alkylating agents is a promising approach. Further combinations with other intravenous drugs do not seem to improve outcome. More prospective trials designed for elderly PCNSL patients are warranted

Background: To investigate prognosis and effects of first-line therapy in elderly primary central nervous system lymphoma (PCNSL) patients. Patients and methods: A systematic review of studies about first-line therapy in immunocompetent patients ≥60 years with PCNSL until 2014 and a meta-analysis of individual patient data from eligible studies and international collaborators were carried out. Results: We identified 20 eligible studies; from 13

Two different hydrothermal mineralisation types (carbonate precipitation and alunitisation) were studied from the Methana peninsula, which is on the western end of the Hellenic volcanic arc. These sub-recent to recent hydrothermal activities were mostly related to NW-SW striking normal faults. Low temperature solutions have altered dacitic-rhyodacitic volcanic rocks in vein type calcite mineralisations or in larger zones containing amorphous silica, alunogen, kaolinite, gypsum, anhydrite and sulphur. With the exception of Fe, Mn, Zn and Ni, other base metals are not enriched. Apart from tectonics, the major controlling factor for these two alteration types was the mixing of hydrothermal with seawater., Two different hydrothermal mineralisation types (carbonate precipitation and alunitisation) were studied from the Methana peninsula, which is on the western end of the Hellenic volcanic arc. These sub-recent to recent hydrothermal activities were mostly related to NW-SW striking normal faults. Low temperature solutions have altered dacitic-rhyodacitic volcanic rocks in vein type calcite mineralisations or in larger zones containing amorphous silica, alunogen, kaolinite, gypsum, anhydrite and sulphur. With the exception of Fe, Mn, Zn and Ni, other base metals are not enriched. Apart from tectonics, the major controlling factor for these two alteration types was the mixing of hydrothermal with seawater.

Sand grains coated with Fe-hydroxide were compared with uncoated sand grains as an adsorbant filtration media for the treatment of metal-bearing waters. Coated and uncoated sand grains were placed into dialysis cells of a multilayer sampler and then placed into a research well. After two months of exposure, the samples were retrieved and analysed for Cr, Pb, Ni, Cd, Mn and Co concentrations. Transmitted light and scanning electron light microscopy showed that the coating prevailed in the field and was not removed. Only Cr showed significant enrichment on the coated material compared to the uncoated material, indicating that the exposure of the Fe-coated surface to groundwater was sufficient for preferential scavenging of Cr from the water. The eight-fold enrichment of Cr may be related to its oxidation state of +3, thereby readily permitting substitution into the Fe3+ position in the coating material. The rest of the studied metals were only slightly enriched in the coated grain., Sand grains coated with Fe-hydroxide were compared with uncoated sand grains as an adsorbant filtration media for the treatment of metal-bearing waters. Coated and uncoated sand grains were placed into dialysis cells of a multilayer sampler and then placed into a research well. After two months of exposure, the samples were retrieved and analysed for Cr, Pb, Ni, Cd, Mn and Co concentrations. Transmitted light and scanning electron light microscopy showed that the coating prevailed in the field and was not removed. Only Cr showed significant enrichment on the coated material compared to the uncoated material, indicating that the exposure of the Fe-coated surface to groundwater was sufficient for preferential scavenging of Cr from the water. The eight-fold enrichment of Cr may be related to its oxidation state of +3, thereby readily permitting substitution into the Fe3+ position in the coating material. The rest of the studied metals were only slightly enriched in the coated grain.

Evidence for prognosis and treatment of elderly patient with primary central nervous system is limited. High-dose methotrexate should be applied whenever possible, especially combination with oral alkylating agents is a promising approach. Further combinations with other intravenous drugs do not seem to improve outcome. More prospective trials designed for elderly PCNSL patients are warranted