Search

Your search keyword '"van Solinge, Wouter W."' showing total 201 results
Start Over Author "van Solinge, Wouter W." Database OAIster
201 results on '"van Solinge, Wouter W."'

1. The Effect of Artificial Intelligence on Patient-Physician Trust: Cross-Sectional Vignette Study

Author

Zondag, Anna G.M., Rozestraten, Raoul, Grimmelikhuijsen, Stephan G., Jongsma, Karin R., van Solinge, Wouter W., Bots, Michiel L., Vernooij, Robin W.M., Haitjema, Saskia, Zondag, Anna G.M., Rozestraten, Raoul, Grimmelikhuijsen, Stephan G., Jongsma, Karin R., van Solinge, Wouter W., Bots, Michiel L., Vernooij, Robin W.M., and Haitjema, Saskia

Abstract

BACKGROUND: Clinical decision support systems (CDSSs) based on routine care data, using artificial intelligence (AI), are increasingly being developed. Previous studies focused largely on the technical aspects of using AI, but the acceptability of these technologies by patients remains unclear. OBJECTIVE: We aimed to investigate whether patient-physician trust is affected when medical decision-making is supported by a CDSS. METHODS: We conducted a vignette study among the patient panel (N=860) of the University Medical Center Utrecht, the Netherlands. Patients were randomly assigned into 4 groups-either the intervention or control groups of the high-risk or low-risk cases. In both the high-risk and low-risk case groups, a physician made a treatment decision with (intervention groups) or without (control groups) the support of a CDSS. Using a questionnaire with a 7-point Likert scale, with 1 indicating "strongly disagree" and 7 indicating "strongly agree," we collected data on patient-physician trust in 3 dimensions: competence, integrity, and benevolence. We assessed differences in patient-physician trust between the control and intervention groups per case using Mann-Whitney U tests and potential effect modification by the participant's sex, age, education level, general trust in health care, and general trust in technology using multivariate analyses of (co)variance. RESULTS: In total, 398 patients participated. In the high-risk case, median perceived competence and integrity were lower in the intervention group compared to the control group but not statistically significant (5.8 vs 5.6; P=.16 and 6.3 vs 6.0; P=.06, respectively). However, the effect of a CDSS application on the perceived competence of the physician depended on the participant's sex (P=.03). Although no between-group differences were found in men, in women, the perception of the physician's competence and integrity was significantly lower in the intervention compared to the control group (P=.00

Published
2024

2. The Effect of Artificial Intelligence on Patient-Physician Trust: Cross-Sectional Vignette Study

Author

CDL Upod, Bioethics & Health Humanities, Child Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Rozestraten, Raoul, Grimmelikhuijsen, Stephan G, Jongsma, Karin R, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, Haitjema, Saskia, CDL Upod, Bioethics & Health Humanities, Child Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Rozestraten, Raoul, Grimmelikhuijsen, Stephan G, Jongsma, Karin R, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, and Haitjema, Saskia

Published
2024

3. Comparison of the Response to an Electronic Versus a Traditional Informed Consent Procedure in Terms of Clinical Patient Characteristics: Observational Study

Author

CDL Upod, Medical Humanities Onderzoek Team 1, Bioethics & Health Humanities, Child Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Team Medisch, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Hollestelle, Marieke J, van der Graaf, Rieke, Nathoe, Hendrik M, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, Haitjema, Saskia, UCC CVRM study group, CDL Upod, Medical Humanities Onderzoek Team 1, Bioethics & Health Humanities, Child Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Team Medisch, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Hollestelle, Marieke J, van der Graaf, Rieke, Nathoe, Hendrik M, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, Haitjema, Saskia, and UCC CVRM study group

Published
2024

4. Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease

Author

CDL Rode cel, Unit Opleiding Aios, Genetica Sectie Metabole Diagnostiek, Poli Van Creveldkliniek Medisch, Circulatory Health, CDL Research analisten, Haematologie patientenzorg, Child Health, Infection & Immunity, Centraal Diagnostisch Laboratorium, Brain, CDL Cluster Speciële Diagnostiek, van Dijk, Myrthe J, Ruiter, Titine J J, van der Veen, Sigrid, Rab, Minke A E, van Oirschot, Brigitte A, Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W, Cnossen, Marjon H, Nur, Erfan, Biemond, Bart J, Bartels, Marije, Schutgens, Roger E G, van Solinge, Wouter W, Jans, Judith J M, van Beers, Eduard J, van Wijk, Richard, CDL Rode cel, Unit Opleiding Aios, Genetica Sectie Metabole Diagnostiek, Poli Van Creveldkliniek Medisch, Circulatory Health, CDL Research analisten, Haematologie patientenzorg, Child Health, Infection & Immunity, Centraal Diagnostisch Laboratorium, Brain, CDL Cluster Speciële Diagnostiek, van Dijk, Myrthe J, Ruiter, Titine J J, van der Veen, Sigrid, Rab, Minke A E, van Oirschot, Brigitte A, Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W, Cnossen, Marjon H, Nur, Erfan, Biemond, Bart J, Bartels, Marije, Schutgens, Roger E G, van Solinge, Wouter W, Jans, Judith J M, van Beers, Eduard J, and van Wijk, Richard

Published
2024

5. Improving acute kidney injury alerts in tertiary care by linking primary care data: An observational cohort using routine care data

Author

CDL Arcadia, CDL Cluster Front office & ext. business, MS Nefrologie, CDL Upod, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Speciële Diagnostiek, Joosse, Huibert-Jan, Groenestege, Wouter Tiel, Vernooij, Robin Wm, De Groot, Mark Ch, Hoefer, Imo E, van Solinge, Wouter W, Kok, Maarten B, Haitjema, Saskia, CDL Arcadia, CDL Cluster Front office & ext. business, MS Nefrologie, CDL Upod, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Speciële Diagnostiek, Joosse, Huibert-Jan, Groenestege, Wouter Tiel, Vernooij, Robin Wm, De Groot, Mark Ch, Hoefer, Imo E, van Solinge, Wouter W, Kok, Maarten B, and Haitjema, Saskia

Published
2024

6. Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease

Author

van Dijk, Myrthe J., Ruiter, Titine J.J., van der Veen, Sigrid, Rab, Minke A.E., van Oirschot, Brigitte A., Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W., Cnossen, Marjon H., Nur, Erfan, Biemond, Bart J., Bartels, Marije, Schutgens, Roger E.G., van Solinge, Wouter W., Jans, Judith J.M., van Beers, Eduard J., van Wijk, Richard, van Dijk, Myrthe J., Ruiter, Titine J.J., van der Veen, Sigrid, Rab, Minke A.E., van Oirschot, Brigitte A., Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W., Cnossen, Marjon H., Nur, Erfan, Biemond, Bart J., Bartels, Marije, Schutgens, Roger E.G., van Solinge, Wouter W., Jans, Judith J.M., van Beers, Eduard J., and van Wijk, Richard

Abstract

Mitapivat is an investigational, oral, small-molecule allosteric activator of pyruvate kinase (PK). PK is a regulatory glycolytic enzyme that is key in providing the red blood cell (RBC) with sufficient amounts of adenosine triphosphate (ATP). In sickle cell disease (SCD), decreased 2,3-DPG levels increase the oxygen affinity of hemoglobin, thereby preventing deoxygenation and polymerization of sickle hemoglobin. The PK activator mitapivat has been shown to decrease levels of 2,3-DPG and increase levels of ATP in RBCs in patients with SCD. In this phase 2, investigator-initiated, open-label study (https://www.clinicaltrialsregister.eu/ NL8517; EudraCT 2019-003438-18), untargeted metabolomics was used to explore the overall metabolic effects of 8-week treatment with mitapivat in the dose-finding period. In total, 1773 unique metabolites were identified in dried blood spots of whole blood from ten patients with SCD and 42 healthy controls (HCs). The metabolic phenotype of patients with SCD revealed alterations in 139/1773 (7.8%) metabolites at baseline when compared to HCs (false discovery rate-adjusted p < 0.05), including increases of (derivatives of) polyamines, purines, and acyl carnitines. Eight-week treatment with mitapivat in nine patients with SCD altered 85/1773 (4.8%) of the total metabolites and 18/139 (12.9%) of the previously identified altered metabolites in SCD (unadjusted p < 0.05). Effects were observed on a broad spectrum of metabolites and were not limited to glycolytic intermediates. Our results show the relevance of metabolic profiling in SCD, not only to unravel potential pathophysiological pathways and biomarkers in multisystem diseases but also to determine the effect of treatment.

Published
2024

7. A novel composition of endogenous metabolic modulators improves red blood cell properties in sickle cell disease

Author

CDL Rode cel, Unit Opleiding Aios, Cancer, Genetica Sectie Metabole Diagnostiek, CDL Research analisten, Centraal Diagnostisch Laboratorium, Brain, Child Health, Poli Van Creveldkliniek Medisch, CDL Cluster Speciële Diagnostiek, Circulatory Health, van Dijk, Myrthe J, Traets, Marissa J M, van Oirschot, Brigitte A, Ruiter, Titine J J, de Wilde, Jonathan R A, Bos, Jennifer, van Solinge, Wouter W, Koziel, Margaret J, Jans, Judith J M, Wani, Revati, van Beers, Eduard J, van Wijk, Richard, Rab, Minke A E, CDL Rode cel, Unit Opleiding Aios, Cancer, Genetica Sectie Metabole Diagnostiek, CDL Research analisten, Centraal Diagnostisch Laboratorium, Brain, Child Health, Poli Van Creveldkliniek Medisch, CDL Cluster Speciële Diagnostiek, Circulatory Health, van Dijk, Myrthe J, Traets, Marissa J M, van Oirschot, Brigitte A, Ruiter, Titine J J, de Wilde, Jonathan R A, Bos, Jennifer, van Solinge, Wouter W, Koziel, Margaret J, Jans, Judith J M, Wani, Revati, van Beers, Eduard J, van Wijk, Richard, and Rab, Minke A E

Published
2024

8. One-year safety and efficacy of mitapivat in sickle cell disease:follow-up results of a phase 2, open-label study

Author

van Dijk, Myrthe J., Rab, Minke A.E., van Oirschot, Brigitte A., Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W., Cnossen, Marjon H., Nur, Erfan, Biemond, Bart J., Bartels, Marije, Jans, Judith J.M., van Solinge, Wouter W., Schutgens, Roger E.G., van Wijk, Richard, van Beers, Eduard J., van Dijk, Myrthe J., Rab, Minke A.E., van Oirschot, Brigitte A., Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W., Cnossen, Marjon H., Nur, Erfan, Biemond, Bart J., Bartels, Marije, Jans, Judith J.M., van Solinge, Wouter W., Schutgens, Roger E.G., van Wijk, Richard, and van Beers, Eduard J.

Published
2023

9. A cluster of blood-based protein biomarkers associated with decreased cerebral blood flow relates to future cardiovascular events in patients with cardiovascular disease

Author

Overmars, L. Malin, Kuipers, Sanne, van Es, Bram, Bresser, Jeroen de, Bron, Esther E., Hoefer, Imo E., Van Solinge, Wouter W., Kappelle, L. Jaap, van Osch, Matthias J.P., Teunissen, Charlotte E., Biessels, Geert Jan, Haitjema, Saskia, Overmars, L. Malin, Kuipers, Sanne, van Es, Bram, Bresser, Jeroen de, Bron, Esther E., Hoefer, Imo E., Van Solinge, Wouter W., Kappelle, L. Jaap, van Osch, Matthias J.P., Teunissen, Charlotte E., Biessels, Geert Jan, and Haitjema, Saskia

Published
2023

10. Sexual dimorphism in peripheral blood cell characteristics linked to recanalization success of endovascular thrombectomy in acute ischemic stroke

Author

CDL Upod, Centraal Diagnostisch Laboratorium, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Neurologen, Brain, Stroke, CDL Cluster Speciële Diagnostiek, Overmars, L Malin, van Solinge, Wouter W, Ruijter, Hester M den, van der Worp, H Bart, Van Es, Bram, Hulsbergen-Veelken, Cornelia A R, Biessels, Geert Jan, Exalto, Lieza G, Haitjema, Saskia, CDL Upod, Centraal Diagnostisch Laboratorium, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Neurologen, Brain, Stroke, CDL Cluster Speciële Diagnostiek, Overmars, L Malin, van Solinge, Wouter W, Ruijter, Hester M den, van der Worp, H Bart, Van Es, Bram, Hulsbergen-Veelken, Cornelia A R, Biessels, Geert Jan, Exalto, Lieza G, and Haitjema, Saskia

Published
2023

11. Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

Author

CDL Upod, Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Experimental Cardiology Laboratory, Experimentele Afd. Cardiologie 2, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, CDL Cluster Speciële Diagnostiek, Overmars, L. Malin, Mekke, Joost M., van Solinge, Wouter W., De Jager, Saskia C.A., Hulsbergen-Veelken, Cornelia A.R., Hoefer, Imo E., de Kleijn, Dominique P.V., de Borst, Gert J., van der Laan, Sander W., Haitjema, Saskia, CDL Upod, Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Experimental Cardiology Laboratory, Experimentele Afd. Cardiologie 2, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, CDL Cluster Speciële Diagnostiek, Overmars, L. Malin, Mekke, Joost M., van Solinge, Wouter W., De Jager, Saskia C.A., Hulsbergen-Veelken, Cornelia A.R., Hoefer, Imo E., de Kleijn, Dominique P.V., de Borst, Gert J., van der Laan, Sander W., and Haitjema, Saskia

Published
2023

12. In-vitro and in-silico evidence for oxidative stress as drivers for RDW

Author

CDL Upod, CDL Rode cel, CDL Nanomedicine, Circulatory Health, Centraal Diagnostisch Laboratorium, CDL Cluster Speciële Diagnostiek, Child Health, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Joosse, Huibert Jan, van Oirschot, Brigitte A., Kooijmans, Sander A.A., Hoefer, Imo E., van Wijk, Richard A.H., Huisman, Albert, van Solinge, Wouter W., Haitjema, Saskia, CDL Upod, CDL Rode cel, CDL Nanomedicine, Circulatory Health, Centraal Diagnostisch Laboratorium, CDL Cluster Speciële Diagnostiek, Child Health, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Joosse, Huibert Jan, van Oirschot, Brigitte A., Kooijmans, Sander A.A., Hoefer, Imo E., van Wijk, Richard A.H., Huisman, Albert, van Solinge, Wouter W., and Haitjema, Saskia

Published
2023

13. Anemiediagnostiek in de eerste lijn: Reflextesten, reflecteren en algoritmes?

Author

CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Huisman, Albert, van Solinge, Wouter W, Cals, Jochen W L, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Huisman, Albert, van Solinge, Wouter W, and Cals, Jochen W L

Published
2023

14. Acht misvattingen over AI in de zorg

Author

UMC Utrecht Academie, Medical Humanities Onderzoek Team 2, Child Health, JC onderzoeksprogramma Methodologie, Centraal Diagnostisch Laboratorium, CDL Cluster Speciële Diagnostiek, Circulatory Health, Jongsma, Karin R., van Solinge, Wouter W., Haitjema, Saskia, UMC Utrecht Academie, Medical Humanities Onderzoek Team 2, Child Health, JC onderzoeksprogramma Methodologie, Centraal Diagnostisch Laboratorium, CDL Cluster Speciële Diagnostiek, Circulatory Health, Jongsma, Karin R., van Solinge, Wouter W., and Haitjema, Saskia

Published
2023

15. Added diagnostic value of routinely measured hematology variables in diagnosing immune checkpoint inhibitor mediated toxicity in the emergency department

Author

CDL Upod, Medische Staf Spoedeisende Hulp, NVIC bedrijfsvoering, MS Medische Oncologie, Cancer, Infection & Immunity, Centraal Diagnostisch Laboratorium, CDL Cluster Front office & ext. business, CDL Cluster Speciële Diagnostiek, Circulatory Health, Niemantsverdriet, Michael S A, Vrijsen, Bram E L, Visser 't Hooft, Therese, Suijkerbuijk, Karijn P M, van Solinge, Wouter W, Ten Berg, Maarten J, Haitjema, Saskia, CDL Upod, Medische Staf Spoedeisende Hulp, NVIC bedrijfsvoering, MS Medische Oncologie, Cancer, Infection & Immunity, Centraal Diagnostisch Laboratorium, CDL Cluster Front office & ext. business, CDL Cluster Speciële Diagnostiek, Circulatory Health, Niemantsverdriet, Michael S A, Vrijsen, Bram E L, Visser 't Hooft, Therese, Suijkerbuijk, Karijn P M, van Solinge, Wouter W, Ten Berg, Maarten J, and Haitjema, Saskia

Published
2023

16. Design, validation and implementation of an automated e-alert for acute kidney injury: 6-month pilot study shows increased awareness

Author

CDL Upod, CDL Cluster Front office & ext. business, MS Nefrologie, Centraal Diagnostisch Laboratorium, Circulatory Health, Epi Infectieziekten, CDL Cluster Speciële Diagnostiek, Niemantsverdriet, Michael S A, Tiel Groenestege, Wouter M, Khairoun, M, Hoefer, Imo E, van Solinge, Wouter W, Bellomo, Domenico, van Vliet, Martin H, Kaasjager, Karin A H, Haitjema, Saskia, CDL Upod, CDL Cluster Front office & ext. business, MS Nefrologie, Centraal Diagnostisch Laboratorium, Circulatory Health, Epi Infectieziekten, CDL Cluster Speciële Diagnostiek, Niemantsverdriet, Michael S A, Tiel Groenestege, Wouter M, Khairoun, M, Hoefer, Imo E, van Solinge, Wouter W, Bellomo, Domenico, van Vliet, Martin H, Kaasjager, Karin A H, and Haitjema, Saskia

Published
2023

17. Shorter laboratory turnaround time is associated with shorter emergency department length of stay: a retrospective cohort study

Author

MS Interne Geneeskunde, NVIC bedrijfsvoering, CDL Cluster Speciële Diagnostiek, Circulatory Health, CDL Upod, Centraal Diagnostisch Laboratorium, CDL Cluster Front office & ext. business, Infection & Immunity, Vrijsen, Bram E L, Haitjema, Saskia, Westerink, Jan, Hulsbergen-Veelken, Cornelia A R, van Solinge, Wouter W, Ten Berg, Maarten J, MS Interne Geneeskunde, NVIC bedrijfsvoering, CDL Cluster Speciële Diagnostiek, Circulatory Health, CDL Upod, Centraal Diagnostisch Laboratorium, CDL Cluster Front office & ext. business, Infection & Immunity, Vrijsen, Bram E L, Haitjema, Saskia, Westerink, Jan, Hulsbergen-Veelken, Cornelia A R, van Solinge, Wouter W, and Ten Berg, Maarten J

Published
2022

18. A Wolf in Sheep's Clothing: Reuse of Routinely Obtained Laboratory Data in Research

Author

CDL Upod, Cardiovasculaire Epi Team 5, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, CDL Cluster 24/7 centraal laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Overmars, L Malin, Niemantsverdriet, Michael S A, Groenhof, T Katrien J, De Groot, Mark C H, Hulsbergen-Veelken, Cornelia A R, Van Solinge, Wouter W, Musson, Ruben E A, Ten Berg, Maarten J, Hoefer, Imo E, Haitjema, Saskia, CDL Upod, Cardiovasculaire Epi Team 5, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, CDL Cluster 24/7 centraal laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Overmars, L Malin, Niemantsverdriet, Michael S A, Groenhof, T Katrien J, De Groot, Mark C H, Hulsbergen-Veelken, Cornelia A R, Van Solinge, Wouter W, Musson, Ruben E A, Ten Berg, Maarten J, Hoefer, Imo E, and Haitjema, Saskia

Published
2022

19. Transfusion burden in early childhood plays an important role in iron overload in Diamond-Blackfan anaemia

Author

CDL Rode cel, Cancer, Unit Opleiding Aios, CDL Cluster Speciële Diagnostiek, Child Health, Circulatory Health, Centraal Diagnostisch Laboratorium, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, Poli Van Creveldkliniek Medisch, Haematologie patientenzorg, de Wilde, Jonathan R A, van Dooijeweert, Birgit, van Vuren, Annelies J, Huisman, Elise J, Smiers, Frans J, van der Veer, Arian, van Wijk, Richard, van Solinge, Wouter W, Nieuwenhuis, Edward E S, van Beers, Eduard J, Bartels, Marije, CDL Rode cel, Cancer, Unit Opleiding Aios, CDL Cluster Speciële Diagnostiek, Child Health, Circulatory Health, Centraal Diagnostisch Laboratorium, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, Poli Van Creveldkliniek Medisch, Haematologie patientenzorg, de Wilde, Jonathan R A, van Dooijeweert, Birgit, van Vuren, Annelies J, Huisman, Elise J, Smiers, Frans J, van der Veer, Arian, van Wijk, Richard, van Solinge, Wouter W, Nieuwenhuis, Edward E S, van Beers, Eduard J, and Bartels, Marije

Published
2022

20. Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in sickle cell disease: a phase 2, open-label study

Author

CDL Rode cel, Unit Opleiding Aios, Circulatory Health, Poli Van Creveldkliniek Medisch, Haematologie patientenzorg, Child Health, Genetica Sectie Metabole Diagnostiek, Centraal Diagnostisch Laboratorium, Infection & Immunity, CDL Cluster Speciële Diagnostiek, van Dijk, Myrthe J, Rab, Minke A E, van Oirschot, Brigitte A, Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W, Cnossen, Marjon H, Nur, Erfan, Biemond, Bart J, Bartels, Marije, Jans, Judith J M, van Solinge, Wouter W, Schutgens, Roger E G, van Wijk, Richard, van Beers, Eduard J, CDL Rode cel, Unit Opleiding Aios, Circulatory Health, Poli Van Creveldkliniek Medisch, Haematologie patientenzorg, Child Health, Genetica Sectie Metabole Diagnostiek, Centraal Diagnostisch Laboratorium, Infection & Immunity, CDL Cluster Speciële Diagnostiek, van Dijk, Myrthe J, Rab, Minke A E, van Oirschot, Brigitte A, Bos, Jennifer, Derichs, Cleo, Rijneveld, Anita W, Cnossen, Marjon H, Nur, Erfan, Biemond, Bart J, Bartels, Marije, Jans, Judith J M, van Solinge, Wouter W, Schutgens, Roger E G, van Wijk, Richard, and van Beers, Eduard J

Published
2022

21. Sepsis labels defined by claims-based methods are ill-suited for training machine learning algorithms

Author

Acute geneeskunde, CDL Upod, Centraal Diagnostisch Laboratorium, MS Interne Geneeskunde, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Circulatory Health, de Hond, Titus A.P., Niemantsverdriet, Michael S.A., van Solinge, Wouter W., Oosterheert, Jan Jelrik, Haitjema, Saskia, Kaasjager, Karin A.H., Acute geneeskunde, CDL Upod, Centraal Diagnostisch Laboratorium, MS Interne Geneeskunde, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Circulatory Health, de Hond, Titus A.P., Niemantsverdriet, Michael S.A., van Solinge, Wouter W., Oosterheert, Jan Jelrik, Haitjema, Saskia, and Kaasjager, Karin A.H.

Published
2022

22. Transportability and Implementation Challenges of Early Warning Scores for Septic Shock in the ICU: A Perspective on the TREWScore

Author

CDL Upod, Sepsis and Inflammation, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Circulatory Health, CDL Arcadia, Centraal Diagnostisch Laboratorium, Medische Staf Intensive Care, Infection & Immunity, DVF Medisch, Niemantsverdriet, Michael S A, Varkila, Meri R J, Vromen-Wijsman, Jacqueline L P, Hoefer, Imo E, Bellomo, Domenico, van Vliet, Martin H, van Solinge, Wouter W, Cremer, Olaf L, Haitjema, Saskia, CDL Upod, Sepsis and Inflammation, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Circulatory Health, CDL Arcadia, Centraal Diagnostisch Laboratorium, Medische Staf Intensive Care, Infection & Immunity, DVF Medisch, Niemantsverdriet, Michael S A, Varkila, Meri R J, Vromen-Wijsman, Jacqueline L P, Hoefer, Imo E, Bellomo, Domenico, van Vliet, Martin H, van Solinge, Wouter W, Cremer, Olaf L, and Haitjema, Saskia

Published
2022

24. International practice variation in perioperative laboratory testing in glioblastoma patients-a retrospective cohort study

Author

Opleiding Neurochirurgie, Cancer, Centraal Diagnostisch Laboratorium, CDL Staf Patiëntenzorg KC, Infection & Immunity, Neurologen, Brain, Senders, Joeky T, Maas, Sybren L N, Draaisma, Kaspar, McNulty, John J, Ashby, Joanna L, Hofer, Imo, van Solinge, Wouter W, Berg, Maarten Ten, Snijders, Tom J, Seute, Tatjana, Robe, Pierre A, Gormley, William B, Smith, Timothy R, Broekman, Marike L D, Opleiding Neurochirurgie, Cancer, Centraal Diagnostisch Laboratorium, CDL Staf Patiëntenzorg KC, Infection & Immunity, Neurologen, Brain, Senders, Joeky T, Maas, Sybren L N, Draaisma, Kaspar, McNulty, John J, Ashby, Joanna L, Hofer, Imo, van Solinge, Wouter W, Berg, Maarten Ten, Snijders, Tom J, Seute, Tatjana, Robe, Pierre A, Gormley, William B, Smith, Timothy R, and Broekman, Marike L D

Published
2022

25. Redundant laboratory testing on referral from general practice to the outpatient clinic: a post-hoc analysis

Author

MS Interne Geneeskunde, NVIC bedrijfsvoering, CDL Staf Patiëntenzorg KC, Infection & Immunity, Centraal Diagnostisch Laboratorium, Circulatory Health, Vrijsen, Bram El, Ten Berg, Maarten J, van Solinge, Wouter W, Westerink, Jan, MS Interne Geneeskunde, NVIC bedrijfsvoering, CDL Staf Patiëntenzorg KC, Infection & Immunity, Centraal Diagnostisch Laboratorium, Circulatory Health, Vrijsen, Bram El, Ten Berg, Maarten J, van Solinge, Wouter W, and Westerink, Jan

Published
2022

26. Fluorescein angiography leads to increased fluorescence of blood cells and may hamper routine haematology analysis of ophthalmology patients

Author

Oogheelkunde Onderzoek, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, MS Oogheelkunde, Infection & Immunity, CDL Arcadia, Circulatory Health, de Groot, Evianne L., Huisman, Albert, van Solinge, Wouter W., Ossewaarde-van Norel, Jeannette, Haitjema, Saskia, Oogheelkunde Onderzoek, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, MS Oogheelkunde, Infection & Immunity, CDL Arcadia, Circulatory Health, de Groot, Evianne L., Huisman, Albert, van Solinge, Wouter W., Ossewaarde-van Norel, Jeannette, and Haitjema, Saskia

Published
2022

27. A Comprehensive Analysis of the Erythropoietin-erythroferrone-hepcidin Pathway in Hereditary Hemolytic Anemias

Author

Van Vuren, Annelies J., Sharfo, Alaa, Grootendorst, Simon T., Van Straaten, Stephanie, Punt, Arjen M., Petersen, Jesper B., El Fassi, Daniel, Van Solinge, Wouter W., Bartels, Marije, Van Wijk, Richard, Glenthøj, Andreas, Van Beers, Eduard J., Van Vuren, Annelies J., Sharfo, Alaa, Grootendorst, Simon T., Van Straaten, Stephanie, Punt, Arjen M., Petersen, Jesper B., El Fassi, Daniel, Van Solinge, Wouter W., Bartels, Marije, Van Wijk, Richard, Glenthøj, Andreas, and Van Beers, Eduard J.

Published
2021

28. A Comprehensive Analysis of the Erythropoietin-erythroferrone-hepcidin Pathway in Hereditary Hemolytic Anemias

Author

Van Vuren, Annelies J., Sharfo, Alaa, Grootendorst, Simon T., Van Straaten, Stephanie, Punt, Arjen M., Petersen, Jesper B., El Fassi, Daniel, Van Solinge, Wouter W., Bartels, Marije, Van Wijk, Richard, Glenthøj, Andreas, Van Beers, Eduard J., Van Vuren, Annelies J., Sharfo, Alaa, Grootendorst, Simon T., Van Straaten, Stephanie, Punt, Arjen M., Petersen, Jesper B., El Fassi, Daniel, Van Solinge, Wouter W., Bartels, Marije, Van Wijk, Richard, Glenthøj, Andreas, and Van Beers, Eduard J.

Published
2021

29. A Comprehensive Analysis of the Erythropoietin-erythroferrone-hepcidin Pathway in Hereditary Hemolytic Anemias

Author

Poli Van Creveldkliniek Medisch, CDL Rode cel, Centraal Diagnostisch Laboratorium, Haematologie patientenzorg, Child Health, CDL Arcadia, Circulatory Health, van Vuren, Annelies J, Sharfo, Alaa, Grootendorst, Simon T, van Straaten, Stephanie, Punt, Arjen M, Petersen, Jesper B, El Fassi, Daniel, van Solinge, Wouter W, Bartels, Marije, van Wijk, Richard, Glenthøj, Andreas, van Beers, Eduard J, Poli Van Creveldkliniek Medisch, CDL Rode cel, Centraal Diagnostisch Laboratorium, Haematologie patientenzorg, Child Health, CDL Arcadia, Circulatory Health, van Vuren, Annelies J, Sharfo, Alaa, Grootendorst, Simon T, van Straaten, Stephanie, Punt, Arjen M, Petersen, Jesper B, El Fassi, Daniel, van Solinge, Wouter W, Bartels, Marije, van Wijk, Richard, Glenthøj, Andreas, and van Beers, Eduard J

Published
2021

30. Defining the awake baseline blood pressure in patients undergoing carotid endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, Medische staf Anesthesiologie, CDL Arcadia, Circulatory Health, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Brain, UMC Utrecht, Fassaert, Leonie M, Heusdens, Julia F, Haitjema, Saskia, Hoefer, Imo E, van Solinge, Wouter W, van Wolfswinkel, Leo, Bijker, Jilles B, Immink, Rogier V, de Borst, Gert J, Zorgeenheid Vaatchirurgie Medisch, Medische staf Anesthesiologie, CDL Arcadia, Circulatory Health, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Brain, UMC Utrecht, Fassaert, Leonie M, Heusdens, Julia F, Haitjema, Saskia, Hoefer, Imo E, van Solinge, Wouter W, van Wolfswinkel, Leo, Bijker, Jilles B, Immink, Rogier V, and de Borst, Gert J

Published
2021

31. Metabolic fingerprint in hereditary spherocytosis correlates with red blood cell characteristics and clinical severity

Author

CDL Rode cel, Genetica Sectie Metabole Diagnostiek, Cancer, Child Health, Centraal Diagnostisch Laboratorium, Poli Van Creveldkliniek Medisch, Unit Opleiding Aios, Circulatory Health, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, Haematologie patientenzorg, CDL Arcadia, Van Dooijeweert, Birgit, Broeks, Melissa H., Verhoeven-Duif, Nanda M., Van Solinge, Wouter W., Van Beers, Eduard J., Rab, Minke A.E., Nieuwenhuis, Edward E.S., Jans, Judith J.M., Bartels, Marije, Van Wijk, Richard, CDL Rode cel, Genetica Sectie Metabole Diagnostiek, Cancer, Child Health, Centraal Diagnostisch Laboratorium, Poli Van Creveldkliniek Medisch, Unit Opleiding Aios, Circulatory Health, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, Haematologie patientenzorg, CDL Arcadia, Van Dooijeweert, Birgit, Broeks, Melissa H., Verhoeven-Duif, Nanda M., Van Solinge, Wouter W., Van Beers, Eduard J., Rab, Minke A.E., Nieuwenhuis, Edward E.S., Jans, Judith J.M., Bartels, Marije, and Van Wijk, Richard

Published
2021

32. Dried blood spot metabolomics reveals a metabolic fingerprint with diagnostic potential for Diamond Blackfan Anaemia

Author

CDL Rode cel, Genetica Sectie Metabole Diagnostiek, Cancer, Poli Van Creveldkliniek Medisch, Child Health, Centraal Diagnostisch Laboratorium, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Arcadia, Circulatory Health, Haematologie patientenzorg, van Dooijeweert, Birgit, Broeks, Melissa H, van Beers, Eduard J, Verhoeven-Duif, Nanda M, van Solinge, Wouter W, Nieuwenhuis, Edward E S, Jans, Judith J, van Wijk, Richard, Bartels, Marije, CDL Rode cel, Genetica Sectie Metabole Diagnostiek, Cancer, Poli Van Creveldkliniek Medisch, Child Health, Centraal Diagnostisch Laboratorium, MDL onderzoek 1, Onderzoek, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Arcadia, Circulatory Health, Haematologie patientenzorg, van Dooijeweert, Birgit, Broeks, Melissa H, van Beers, Eduard J, Verhoeven-Duif, Nanda M, van Solinge, Wouter W, Nieuwenhuis, Edward E S, Jans, Judith J, van Wijk, Richard, and Bartels, Marije

Published
2021

33. Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency

Author

CDL Rode cel, Genetica Sectie Metabole Diagnostiek, Genetica, Cancer, Child Health, Poli Van Creveldkliniek Medisch, Onderzoek, MDL onderzoek 1, Infection & Immunity, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Haematologie patientenzorg, CDL Arcadia, Circulatory Health, Van Dooijeweert, Birgit, Broeks, Melissa H, Verhoeven-Duif, Nanda M, Van Beers, Eduard J, Nieuwenhuis, Edward E S, Van Solinge, Wouter W, Bartels, Marije, Jans, Judith J, Van Wijk, Richard, CDL Rode cel, Genetica Sectie Metabole Diagnostiek, Genetica, Cancer, Child Health, Poli Van Creveldkliniek Medisch, Onderzoek, MDL onderzoek 1, Infection & Immunity, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Haematologie patientenzorg, CDL Arcadia, Circulatory Health, Van Dooijeweert, Birgit, Broeks, Melissa H, Verhoeven-Duif, Nanda M, Van Beers, Eduard J, Nieuwenhuis, Edward E S, Van Solinge, Wouter W, Bartels, Marije, Jans, Judith J, and Van Wijk, Richard

Published
2021

34. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes

Author

Unit Opleiding Aios, CDL Rode cel, Circulatory Health, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Centraal Diagnostisch Laboratorium, Poli Van Creveldkliniek Medisch, CDL Arcadia, Rab, Minke A E, van Oirschot, Brigitte A, Kosinski, Penelope A, Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, van Straaten, Stephanie, van Solinge, Wouter W, van Beers, Eduard J, Kung, Charles, van Wijk, Richard, Unit Opleiding Aios, CDL Rode cel, Circulatory Health, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Centraal Diagnostisch Laboratorium, Poli Van Creveldkliniek Medisch, CDL Arcadia, Rab, Minke A E, van Oirschot, Brigitte A, Kosinski, Penelope A, Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, van Straaten, Stephanie, van Solinge, Wouter W, van Beers, Eduard J, Kung, Charles, and van Wijk, Richard

Published
2021

35. Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis

Author

Huisjes, Rick, Makhro, Asya, Llaudet-Planas, Esther, Hertz, Laura, Petkova-Kirova, Polina, Verhagen, Liesbeth P, Pignatelli, Silvia, Rab, Minke A E, Schiffelers, Raymond M, Seiler, Elena, van Solinge, Wouter W, Vives Corrons, Joan-Luis, Mañú-Pereira, Maria, Kaestner, Lars, Bogdanova, Anna; https://orcid.org/0000-0003-0502-5381, van Wijk, Richard, Huisjes, Rick, Makhro, Asya, Llaudet-Planas, Esther, Hertz, Laura, Petkova-Kirova, Polina, Verhagen, Liesbeth P, Pignatelli, Silvia, Rab, Minke A E, Schiffelers, Raymond M, Seiler, Elena, van Solinge, Wouter W, Vives Corrons, Joan-Luis, Mañú-Pereira, Maria, Kaestner, Lars, Bogdanova, Anna; https://orcid.org/0000-0003-0502-5381, and van Wijk, Richard

Published
2020

36. Neutrophil fluorescence in clozapine users is attributable to a 14kDa secretable protein

Author

Ontwikkelingsstoornissen Med., Brain, Apotheek Opleiding, LKCH Medewerkers Bloedafname, CDL Staf Research, Circulatory Health, CDL Staf Patiëntenzorg KC, Infection & Immunity, Onderzoek, Centraal Diagnostisch Laboratorium, de With, Sera A.J., Man, Wai H., Maas, Coen, Ten Berg, Maarten, Cahn, Wiepke, Koekman, Arnold C., van Solinge, Wouter W., Tak, Tamar, Ontwikkelingsstoornissen Med., Brain, Apotheek Opleiding, LKCH Medewerkers Bloedafname, CDL Staf Research, Circulatory Health, CDL Staf Patiëntenzorg KC, Infection & Immunity, Onderzoek, Centraal Diagnostisch Laboratorium, de With, Sera A.J., Man, Wai H., Maas, Coen, Ten Berg, Maarten, Cahn, Wiepke, Koekman, Arnold C., van Solinge, Wouter W., and Tak, Tamar

Published
2020

37. Fragile neutrophils in surgical patients: A phenomenon associated with critical illness

Author

Zorgeenheid Traumatologie, Other research (not in main researchprogram), CDL Arcadia, CDL Staf Patiëntenzorg KC, Centraal Diagnostisch Laboratorium, Infection & Immunity, Experimentele Afdeling Longziekten, Hesselink, Lillian, Spijkerman, Roy, Hellebrekers, Pien, van Bourgondiën, Robert J, Blasse, Enja, Haitjema, Saskia, Huisman, Albert, van Solinge, Wouter W, Van Wessem, Karlijn J P, Koenderman, Leo, Leenen, Luke P H, Hietbrink, Falco, Zorgeenheid Traumatologie, Other research (not in main researchprogram), CDL Arcadia, CDL Staf Patiëntenzorg KC, Centraal Diagnostisch Laboratorium, Infection & Immunity, Experimentele Afdeling Longziekten, Hesselink, Lillian, Spijkerman, Roy, Hellebrekers, Pien, van Bourgondiën, Robert J, Blasse, Enja, Haitjema, Saskia, Huisman, Albert, van Solinge, Wouter W, Van Wessem, Karlijn J P, Koenderman, Leo, Leenen, Luke P H, and Hietbrink, Falco

Published
2020

38. Low-Density Lipoprotein Cholesterol Target Attainment in Patients With Established Cardiovascular Disease: Analysis of Routine Care Data

Author

Cardiovasculaire Epi Team 5, Circulatory Health, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, CDL Arcadia, Centraal Diagnostisch Laboratorium, MS Verloskunde, Child Health, Groenhof, T Katrien J, Kofink, Daniel, Bots, Michiel L, Nathoe, Hendrik M, Hoefer, Imo E, Van Solinge, Wouter W, Lely, A Titia, Asselbergs, Folkert W, Haitjema, Saskia, Cardiovasculaire Epi Team 5, Circulatory Health, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, CDL Arcadia, Centraal Diagnostisch Laboratorium, MS Verloskunde, Child Health, Groenhof, T Katrien J, Kofink, Daniel, Bots, Michiel L, Nathoe, Hendrik M, Hoefer, Imo E, Van Solinge, Wouter W, Lely, A Titia, Asselbergs, Folkert W, and Haitjema, Saskia

Published
2020

39. Reticulated Platelets as Predictor of Myocardial Injury and 30 Day Mortality After Non-cardiac Surgery

Author

Zorgeenheid Vaatchirurgie Medisch, Medische staf Anesthesiologie, Circulatory Health, Management Vitale Functies, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), CDL Arcadia, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Brain, Meershoek, Armelle J A, Leunissen, Tesse C, van Waes, Judith A R, Klei, Wilton A, Huisman, Albert, de Groot, Mark C H, Hoefer, Imo E, van Solinge, Wouter W, Moll, Frans L, de Borst, Gert J, Zorgeenheid Vaatchirurgie Medisch, Medische staf Anesthesiologie, Circulatory Health, Management Vitale Functies, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), CDL Arcadia, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Brain, Meershoek, Armelle J A, Leunissen, Tesse C, van Waes, Judith A R, Klei, Wilton A, Huisman, Albert, de Groot, Mark C H, Hoefer, Imo E, van Solinge, Wouter W, Moll, Frans L, and de Borst, Gert J

Published
2020

40. Unbound Fraction of Clozapine Significantly Decreases with Elevated Plasma Concentrations of the Inflammatory Acute-Phase Protein Alpha-1-Acid Glycoprotein

Author

Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R, Hugenholtz, Gerard W K, Bognár, Tim, Ten Berg, Maarten J, van Solinge, Wouter W, Egberts, Toine C G, van Maarseveen, Erik M, Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R, Hugenholtz, Gerard W K, Bognár, Tim, Ten Berg, Maarten J, van Solinge, Wouter W, Egberts, Toine C G, and van Maarseveen, Erik M

Abstract

BACKGROUND: During inflammation, elevated total (unbound plus protein-bound) clozapine plasma concentrations have been observed. Elevated alpha-1-acid glycoprotein concentrations during inflammation are suggested to cause increased plasma clozapine-alpha-1-acid glycoprotein binding, resulting in elevated total clozapine plasma concentrations without significant changes in unbound concentrations. Here, we investigated the association between alpha-1-acid glycoprotein plasma concentrations and clozapine unbound fraction.METHODS: First, 25 and 60 µL of alpha-1-acid glycoprotein solution (20 mg/mL) were added to plasma samples (n = 3) of clozapine users (spiking experiment). Second, the association between alpha-1-acid glycoprotein plasma concentration and clozapine unbound fraction was assessed in patient samples (patient study). Samples were determined by liquid chromatography-tandem mass spectrometry. Data were analyzed with a paired t test (spiking experiment) and an unpaired t test (patient study).RESULTS: The spiking experiment showed significantly lower mean unbound fractions following 25- and 60-µL alpha-1-acid glycoprotein spikes (relative reductions of 28.3%, p = 0.032 and 43.4%, p = 0.048). In the patient study, total clozapine plasma concentrations were 10% higher in elevated (n = 6) compared with normal alpha-1-acid glycoprotein (n = 20) samples [525 µg/L vs. 479 µg/L, mean difference = 47 µg/L (95% confidence interval -217 to 310), p = 0.72]. Elevated alpha-1-acid glycoprotein samples had a 26% lower mean unbound fraction compared with normal samples [1.22% vs. 1.65%, mean difference = -0.43% (95% confidence interval -0.816 to -0.0443), p = 0.03].CONCLUSIONS: Both the spiking experiment and patient study showed a significant association between elevated alpha-1-acid glycoprotein plasma concentrations and a lower clozapine unbound fraction. Future studies should include clinical data to examine whether this association is clinically

Published
2019

41. Data-gedreven integrale diagnostiek

Author

van Solinge, Wouter W., Ten Berg, Maarten J., Haitjema, Saskia, van Solinge, Wouter W., Ten Berg, Maarten J., and Haitjema, Saskia

Published
2019

42. Unbound Fraction of Clozapine Significantly Decreases with Elevated Plasma Concentrations of the Inflammatory Acute-Phase Protein Alpha-1-Acid Glycoprotein

Author

Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R., Hugenholtz, Gerard W.K., Bognár, Tim, ten Berg, Maarten J., van Solinge, Wouter W., Egberts, Toine A.C.G., van Maarseveen, Erik M., Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R., Hugenholtz, Gerard W.K., Bognár, Tim, ten Berg, Maarten J., van Solinge, Wouter W., Egberts, Toine A.C.G., and van Maarseveen, Erik M.

Published
2019

43. Association of a Multifaceted Intervention With Ordering of Unnecessary Laboratory Tests Among Caregivers in Internal Medicine Departments

Author

Bindraban, Renuka S, van Beneden, Marlou, Kramer, Mark H H, van Solinge, Wouter W, van de Ven, Peter M, Naaktgeboren, Christiana A, Al-Dulaimy, Muhammad, van der Wekken, Lena C, Bandt, Yvonne C, Stam, Frank, Neppelenbroek, Suzanne I M, Griffioen-Keijzer, Anita, Castelijn, Daan A R, Wevers, Brigitte A, Boerman, Anneroos W, van Wijnen, Merel, Ten Berg, Maarten J, Nanayakkara, Prabath W B, Bindraban, Renuka S, van Beneden, Marlou, Kramer, Mark H H, van Solinge, Wouter W, van de Ven, Peter M, Naaktgeboren, Christiana A, Al-Dulaimy, Muhammad, van der Wekken, Lena C, Bandt, Yvonne C, Stam, Frank, Neppelenbroek, Suzanne I M, Griffioen-Keijzer, Anita, Castelijn, Daan A R, Wevers, Brigitte A, Boerman, Anneroos W, van Wijnen, Merel, Ten Berg, Maarten J, and Nanayakkara, Prabath W B

Published
2019

46. Routine Blood Tests Do Not Predict Survival in Patients with Glioblastoma—Multivariable Analysis of 497 Patients

Author

Maas, Sybren L.N., Draaisma, Kaspar, Snijders, Tom J., Senders, Joeky T., Berendsen, Sharon, Seute, Tatjana, Schiffelers, Raymond M., van Solinge, Wouter W., Ten Berg, Maarten J., Robe, Pierre A., Broekman, Marike L.D., Maas, Sybren L.N., Draaisma, Kaspar, Snijders, Tom J., Senders, Joeky T., Berendsen, Sharon, Seute, Tatjana, Schiffelers, Raymond M., van Solinge, Wouter W., Ten Berg, Maarten J., Robe, Pierre A., and Broekman, Marike L.D.

Published
2019

47. A Rise in Neutrophil Cell Size Precedes Organ Dysfunction After Trauma

Author

Hesselink, Lillian, Heeres, Marjolein, Paraschiakos, Fotis, Ten Berg, Maarten, Huisman, Albert, Hoefer, Imo E., de Groot, Mark C.H., van Solinge, Wouter W., Dijkgraaf, Marcel, Hellebrekers, Pien, Van Wessem, Karlijn J.P., Koenderman, Leo, Leenen, Luke P.H., Hietbrink, Falco, Hesselink, Lillian, Heeres, Marjolein, Paraschiakos, Fotis, Ten Berg, Maarten, Huisman, Albert, Hoefer, Imo E., de Groot, Mark C.H., van Solinge, Wouter W., Dijkgraaf, Marcel, Hellebrekers, Pien, Van Wessem, Karlijn J.P., Koenderman, Leo, Leenen, Luke P.H., and Hietbrink, Falco

Published
2019

48. A single preoperative blood test predicts postoperative sepsis and pneumonia after coronary bypass or open aneurysm surgery

Author

van Koeverden, Ian D., den Ruijter, Hester M., Scholtes, Vincent P.W., G. E. H. Lam, Marnix, Haitjema, Saskia, Buijsrogge, Marc P., J. L. Suyker, Willem, van Wijk, Richard H., de Groot, Mark C.H., van Herwaarden, Joost A., van Solinge, Wouter W., de Borst, Gert J., Pasterkamp, Gerard, Hoefer, Imo E., van Koeverden, Ian D., den Ruijter, Hester M., Scholtes, Vincent P.W., G. E. H. Lam, Marnix, Haitjema, Saskia, Buijsrogge, Marc P., J. L. Suyker, Willem, van Wijk, Richard H., de Groot, Mark C.H., van Herwaarden, Joost A., van Solinge, Wouter W., de Borst, Gert J., Pasterkamp, Gerard, and Hoefer, Imo E.

Published
2019

49. A Human(e) Factor in Clinical Decision Support Systems

Author

Bezemer, Tim, De Groot, Mark C.H., Blasse, Enja, Ten Berg, Maarten J., Kappen, Teus H., Bredenoord, Annelien L., Van Solinge, Wouter W., Hoefer, Imo E., Haitjema, Saskia, Bezemer, Tim, De Groot, Mark C.H., Blasse, Enja, Ten Berg, Maarten J., Kappen, Teus H., Bredenoord, Annelien L., Van Solinge, Wouter W., Hoefer, Imo E., and Haitjema, Saskia

Published
2019

50. Unbound Fraction of Clozapine Significantly Decreases with Elevated Plasma Concentrations of the Inflammatory Acute-Phase Protein Alpha-1-Acid Glycoprotein

Author

Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R, Hugenholtz, Gerard W K, Bognár, Tim, Ten Berg, Maarten J, van Solinge, Wouter W, Egberts, Toine C G, van Maarseveen, Erik M, Man, Wai Hong, Wilting, Ingeborg, Heerdink, Eibert R, Hugenholtz, Gerard W K, Bognár, Tim, Ten Berg, Maarten J, van Solinge, Wouter W, Egberts, Toine C G, and van Maarseveen, Erik M

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results