1,173 results on '"A. Fazzio"'
Search Results
2. Uncovering the Structural Evolution of Arsenene on SiC Substrate
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Anderson K. Okazaki, Rafael Furlan de Oliveira, Rafael Luiz Heleno Freire, Adalberto Fazzio, and Felipe Crasto de Lima
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Condensed Matter - Materials Science ,General Energy ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Physical and Theoretical Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Two-dimensional arsenic allotropes have been grown on metallic surfaces, while topological properties have been theoretically described on strained structures. Here we experimentally grow arsenene by molecular beam epitaxy over the insulating SiC substrate. The arsenene presents a flat structure with a strain field that follows the SiC surface periodicity. Our ab initio simulations, based on the density functional theory, corroborate the experimental observation. The strained structure presents a new arsenene allotrope with a triangular structure, rather than the honeycomb previously predicted for other pnictogens. This strained structure presents a Peierls-like transition leading to an indirect gap semiconducting behavior.
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- 2023
3. Metodologie di rilevamento dati e analisi per la valutazione del Piano di Protezione Civile comunale
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Valentina Tomassoni, Angelo Gigliotti, Fabrizio Bramerini, Gianluca Carbone, Francesco Fazzio, and Cora Fontana
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Urban Studies ,Visual Arts and Performing Arts ,Geography, Planning and Development - Abstract
L'importanza del Piano di Protezione Civile, come strumento utile alla mitigazione dei rischi e al miglioramento dell'efficacia degli interventi in emergenza, è questione consolidata in letteratura. Le attività di preparazione, che definiscono in anticipo scenari di rischio attesi, attori coinvolti, procedure di intervento, risorse necessarie e disponibili, sono un presupposto indispensabile per garantire una tempestiva risposta in emergenza. L'articolo descrive una scheda di rilevamento dati proposta dagli autori e finalizzata all'analisi del Piano. Applicata in questa fase su un campione di 10 Piani, la scheda fornisce uno strumento di analisi utile a valutare quelle componenti dei Piani che richiedono un miglioramento e ad orientarne la revisione in vista di una maggiore incisività.
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- 2023
4. Redescription of Neocarus platensis Silvestri, 1905 (Acari: Opilioacaridae) and a new species from the syntype series
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MARCEL SANTOS DE ARAÚJO, ANTONELLA DI PALMA, REINALDO JOSÉ FAZZIO FERES, and ANGELICA MARIA PENTEADO-DIAS
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Arthropoda ,Arachnida ,Opilioacaridae ,Animalia ,Animal Science and Zoology ,Biodiversity ,Opilioacarida ,Ecology, Evolution, Behavior and Systematics ,Taxonomy - Abstract
Neocarus platensis is redescribed from part of the syntype series collected in Argentina and lectotype specimens are designated. The remaining syntype material from Uruguay represents a new species, herein named Neocarus paraplatensis sp. nov. Taxonomic problems within the Opilioacaridae are discussed in light of a comparative morphological discussion including setae quantity variation.
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- 2023
5. HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor
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Idam, de Oliveira-Junior, Flávia Fazzio, Barbin, Anapaula Hidemi Uema, Watanabe, Ricardo, Dos Reis, and René Aloisio, da Costa Vieira
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Cancer Research ,Oncology ,Papillomavirus Infections ,Carcinoma, Squamous Cell ,Humans ,Uterine Cervical Neoplasms ,Female ,Breast Neoplasms ,Breast ,General Medicine - Abstract
INTRODUCTION: Metastatic disease to the breast is a rare condition, with contralateral breast metastasis being the most common primary site. CASE PRESENTATION: We present the case of a patient who underwent treatment for an HPV positive squamous cell carcinoma (SCC) of the cervix who, during follow-up, complained of a nodule in her left breast. Anatomopathological results indicating squamous carcinoma, which was not able to be differentiated from breast metaplastic carcinoma. Resection of the lesion was carried out, confirming carcinoma with squamous cell differentiation with negativity for GCDFP-15, mammaglobin, p63 and SOX10, but with positivity for p16 and for high risk HPV, confirming a single metastatic lesion of cervical carcinoma. DISCUSSION/CONCLUSION: In the presence of SCC in the breast, the differential diagnosis may consider the presence of primary lesion, metaplastic carcinoma with squamous cell differentiation or metastatic disease. The use of markers such as p63, SOX10 and p16, may help for a definitive diagnosis.
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- 2022
6. Unveiling electrical anisotropy of hierarchical pyrolytic biocarbons from wood cellulose
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Marcus Vinicius de Paiva, Jefferson Bettini, Felippe Mariano Colombari, Adalberto Fazzio, and Mathias Strauss
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2022
7. A Note on the McCormick Second-Order Constraint Qualification
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FAZZIO, N. S., NCHEZ, M. D. SÁ, and SCHUVERDT, M. L.
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constraint qualification ,Nonlinear programming ,General Medicine ,second-order optimality conditions - Abstract
The study of optimality conditions and constraint qualification is a key topic in nonlinear optimization. In this work, we present a reformulation of the well-known second-order constraint qualification described by McCormick in [17]. This reformulation is based on the use of feasible arcs, but is independent of Lagrange multipliers. Using such a reformulation, we can show that a local minimizer verifies the strong second-order necessary optimality condition. We can also prove that the reformulation is weaker than the known relaxed constant rank constraint qualification in [19]. Furthermore, we demonstrate that the condition is neither related to the MFCQ+WCR in [8] nor to the CCP2 condition, the companion constraint qualification associated with the second-order sequential optimality condition AKKT2 in [5].
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- 2022
8. Substrate suppression of oxidation process in pnictogen monolayers
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Freire, R. L. H., de Lima, F. Crasto, and Fazzio, A.
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Condensed Matter - Materials Science ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences - Abstract
2D materials present an interesting platform for device designs. However, oxidation can drastically change the system's properties, which need to be accounted for. Through {\it ab initio} calculations, we investigated freestanding and SiC-supported As, Sb, and Bi mono-elemental layers. The oxidation process occurs through an O$_2$ spin-state transition, accounted for within the Landau-Zener transition. Additionally, we have investigated the oxidation barriers and the role of spin-orbit coupling. Our calculations pointed out that the presence of SiC substrate reduces the oxidation time scale compared to a freestanding monolayer. We have extracted the energy barrier transition, compatible with our spin-transition analysis. Besides, spin-orbit coupling is relevant to the oxidation mechanisms and alters time scales. The energy barriers decrease as the pnictogen changes from As to Sb to Bi for the freestanding systems, while for SiC-supported, they increase across the pnictogen family. Our computed energy barriers confirm the enhanced robustness against oxidation for the SiC-supported systems.
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- 2023
9. Implications of Anion Structure on Physicochemical Properties of DBU-Based Protic Ionic Liquids
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Giselle de Araujo Lima e Souza, Maria Enrica Di Pietro, Franca Castiglione, Pedro Henrique Marques Mezencio, Patricia Fazzio Martins Martinez, Alessandro Mariani, Hanno Maria Schütz, Stefano Passerini, Maleen Middendorf, Monika Schönhoff, Alessandro Triolo, Giovanni Battista Appetecchi, and Andrea Mele
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ionic liquids ,NMR spectroscopy ,Materials Chemistry ,conductivity ,Physical and Theoretical Chemistry ,ionic liquids, NMR spectroscopy, calorimetry, lithium ion batteries, conductivity ,calorimetry ,lithium ion batteries ,Surfaces, Coatings and Films - Abstract
Protic ionic liquids (PILs) are potential candidates as electrolyte components in energy storage devices. When replacing flammable and volatile organic solvents, PILs are expected to improve the safety and performance of electrochemical devices. Considering their technical application, a challenging task is the understanding of the key factors governing their intermolecular interactions and physicochemical properties. The present work intends to investigate the effects of the structural features on the properties of a promising PIL based on the 1,8-diazabicyclo[5.4.0]undec-7-ene (DBUH
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- 2022
10. Role of Functional Thiolated Molecules on the Enhanced Electronic Transport of Interconnected MoS2 Nanostructures
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Rafael L. H. Freire, Felipe Crasto de Lima, Rafael Furlan de Oliveira, Rodrigo B. Capaz, and Adalberto Fazzio
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Condensed Matter - Materials Science ,General Energy ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Physical and Theoretical Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Molecular linkers have emerged as an effective strategy to improve electronic transport properties on solution-processed layered materials via defect functionalization. However, a detailed discussion on the microscopic mechanisms behind the beneficial effects of functionalization is still missing. Here, by first-principles calculations based on density functional theory, we investigate the effects on the electronic properties of interconnected MoS$_2$ model flakes systems upon functionalization with different thiol molecule linkers, namely thiophenol, 1,4-benzenedithiol, 1,2-ethanedithiol, and 1,3-propanedithiol. The bonding of benzene- and ethanedithiol bridging adjacent armchair MoS$_2$ nanoflakes leads to electronic states just above or at the Fermi level, thus forming a molecular channel for electronic transport between flakes. In addition, the molecular linker reduces the potential barrier for thermally activated hopping between neighboring flakes, improving the conductivity as verified in experiments. The comprehension of such mechanisms helps in future developments of solution-processed layered materials for use on 2D electronic devices.
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- 2022
11. Linear Jacobi-Legendre expansion of the charge density for machine learning-accelerated electronic structure calculations
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Focassio, Bruno, Domina, Michelangelo, Patil, Urvesh, Fazzio, Adalberto, and Sanvito, Stefano
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linear model ,Condensed Matter - Materials Science ,charge density ,Mechanics of Materials ,Modeling and Simulation ,Machine learning ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,General Materials Science ,density functional theory ,Computer Science Applications - Abstract
This dataset contains DFT inputs and outputs consisting of POSCAR, CHGCAR and vasprun.xml files from the code VASP, scripts and code to generate the fingerprints using the Jacobi-Legendre many-body expansion of local atomic environments, machine learning trained models and related scripts to create CHGCAR files from machine learning models., The files in this dataset can be used in conjunction with up-to-date code from the following GitHub repository: https://github.com/StefanoSanvitoGroup/MLdensity
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- 2023
12. Statistical Analysis Plan for a Cluster Randomised trial in Madhya Pradesh, India: support to rural India’s public education system and impact on numeracy and literacy scores (STRIPES2)
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Suzanne Keddie, Ila Fazzio, Siddharudha Shivalli, Nicholas Magill, Diana Elbourne, Dropti Sharma, Sajjan Singh Shekhawat, Rukmini Banerji, Sridevi Karnati, Harshavardhan Reddy, Alex Eble, Peter Boone, and Chris Frost
- Abstract
Background India has made steady progress in improving rates of primary school enrolment but levels of learning achievement remain low. The Support To Rural India’s Public Education System (STRIPES) trial provided evidence that an after-school para-teacher intervention improved numeracy and literacy levels in Telangana, India. The STRIPES2 trial investigates whether such an intervention will have a similar effect on the literacy and numeracy of primary school age children in the Satna District of Madhya Pradesh, India. Methods/design The STRIPES2 trial forms one part of a cluster-randomised controlled trial with villages (clusters) randomised to receive either a health (CHAMPION2) or education (STRIPES2) intervention. Building on the design of the earlier CHAMPION/STRIPES trial, villages receiving the health intervention are controls for the education intervention and vice versa. The primary outcome is a combined literacy and numeracy score. Secondary outcomes include separate scores for literacy and numeracy; caregivers’ engagement with child’s learning; expenditure on education; enrolment in school; parent’s report of school attendance and the cost effectiveness of the intervention. Over 7000 primary school age children have been recruited and randomised in STRIPES2. Discussion This update to the published trial protocol gives a detailed plan for the statistical analysis of the STRIPES 2 trial. Trial registration. Registry of India: CTRI/2019/05/019296. Registered on 23 May 2019
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- 2023
13. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
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Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya N. Parikh, Yvette Lopez-Diaz, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Sachliv K. Chana, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, and Marcus Ruscetti
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Cancer Research ,Oncology - Published
- 2023
14. Supplementary Figure legend from Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells
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Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, and Guodong Tie
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supplementary figure legends
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- 2023
15. Data from Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells
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Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, and Guodong Tie
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Obesity will soon surpass smoking as the most preventable cause of cancer. Hypercholesterolemia, a common comorbidity of obesity, has been shown to increase cancer risk, especially colorectal cancer. However, the mechanism by which hypercholesterolemia or any metabolic disorder increases cancer risk remains unknown. In this study, we show that hypercholesterolemia increases the incidence and pathologic severity of colorectal neoplasia in two independent mouse models. Hypocholesterolemia induced an oxidant stress–dependent increase in miR101c, which downregulated Tet1 in hematopoietic stem cells (HSC), resulting in reduced expression of genes critical to natural killer T cell (NKT) and γδ T-cell differentiation. These effects reduced the number and function of terminally differentiated NKT and γδ T cells in the thymus, the colon submucosa, and during early tumorigenesis. These results suggest a novel mechanism by which a metabolic disorder induces epigenetic changes to reduce lineage priming of HSC toward immune cells, thereby compromising immunosurveillance against cancer. Cancer Res; 77(9); 2351–62. ©2017 AACR.
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- 2023
16. Supplementary Methods from Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells
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Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, and Guodong Tie
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supplementary methods
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- 2023
17. Supplementary Figures and Table from Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells
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Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, and Guodong Tie
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This file contains 9 supplemental figures and one supplemental table in which we show that WT recipient mice reconstituted with HSCs from hypercholesterolemic ApoE-/- mice have normal serum cholesterol levels and white blood cell counts (S1); Hypercholesterolemia reduces the frequency and alters specific subsets and maturation of NKT and gammadelta T cells in the thymus (S2); Hypercholesterolemia-induced oxidant stress in HSCs strongly correlates with the incidence of AOM-induced colorectal neoplasia (S3); The frequency of T cell intermediate populations in thymus and cellular components related to cancer immunosurveillance in peripheral blood and colon of WT and Tet-/- mice (S4); The expression of Tet1 determines the differentiation of HSCs towards NKT and gammadelta T cells in vitro (S5); The expression of miRNA in HSCs from hypercholesterolemic mice (S6); That In HSCs, Tet1 overexpression reduces the expression of the key regulatory genes in their differentiation of NKT and gammadeltaT cells (S7); That Tet1 regulates H3K4me3 modification of the key regulatory genes in the differentiation of HSCs towards NKT and gammadeltaT cells in vitro (S8); That oxLDL impairs the differentiation of human HSCs towards NKT and gammadelta T cells in vitro (S9); and the genes related to the differentiation of NKT and gammadelta T cells (Supplemental Table 1).
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- 2023
18. Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry
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Pazdernik, Michal, Iung, Bernard, Mutlu, Bulent, Alla, François, Riezebos, Robert, Kong, William, Nunes, Maria Carmo Pereira, Pierard, Luc, Srdanovic, Ilija, Yamada, Hirotsugu, de Martino, Andrea, Miglioranza, Marcelo Haertel, Magne, Julien, Piper, Cornelia, Laroche, C. cile, Maggioni, Aldo P., Lancellotti, Patrizio, Habib, Gilbert, Selton-Suty, Christine, Ronderos, R., Avegliano, G., Oses, P. Fernandez, Filipini, E., Granada, I., Iribarren, A., Mahia, M., Nacinovich, F., Ressi, S., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M. L., Novas, V., Shigel, C., Reyes, G., de Santos, M., Gastaldello, N., Fernandez, M. Granillo, Potito, M., Streitenberger, G., Velazco, P., Casabé, J. H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C. Y., Perschy, L., Puskas, L., Goliasch, G., Binder, C., Rosenhek, R., Schneider, M., Winter, M. P., Hoffer, E., Melissopoulou, M., Lecoq, E., Legrand, D., Jacquet, S., Massoz, M., Lancellotti, P., Pierard, L., Dulgheru, R., Marchetta, S., D´Emal, C., Oury, C., Cosyns, B., Droogmans, S., Kerkhove, D., Motoc, A., Plein, D., Roosens, B., Soens, L., Weytjens, C., Lemoine, I., Rodrigus, I., Paelinck, B., Amsel, B., Unger, P., Konopnicki, D., Beauloye, C., Pasquet, A., Pierard, S., Vancraeynest, D., Vanoverschelde, J. L., Sinnaeve, F., Andrade, J. L., Rodrigues, A. C. Tude, Staszko, K., Dos Santos Monteiro, R., Miglioranza, M. H., Shuha, D. L., Alcantara, M., Cravo, V., Fazzio, L., Felix, A., Iso, M., Musa, C., Siciliano, A. P., Filho, F. Villaca, Braga, J., Rodrigues, A., Silva, R., Vilela, F., Rodrigues, D., Silva, L., Morhy, S., Fischer, C., Vieira, M., Afonso, T., Abreu, J., Falcao, S. N., Moises, V., Gouvea, A., João, G., Mancuso, F., Silva, C., Souza, A. C., Abboud, C. S., de Mattos Barretto, R. Bellio, Ramos, A., Arnoni, R., Assef, J. E., Togna, D. J. Della, le Bihan, D., Miglioli, L., Oliveira, A. P. Romero, Kroll, R. Tadeu Magro, Cortez, D., Gelape, C. L., Nunes, M. d. C. Peirira, de Abreu Ferrari, T. C., Chan, K. L., Hay, K., le, V., Page, M., Poulin, F., Sauve, C., Serri, K., Mercure, C., Beaudoin, J., Pibarot, P., Sebag, I., Rudski, L., Ricafort, G., Barsic, B., Krajinovic, V., Vargovic, M., Separovic-Hanzevacki, J., Lovric, D., Reskovic-Luksic, V., Vincelj, J., Jurinjak, S. Jaksic, Yiannikourides, V., Ioannides, M., Kyriakou, C., Pofaides, C., Masoura, V., Yiangou, K., Pudich, J., Linhart, A., Siranec, M., Marek, J., Blechova, K., Kamenik, M., Pazdernik, M., Pelouch, R., Coufal, Z., Mikulica, M., Griva, M., Jancova, E., Mikulcova, M., Taborsky, M., Precek, J., Jecmenova, M., Latal, J., Widimsky, J., Butta, T., Machacek, S., Vancata, R., Spinar, J., Holicka, M., Long, F. Pow Chon, Anzules, N., Carpio, A. Bajana, Largacha, G., Penaherrera, E., Moreira, D., Mahfouz, E., Elsafty, E., Soliman, A., Zayed, Y., Aboulenein, J., Abdel-Hay, M., Almaghraby, A., Abdelnaby, M., Ahmed, M., Hammad, B., Saleh, Y., Zahran, H., Elgebaly, O., Saad, A., Ali, M., Zeid, A., Sharkawy, R. El, Meshaal, M., Al Kholy, A., Doss, R., Osama, D., Rizk, H., Elmogy, A., Mishriky, M., Assayag, P., Hatimi, S. El, Botelho-Nevers, Saint- E., Campisi, S., Fuzellier, J. F., Gagneux-Brunon, A., Pierrard, R., Tulane, C., Detoc, M., Mehalla, T., Boutoille, D., Al Habash, O., Asseray-Madani, N., Biron, C., Brochard, J., Caillon, J., Cueff, C., le Tourneau, T., Lecompte, A. S., Lecomte, R., Lefebvre, M., Michel, M. M. Magali, Pattier, S., Delarue, S., le Bras, M., Orain, J., Faucher, J. F., Aboyans, V., Beeharry, A., Durox, H., Lacoste, M., Magne, J., Mohty, D., David, A., Pradel, V., Sierra, V., Neykova, A., Bettayeb, B., Elkentaoui, S., Tzvetkov, B., Landry, G., Strady, C., Ainine, K., Baumard, S., Brasselet, C., Tassigny, C., Valente-Pires, V., Lefranc, M., Hoen, B., Lefevre, B., Curlier, E., Callier, C., Fourcade, N., Jobic, Y., Ansard, S., le Berre, R., le Roux, P., le Ven, F., Pouliquen, M. C., Prat, G., Bouchart, F., Savoure, A., Alarcon, C., Chapuzet, C., Gueit, I., Tribouilloy, C., Bohbot, Y., Peugnet, F., Gun, M., Iung, B., Duval, X., Lescure, X., Ilic-Habensus, E., Sadoul, N., Selton-Suty, C., Alla, F., Chevalier, E., Goehringer, F., Huttin, O., Garcia, R., le Marcis, V., Tattevin, P., Donal, E., Flecher, E., Revest, M., Habib, G., Hubert, S., Casalta, J. P., Gouriet, F., Arregle, F., Cammilleri, S., Tessonnier, L., Riberi, A., Chirouze, C., Bouiller, K., Brunel, A. S., Fournier, D., Hustache-Mathieu, L., Klopfenstein, T., Moreau, J., Lim, P., Oliver, L., Ternacle, J., Moussafeur, A., Chavanet, P., Piroth, L., Buisson, M., Mahy, S., Martins, C., Salmon-Rousseau, A., Gohier, S., Piper, C., Börgermann, J., Guckel, D., Horstkotte, D., Brockmeier, B., Winkelmann, E., Hagendorff, A., Grey, D., Nickenig, G., Schueler, R., Öztürk, C., Stöhr, E., Hamm, C., Walther, T., Brandt, R., Frühauf, A. C., Hartung, C. T., Hellner, C., Wild, C., Becker, M., Hamada, S., Kaestner, W., Stangl, K., Knebel, F., Baldenhofer, G., Brecht, A., Dreger, H., Isner, C., Pfafflin, F., Stegemann, M., Zahn, R., Fraiture, B., Kilkowski, C., Karcher, A. K., Klinger, S., Tolksdorf, H., Tousoulis, D., Aggeli, C., Sarri, G., Sideris, S., Venieri, E., Athanassopoulos, G., Tsiapras, D., Armenis, I., Koutsiari, A., Floros, G., Grassos, C., Dragasis, S., Rallidis, L., Varlamos, C., Michalis, L., Naka, K., Bechlioulis, A., Kotsia, A., Lakkas, L., Pappas, K., Papadopoulos, C., Kiokas, S., Lioni, A., Misailidou, S., Barbetseas, J., Bonou, M., Kapelios, C., Tomprou, I., Zerva, K., Manolis, A., Hamodraka, E., Athanasiou, D., Haralambidis, G., Poulimenos, L., Samaras, H., Nagy, A., Bartykowszki, A., Gara, E., Sengupta, S., Mungulmare, K., Kasliwal, R., Bansal, M., Bhan, A., Ranjan, S., Kyavar, M., Maleki, M., Bezanjani, F. Noohi, Sadeghpour, A., Alizadehasl, A., Boudagh, S., Ghavidel, A., Moradnejad, P., Pasha, H. R., Ghadrdoost, B., Gilon, D., Strahilevitz, J., Israel, S., Wanounou, M., d’Agostino, C., Colonna, P., de Michele, L., Fumarola, F., Stante, M., Marchionni, N., Scheggi, V., Alterini, B., del Pace, S., Stefano, P., Sparano, C., Badano, L. P., Muraru, D., Ruozi, N., Tenaglia, R., Limbruno, U., Cresti, A., Baratta, P., Solari, M., Giannattasio, C., Moreo, A., de Chiara, B., Montero, B. Lopez, Musca, F., Orcese, C. A., Panzeri, F., Russo, C. F., Spano, F., Alfieri, O., de Bonis, M., Agricola, E., Busnardo, E., Carletti, S., Castiglioni, B., Chiappetta, S., del Forno, B., Ferrara, D., Guffanti, M., Iaci, G., Lapenna, E., Nisi, T., Oltolini, C., Pajoro, U., Pasciuta, R., Ripa, M., Scarpellini, P., Din, C. Tassan, Meneghin, R., Schiavi, D., Piscione, F., Citro, R., Benvenga, R. M., Greco, L., Prota, C., Radano, I., Soriente, L., Bellino, M., di Vece, D., Santini, F., Salsano, A., Olivieri, G. M., Turrini, F., Messora, R., Tondi, S., Olaru, A., Agnoletto, V., Grassi, L., Leonardi, C., Sansoni, S., del Ponte, S., Dato, G. M. Actis, de Martino, A., Ohte, N., Kikuchi, S., Wakami, K., Aonuma, K., Seo, Y., Ishizu, T., Machino-Ohtsuka, T., Yamamoto, M., Iida, N., Nakajima, H., Nakagawa, Y., Izumi, C., Amano, M., Miyake, M., Takahashi, K., Shiojima, I., Miyasaka, Y., Maeba, H., Suwa, Y., Taniguchi, N., Tsujimoto, S., Kitai, T., Ota, M., Yuda, S., Sasaki, S., Hagiwara, N., Yamazaki, K., Ashihara, K., Arai, K., Saitou, C., Saitou, S., Suzuki, G., Shibata, Y., Watanabe, N., Nishino, S., Ashikaga, K., Kuriyama, N., Mahara, K., Abe, K., Fujimaki, H., Okubo, T., Shitan, H., Takanashi, S., Terada, M., Yamamoto, H., Sata, M., Yamada, H., Kusunose, K., Saijo, Y., Seno, H., Yuichiro, O., Sakata, Y., Mizuno, H., Nakatani, S., Onishi, T., Sengoku, K., Sera, F., Park, S. W., Kyoung, K. Eun, Yeon, L. Ga, Hwang, J. W., Jin-Oh, C., Park, S. J., Sang-Chol, L., Sung-A, C., Jang, S. Y., Kang, D. H., Heo, R., Lee, S., Song, J. M., Jung, E., Plisiene, J., Dambrauskaite, A., Gruodyte, G., Jonkaitiene, R., Vaskelyte, J., Mizariene, V., Atkocaityte, J., Zvirblyte, R., Sow, R., Codreanu, A., de la Vega, E. C. L., Michaux, C., Staub, T., Jacobs-Orazi, L., Azzopardi, C. Mallia, Xuereb, R. G., Piscopo, T., Borg, D., Casha, R., Farrugia, J., Fenech, M., Pllaha, E., Vella, C., Yamagata, K., Grib, L., Raevschi, E., Grejdieru, A., Balan, G., Cardaniuc, I., Cardaniuc, L., Corcea, V., Feodorovici, A., Gaina, V., Girbu, L., Jimbei, P., Kravcenco, D., Panfile, E., Prisacari, E., Samohvalov, E., Samohvalov, S., Sceglova, N., Benesco, I., Marian, V., Sumarga, N., Mirocevic, M., Bozovic, B., Bulatovic, N., Lakovic, P., Music, L., Roos-Hesselink, J., Budde, R., Gamela, T., Wahadat, A., Kamp, O., Meijers, T., van Melle, J. P., Deursen, V. M., Crijns, H., Bekkers, S., Cheriex, E., Gilbers, M., Kietselaer, B., Knackstedt, C., Lorusso, R., Schalla, S., Streukens, S., Chamuleau, S., Cramer, M. J., Teske, A., van der Spoel, T., Wind, A., Liesbek, O., Lokhorst, J., van Heusden, H., Tanis, W., van der Bilt, I., Vriend, J., de Lange-van Bruggen, H., Karijodikoro, E., Riezebos, R., van Dongen, E., Schoep, J., Stolk, V., Axler, O., Baumann, F., Lebras, S., Edvardsen, T., Offstad, J. T., Beitnes, J. O., Helle-Valle, T., Skulstad, H., Skardal, R., Qamar, N., Furnaz, S., Ahmed, B., Butt, M. H., Khanzada, M. F., Saghir, T., Wahid, A., Hryniewiecki, T., Szymanski, P., Marzec, K., Misztal-Ogonowska, M., Kosmala, W., Przewlocka-Kosmala, M., Rojek, A., Woznicka, K., Zachwyc, J., Lisowska, A., Kaminska, M., Kasprzak, J., Kowalczyk, E., Strzecka, D. F., Wejner-Mik, P., Trabulo, M., Freitas, P., Ranchordas, S., Rodrigues, G., Pinto, P., Queiros, C., Azevedo, J., Marques, L., Seabra, D., Branco, L., Cruz, M., Galrinho, A., Moreira, R., Rio, P., Timoteo, A. T., Selas, M., Cardim, N. M., Carmelo, V., Neves, B. Duque, Pereira, H., Cruz, I., Guerra, A., Marques, A., Pintassilgo, I., Tomescu, M. C., Trofenciuc, N. M., Andor, M., Bordejevic, A., Branea, H. S., Caruntu, F., Cirin, L., Citu, I. M., Cotoraci, C. A., Darabantiu, D., Farcas, R., Marincu, I., Mavrea, A., Onel, M. F., Parvanescu, T., Pop, D., Pop-Moldovan, A. L., Puticiu, M. I., Velcean, L. A., Ionac, A., Cozma, D., Mornos, C., Goanta, F., Popescu, I., Beyer, R., Mada, R., Rancea, R., Rosianu, H., Tomoaia, R., Stanescu, C., Kobalava, Z., Karaulova, J., Kotova, E., Milto, A., Pisaryuk, A., Povalyaev, N., Sorokina, M., Alrahimi, J., Elshiekh, A., Jamiel, A., Ahmed, A., Al-Mallah, M., Attia, N., Putnikovic, B., Neskovic, A., Dimic, A., Ivanovic, B., Matic, S., Trifunovic, D., Petrovic, J., Kosevic, D., Dabic, P., Milojevic, P., Petrovic, I., Stojanovic, I., Srdanovic, I., Kovacevic, M., Redzek, A., Stefanovic, M., Susak, S., Velicki, L., Vulin, A., Yeo, T. C., Kong, W. K. F., Poh, K. K., Vilacosta, I., Nasser, M. Abd El, Ferrera, C., Olmos, C., Iglesias, F. Calvo, Blanco-Gonzalez, E., Amaro, M. Bravo, Germinas, A. N., Lopez-Rodriguez, E., Adan, J. Lugo, Pazos-Lopez, P., Loureiro, M. Pereira, Perez, M. T., Raposeiras-Roubin, S., Yas, S. Rasheed, Suarez-Varela, M. M., Vidal, F. Vasallo, Garcia-Dorado, D., Sambola, A., Fernandez-Hidalgo, N., Gonzalez-Alujas, T., Lozano, J., Maisterra, O., Pizzi, N., Rios, R., Tornos, P., Bayes-Genis, A., Botet, L. Pedro, Vallejo, N., Berastegui, E., Llibre, C., Mateu, L., Nunez, R., Quesada, D., Portell, D. Bosch, Vinas, J. Aboal, Bertran, X. Albert, Tarradellas, R. Brugada, Ricon, P. Loma-Osorio, de Llano, C. Tiron, Arnau, M. A., Bel, A., Blanes, M., Osa, A., Anguita, M., Carrasco, F., Castillo, J., Zamorano, J. L., Mur, J. L. Moya, Alvaro, M., Fernandez-Golfin, C., Monteagudo, J. M., Elorza, E. Navas, Alvarez, M. C. Farinas, Balbin, J. Aguero, Arminanzas, C., de las Revillas, F. Arnaiz, Garcia, A. Arnaiz, Belaustegui, M. Cobo, Sampedro, M. Fernandez, Cuadra, M. Gutierrez, Gutierrez-Diez, J. F., Zarauza, J., Cuello, L. Garcia, Rico, C. Gonzalez, Rodriguez-Alvarez, R., Goikoetxea, J., Montejo, M., Miro, J., Almela, M., Ambrosioni, J., Falces, C., Fuster, D., Garcia-de-la-Maria, C., Hernandez-Meneses, M., Llopis, J., Marco, F., Moreno, A., Quintana, E., Sandoval, E., Tellez, A., Tolosana, J. M., Vidal, B., Ruiz-Zamora, I., Ruiz, A. Bardaji, Girgas, E. Sanz, Garcia-Pardo, G., Marzo, M. Guillen, Oviedo, A. Rodriguez, Jimenez, A. Villares, Abid, L., Hammami, R., Kammoun, S., Mourali, M. S., Zghal, F. Mghaieth, Hlima, M. Ben, Boudiche, S., Ouali, S., Zakhama, L., Antit, S., Slama, I., Gulel, O., Sahin, M., Sade, L. E., Karacaglar, E., Kucukoglu, S., Cetinarslan, O., Yasar, U. S., Canpolat, U., Mutlu, B., Atas, H., Dervishova, R., Ileri, C., Zaky, H., Alhashmi, J., Baslib, F., Tahir, J., Zarger, P., Woldman, S., Menezes, L., Primus, C., Uppal, R., Bvekerwa, I., Chandrasekaran, B., Kopanska, A., Prendergast, B., Cannata, S., Chambers, J., Hancock, J., Klein, J., Rajani, R., Ursi, M. P., Dworakowski, R., Fife, A., Breeze, J., Browne-Morgan, M., Gunning, M., Streather, S., Asch, F., Zemedkun, M., Alyavi, B., Uzokov, J., Cardiology, ACS - Heart failure & arrhythmias, Pazdernik, M, Iung, B, Mutlu, B, Alla, F, Riezebos, R, Kong, W, Nunes, M, Pierard, L, Srdanovic, I, Yamada, H, De Martino, A, Miglioranza, M, Magne, J, Piper, C, Laroche, C, Maggioni, A, Lancellotti, P, Habib, G, Selton-Suty, C, Ronderos, R, Avegliano, G, Oses, P, Filipini, E, Granada, I, Iribarren, A, Mahia, M, Nacinovich, F, Ressi, S, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Goliasch, G, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Dulgheru, R, Marchetta, S, Demal, C, Oury, C, Cosyns, B, Droogmans, S, Kerkhove, D, Motoc, A, Plein, D, Roosens, B, Soens, L, Weytjens, C, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Pierard, S, Vancraeynest, D, Vanoverschelde, J, Sinnaeve, F, Andrade, J, Rodrigues, A, Staszko, K, Dos Santos Monteiro, R, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Filho, F, Braga, J, Silva, R, Vilela, F, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Joao, G, Mancuso, F, Silva, C, Souza, A, Abboud, C, de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Togna, D, Le Bihan, D, Miglioli, L, Oliveira, A, Kroll, R, Cortez, D, Gelape, C, De Abreu Ferrari, T, Chan, K, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Separovic-Hanzevacki, J, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jurinjak, S, Yiannikourides, V, Ioannides, M, Kyriakou, C, Pofaides, C, Masoura, V, Yiangou, K, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Long, F, Anzules, N, Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, Sharkawy, R, Meshaal, M, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, Hatimi, S, Botelho-Nevers, S, Campisi, S, Fuzellier, J, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Detoc, M, Mehalla, T, Boutoille, D, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecompte, A, Lecomte, R, Lefebvre, M, Michel, M, Pattier, S, Delarue, S, Le Bras, M, Orain, J, Faucher, J, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Roux, P, Le Ven, F, Pouliquen, M, Prat, G, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Chevalier, E, Goehringer, F, Huttin, O, Garcia, R, Le Marcis, V, Tattevin, P, Donal, E, Flecher, E, Revest, M, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Chirouze, C, Bouiller, K, Brunel, A, Fournier, D, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Buisson, M, Mahy, S, Martins, C, Salmon-Rousseau, A, Gohier, S, Borgermann, J, Guckel, D, Horstkotte, D, Brockmeier, B, Winkelmann, E, Hagendorff, A, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sarri, G, Sideris, S, Venieri, E, Athanassopoulos, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Poulimenos, L, Samaras, H, Nagy, A, Bartykowszki, A, Gara, E, Sengupta, S, Mungulmare, K, Kasliwal, R, Bansal, M, Bhan, A, Ranjan, S, Kyavar, M, Maleki, M, Bezanjani, F, Sadeghpour, A, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Israel, S, Wanounou, M, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Badano, L, Muraru, D, Ruozi, N, Tenaglia, R, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Montero, B, Musca, F, Orcese, C, Panzeri, F, Russo, C, Spano, F, Alfieri, O, De Bonis, M, Agricola, E, Busnardo, E, Carletti, S, Castiglioni, B, Chiappetta, S, Del Forno, B, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Pajoro, U, Pasciuta, R, Ripa, M, Scarpellini, P, Din, C, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Prota, C, Radano, I, Soriente, L, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Dato, G, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Abe, K, Fujimaki, H, Okubo, T, Shitan, H, Takanashi, S, Terada, M, Yamamoto, H, Sata, M, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Sakata, Y, Mizuno, H, Nakatani, S, Onishi, T, Sengoku, K, Sera, F, Park, S, Kyoung, K, Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Kang, D, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Vaskelyte, J, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, De la Vega, E, Michaux, C, Staub, T, Jacobs-Orazi, L, Azzopardi, C, Xuereb, R, Piscopo, T, Borg, D, Casha, R, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Yamagata, K, Grib, L, Raevschi, E, Grejdieru, A, Balan, G, Cardaniuc, I, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Kravcenco, D, Panfile, E, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Benesco, I, Marian, V, Sumarga, N, Mirocevic, M, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Roos-Hesselink, J, Budde, R, Gamela, T, Wahadat, A, Kamp, O, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Liesbek, O, Lokhorst, J, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, van Dongen, E, Schoep, J, Stolk, V, Axler, O, Baumann, F, Lebras, S, Edvardsen, T, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Cardim, N, Carmelo, V, Neves, B, Pereira, H, Cruz, I, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Velcean, L, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Rosianu, H, Tomoaia, R, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Al-Mallah, M, Attia, N, Putnikovic, B, Neskovic, A, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Dabic, P, Milojevic, P, Petrovic, I, Stojanovic, I, Kovacevic, M, Redzek, A, Stefanovic, M, Susak, S, Velicki, L, Vulin, A, Yeo, T, Poh, K, Vilacosta, I, Nasser, M, Ferrera, C, Olmos, C, Iglesias, F, Blanco-Gonzalez, E, Amaro, M, Germinas, A, Lopez-Rodriguez, E, Adan, J, Pazos-Lopez, P, Loureiro, M, Perez, M, Raposeiras-Roubin, S, Yas, S, Suarez-Varela, M, Vidal, F, Garcia-Dorado, D, Sambola, A, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Tornos, P, Bayes-Genis, A, Botet, L, Vallejo, N, Berastegui, E, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Portell, D, Vinas, J, Bertran, X, Tarradellas, R, Ricon, P, de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Elorza, E, Alvarez, M, Balbin, J, Arminanzas, C, de las Revillas, F, Garcia, A, Belaustegui, M, Sampedro, M, Cuadra, M, Gutierrez-Diez, J, Zarauza, J, Cuello, L, Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Ruiz-Zamora, I, Ruiz, A, Girgas, E, Garcia-Pardo, G, Marzo, M, Oviedo, A, Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Zghal, F, Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Sade, L, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Yasar, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Zaky, H, Alhashmi, J, Baslib, F, Tahir, J, Zarger, P, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Prendergast, B, Cannata, S, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Clinical sciences, Cardio-vascular diseases, Medical Imaging, Pazdernik M., Iung B., MUTLU B., Alla F., Riezebos R., Kong W., Pereira Nunes M. C., Pierard L., Srdanovic I., Yamada H., et al., Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiology Dept, CHU Limoges, INSERM 1094, University Hospital Dupuytren, 87042, Limoges, Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, European Infective Endocarditis Registry (Euro-Endo), Abbott Vascular, AstraZeneca, ResMed, Sanofi, Servier, Vifor Pharma, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, Daiichi Sankyo Europe, Eli Lilly and Company, Gedeon Richter, and Novartis Pharma
- Subjects
Microbiology (medical) ,Prognosi ,Immunology ,Infective endocarditi ,Life Sciences (LIFE) ,INTERNATIONAL COLLABORATION ,PROFILE ,AGE ,Elderly ,Propensity analysis ,Yaşam Bilimleri ,Health Sciences ,RISK ,İmmünoloji ,General Immunology and Microbiology ,Infective endocarditis ,Prognosis ,Surgery ,Temel Bilimler ,Life Sciences ,General Medicine ,INFECTIOUS DISEASES ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,BULAŞICI HASTALIKLAR ,Yaşam Bilimleri (LIFE) ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Propensity analysi ,Natural Sciences - Abstract
Purpose: High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods: Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results: As compared to < 80yo patients, ≥ 80yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43–3.66]). By propensity analysis, 304 ≥ 80yo were matched to 608 < 80yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80yo. Overall mortality remained higher in ≥ 80yo (in-hospital: HR 1.50[1.06–2.13], p = 0.0210; 1-yr: HR 1.58[1.21–2.05], p = 0.0006), but was not different from that of < 80yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion: Although mortality rates are consistently higher in ≥ 80yo patients than in < 80yo patients in the general population, mortality of surgery in ≥ 80yo is similar to < 80yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80yo patients.
- Published
- 2022
19. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure:a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry
- Author
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Bohbot, Yohann, Habib, Gilbert, Laroche, Cécile, Stöhr, Elisabeth, Chirouze, Catherine, Hernandez-Meneses, Marta, Melissopoulou, Maria, Mutlu, Bülent, Scheggi, Valentina, Branco, Luísa, Olmos, Carmen, Reyes, Graciela, Pazdernik, Michal, Iung, Bernard, Sow, Rouguiatou, Mirocevic, Maja, Lancellotti, Patrizio, Tribouilloy, Christophe, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, R Dos Santos Monteiro, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, F Villaca Filho, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, R Bellio de Mattos Barretto, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, D Le Bihan, Miglioli, L, P Romero Oliveira, A, R Tadeu Magro Kroll, Cortez, D, L Gelape, C, M D, C Peirira Nunes, C De Abreu Ferrari, T, Hay, K, V, Le, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, S Jaksic Jurinjak, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, F Pow Chon Long, Anzules, N, A Bajana Carpio, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, R El Sharkawy, A Al Kholy, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, S El Hatimi, Hubert, S, J-P, Casalta, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, J-F, Fuzellier, Detoc, M, Mehalla, T, Boutoille, D, S Lecompte, A, Lefebvre, M, Pattier, S, O Al Habash, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, T Le Tourneau, Lecomte, R, M Magali Michel, M, Orain, J, Delarue, S, M Le Bras, J-F, Faucher, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, R Le Berre, F Le Ven, M-C, Pouliquen, Prat, G, P Le Roux, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, V Le Marcis, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, A-S, Brunel, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Börgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Öztürk, C, Stöhr, E, Hamm, C, Walther, T, Brandt, R, A-C, Frühauf, T Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, A-K, Karcher, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, F Noohi Bezanjani, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, R Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, L De Michele, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, S Del Pace, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, B De Chiara, B Lopez Montero, Musca, F, A Orcese, C, Panzeri, F, Spano, F, F Russo, C, Alfieri, O, M De Bonis, Chiappetta, S, B Del Forno, Ripa, M, Scarpellini, P, C Tassan Din, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, M Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, D Di Vece, Santini, F, Salsano, A, M Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, S Del Ponte, M Actis Dato, G, A De Martino, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, W Park, S, K Eun Kyoung, L Ga Yeon, J-W, Hwang, Jin-Oh, C, S-J, Park, Sang-Chol, L, Sung-A, C, Y Jang, S, Heo, R, Lee, S, J-M, Song, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, E C, L De la Vega, Jacobs-Orazi, L, C Mallia Azzopardi, G Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, P Van Melle, J, M Deursen, V, J Crijns, H, C Bekkers, S, C Cheriex, E, Gilbers, M, L Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, A Streukens, S, Chamuleau, S, M-J, Cramer, Teske, A, T Van der Spoel, Wind, A, Lokhorst, J, Liesbek, O, H Van Heusden, Tanis, W, I Van der Bilt, Vriend, J, H De Lange-van Bruggen, Karijodikoro, E, Riezebos, R, E van Dongen, Schoep, J, Stolk, V, T Offstad, J, O Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, H Butt, M, F Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, D Kasprzak, J, Kowalczyk, E, F Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, T Timoteo, A, Selas, M, Carmelo, V, B Duque Neves, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, C Tomescu, M, N-M, Trofenciuc, Andor, M, Bordejevic, A, S Branea, H, Caruntu, F, A Velcean, L, Mavrea, A, F Onel, M, Parvanescu, T, Pop, D, L Pop-Moldovan, A, I Puticiu, M, Cirin, L, M Citu, I, A Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, C Yeo, T, W Kf Kong, K Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, M Abd El-Nasser, F Calvo Iglesias, Blanco-Gonzalez, E, M Bravo Amaro, Lopez-Rodriguez, E, J Lugo Adan, N Germinas, A, Pazos-Lopez, P, M Pereira Loureiro, T Perez, M, Raposeiras-Roubin, S, S Rasheed Yas, M-M, Suarez-Varela, F Vasallo Vidal, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, L Pedro Botet, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, D Bosch Portell, J Aboal Vinas, X Albert Bertran, R Brugada Tarradellas, P Loma-Osorio Ricon, C Tiron de Llano, A Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, C Castillo, J, L Zamorano, J, L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, E Navas Elorza, C Farinas Alvarez, M, J Aguero Balbin, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, A Bardaji Ruiz, E Sanz Girgas, Garcia-Pardo, G, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, F Mghaieth Zghal, M Ben Hlima, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Y Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, European Infective Endocarditis Registry (Euro-Endo), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, CHU Amiens-Picardie, CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), EURObservational Research Programme, European Society of Cardiology, Careggi University Hospital [Florence, Italie], Hospital de Alta Complejidad El Cruce 'Nestor Kirchner', Florencio Varela, Buenos Aires, Centre Hospitalier Universitaire de Liège (CHU-Liège), Maria Cecilia Hospital [Cotignola], Anthea Hospital [Bari, Italy], Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Bohbot, Yohann, Habib, Gilbert, Laroche, Cécile, Stöhr, Elisabeth, Chirouze, Catherine, Hernandez-Meneses, Marta, Melissopoulou, Maria, Mutlu, Bülent, Scheggi, Valentina, Branco, Luísa, Olmos, Carmen, Reyes, Graciela, Pazdernik, Michal, Iung, Bernard, Sow, Rouguiatou, Mirocevic, Maja, Lancellotti, Patrizio, Tribouilloy, Christophe, Agricola, Eustachio, Cardiology, ACS - Heart failure & arrhythmias, Neurosurgery, Graduate School, Radiotherapy, ACS - Atherosclerosis & ischemic syndromes, Clinical sciences, Cardio-vascular diseases, Medical Imaging, Bohbot Y., Habib G., Laroche C., Stohr E., Chirouze C., Hernandez-Meneses M., Melissopoulou M., Mutlu B., Scheggi V., Branco L., et al., Bohbot, Y, Habib, G, Laroche, C, Stohr, E, Chirouze, C, Hernandez-Meneses, M, Melissopoulou, M, Mutlu, B, Scheggi, V, Branco, L, Olmos, C, Reyes, G, Pazdernik, M, Iung, B, Sow, R, Mirocevic, M, Lancellotti, P, Tribouilloy, C, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Neskovic, A, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alfieri, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Kyoung, K, Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vilacosta, I, Ferrera, C, Abd El- Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tarradellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, and Uzokov, J
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Male ,Congestive heart failure ,Survival ,SURGERY ,IMPACT ,Hospital mortality ,Infective endocarditi ,Sağlık Bilimleri ,Cardiovascular ,Clinical Medicine (MED) ,Endocarditis, Bacterial/complications ,PROGNOSTIC-FACTORS ,KALP VE KALP DAMAR SİSTEMLERİ ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Early surgery ,Klinik Tıp (MED) ,Prospective Studies ,Registries ,PREDICTORS ,ComputingMilieux_MISCELLANEOUS ,Outcome ,RISK ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Klinik Tıp ,DEATH ,Middle Aged ,Tıp ,Heart Failure/complications ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Medicine ,Female ,EURO-ENDO ,Cardiology and Cardiovascular Medicine ,Kardiyoloji ,Kardiyoloji ve Kardiyovasküler Tıp ,NATIVE VALVE ENDOCARDITIS ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Endocarditis/complications ,Health Sciences ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Retrospective Studies ,Internal Medicine Sciences ,MORTALITY ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Dahili Tıp Bilimleri ,ADULTS ,Infective endocarditis ,CLINICAL MEDICINE ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,CARDIAC & CARDIOVASCULAR SYSTEMS - Abstract
International audience; AIMS: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. METHODS AND RESULTS: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n~=~698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10\,mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p\,≤q\,0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73-3.24; p\,10\,mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12-0.38; p\
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- 2022
20. S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress
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Adwait A Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander L Munden, Dominique S Lui, Matthew J Fanelli, Paula Vo, Caroline A Lewis, Jessica B Spinelli, Thomas G Fazzio, and Amy K Walker
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General Immunology and Microbiology ,General Neuroscience ,General Medicine ,General Biochemistry, Genetics and Molecular Biology - Abstract
Methylation is a widely occurring modification that requires the methyl donor S-adenosylmethionine (SAM) and acts in regulation of gene expression and other processes. SAM is synthesized from methionine, which is imported or generated through the 1-carbon cycle (1 CC). Alterations in 1 CC function have clear effects on lifespan and stress responses, but the wide distribution of this modification has made identification of specific mechanistic links difficult. Exploiting a dynamic stress-induced transcription model, we find that two SAM synthases in Caenorhabditis elegans, SAMS-1 and SAMS-4, contribute differently to modification of H3K4me3, gene expression and survival. We find that sams-4 enhances H3K4me3 in heat shocked animals lacking sams-1, however, sams-1 cannot compensate for sams-4, which is required to survive heat stress. This suggests that the regulatory functions of SAM depend on its enzymatic source and that provisioning of SAM may be an important regulatory step linking 1 CC function to phenotypes in aging and stress.
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- 2023
21. Author response: S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress
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Adwait A Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander L Munden, Dominique S Lui, Matthew J Fanelli, Paula Vo, Caroline A Lewis, Jessica B Spinelli, Thomas G Fazzio, and Amy K Walker
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- 2023
22. Electronic transport properties of MoS$_2$ nanoribbons embedded on butadiene solvent
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Matheus P. Lima, Marcio Costa, Armando Pezo, and Adalberto Fazzio
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Work (thermodynamics) ,Condensed Matter - Materials Science ,Materials science ,Condensed Matter - Mesoscale and Nanoscale Physics ,General Physics and Astronomy ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Exfoliation joint ,0104 chemical sciences ,Metal ,Nanoelectronics ,Transition metal ,Zigzag ,Chemical physics ,visual_art ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,visual_art.visual_art_medium ,Molecule ,Density functional theory ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
Transition metal dichalcogenides (TMDCs) are promising materials for applications in nanoelectronics and correlated fields, where their metallic edge states play a fundamental role in the electronic transport. In this work, we investigate the transport properties of MoS$_2$ zigzag nanoribbons under a butadiene (C$_4$H$_6$) atmosphere, as this compound has been used to obtain MoS$_2$ flakes by exfoliation. We use density functional theory combined with non-equilibrium Green's function techniques, in a methodology contemplating disorder and different coverages. Our results indicate a strong modulation of the TMDC electronic transport properties driven by butadiene molecules anchored at their edges, producing the suppression of currents due to a backscattering process. Our results indicate a high sensitivity of the TMDC edge states. Thus, the mechanisms used to reduce the dimensionality of MoS$_2$ considerably modify its transport properties.
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- 2023
23. Neocarus platensis Silvestri 1905
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Araújo, Marcel Santos De, Palma, Antonella Di, Feres, Reinaldo José Fazzio, and Penteado-Dias, Angelica Maria
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Neocarus platensis ,Arthropoda ,Arachnida ,Opilioacaridae ,Animalia ,Biodiversity ,Opilioacarida ,Neocarus ,Taxonomy - Abstract
Neocarus platensis Silvestri 1905 (Figures 3–5) Material examined. Lectotype F (UNINA), ARGENTINA, Misiones, Posadas, coll. F. Silvestri, ex. under stones, 27.MAY.1899. There is no information about the coordinates or specific location. Paralectotypes. Same data as for the lectotype: F (UNINA), M (UNINA). Remarks. The type material was evaluated by Araújo et al. (2020) as syntypes: 5 M, TN/M (UNINA). URUGUAY, Salto, Salto, La Sierra, 27.MAY.1899, coll. F. Silvestri, under stones; 3 F (UNINA), M (UNINA), ARGENTINA, Misiones, Posadas, same data and collector. Diagnosis. Male pregenital area with 6 stout ribbed setae and genital area with 5 acute smooth setae. Female with no pregenital and genital setae. Female ovipositor with no projections, 4–10 smooth eugenital setae. Male palp tarsus with 17–18 ch and female with 22–25 ch setae; adults with 5–6 d setae. Description Based on female (N = 2) and male (N = 1). IDIOSOMA. Distinct segmentation; integument corniculate; dorsal segments between prodorsal shield and preanal segments without setae, but with numerous lyrifissures arranged in transverse rows; with four pairs of dorsal stigmata without peritremes; anus positioned terminally. Prodorsal shield (Figure 3A). With rounded area anteriorly; without dense patch; with 2 pairs of dorsolateral eyes; 2 pairs of lyrifissures, one close to apical part and other smaller close to first pair of eyes; female with 140–142 and male with>100 (not clearly distinguishable) stout ribbed setae. Preanal region (Figures 3D, E). Segment XVI without setae; preanal segment XVII with a single dorsal and a pair of lateroventral stout ribbed setae. Anal valves (Figures 3D, E). Each with 12–14 (female) and 11–12 (male) stout ribbed setae. Tritosternum. Each digitiform structure with 2 pairs of setae, 1 small at tip and 1 long, barbed positioned more basally. Sternitogenital area (Figures 3B, C). Sternal verrucae. In both adults, each with a longer ribbed smooth tapering seta (st1); female with 3–5 and male with 2 acute ribbed setae. Sternal region. With a pair of ventral and lateroventral lyrifissures. Adults with st2 and st3 ribbed tapering; female with 5–7 and male 4–5 pairs of stout ribbed setae. Sternal region without p setae. Pregenital area. Female without setae. Male with 6 stout ribbed setae. Each pregenital capsules in both adults with a ribbed, smooth tapering setae (st5); female with 4–6 and male with 5 stout ribbed setae. Genital area. Female without setae, but with 4–10 smooth eugenital setae. Male genital area trapezoid with 5 acute smooth setae; Ovipositor. Consisting of a tube-shaped structure; slightly striated; without digitiform or seta-like projections; large basal structures; terminal setae; gland-like structures or accessory glands. Male glands. 2 pairs of glands, one larger and one smaller, without reel-like structures. GNATHOSOMA. Chelicera (Figures 4B, D). Both adults presenting chelicera basal segment with 1 seta ( cht 1 ); normal size; and denticulate paraxial surface; fixed digit with 3 dorsal setae ( ch 1, ch 2, ch 3 ) and id and iα lyrifissures; well-developed hook; movable digit with 1 ventral denticle; lateral denticle absent; ogc present. Subcapitulum (Figures 4A, C). Both adults with paralabial setae present; pl1 conical, obtuse, inserted between cb 2 and cb 3 ; pl2 (With’s organ); discoid, marginally barbed; pl3 (rutella) inserted dorsolaterally; with distinct row of 5 teeth; pl4 tiny, conical, inserted dorsally near base of pl3; all 4 pairs of circumbuccal setae (cb) with bifurcate tips; cb 4 equal size of other cb setae; lateral lips with distinct canals (dl1, dl2) and their orifices (ogl1, ogl2). Female with 2 rounded tip setae; 5–7 pairs of pointed setae (vm, lvm, vp, lvp) and 1 ldm seta; male with 1 rounded tip seta; 5 pairs of pointed setae (vm, lvm, vp, lvp) and 1 ldm seta. Palps (Figure 5). Female. Trochanter with 3–4 r setae. Femur with 8–19 r; 9–10 p setae; spike-like setae absent. Genu with 28–41 r; 4–6 p setae. Tibia with subequal setae; 47–60 r; 3 s. Tarsus with iα and iπ lyrifissures; 5–6 d1 foliate stout pointed setae; 4–5 v1; 4–6 v2; v3 absent; 3 s; 9–11 sm1; 22–25 ch setae. Tarsus apotele distal; ventral margin smooth. Male. Trochanter with 3 r setae. Femur setation was not possible to count due the angle and condition of the material assemble. Genu with 23 r; 0 p setae. Tibia with 42–44 r; subequal length; 3 s setae; tarsus with ia and iπ lyrifissures; 6 d1; foliate stout pointed setae with 4–5 lobules; 3 s; 2–3 v1; 3–4 v2; v3 absent; 9–10 sm1; sm3 absent; 17–18 ch setae; apotele distal; ventral margin smooth. LEGS. Papilliform setae longer than broad. Legs I–IV thin. Legs I. Legs I longer than others; tibia I distal long setae absent; basitarsus I proximal long setae absent; telotarsus I with a highly modified group of dorsal distal setae; ω1 conical, ω2 ligulate, ω3 subulate acuminate, ω4 acicular; ζ1 small with crown-like tip inserted close to sensilla group and a ζ2 filiform with bifid tip. Legs II. Acrotarsus II with a bifid seta longer than wide. And a smooth dorsal seta and ωa solenidion. Legs I–IV. All other leg segments with 3 types of setae arranged in distal to basal lines: 1) tapering and barbed, 2) papilliform and 3) smooth setae. Legs II–IV. Femora II–IV without ventral trichobothria. Genua and tibiae II–IV without coronidia. Basitarsi II–IV with coronidia. Acrotarsi II–IV with 3 ventral setae pairs v; 3 lateral setae pairs l/dl; a pair of long serrated dorsolateral setae; and a pair of distal bifid setae lv; lightly bifid. Pretarsi II–IV with 1 pair of well-developed sessile claws and 2 pairs of setae, 1 setal pair long and curved, other pair smaller and apically pectinate; ambulacrum rounded and smooth; with a pair of well-developed sessile claws. Legs III–IV. Acrotarsi III–IV with a long dorsal serrated seta. Measurements. Female. Idiosoma: length 1947–2141; width at level of ocelli 331–363, palp: trochanter 105– 119, femur 246–247, genu 183–186, tibiotarsus 295–313; chelicera length: basal segment 250–250, fixed digit 281– 281; leg I: trochanter 493–540, basifemur 93–95, telofemur 922–1055, genu 684–732, tibia 976–1105, basitarsus 311–342, telotarsus 435–488; leg II: trochanter 250–287, femur 579–615, genu 322–323, tibia 340–368, basitarsus 405–407, telotarsus 334–334, acrotarsus 98–98; leg III: basitrochanter 211–238, telotrochanter 180–226, femur 481–527, genu 351–365, tibia 362–382, basitarsus 417–417, telotarsus 321–321, acrotarsus 104–104; leg IV: basitrochanter 376–388, telotrochanter 347–369, femur 837–853, genu 505–524, tibia 629–652, basitarsus 579–589, telotarsus 397–406, acrotarsus 123–155. Male. Idiosoma: length 1755–2283, width at level of ocelli 303–355; palp: trochanter 83–121, femur 181–233, genu 120–198, tibiotarsus 246–284; chelicera length: basal segment 169, fixed digit 266; leg I: trochanter 438, basifemur 83, telofemur 883, genu 605, basitibia 444, telotibia 475, basitarsus 327, telotarsus 376; leg II: trochanter 230, femur 491, genu 287, tibia 254, basitarsus 292, telotarsus 256, acrotarsus 90; leg III: basitrochanter 185, telotrochanter 151, femur 442, genu 269, tibia 294, basitarsus 341, telotarsus 287, acrotarsus 82; leg IV: basitrochanter 306, telotrochanter 279, femur 698, genu 451, tibia 492, basitarsus 456, telotarsus 358, acrotarsus 107., Published as part of Araújo, Marcel Santos De, Palma, Antonella Di, Feres, Reinaldo José Fazzio & Penteado-Dias, Angelica Maria, 2023, Redescription of Neocarus platensis Silvestri, 1905 (Acari: Opilioacaridae) and a new species from the syntype series, pp. 209-224 in Zootaxa 5230 (2) on pages 212-216, DOI: 10.11646/zootaxa.5230.2.5, http://zenodo.org/record/7553538, {"references":["Silvestri, F. (1905) Note Aracnologiche III. Una nuova specie di Opilioacarus (Acari Notostigmata) dell'America meridionale. Redia, 2, 239 - 261.","Araujo, M. S., Di Palma, A. & Feres, R. J. F. (2020) Catalog of the Opilioacarida (Acari: Parasitiformes). Zootaxa, 4895 (3), 332 - 356. https: // doi. org / 10.11646 / zootaxa. 4895.3.2"]}
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- 2023
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24. Neocarus paraplatensis Araujo 2023, n. sp
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Araújo, Marcel Santos De, Palma, Antonella Di, Feres, Reinaldo José Fazzio, and Penteado-Dias, Angelica Maria
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Arthropoda ,Neocarus paraplatensis ,Arachnida ,Opilioacaridae ,Animalia ,Biodiversity ,Opilioacarida ,Neocarus ,Taxonomy - Abstract
Neocarus paraplatensis Araújo n. sp. (Figures 6–10) Material examined. Holotype F (UNINA), URUGUAY, Salto, coll. F. Silvestri, ex. under stones, MAY.1899. From original syntype material of N. platensis. There is no information about the coordinates or specific location. Paratypes. Same data as for the holotype: 6 M (UNINA). Etymology. From the Greek word para, meaning “side by side” + platensis, the original species that contained the type series. Diagnosis. Male pregenital area with 4–6 stout ribbed setae, genital area with 5–7 acute smooth setae. Female pregenital and genital area with no setae. Ovipositor with 13 smooth eugenital setae, 8 digitiform projections with bifid tip, and rugose basilateral patch [internal papillate hooks] at each side. Male palp tarsus with 17–20 ch and female with 20 ch setae. Adults palp genus with 0–6 p setae, palp tarsus with 5–6 d setae with four rounded lobes. Description Based on female (N = 1) and male (N = 6). IDIOSOMA. Distinct segmentation; integument coniculate; dorsal segments between prodorsal shield and preanal segments without setae, but with numerous lyrifissures arranged in transverse rows; with four pairs of dorsal stigmata without peritremes; ventral suckers absent; posterior border without elongated setae; anus positioned terminally. Prodorsal shield (Figures 6A, 9A). With rounded area anteriorly; without dense patch; with 2 pairs of dorsolateral eyes; 2 pairs of lyrifissures, one close to apical part and other smaller close to first pair of eyes; female with 143 and male with 137 stout ribbed setae. Preanal region (Figures 6B, 9E). Segment XVI without setae; preanal segment XVII with a single dorsal and a pair of lateroventral stout ribbed setae. Anal valves. Each with 12–13 (female) and 10–13 (male) stout ribbed setae. Tritosternum. Each digitiform structure with 2 pairs of setae, 1 small at tip and 1 long, barbed positioned more basally. Sternitogenital area (Figures 6C–D, 9C). Sternal verrucae. In both adults, each with a longer ribbed smooth tapering seta (st1), female with 2–4 and male with 2 ribbed acute setae. Sternal region. Adults with a pair of ventral and lateroventral lyrifissures, s t2 and st3 ribbed tapering, female with 7–8 pairs and male with 4–8 pairs of stout ribbed setae. Sternal region without p setae. Pregenital area. Female without setae. Male with 4–6 stout ribbed setae. Each pregenital capsules in both adults with a ribbed, smooth, tapering setae (st5); female with 6 and male with 4–6 stout ribbed setae. Genital area. Without setae, but with 13 smooth eugenital setae. Male genital area trapezoid and with 5–7 acute smooth setae. Ovipositor (Figures 6D, 8A–C). Consisting of a tube-shaped structure, slightly striated with 4 pairs of smooth forked digitiform projections and a rugose basolateral patch (Figures 6D, 8A–C) without terminal setae; gland-like structures or accessory glands. Male glands. 2 pairs of glands, one larger and one smaller, without reel-like structures. GNATHOSOMA. Chelicera (Figure 9B). Male presenting chelicera basal segment with 1 seta ( cht 1 ) (female chelicera was lost); normal size; and denticulate paraxial surface; fixed digit with 3 dorsal setae ( ch 1, ch 2, ch 3 ) and id and iα lyrifissures; well-developed hook; movable digit with 1 ventral denticle; lateral denticle absent; ogc present. Subcapitulum (Figures 7A, 9D). Paralabial setae present; pl1 conical, obtuse, inserted between cb 2 and cb 3 ; pl2 (With’s organ); discoid, marginally barbed; pl3 (rutella) inserted dorsolaterally; with distinct row of 5 teeth; pl4 tiny, conical, inserted dorsally near base of pl3; all 4 pairs of circumbuccal setae (cb) with bifurcate tips; cb 4 equal size of other cb setae; lateral lips with distinct canals (dl1, dl2) and their orifices (ogl1, ogl2). Female with 3 rounded tip setae; 7–8 pairs of pointed setae (vm, lvm, vp, lvp) and 1 ldm seta. Palps (Figures 7B–C, 8D, 10). Female. Trochanter with 4 r setae. Femur with 13 r; 5–13 p setae; spike-like setae absent. Genu with 38 r; 7 p setae. Tibia with subequal setae; 65 r; 3 s setae. Tarsus with iα and iπ lyrifissures; 5–6 d1 foliate stout pointed setae; 4 v1, 4 v2; v3 absent; 3 s; 11 sm1; 20 ch setae. Tarsus apotele distal; ventral margin smooth. Male. Trochanter with 3–4 r setae. Femur with 7–13 r; 5–13 p setae; spike-like setae absent. Genu with 24–38 r; 1–7 p setae. Tibia with 45–65 r; subequal length; 3 s setae; tarsus with ia and iπ lyrifissures; 5–6 d1; 3 s; 2–4 v1, 4–6 v2; v3 absent; 9–11 sm1; sm3 absent; 17–20 ch setae; apotele distal; ventral margin smooth. LEGS. Papilliform setae longer than broad. Legs I–IV thin. Legs I. Legs I longer than others; tibia I distal long setae absent; basitarsus I proximal long setae absent; telotarsus I with a highly modified group of dorsal distal setae in a depression; ω1 conical, ω2 ligulate, ω3 subulate acuminate, ω4 acicular; ζ1 small with crown-like tip inserted close to sensilla group and a ζ2 filiform with bifid tip. Legs II. Acrotarsus II with a bifid seta longer than wide. And a smooth dorsal seta and ωa solenidion. Legs I–IV. All other leg segments with 3 types of setae arranged in distal to basal lines: 1) tapering and barbed, 2) papilliform and 3) smooth setae. Legs II–IV. Femora II–IV without ventral trichobothria. Genua and tibiae II–IV without coronidia. Basitarsi II–IV with coronidia. Acrotarsi II–IV with 3 ventral setae pairs v; 3 lateral setae pairs l/dl; a pair of long serrated dorsolateral setae; and a pair of distal bifid setae lv; lightly bifid. Pretarsi II–IV with 1 pair of well-developed sessile claws and 2 pairs of setae, 1 setal pair long and curved, other pair smaller and apically pectinate; ambulacrum rounded and smooth; with a pair of well-developed sessile claws. Legs III–IV. Acrotarsi III–IV with a long dorsal serrated seta. Measurements. Female. Idiosoma: length 2283–2283; width at level of ocelli 355–355, palp: trochanter 121– 121, femur 233–233, genu 198–198, tibiotarsus 284–284. Male. Idiosoma: length 1755–2301, width at level of ocelli 303–403; palp: trochanter 83–121, femur 181–233, genu 120–172, tibiotarsus 246–329; chelicera length: basal segment 169–353, fixed digit 266–448; leg I: trochanter 438–443, basifemur 83–83, telofemur 883–916, genu 605–605, basitibia 444–575, telotibia 475–491, basitarsus 327–327, telotarsus 376–376; leg II: trochanter 230–242, femur 491–509, genu 287–287, tibia 254–254, basitarsus 292–292, telotarsus 256–256, acrotarsus 90–90; leg III: basitrochanter 185–308, telotrochanter 151–223, femur 442–575, genu 269–446, tibia 294–457, basitarsus 341–424, telotarsus 287–356, acrotarsus 82–113; leg IV: basitrochanter 306–312, telotrochanter 279–314, femur 698–706, genu 451–475, tibia 492–503, basitarsus 456–500, telotarsus 358–360, acrotarsus 107–108., Published as part of Araújo, Marcel Santos De, Palma, Antonella Di, Feres, Reinaldo José Fazzio & Penteado-Dias, Angelica Maria, 2023, Redescription of Neocarus platensis Silvestri, 1905 (Acari: Opilioacaridae) and a new species from the syntype series, pp. 209-224 in Zootaxa 5230 (2) on pages 216-222, DOI: 10.11646/zootaxa.5230.2.5, http://zenodo.org/record/7553538
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- 2023
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25. Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1
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Michelle M. Conti, Rui Li, Michelle A. Narváez Ramos, Lihua Julie Zhu, Thomas G. Fazzio, and Jennifer A. Benanti
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Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
Ordered cell cycle progression is coordinated by cyclin dependent kinases (CDKs). CDKs often phosphorylate substrates at multiple sites clustered within disordered regions. However, for most substrates, it is not known which phosphosites are functionally important. We developed a high-throughput approach, Phosphosite Scanning, that tests the importance of each phosphosite within a multisite phosphorylated domain. We show that Phosphosite Scanning identifies multiple combinations of phosphosites that can regulate protein function and reveals specific phosphorylations that are required for phosphorylation at additional sites within a domain. We applied this approach to the yeast transcription factor Hcm1, a conserved regulator of mitotic genes that is critical for accurate chromosome segregation. Phosphosite Scanning revealed a complex CDK-regulatory circuit that mediates processive phosphorylation of key activating sites in vivo. These results illuminate the mechanism of Hcm1 activation by CDK and establish Phosphosite Scanning as a powerful tool for decoding multisite phosphorylated domains.
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- 2023
26. POLÍTICA EM FOCO
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Felipe Vidal Benvenuto Alberto, Brian O’Neal Rocha, Kátia Eliane Santos Avelar, Ana Carolina Fazzio Soares, Dayane Florentino Fereira de Moura, Cristinne Leus Tomé, José Henrique Mendes Crizostomo, Renata de Lourdes Azevedo Saul, Eva Quembo, Fernanda Analu Marcolla, Sabrina Lehnen Stoll, and Alejandro Knaesel Arrabal
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- 2023
27. Macroscopic quorum sensing sustains differentiating embryonic stem cells
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Hirad Daneshpour, Pim van den Bersselaar, Chun-Hao Chao, Thomas G. Fazzio, and Hyun Youk
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Cell Biology ,Molecular Biology - Abstract
Cells can secrete molecules that help each other’s replication. In cell cultures, chemical signals might diffuse only within a cell colony or between colonies. A chemical signal’s interaction length—how far apart interacting cells are—is often assumed to be some value without rigorous justifications because molecules’ invisible paths and complex multicellular geometries pose challenges. Here we present an approach, combining mathematical models and experiments, for determining a chemical signal’s interaction length. With murine embryonic stem (ES) cells as a testbed, we found that differentiating ES cells secrete FGF4, among others, to communicate over many millimeters in cell culture dishes and, thereby, form a spatially extended, macroscopic entity that grows only if its centimeter-scale population density is above a threshold value. With this ‘macroscopic quorum sensing’, an isolated macroscopic, but not isolated microscopic, colony can survive differentiation. Our integrated approach can determine chemical signals’ interaction lengths in generic multicellular communities.
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- 2023
28. Revisiting chromatin packaging in mouse sperm
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Qiangzong Yin, Chih-Hsiang Yang, Olga S. Strelkova, Yu Sun, Sneha Gopalan, Liyan Yang, Job Dekker, Thomas G. Fazzio, Xin Zhiguo Li, Johan Gibcus, and Oliver J. Rando
- Abstract
Mammalian sperm exhibit an unusual and heavily-compacted genomic packaging state. In addition to its role in organizing the compact and hydrodynamic sperm head, it has been proposed that sperm chromatin architecture helps to program gene expression in the early embryo. Scores of genome-wide surveys in sperm have reported patterns of chromatin accessibility, histone localization, histone modification, and chromosome folding. Here, we revisit these studies in light of our recent finding that sperm obtained from the mouse epididymis are contaminated with low levels of cell-free chromatin. In the absence of proper sperm lysis we readily recapitulate multiple prominent genomewide surveys of sperm chromatin, suggesting that these profiles primarily reflect contaminating cell-free chromatin. Removal of cell-free DNA, along with appropriate lysis conditions, are required to reveal a sperm chromatin state distinct from any yet reported. Using ATAC-Seq to explore relatively accessible genomic loci, we identify a landscape of open loci associated with genes expressed during late spermiogenesis. Histone modification and chromosome folding studies also strongly support the hypothesis that prior studies suffer from contamination, but technical challenges associated with reliably preserving the architecture of the compacted sperm head prevent us from confidently assaying true localization patterns for these epigenetic marks. Together, our studies strongly argue that our knowledge of mammalian chromosome packaging remains largely incomplete, and motivate future efforts to more accurately characterize genome organization in mature sperm.
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- 2022
29. Nanoscale structural and electronic properties of cellulose/graphene interfaces
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G. H. Silvestre, F. Crasto de Lima, J. S. Bernardes, A. Fazzio, and R. H. Miwa
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Condensed Matter - Materials Science ,Electricity ,General Physics and Astronomy ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Graphite ,Physical and Theoretical Chemistry ,Electronics ,Cellulose ,Carbon - Abstract
The development of electronic devices based on the functionalization of (nano)cellulose platforms relies upon an atomistic understanding of the structural, and electronic properties of the combined system, cellulose/functional element. In this work, we present a theoretical study of the nanocellulose/graphene interface (nCL/G) based on first-principles calculations. We find that the binding energies of both hydrophobic/G (nCL$^{\rm phob}$/G) and hydrophilic/G (nCL$^{\rm phil}$/G) interfaces are primarily dictated by the van der Waals interactions, and are comparable with that of their 2D interface counterparts. We verify that the energetic preference of nCL$^{\rm phob}$/G has been reinforced by the inclusion of an aqueous media via the implicit solvation model. Further structural characterization was carried out using a set of simulations of Carbon K-edge X-ray absorption spectra to identify and distinguish the key absorption features of the nCL$^{\rm phob}$/G and nCL$^{\rm phil}$/G interfaces. The electronic structure calculations reveal that the linear energy bands of graphene lie in the band gap of the nCL, sheet, while depletion/accumulation charge density regions are observed. We show that external agents, i.e. electric field and mechanical strain, allow for tunability of the Dirac cone and the charge density at the interface. The control/maintenance of the Dirac cone states in nCL/G is an important feature for the development of electronic devices based on cellulosic platforms.
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- 2022
30. Topological insulating phase arising in transition metal dichalcogenide alloy
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F Crasto de Lima, B Focassio, R H Miwa, and A Fazzio
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Condensed Matter - Materials Science ,Mechanics of Materials ,Mechanical Engineering ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,General Materials Science ,General Chemistry ,Condensed Matter Physics - Abstract
Transition metal dichalcogenides have been the subject of numerous studies addressing technological applications and fundamental issues. Single-layer PtSe2 is a semiconductor with a trivial bandgap, in contrast, its counterpart with 25 % of Se atoms substituted by Hg, Pt2HgSe3 (jacutingaite, a naturally occurring mineral) is a 2D topological insulator with a large bandgap. Based on ab-initio calculations, we investigate the energetic stability, and the topological transition in Pt(Hg x Se 1 − x )2 as a function of alloy concentration, and the distribution of Hg atoms embedded in the PtSe2 host. Our findings reveal the dependence of the topological phase with respect to the alloy concentration and robustness with respect to the distribution of Hg. Through a combination of our ab-initio results and a defect wave function percolation model, we estimate the random alloy concentration threshold for the topological transition to be only 9 % . Our results expand the possible search for non-trivial topological phases in random alloy systems.
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- 2022
31. Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry
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Sengupta, Shantanu P, Prendergast, Bernard, Laroche, Cécile, Furnaz, Shumaila, Ronderos, Ricardo, Almaghraby, Abdallah, Asch, Federico M, Blechova, Kamila, Zaky, Hosam, Strahilevitz, Jacob, Dworakowski, Rafal, Miyasaka, Yoko, Sebag, Igal, Izumi, Chisato, Axler, Olivier, Jamiel, Abdulrahman, Philip, Mary, Campos Vieira, Marcelo Luiz, Lancellotti, Patrizio, Habib, Gilbert, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, R Dos Santos Monteiro, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, F Villaca Filho, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, R Bellio de Mattos Barretto, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, D Le Bihan, Miglioli, L, P Romero Oliveira, A, R Tadeu Magro Kroll, Cortez, D, L Gelape, C, M D, C Peirira Nunes, C De Abreu Ferrari, T, Hay, K, V, Le, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, S Jaksic Jurinjak, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, F Pow Chon Long, Anzules, N, A Bajana Carpio, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, R El Sharkawy, A Al Kholy, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, S El Hatimi, Hubert, S, J-P, Casalta, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, J-F, Fuzellier, Detoc, M, Mehalla, T, Boutoille, D, S Lecompte, A, Lefebvre, M, Pattier, S, O Al Habash, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, T Le Tourneau, Lecomte, R, M Magali Michel, M, Orain, J, Delarue, S, M Le Bras, J-F, Faucher, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, R Le Berre, F Le Ven, M-C, Pouliquen, Prat, G, P Le Roux, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, V Le Marcis, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, A-S, Brunel, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Börgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Öztürk, C, Stöhr, E, Hamm, C, Walther, T, Brandt, R, A-C, Frühauf, T Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, A-K, Karcher, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, F Noohi Bezanjani, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, R Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, L De Michele, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, S Del Pace, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, B De Chiara, B Lopez Montero, Musca, F, A Orcese, C, Panzeri, F, Spano, F, F Russo, C, Alfieri, O, M De Bonis, Chiappetta, S, B Del Forno, Ripa, M, Scarpellini, P, C Tassan Din, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, M Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, D Di Vece, Santini, F, Salsano, A, M Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, S Del Ponte, M Actis Dato, G, A De Martino, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, W Park, S, K Eun Kyoung, L Ga Yeon, J-W, Hwang, Jin-Oh, C, S-J, Park, Sang-Chol, L, Sung-A, C, Y Jang, S, Heo, R, Lee, S, J-M, Song, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, E C, L De la Vega, Jacobs-Orazi, L, C Mallia Azzopardi, G Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, P Van Melle, J, M Deursen, V, J Crijns, H, C Bekkers, S, C Cheriex, E, Gilbers, M, L Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, A Streukens, S, Chamuleau, S, M-J, Cramer, Teske, A, T Van der Spoel, Wind, A, Lokhorst, J, Liesbek, O, H Van Heusden, Tanis, W, I Van der Bilt, Vriend, J, H De Lange-van Bruggen, Karijodikoro, E, Riezebos, R, E van Dongen, Schoep, J, Stolk, V, T Offstad, J, O Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, H Butt, M, F Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, D Kasprzak, J, Kowalczyk, E, F Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, T Timoteo, A, Selas, M, Carmelo, V, B Duque Neves, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, C Tomescu, M, N-M, Trofenciuc, Andor, M, Bordejevic, A, S Branea, H, Caruntu, F, A Velcean, L, Mavrea, A, F Onel, M, Parvanescu, T, Pop, D, L Pop-Moldovan, A, I Puticiu, M, Cirin, L, M Citu, I, A Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, C Yeo, T, W K, F Kong, K Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, M Abd El Nasser, F Calvo Iglesias, Blanco-Gonzalez, E, M Bravo Amaro, Lopez-Rodriguez, E, J Lugo Adan, N Germinas, A, Pazos-Lopez, P, M Pereira Loureiro, T Perez, M, Raposeiras-Roubin, S, S Rasheed Yas, M-M, Suarez-Varela, F Vasallo Vidal, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, L Pedro Botet, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, D Bosch Portell, J Aboal Vinas, X Albert Bertran, R Brugada Tarradellas, P Loma-Osorio Ricon, C Tiron de Llano, A Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, C Castillo, J, L Zamorano, J, L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, E Navas Elorza, C Farinas Alvarez, M, J Aguero Balbin, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, A Bardaji Ruiz, E Sanz Girgas, Garcia-Pardo, G, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, F Mghaieth Zghal, M Ben Hlima, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, S Yasar, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2011–21, Abbott Vascular, 2009–18, Amgen, 2016–19, Edwards, 2014–16, Gedeon Richter, 2009–12, Menarini Group, 2011–14, MSD, 2014–20, Novartis Pharma, 2014–16, ResMed Foundation, 2009–11, Sanofi, 2009–21, Servier, 2019–22, Vifor Pharma, 2014–21, AstraZeneca, 2009–18, Bayer AG, 2009–19, Boehringer Ingelheim, 2009–12, Boston Scientific, Bristol Myers Squibb, 2011–19, Pfizer Alliance, 2011–20, Daiichi Sankyo Company, 2014–17, Eli Lilly and Company, Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Sade, L, Sadeghpour, A, Sambola, A, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Granada, I, Mahia, M, Ressi, S, Na-Cinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streit-Enberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melis-Sopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droog-Mans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Am-Sel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gou-Vea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, and Uzokov, J
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Socioeconomic ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Endocarditis ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Health Policy ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Socio-economic ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Endocarditi ,Cardiology and Cardiovascular Medicine ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology - Abstract
Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53–75) years; group 2, 57 (41–68) years; group 3, 33 (26–43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3–35); group 2, 19 (6–54); group 3, 31 (12–62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
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- 2022
32. How lignin sticks to cellulose-insights from atomic force microscopy enhanced by machine-learning analysis and molecular dynamics simulations
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Diego M. Nascimento, Felippe M. Colombari, Bruno Focassio, Gabriel R. Schleder, Carlos A. R. Costa, Cleyton A. Biffe, Liu Y. Ling, Rubia F. Gouveia, Mathias Strauss, George J. M. Rocha, Edson Leite, Adalberto Fazzio, Rodrigo B. Capaz, Carlos Driemeier, and Juliana S. Bernardes
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General Materials Science - Abstract
Elucidating cellulose-lignin interactions at the molecular and nanometric scales is an important research topic with impacts on several pathways of biomass valorization. Here, the interaction forces between a cellulosic substrate and lignin are investigated. Atomic force microscopy with lignin-coated tips is employed to probe the site-specific adhesion to a cellulose film in liquid water. Over seven thousand force-curves are analyzed by a machine-learning approach to cluster the experimental data into types of cellulose-tip interactions. The molecular mechanisms for distinct types of cellulose-lignin interactions are revealed by molecular dynamics simulations of lignin globules interacting with different cellulose Iβ crystal facets. This unique combination of experimental force-curves, data-driven analysis, and molecular simulations opens a new approach of investigation and updates the understanding of cellulose-lignin interactions at the nanoscale.
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- 2022
33. Body and Decoloniality in Performing Poetic Composition
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Marina Fazzio Simão and Juliano Casimiro de Camargo Sampaio
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Corporeidade ,Performing Practice ,lcsh:PN1600-3307 ,lcsh:Drama ,Descolonização do Imaginário ,Composição Poética Cênica ,Conhecimento Emancipatório ,Performing Poetic Composition ,Theater. Decoloniality. Body. Performing Poetic Composition. Performing Practice ,Ensino de Arte ,Theater ,Body ,lcsh:PN2000-3307 ,Decoloniality ,lcsh:Dramatic representation. The theater - Abstract
The text is situated between the arts, anthropology and philosophy and aims to answer the question: can the artistic process be understood as a means of decoloniality of the ordinary body? Methodologically, a literature review was carried out and it was analyzed an artistic process in which the authors participated. It emerges from Sampaio’s proposal (2007) concerning the atense body for the scene, which can be a fruitful way to reach the decoloniality of the everyday body., Body and Decoloniality in Scenic Poetic Composition - The text is situated between the arts, anthropology and philosophy and aims to answer the question: can the artistic process be understood as a means of decoloniality of ordinary body? Methodologically literature review was carried out an artistic process was analyzed that the authors participated in. It emerges from the experience that Sampaio’s (2007) proposal for the atenso body for the scene can be a fruitful way to reach the decoloniality of the everyday body.
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- 2022
34. Corpo e Descolonialidade em Composição Poética Cênica
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Simão (Universidade Federal da Integração Latino-Americana – Foz do Iguaçu/PR, Brasil), Marina Fazzio and Sampaio (Universidade Federal do Tocantins – UFT, Palmas/TO, Brasil ), Juliano Casimiro de Camargo
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Teatro. Descolonialidade. Corpo. Composição Poética Cênica. Prática Cênica ,Théâtre. Descolonialite. Corps. Composition Poétique Scénique. Pratique Scénique - Abstract
Ce texte est placé entre les arts, l’anthropologie et la philosophie et vise à répondre à la question: le processus artistique peut-il être compris comme un moyen de décolonialisation du corps quotidien? Sur le plan méthodologique, nous avons effectué une revue de la littérature et nous analysons un processus artistique auquel les auteurs ont participé. Il ressort de l’expérience que la proposition de Sampaio (2007) pour le corps (pas)tendu de la scène peut être un moyen fructueux d’atteindre la décolonialité du corps quotidien., O texto se situa entre as artes, a antropologia e a filosofia e pretende responder à questão: o processo artístico pode ser entendido como meio de descolonialidade do corpo cotidiano? Metodologicamente, realiza-se revisão de literatura e faz-se uma análise de um processo artístico de que os autores participaram. Resulta da experiência que a proposta de Sampaio (2007) a respeito do corpo atenso para a cena pode ser um frutífero caminho para se chegar à descolonialidade do corpo cotidiano.
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- 2022
35. Correction to: Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry (Infection, (2022), 50, 5, (1191-1202), 10.1007/s15010-022-01792-0)
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Pazdernik, Michal, Iung, Bernard, Mutlu, Bulent, Alla, François, Riezebos, Robert, Kong, William, Nunes, Maria Carmo Pereira, Pierard, Luc, Srdanovic, Ilija, Yamada, Hirotsugu, de Martino, Andrea, Miglioranza, Marcelo Haertel, Magne, Julien, Piper, Cornelia, Laroche, C. cile, Maggioni, Aldo P., Lancellotti, Patrizio, Habib, Gilbert, Selton-Suty, Christine, Ronderos, R., Avegliano, G., Oses, P. Fernandez, Filipini, E., Granada, I., Iribarren, A., Mahia, M., Nacinovich, F., Ressi, S., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M. L., Novas, V., Shigel, C., Reyes, G., de Santos, M., Gastaldello, N., Fernandez, M. Granillo, Potito, M., Streitenberger, G., Velazco, P., Casabé, J. H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C. Y., Perschy, L., Puskas, L., Goliasch, G., Binder, C., Rosenhek, R., Schneider, M., Winter, M. P., Hoffer, E., Melissopoulou, M., Lecoq, E., Legrand, D., Jacquet, S., Massoz, M., Lancellotti, P., Pierard, L., Dulgheru, R., Marchetta, S., D´Emal, C., Oury, C., Cosyns, B., Droogmans, S., Kerkhove, D., Motoc, A., Plein, D., Roosens, B., Soens, L., Weytjens, C., Lemoine, I., Rodrigus, I., Paelinck, B., Amsel, B., Unger, P., Konopnicki, D., Beauloye, C., Pasquet, A., Pierard, S., Vancraeynest, D., Vanoverschelde, J. L., Sinnaeve, F., Andrade, J. L., Rodrigues, A. C. Tude, Staszko, K., Dos Santos Monteiro, R., Miglioranza, M. H., Shuha, D. L., Alcantara, M., Cravo, V., Fazzio, L., Felix, A., Iso, M., Musa, C., Siciliano, A. P., Filho, F. Villaca, Braga, J., Rodrigues, A., Silva, R., Vilela, F., Rodrigues, D., Silva, L., Morhy, S., Fischer, C., Vieira, M., Afonso, T., Abreu, J., Falcao, S. N., Moises, V., Gouvea, A., João, G., Mancuso, F., Silva, C., Souza, A. C., Abboud, C. S., de Mattos Barretto, R. Bellio, Ramos, A., Arnoni, R., Assef, J. E., Togna, D. J. Della, le Bihan, D., Miglioli, L., Oliveira, A. P. Romero, Kroll, R. Tadeu Magro, Cortez, D., Gelape, C. L., Nunes, M. d. C. Peirira, de Abreu Ferrari, T. C., Chan, K. L., Hay, K., le, V., Page, M., Poulin, F., Sauve, C., Serri, K., Mercure, C., Beaudoin, J., Pibarot, P., Sebag, I., Rudski, L., Ricafort, G., Barsic, B., Krajinovic, V., Vargovic, M., Separovic-Hanzevacki, J., Lovric, D., Reskovic-Luksic, V., Vincelj, J., Jurinjak, S. Jaksic, Yiannikourides, V., Ioannides, M., Kyriakou, C., Pofaides, C., Masoura, V., Yiangou, K., Pudich, J., Linhart, A., Siranec, M., Marek, J., Blechova, K., Kamenik, M., Pazdernik, M., Pelouch, R., Coufal, Z., Mikulica, M., Griva, M., Jancova, E., Mikulcova, M., Taborsky, M., Precek, J., Jecmenova, M., Latal, J., Widimsky, J., Butta, T., Machacek, S., Vancata, R., Spinar, J., Holicka, M., Long, F. Pow Chon, Anzules, N., Carpio, A. Bajana, Largacha, G., Penaherrera, E., Moreira, D., Mahfouz, E., Elsafty, E., Soliman, A., Zayed, Y., Aboulenein, J., Abdel-Hay, M., Almaghraby, A., Abdelnaby, M., Ahmed, M., Hammad, B., Saleh, Y., Zahran, H., Elgebaly, O., Saad, A., Ali, M., Zeid, A., Sharkawy, R. El, Meshaal, M., Al Kholy, A., Doss, R., Osama, D., Rizk, H., Elmogy, A., Mishriky, M., Assayag, P., Hatimi, S. El, Botelho-Nevers, Saint- E., Campisi, S., Fuzellier, J. F., Gagneux-Brunon, A., Pierrard, R., Tulane, C., Detoc, M., Mehalla, T., Boutoille, D., Al Habash, O., Asseray-Madani, N., Biron, C., Brochard, J., Caillon, J., Cueff, C., le Tourneau, T., Lecompte, A. S., Lecomte, R., Lefebvre, M., Michel, M. M. Magali, Pattier, S., Delarue, S., le Bras, M., Orain, J., Faucher, J. F., Aboyans, V., Beeharry, A., Durox, H., Lacoste, M., Magne, J., Mohty, D., David, A., Pradel, V., Sierra, V., Neykova, A., Bettayeb, B., Elkentaoui, S., Tzvetkov, B., Landry, G., Strady, C., Ainine, K., Baumard, S., Brasselet, C., Tassigny, C., Valente-Pires, V., Lefranc, M., Hoen, B., Lefevre, B., Curlier, E., Callier, C., Fourcade, N., Jobic, Y., Ansard, S., le Berre, R., le Roux, P., le Ven, F., Pouliquen, M. C., Prat, G., Bouchart, F., Savoure, A., Alarcon, C., Chapuzet, C., Gueit, I., Tribouilloy, C., Bohbot, Y., Peugnet, F., Gun, M., Iung, B., Duval, X., Lescure, X., Ilic-Habensus, E., Sadoul, N., Selton-Suty, C., Alla, F., Chevalier, E., Goehringer, F., Huttin, O., Garcia, R., le Marcis, V., Tattevin, P., Donal, E., Flecher, E., Revest, M., Habib, G., Hubert, S., Casalta, J. P., Gouriet, F., Arregle, F., Cammilleri, S., Tessonnier, L., Riberi, A., Chirouze, C., Bouiller, K., Brunel, A. S., Fournier, D., Hustache-Mathieu, L., Klopfenstein, T., Moreau, J., Lim, P., Oliver, L., Ternacle, J., Moussafeur, A., Chavanet, P., Piroth, L., Buisson, M., Mahy, S., Martins, C., Salmon-Rousseau, A., Gohier, S., Piper, C., Börgermann, J., Guckel, D., Horstkotte, D., Brockmeier, B., Winkelmann, E., Hagendorff, A., Grey, D., Nickenig, G., Schueler, R., Öztürk, C., Stöhr, E., Hamm, C., Walther, T., Brandt, R., Frühauf, A. C., Hartung, C. T., Hellner, C., Wild, C., Becker, M., Hamada, S., Kaestner, W., Stangl, K., Knebel, F., Baldenhofer, G., Brecht, A., Dreger, H., Isner, C., Pfafflin, F., Stegemann, M., Zahn, R., Fraiture, B., Kilkowski, C., Karcher, A. K., Klinger, S., Tolksdorf, H., Tousoulis, D., Aggeli, C., Sarri, G., Sideris, S., Venieri, E., Athanassopoulos, G., Tsiapras, D., Armenis, I., Koutsiari, A., Floros, G., Grassos, C., Dragasis, S., Rallidis, L., Varlamos, C., Michalis, L., Naka, K., Bechlioulis, A., Kotsia, A., Lakkas, L., Pappas, K., Papadopoulos, C., Kiokas, S., Lioni, A., Misailidou, S., Barbetseas, J., Bonou, M., Kapelios, C., Tomprou, I., Zerva, K., Manolis, A., Hamodraka, E., Athanasiou, D., Haralambidis, G., Poulimenos, L., Samaras, H., Nagy, A., Bartykowszki, A., Gara, E., Sengupta, S., Mungulmare, K., Kasliwal, R., Bansal, M., Bhan, A., Ranjan, S., Kyavar, M., Maleki, M., Bezanjani, F. Noohi, Sadeghpour, A., Alizadehasl, A., Boudagh, S., Ghavidel, A., Moradnejad, P., Pasha, H. R., Ghadrdoost, B., Gilon, D., Strahilevitz, J., Israel, S., Wanounou, M., d’Agostino, C., Colonna, P., de Michele, L., Fumarola, F., Stante, M., Marchionni, N., Scheggi, V., Alterini, B., del Pace, S., Stefano, P., Sparano, C., Badano, L. P., Muraru, D., Ruozi, N., Tenaglia, R., Limbruno, U., Cresti, A., Baratta, P., Solari, M., Giannattasio, C., Moreo, A., de Chiara, B., Montero, B. Lopez, Musca, F., Orcese, C. A., Panzeri, F., Russo, C. F., Spano, F., Alfieri, O., de Bonis, M., Agricola, E., Busnardo, E., Carletti, S., Castiglioni, B., Chiappetta, S., del Forno, B., Ferrara, D., Guffanti, M., Iaci, G., Lapenna, E., Nisi, T., Oltolini, C., Pajoro, U., Pasciuta, R., Ripa, M., Scarpellini, P., Din, C. Tassan, Meneghin, R., Schiavi, D., Piscione, F., Citro, R., Benvenga, R. M., Greco, L., Prota, C., Radano, I., Soriente, L., Bellino, M., di Vece, D., Santini, F., Salsano, A., Olivieri, G. M., Turrini, F., Messora, R., Tondi, S., Olaru, A., Agnoletto, V., Grassi, L., Leonardi, C., Sansoni, S., del Ponte, S., Dato, G. M. Actis, de Martino, A., Ohte, N., Kikuchi, S., Wakami, K., Aonuma, K., Seo, Y., Ishizu, T., Machino-Ohtsuka, T., Yamamoto, M., Iida, N., Nakajima, H., Nakagawa, Y., Izumi, C., Amano, M., Miyake, M., Takahashi, K., Shiojima, I., Miyasaka, Y., Maeba, H., Suwa, Y., Taniguchi, N., Tsujimoto, S., Kitai, T., Ota, M., Yuda, S., Sasaki, S., Hagiwara, N., Yamazaki, K., Ashihara, K., Arai, K., Saitou, C., Saitou, S., Suzuki, G., Shibata, Y., Watanabe, N., Nishino, S., Ashikaga, K., Kuriyama, N., Mahara, K., Abe, K., Fujimaki, H., Okubo, T., Shitan, H., Takanashi, S., Terada, M., Yamamoto, H., Sata, M., Yamada, H., Kusunose, K., Saijo, Y., Seno, H., Yuichiro, O., Sakata, Y., Mizuno, H., Nakatani, S., Onishi, T., Sengoku, K., Sera, F., Park, S. W., Kyoung, K. Eun, Yeon, L. Ga, Hwang, J. W., Jin-Oh, C., Park, S. J., Sang-Chol, L., Sung-A, C., Jang, S. Y., Kang, D. H., Heo, R., Lee, S., Song, J. M., Jung, E., Plisiene, J., Dambrauskaite, A., Gruodyte, G., Jonkaitiene, R., Vaskelyte, J., Mizariene, V., Atkocaityte, J., Zvirblyte, R., Sow, R., Codreanu, A., de la Vega, E. C. L., Michaux, C., Staub, T., Jacobs-Orazi, L., Azzopardi, C. Mallia, Xuereb, R. G., Piscopo, T., Borg, D., Casha, R., Farrugia, J., Fenech, M., Pllaha, E., Vella, C., Yamagata, K., Grib, L., Raevschi, E., Grejdieru, A., Balan, G., Cardaniuc, I., Cardaniuc, L., Corcea, V., Feodorovici, A., Gaina, V., Girbu, L., Jimbei, P., Kravcenco, D., Panfile, E., Prisacari, E., Samohvalov, E., Samohvalov, S., Sceglova, N., Benesco, I., Marian, V., Sumarga, N., Mirocevic, M., Bozovic, B., Bulatovic, N., Lakovic, P., Music, L., Roos-Hesselink, J., Budde, R., Gamela, T., Wahadat, A., Kamp, O., Meijers, T., van Melle, J. P., Deursen, V. M., Crijns, H., Bekkers, S., Cheriex, E., Gilbers, M., Kietselaer, B., Knackstedt, C., Lorusso, R., Schalla, S., Streukens, S., Chamuleau, S., Cramer, M. J., Teske, A., van der Spoel, T., Wind, A., Liesbek, O., Lokhorst, J., van Heusden, H., Tanis, W., van der Bilt, I., Vriend, J., de Lange-van Bruggen, H., Karijodikoro, E., Riezebos, R., van Dongen, E., Schoep, J., Stolk, V., Axler, O., Baumann, F., Lebras, S., Edvardsen, T., Offstad, J. T., Beitnes, J. O., Helle-Valle, T., Skulstad, H., Skardal, R., Qamar, N., Furnaz, S., Ahmed, B., Butt, M. H., Khanzada, M. F., Saghir, T., Wahid, A., Hryniewiecki, T., Szymanski, P., Marzec, K., Misztal-Ogonowska, M., Kosmala, W., Przewlocka-Kosmala, M., Rojek, A., Woznicka, K., Zachwyc, J., Lisowska, A., Kaminska, M., Kasprzak, J., Kowalczyk, E., Strzecka, D. F., Wejner-Mik, P., Trabulo, M., Freitas, P., Ranchordas, S., Rodrigues, G., Pinto, P., Queiros, C., Azevedo, J., Marques, L., Seabra, D., Branco, L., Cruz, M., Galrinho, A., Moreira, R., Rio, P., Timoteo, A. T., Selas, M., Cardim, N. M., Carmelo, V., Neves, B. Duque, Pereira, H., Cruz, I., Guerra, A., Marques, A., Pintassilgo, I., Tomescu, M. C., Trofenciuc, N. M., Andor, M., Bordejevic, A., Branea, H. S., Caruntu, F., Cirin, L., Citu, I. M., Cotoraci, C. A., Darabantiu, D., Farcas, R., Marincu, I., Mavrea, A., Onel, M. F., Parvanescu, T., Pop, D., Pop-Moldovan, A. L., Puticiu, M. I., Velcean, L. A., Ionac, A., Cozma, D., Mornos, C., Goanta, F., Popescu, I., Beyer, R., Mada, R., Rancea, R., Rosianu, H., Tomoaia, R., Stanescu, C., Kobalava, Z., Karaulova, J., Kotova, E., Milto, A., Pisaryuk, A., Povalyaev, N., Sorokina, M., Alrahimi, J., Elshiekh, A., Jamiel, A., Ahmed, A., Al-Mallah, M., Attia, N., Putnikovic, B., Neskovic, A., Dimic, A., Ivanovic, B., Matic, S., Trifunovic, D., Petrovic, J., Kosevic, D., Dabic, P., Milojevic, P., Petrovic, I., Stojanovic, I., Srdanovic, I., Kovacevic, M., Redzek, A., Stefanovic, M., Susak, S., Velicki, L., Vulin, A., Yeo, T. C., Kong, W. K. F., Poh, K. K., Vilacosta, I., Nasser, M. Abd El, Ferrera, C., Olmos, C., Iglesias, F. Calvo, Blanco-Gonzalez, E., Amaro, M. Bravo, Germinas, A. N., Lopez-Rodriguez, E., Adan, J. Lugo, Pazos-Lopez, P., Loureiro, M. Pereira, Perez, M. T., Raposeiras-Roubin, S., Yas, S. Rasheed, Suarez-Varela, M. M., Vidal, F. Vasallo, Garcia-Dorado, D., Sambola, A., Fernandez-Hidalgo, N., Gonzalez-Alujas, T., Lozano, J., Maisterra, O., Pizzi, N., Rios, R., Tornos, P., Bayes-Genis, A., Botet, L. Pedro, Vallejo, N., Berastegui, E., Llibre, C., Mateu, L., Nunez, R., Quesada, D., Portell, D. Bosch, Vinas, J. Aboal, Bertran, X. Albert, Tarradellas, R. Brugada, Ricon, P. Loma-Osorio, de Llano, C. Tiron, Arnau, M. A., Bel, A., Blanes, M., Osa, A., Anguita, M., Carrasco, F., Castillo, J., Zamorano, J. L., Mur, J. L. Moya, Alvaro, M., Fernandez-Golfin, C., Monteagudo, J. M., Elorza, E. Navas, Alvarez, M. C. Farinas, Balbin, J. Aguero, Arminanzas, C., de las Revillas, F. Arnaiz, Garcia, A. Arnaiz, Belaustegui, M. Cobo, Sampedro, M. Fernandez, Cuadra, M. Gutierrez, Gutierrez-Diez, J. F., Zarauza, J., Cuello, L. Garcia, Rico, C. Gonzalez, Rodriguez-Alvarez, R., Goikoetxea, J., Montejo, M., Miro, J., Almela, M., Ambrosioni, J., Falces, C., Fuster, D., Garcia-de-la-Maria, C., Hernandez-Meneses, M., Llopis, J., Marco, F., Moreno, A., Quintana, E., Sandoval, E., Tellez, A., Tolosana, J. M., Vidal, B., Ruiz-Zamora, I., Ruiz, A. Bardaji, Girgas, E. Sanz, Garcia-Pardo, G., Marzo, M. Guillen, Oviedo, A. Rodriguez, Jimenez, A. Villares, Abid, L., Hammami, R., Kammoun, S., Mourali, M. S., Zghal, F. Mghaieth, Hlima, M. Ben, Boudiche, S., Ouali, S., Zakhama, L., Antit, S., Slama, I., Gulel, O., Sahin, M., Sade, L. E., Karacaglar, E., Kucukoglu, S., Cetinarslan, O., Sinan, Umit Yasar, Canpolat, U., Mutlu, B., Atas, H., Dervishova, R., Ileri, C., Zaky, H., Alhashmi, J., Baslib, F., Tahir, J., Zarger, P., Woldman, S., Menezes, L., Primus, C., Uppal, R., Bvekerwa, I., Chandrasekaran, B., Kopanska, A., Prendergast, B., Cannata, S., Chambers, J., Hancock, J., Klein, J., Rajani, R., Ursi, M. P., Dworakowski, R., Fife, A., Breeze, J., Browne-Morgan, M., Gunning, M., Streather, S., Asch, F., Zemedkun, M., Alyavi, B., Uzokov, J., Graduate School, ACS - Heart failure & arrhythmias, Cardiology, Radiotherapy, CCA - Imaging and biomarkers, and ACS - Atherosclerosis & ischemic syndromes
- Abstract
In this article the “EURO-ENDO Investigators group” member U. Y. Sinan was incorrectly written as U.S. Yasar. The original article has been corrected.
- Published
- 2022
36. From micro- to nano- and time-resolved x-ray computed tomography: Bio-based applications, synchrotron capabilities, and data-driven processing
- Author
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Pedro I. C. Claro, Egon P. B. S. Borges, Gabriel R. Schleder, Nathaly L. Archilha, Allan Pinto, Murilo Carvalho, Carlos E. Driemeier, Adalberto Fazzio, and Rubia F. Gouveia
- Subjects
General Physics and Astronomy - Abstract
X-ray computed microtomography (μCT) is an innovative and nondestructive versatile technique that has been used extensively to investigate bio-based systems in multiple application areas. Emerging progress in this field has brought countless studies using μCT characterization, revealing three-dimensional (3D) material structures and quantifying features such as defects, pores, secondary phases, filler dispersions, and internal interfaces. Recently, x-ray computed tomography (CT) beamlines coupled to synchrotron light sources have also enabled computed nanotomography (nCT) and four-dimensional (4D) characterization, allowing in situ, in vivo, and in operando characterization from the micro- to nanostructure. This increase in temporal and spatial resolutions produces a deluge of data to be processed, including real-time processing, to provide feedback during experiments. To overcome this issue, deep learning techniques have risen as a powerful tool that permits the automation of large amounts of data processing, availing the maximum beamline capabilities. In this context, this review outlines applications, synchrotron capabilities, and data-driven processing, focusing on the urgency of combining computational tools with experimental data. We bring a recent overview on this topic to researchers and professionals working not only in this and related areas but also to readers starting their contact with x-ray CT techniques and deep learning.
- Published
- 2023
37. The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry
- Author
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Habib G., Lancellotti P., Erba P. -A., Sadeghpour A., Meshaal M., Sambola A., Furnaz S., Citro R., Ternacle J., Donal E., Cosyns B., Popescu B., Iung B., Prendergast B., Laroche C., Tornos P., Pazdernik M., Maggioni A., Gale C. P., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L, Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. -L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. -H., Kong W., Matskeplishvili S., Mirocevic M., Neskovic A. N., Plonska-Gosciniak E., Popescu B. A., Raissouni M., Ronderos R., Sade L. E., Sengupta S., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Vaskelyte J., Yamagata K., Yiangou K., Zaky H., Granada I., Mahia M., Ressi S., Nacinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streitenberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Melissopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., Emal C. D., Oury C., Droogmans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Amsel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Vieira M., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gouvea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio De Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Bihan D. L., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes M. D. C., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I. A., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., MacHacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. -F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Tourneau T. L., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Bras M. L., Faucher J. -F., Aboyans V., Beeharry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Berre R. L., Ven F. L., Pouliquen M. -C., Prat G., Roux P. L., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Marcis V. L., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. -S., Lim P., Oliver L., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Gohier S., Axler O., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nickenig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Wanounou M., Israel S., D'Agostino C., Colonna P., Michele L. D., Fumarola F., Stante M., Marchionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., Chiara B. D., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alfieri O., Bonis M. D., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasciuta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Vece D. D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., Martino A. D., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., MacHino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Izumi C., Amano M., Miyake M., Takahashi K., Shiojima I., Miyasaka Y., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shitan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Sow R., Codreanu A., Staub T., Michaux C., De La Vega E. C. L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Piscopo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Grejdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfile E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Wahadat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van Der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van Der Bilt I., Vriend J., Lange-Van Bruggen H. D., Karijodikoro E., Riezebos R., Van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vilacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Blanco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tarradellas R., Loma-Osorio Ricon P., Tiron De Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz De Las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-De-La-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Yasar U. S., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. M., Zemedkun M., Alyavi B., Uzokov J., Cardiovascular Centre (CVC), Universidad de Cantabria, Habib, G, Lancellotti, P, Erba, P, Sadeghpour, A, Meshaal, M, Sambola, A, Furnaz, S, Citro, R, Ternacle, J, Donal, E, Cosyns, B, Popescu, B, Iung, B, Prendergast, B, Laroche, C, Tornos, P, Pazdernik, M, Maggioni, A, Gale, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Mirocevic, M, Neskovic, A, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio De Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Bras, M, Faucher, J, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Berre, R, Ven, F, Pouliquen, M, Prat, G, Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, Michele, L, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alfieri, O, Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, MacHino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De La Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van Der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van Der Bilt, I, Vriend, J, Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, Van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, 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de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Cardiovasculaire, University Hospital of Cruces, Geneva University Hospital (HUG), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Preventive Medicine Unit, University Hospital Joan XXIII, IISPV, Rovira and Virgili University, Habib, G., Lancellotti, P., Erba, P. -A., Sadeghpour, A., Meshaal, M., Sambola, A., Furnaz, S., Citro, R., Ternacle, J., Donal, E., Cosyns, B., Popescu, B., Iung, B., Prendergast, B., Laroche, C., Tornos, P., Pazdernik, M., Maggioni, A., Gale, C. 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Y., Heo, R., Lee, S., Song, J. -M., Jung, E., Plisiene, J., Dambrauskaite, A., Gruodyte, G., Jonkaitiene, R., Mizariene, V., Atkocaityte, J., Zvirblyte, R., Sow, R., Codreanu, A., Staub, T., Michaux, C., De La Vega, E. C. L., Jacobs-Orazi, L., Mallia Azzopardi, C., Xuereb, R. G., Piscopo, T., Farrugia, J., Fenech, M., Pllaha, E., Vella, C., Borg, D., Casha, R., Grib, L., Raevschi, E., Grejdieru, A., Kravcenco, D., Prisacari, E., Samohvalov, E., Samohvalov, S., Sceglova, N., Panfile, E., Cardaniuc, L., Corcea, V., Feodorovici, A., Gaina, V., Girbu, L., Jimbei, P., Balan, G., Cardaniuc, I., Benesco, I., Marian, V., Sumarga, N., Bozovic, B., Bulatovic, N., Lakovic, P., Music, L., Budde, R., Wahadat, A., Gamela, T., Meijers, T., Van Melle, J. P., Deursen, V. M., Crijns, H. J., Bekkers, S. C., Cheriex, E. C., Gilbers, M., Kietselaer, B. L., Knackstedt, C., Lorusso, R., Schalla, S., Streukens, S. A., Chamuleau, S., Cramer, M. -J., Teske, A., Van Der Spoel, T., Wind, A., Lokhorst, J., Liesbek, O., Van Heusden, H., Tanis, W., Van Der Bilt, I., Vriend, J., Lange-Van Bruggen, H. D., Karijodikoro, E., Riezebos, R., Van Dongen, E., Schoep, J., Stolk, V., Offstad, J. T., Beitnes, J. O., Helle-Valle, T., Skulstad, H., Skardal, R., Qamar, N., Ahmed, B., Butt, M. H., Khanzada, M. F., Saghir, T., Wahid, A., Hryniewiecki, T., Szymanski, P., Marzec, K., Misztal-Ogonowska, M., Kosmala, W., Przewlocka-Kosmala, M., Rojek, A., Woznicka, K., Zachwyc, J., Lisowska, A., Kaminska, M., Kasprzak, J. D., Kowalczyk, E., Strzecka, D. F., Wejner-Mik, P., Trabulo, M., Freitas, P., Ranchordas, S., Rodrigues, G., Pinto, P., Queiros, C., Azevedo, J., Marques, L., Seabra, D., Branco, L., Cruz, M., Galrinho, A., Moreira, R., Rio, P., Timoteo, A. T., Selas, M., Carmelo, V., Duque Neves, B., Pereira, H., Guerra, A., Marques, A., Pintassilgo, I., Tomescu, M. C., Trofenciuc, N. -M., Andor, M., Bordejevic, A., Branea, H. S., Caruntu, F., Velcean, L. A., Mavrea, A., Onel, M. F., Parvanescu, T., Pop, D., Pop-Moldovan, A. L., Puticiu, M. I., Cirin, L., Citu, I. M., Cotoraci, C. A., Darabantiu, D., Farcas, R., Marincu, I., Ionac, A., Cozma, D., Mornos, C., Goanta, F., Popescu, I., Beyer, R., Mada, R., Rancea, R., Tomoaia, R., Rosianu, H., Stanescu, C., Kobalava, Z., Karaulova, J., Kotova, E., Milto, A., Pisaryuk, A., Povalyaev, N., Sorokina, M., Alrahimi, J., Elshiekh, A., Jamiel, A., Ahmed, A., Attia, N., Putnikovic, B., Dimic, A., Ivanovic, B., Matic, S., Trifunovic, D., Petrovic, J., Kosevic, D., Stojanovic, I., Petrovic, I., Dabic, P., Milojevic, P., Srdanovic, I., Susak, S., Velicki, L., Vulin, A., Kovacevic, M., Redzek, A., Stefanovic, M., Yeo, T. C., Kong, W. K. F., Poh, K. K., Vilacosta, I., Ferrera, C., Olmos, C., Abd El-Nasser, M., Calvo Iglesias, F., Blanco-Gonzalez, E., Bravo Amaro, M., Lopez-Rodriguez, E., Lugo Adan, J., Germinas, A. N., Pazos-Lopez, P., Pereira Loureiro, M., Perez, M. T., Raposeiras-Roubin, S., Rasheed Yas, S., Suarez-Varela, M. -M., Vasallo Vidal, F., Garcia-Dorado, D., Fernandez-Hidalgo, N., Gonzalez-Alujas, T., Lozano, J., Maisterra, O., Pizzi, N., Rios, R., Bayes-Genis, A., Pedro Botet, L., Vallejo, N., Llibre, C., Mateu, L., Nunez, R., Quesada, D., Berastegui, E., Bosch Portell, D., Aboal Vinas, J., Albert Bertran, X., Brugada Tarradellas, R., Loma-Osorio Ricon, P., Tiron De Llano, C., Arnau, M. A., Bel, A., Blanes, M., Osa, A., Anguita, M., Carrasco, F., Castillo, J. C., Zamorano, J. L., Moya Mur, J. L., Alvaro, M., Fernandez-Golfin, C., Monteagudo, J. M., Navas Elorza, E., Farinas Alvarez, M. C., Aguero Balbin, J., Zarauza, J., Gutierrez-Diez, J. F., Arminanzas, C., Arnaiz De Las Revillas, F., Arnaiz Garcia, A., Cobo Belaustegui, M., Fernandez Sampedro, M., Gutierrez Cuadra, M., Garcia Cuello, L., Gonzalez Rico, C., Rodriguez-Alvarez, R., Goikoetxea, J., Montejo, M., Miro, J. M., Almela, M., Ambrosioni, J., Moreno, A., Quintana, E., Sandoval, E., Tellez, A., Tolosana, J. M., Vidal, B., Falces, C., Fuster, D., Garcia-De-La-Maria, C., Hernandez-Meneses, M., Llopis, J., Marco, F., Ruiz-Zamora, I., Bardaji Ruiz, A., Sanz Girgas, E., Garcia-Pardo, G., Guillen Marzo, M., Rodriguez Oviedo, A., Villares Jimenez, A., Abid, L., Hammami, R., Kammoun, S., Mourali, M. S., Ben Hlima, M., Boudiche, S., Ouali, S., Zakhama, L., Antit, S., Slama, I., Gulel, O., Sahin, M., Karacaglar, E., Kucukoglu, S., Cetinarslan, O., Yasar, U. S., Canpolat, U., Mutlu, B., Atas, H., Dervishova, R., Ileri, C., Alhashmi, J., Tahir, J., Zarger, P., Baslib, F., Woldman, S., Menezes, L., Primus, C., Uppal, R., Bvekerwa, I., Chandrasekaran, B., Kopanska, A., Chambers, J., Hancock, J., Klein, J., Rajani, R., Ursi, M. P., Cannata, S., Dworakowski, R., Fife, A., Breeze, J., Browne-Morgan, M., Gunning, M., Streather, S., Asch, F. M., Zemedkun, M., Alyavi, B., Uzokov, J., RS: Carim - H01 Clinical atrial fibrillation, MUMC+: MA Cardiologie (9), Cardiologie, RS: CARIM - R3.11 - Imaging, RS: CARIM - R2.01 - Clinical atrial fibrillation, MUMC+: MA Med Staf Artsass CTC (9), Promovendi CD, Fysiologie, RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - V04 Surgical intervention, CTC, MUMC+: MA Med Staf Spec CTC (9), RS: CARIM - R2.12 - Surgical intervention, RS: Carim - H02 Cardiomyopathy, and RS: CARIM - R2.02 - Cardiomyopathy
- Subjects
medicine.medical_specialty ,Registry ,MEDLINE ,Infective endocarditi ,infective endocarditis ,registry ,valve disease ,Disease ,Infective endocarditis ,Valve disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,Journal Article ,MANAGEMENT ,Endocarditis ,Humans ,030212 general & internal medicine ,Registries ,Intensive care medicine ,health care economics and organizations ,Surrogate endpoint ,business.industry ,Health Policy ,Patient data ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,medicine.disease ,3. Good health ,Cardiac surgery ,Europe ,Practice Guidelines as Topic ,business ,Cardiology and Cardiovascular Medicine ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. Methods and results Patients (n = 3116) aged over 18 years with a diagnosis of IE based on the ESC 2015 IE diagnostic criteria were prospectively identified between 1 January 2016 and 31 March 2018. Individual patient data were collected across 156 centres and 40 countries. The primary endpoint is all-cause mortality in hospital and at 1 year. Secondary endpoints are 1-year morbidity (all-cause hospitalization, any cardiac surgery, and IE relapse), the clinical, epidemiological, microbiological, and therapeutic characteristics of patients, the number and timing of non-invasive imaging techniques, and adherence to recommendations as stated in the 2015 ESC Clinical Practice Guidelines for the management of IE. Conclusion EURO-ENDO is an international registry of care and outcomes of patients hospitalized with IE which will provide insights into the contemporary profile and management of patients with this challenging disease.
- Published
- 2019
38. Non-coronary cardiac events, younger age, and IVIG unresponsiveness increase the risk for coronary aneurysms in Italian children with Kawasaki disease
- Author
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Paola Sogno Valin, Marcello Lanari, Ada Dormi, Giorgia Di Fazzio, Ilaria Frabboni, Federico Marchetti, Lorenzo Iughetti, Laura Andreozzi, Barbara Bigucci, Claudia Balsamo, Andrea Donti, Cristina Cicero, Francesca Lami, Enrico Valletta, Elena Corinaldesi, Rosa Francavilla, Monica Sprocati, Bertrand Tchana, Marianna Fabi, Fabi M., Andreozzi L., Frabboni I., Dormi A., Corinaldesi E., Lami F., Cicero C., Tchana B., Francavilla R., Sprocati M., Bigucci B., Balsamo C., Valin P.S., Di Fazzio G., Iughetti L., Valletta E., Marchetti F., Donti A., and Lanari M.
- Subjects
Male ,medicine.medical_specialty ,Heart disease ,Caucasian ,Coronary aneurysms ,Coronary lesions ,Kawasaki disease ,Non-coronary lesions ,Seasonality ,Mucocutaneous Lymph Node Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Rheumatology ,Internal medicine ,medicine ,Humans ,Prospective Studies ,cardiovascular diseases ,030212 general & internal medicine ,Risk factor ,Child ,Prospective cohort study ,Retrospective Studies ,030203 arthritis & rheumatology ,business.industry ,Immunoglobulins, Intravenous ,Infant ,Coronary aneurysm ,Non-coronary lesion ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Italy ,Child, Preschool ,Cohort ,business ,Coronary lesion ,Artery - Abstract
Objectives: Kawasaki disease (KD) is the most frequent cause of acquired heart disease in children in high-income countries because of coronary artery involvement. Risk factors for coronary lesions can vary in consideration of different genetic background and environmental factors. Methods: Multicenter retrospective and prospective study including 372 consecutive children (58% boys; mean age 34.3 ± 30.3 months, Caucasian 85%) was diagnosed with KD. We divided the cohort into 2 groups according to the presence of coronary anomalies (CAA) and aneurysms. We compared the groups and studied the risk factors for CAA and for aneurysms, the most severe lesions. Results: Children with CAA were 91/372 (24.46%, aneurysms 20/372, 5.37%). Children with CAA were more likely to have a longer duration of fever (p < 0.001), later day of treatment (p < 0.001), to be IVIG non-responders and late treated (p < 0.001), while age, clinical presentation, and seasonality were not different. They also had significantly higher WBC and neutrophils, lower lymphocytes, Hb and Na during the acute stage, and slower resolution of inflammation. Age, IVIG unresponsiveness, and presence of non-coronary cardiac findings were independent risk factors for CAA and for aneurysms, while neutrophils just for CAA. Age under 6 months was a risk factor for the aneurysm. Aneurysms occurred more frequently in the first quartile of the age of KD onset (under 14 months). Conclusion: Very young children with non-coronary cardiac findings are at increased risk for a more severe form of KD with aneurysms. These children could benefit from adjunctive therapy beside IVIG, especially if they have higher markers of inflammation, particularly neutrophils.Key points• Risk factors for coronary lesions can vary in consideration of different genetic background and environmental factors.• Risk factors for coronary involvement have been extensively studied in the Asian population, and others have been validated in cohorts with mixed ethnicities.• In our predominantly Caucasian population, non-coronary cardiac findings, age younger than 6 months, and IVIG unresponsiveness are independent risk factors for a more severe form of KD with aneurysms.
- Published
- 2020
39. Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers
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Robert T. Fazzio, Mostafa Fatemi, Azra Alizad, Judy C. Boughey, Eric C. Polley, and Juanjuan Gu
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Adult ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Breast imaging ,Biophysics ,Breast Neoplasms ,Article ,Standard deviation ,030218 nuclear medicine & medical imaging ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Predictive Value of Tests ,Biomarkers, Tumor ,Humans ,Medicine ,Neoplasm Invasiveness ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Elasticity (economics) ,Correlation of Data ,Lymph node ,Aged ,Aged, 80 and over ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Confidence interval ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Elasticity Imaging Techniques ,Female ,Ultrasonography, Mammary ,Elastography ,Radiology ,business - Abstract
This purpose of this study is to correlate a new shear-wave elastography (SWE) parameter, mass characteristic frequency (fmass) and other elasticity measure with the prognostic histological factors and immunohistochemical (IHC) biomarkers for the evaluation of heterogeneous breast carcinomas. The new parameter, fmass, first introduced in this paper, is defined as the ratio of the averaged minimum shear wave speed taken spatially within regions of interest to the largest mass dimension. 264 biopsy-proven breast cancerous masses were included in this study. Mean (Emean), maximum (Emax), minimum (Emin) shear wave elasticity and standard deviation (Esd) of shear wave elasticity were found significantly correlated with tumor size, axillary lymph node (ALN) status, histological subtypes and IHC subtypes. The areas under the curve for the ALN prediction are 0.73 (95% confidence interval [CI]: 0.67-0.80) and 0.75 (95% CI: 0.69-0.81) for the combination of Emean with Breast Imaging Reporting and Data System (BI-RADS) score and Emax with BI-RADS score, respectively. fmass was significantly correlated with the presence of calcifications, ALN status, histological grade, the expressions of IHC biomarkers and IHC subtypes. To conclude, poor prognostic factors were associated with high shear wave elasticity values and low mass characteristic frequency value. Therefore, SWE provides valuable information that may help with prediction of breast cancer invasiveness.
- Published
- 2021
40. Author Correction: High-throughput inverse design and Bayesian optimization of functionalities: spin splitting in two-dimensional compounds
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Gabriel M. Nascimento, Elton Ogoshi, Adalberto Fazzio, Carlos Mera Acosta, and Gustavo M. Dalpian
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Statistics and Probability ,Library and Information Sciences ,Statistics, Probability and Uncertainty ,Computer Science Applications ,Education ,Information Systems - Published
- 2022
41. Two new species of Neocarus (Acari: Opilioacaridae) from Piauí and Rio de Janeiro, Brazil, with remarks on integument and seta shape as characters
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Marcel Santos De Araújo, Antonella Di Palma, Ronald Ochoa, Reinaldo José Fazzio Feres, Thaís Coimbra Marigo, and Angélica Maria Penteado-Dias
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Ecology ,Insect Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Two new opilioacarid species from Northeast and Southeast of Brazil are described. Neocarus setilatus sp. nov. from a gallery forest in Piauí and Neocarus marambaia sp. nov. from a restinga area in Rio de Janeiro. Both species have the similar starshaped integument character and smaller, broader setae. We discuss the importance of these characters with systematic value and present an updated taxonomic key for the genus Neocarus.
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- 2022
42. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
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Loretah Chibaya, Katherine C. Murphy, Yvette Lopez-Diaz, Kelly D. DeMarco, Haibo Liu, Sneha Gopalan, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, and Marcus Ruscetti
- Abstract
T cell-activating immunotherapies that produce durable and even curative responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor tumor immunogenicity. We and others have demonstrated that induction of cellular senescence and its accompanying senescence-associated secretory phenotype (SASP) can be an effective approach to activate not only T cell but also cytotoxic Natural Killer (NK) cell-mediated anti-tumor immunity. Here we found that the pancreas tumor microenvironment (TME) suppresses NK and T cell surveillance following therapy-induced senescence through EZH2-mediated repression of pro-inflammatory SASP genes. Genetic or pharmacological inhibition of EZH2 or its methyltransferase activity stimulated the production of pro-inflammatory SASP chemokines CCL2 and CXCL9/10 that led to enhanced NK and T cell infiltration and tumor eradication in preclinical PDAC mouse models. EZH2 activity was also associated with suppression of SASP-associated inflammatory chemokines and cytotoxic lymphocyte immunity and reduced overall survival in a PDAC patient cohort. These results demonstrate that EZH2 mediates epigenetic repression of the pro-inflammatory SASP in the pancreas TME, and that EZH2 blockade in combination with senescence-inducing therapies could be a powerful means to potentiate NK and T cell surveillance in PDAC to achieve immune-mediated tumor control.
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- 2022
43. Comparison of breast density assessments between synthesized C-View™ & intelligent 2D™ mammography
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Sadia, Khanani, Lekui, Xiao, Matthew R, Jensen, Amy L, Conners, Robert T, Fazzio, Carrie B, Hruska, Stacey, Winham, Fang Fang, Wu, Christopher G, Scott, and Celine M, Vachon
- Subjects
Child, Preschool ,Humans ,Breast Neoplasms ,Female ,Radiology, Nuclear Medicine and imaging ,Breast ,General Medicine ,Child ,Early Detection of Cancer ,Breast Density ,Mammography ,Retrospective Studies - Abstract
Objective To compare breast density assessments between C-View™ and Intelligent 2D™, different generations of synthesized mammography (SM) from Hologic. Methods: In this retrospective study, we identified a subset of females between March 2017 and December 2019 who underwent screening digital breast tomosynthesis (DBT) with C-View followed by DBT with Intelligent 2D. Clinical Breast Imaging Reporting and Database System breast density was obtained along with volumetric breast density measures (including density grade, breast volume, percentage volumetric density, dense volume) using VolparaTM. Differences in density measures by type of synthesized image were calculated using the pairwise t-test or McNemar’s test, as appropriate. Results 67 patients (avg age 62.7; range 40–84) were included with an average of 13.3 months between the two exams. No difference was found in Breast Imaging Reporting and Database System density between the SM reconstructions (p = 0.74). Similarly, there was no difference in VolparaTM mean density grade (p = 0.71), mean breast volume (p = 0.48), mean dense volume (p = 0.43) or mean percent volumetric density (p = 0.12) between the exams. Conclusion We found no significant differences in clinical and automated breast density assessments between these two versions of SM. Advances in knowledge Lack of differences in density estimates between the two SM reconstructions is important as density assignment impacts risk stratification and adjunct screening recommendations.
- Published
- 2022
44. Disassembly of TEMPO-Oxidized Cellulose Fibers: Intersheet and Interchain Interactions in the Isolation of Nanofibers and Unitary Chains
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Gustavo H. Silvestre, Juliana S. Bernardes, Lidiane O. Pinto, Adalberto Fazzio, and Roberto H. Miwa
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chemistry.chemical_classification ,Materials science ,010304 chemical physics ,Hydrogen bond ,Binding energy ,Oxidized cellulose ,Polymer ,010402 general chemistry ,Electrostatics ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Nanofiber ,0103 physical sciences ,Materials Chemistry ,Carboxylate ,Physical and Theoretical Chemistry ,Cellulose - Abstract
Cellulose disassembly is an important issue in designing nanostructures using cellulose-based materials. In this work, we present a combination of experimental and theoretical study addressing the disassembly of cellulose nanofibrils. Through 2,2,6,6-tetramethylpiperidine-1-oxyl-mediated oxidation processes, combined with atomic force microscopy results, we show the formation of nanofibers with diameters corresponding to that of a single-cellulose polymer chain. The formation of these polymer chains is controlled by repulsive electrostatic interactions between the oxidized chains. Further, first-principles calculations have been performed in order to provide an atomistic understanding of the cellulose disassembling processes, focusing on the balance between the interchain (IC) and intersheet (IS) interactions upon oxidation. First, we analyze these interactions in pristine systems, where we found the IS interaction to be stronger than the IC interaction. In the oxidized systems, we have considered the formation of (charged) carboxylate groups along the inner sites of elementary fibrils. We show a net charge concentration on the carboxylate groups, supporting the emergence of repulsive electrostatic interactions between the cellulose nanofibers. Indeed, our total energy results show that the weakening of the binding strength between the fibrils is proportional to the concentration and net charge density of the carboxylate group. Moreover, by comparing the IC and IS binding energies, we found that most of the disassembly processes should take place by breaking the IC O-H···O hydrogen bond interactions and thus supporting the experimental observation of single- and double-cellulose polymer chains.
- Published
- 2021
45. Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer
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Adriana Gregory, Mostafa Fatemi, Azra Alizad, Max Denis, Judy C. Boughey, Sandhya Pruthi, Robert T. Fazzio, Juanjuan Gu, Eric C. Polley, and Jodi M. Carter
- Subjects
Adult ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Breast Neoplasms ,Neoadjuvant chemotherapy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Immunohistochemical biomarkers ,Surgical oncology ,Internal medicine ,Biopsy ,Biomarkers, Tumor ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,RC254-282 ,Aged ,Chemotherapy ,Shear wave elastography ,biology ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Middle Aged ,medicine.disease ,Mass characteristic frequency ,Neoadjuvant Therapy ,Treatment Outcome ,ROC Curve ,030220 oncology & carcinogenesis ,Ki-67 ,biology.protein ,Elasticity Imaging Techniques ,Female ,business ,Research Article - Abstract
Background Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in patients with invasive breast cancer. Methods In a prospective study, 62 patients with biopsy-proven invasive breast cancer were enrolled. Three SWE studies were conducted on each patient: before, at mid-course, and after NACT but before surgery. A new parameter, mass characteristic frequency (fmass), along with SWE measurements and mass size was obtained from each SWE study visit. The clinical biomarkers were acquired from the pre-NACT core-needle biopsy. The efficacy of different models, generated with the leave-one-out cross-validation, in predicting response to NACT was shown by the area under the receiver operating characteristic curve and the corresponding sensitivity and specificity. Results A significant difference was found for SWE parameters measured before, at mid-course, and after NACT between the responders and non-responders. The combination of Emean2 and mass size (s2) gave an AUC of 0.75 (0.95 CI 0.62–0.88). For the ER+ tumors, the combination of Emean_ratio1, s1, and Ki-67 index gave an improved AUC of 0.84 (0.95 CI 0.65–0.96). For responders, fmass was significantly higher during the third visit. Conclusions Our study findings highlight the value of SWE estimation in the mid-course of NACT for the early prediction of treatment response. For ER+ tumors, the addition of Ki-67improves the predictive power of SWE. Moreover, fmass is presented as a new marker in predicting the endpoint of NACT in responders.
- Published
- 2021
46. Discovery of higher-order topological insulators using the spin Hall conductivity as a topology signature
- Author
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Gabriel R. Schleder, Carlos Mera Acosta, Marco Buongiorno Nardelli, Frank T. Cerasoli, A. C. M. Padilha, Adalberto Fazzio, and Marcio Costa
- Subjects
Boundary (topology) ,FOS: Physical sciences ,02 engineering and technology ,Topology ,01 natural sciences ,QA76.75-76.765 ,Ab initio quantum chemistry methods ,0103 physical sciences ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,General Materials Science ,Computer software ,010306 general physics ,Materials of engineering and construction. Mechanics of materials ,Topology (chemistry) ,Spin-½ ,Physics ,Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Materials Science (cond-mat.mtrl-sci) ,021001 nanoscience & nanotechnology ,Computer Science Applications ,Mechanics of Materials ,Modeling and Simulation ,Topological insulator ,Spin Hall effect ,TA401-492 ,Density functional theory ,0210 nano-technology ,Realization (systems) - Abstract
The discovery and realization of topological insulators, a phase of matter which hosts metallic boundary states when the d-dimension insulating bulk is confined to (d − 1)-dimensions, led to several potential applications. Recently, it was shown that protected topological states can manifest in (d − 2)-dimensions, such as hinge and corner states for three- and two-dimensional systems, respectively. These nontrivial materials are named higher-order topological insulators (HOTIs). Here we show a connection between spin Hall effect and HOTIs using a combination of ab initio calculations and tight-binding modeling. The model demonstrates how a non-zero bulk midgap spin Hall conductivity (SHC) emerges within the HOTI phase. Following this, we performed high-throughput density functional theory calculations to find unknown HOTIs, using the SHC as a criterion. We calculated the SHC of 693 insulators resulting in seven stable two-dimensional HOTIs. Our work guides novel experimental and theoretical advances towards higher-order topological insulator realization and applications.
- Published
- 2021
47. Pair Distribution Function Obtained from Electron Diffraction: An Advanced Real-Space Structural Characterization Tool
- Author
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Edson R. Leite, João B. Souza Junior, Gabriel R. Schleder, Jefferson Bettini, I. C. Nogueira, and Adalberto Fazzio
- Subjects
Materials science ,Electron diffraction ,law ,Transmission electron microscopy ,Scattering ,Pair distribution function ,General Materials Science ,Nanotechnology ,Electron ,Synchrotron ,Characterization (materials science) ,law.invention ,Nanomaterials - Abstract
Summary Atomic-scale structure determination is crucial to the understanding of nanomaterial properties and development of new technologies. Although pair distribution function (PDF) analysis by neutrons and X-ray scattering profile has been used to study materials, electron diffraction can offer advantages to characterize the atomic structure of clusters, amorphous samples, and nanomaterials. Electrons have higher scattering power than X-rays, allowing the acquirement of PDF from electron diffraction (ePDF) for small sample amounts and with time-efficient data acquisition. Compared with synchrotron X-rays and neutrons as sources for PDF, the availability of electron microscopes worldwide is advantageous. Nowadays, with the rise of methodologies and specific software for ePDF data analysis, the scientific community can benefit from advanced transmission electron microscopy (TEM) structure determination integrating commonly available TEM analyses—size, distribution, shape, and high-resolution TEM atomic visualization—with ePDF atomic structure determination, both for bulk and surface configurations. Therefore, ePDF has the potential to become a routine and advanced characterization tool for nanomaterials science.
- Published
- 2021
48. Bandgap evolution in nanographene assemblies
- Author
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Adalberto Fazzio and F. Crasto de Lima
- Subjects
Condensed Matter - Materials Science ,Monatomic gas ,Valence (chemistry) ,Materials science ,Condensed matter physics ,Bond strength ,Band gap ,Bandwidth (signal processing) ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,General Physics and Astronomy ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Thermal conduction ,01 natural sciences ,0104 chemical sciences ,Interpretation (model theory) ,Density functional theory ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
Recently cycloarene has been experimentally obtained in a self-assembled structure, forming graphene-like monoatomic layered systems. Here, we established bandgap engineering/prediction in cycloarene assemblies within a combination of density functional theory and tight-binding Hamiltonians. Our results show that the inter-molecule bond density rules the bandgap. The increase in such bond density increases the valence/conduction bandwidth decreasing the energy gap linearly. We derived an effective model that allows the interpretation of the arising energy gap for general particle-hole symmetric molecular arrangements based on inter-molecular bond strength.
- Published
- 2021
49. Multi-parameter Sub-Hertz Analysis of Viscoelasticity With a Quality Metric for Differentiation of Breast Masses
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Jeremy M. Webb, Rohit Nayak, Duane D. Meixner, Michael F. Insana, Mostafa Fatemi, Alireza Nabavizadeh, Adriana Gregory, Azra Alizad, Mahdi Bayat, and Robert T. Fazzio
- Subjects
Acoustics and Ultrasonics ,Breast lesion ,Biophysics ,Breast Neoplasms ,Article ,Viscoelasticity ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,Breast Diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality (physics) ,Humans ,Radiology, Nuclear Medicine and imaging ,Multi parameter ,Mathematics ,Radiological and Ultrasound Technology ,Viscosity ,business.industry ,Ultrasound ,Middle Aged ,Elasticity ,030220 oncology & carcinogenesis ,Metric (mathematics) ,Elasticity Imaging Techniques ,Female ,Ultrasonic sensor ,business ,Biomedical engineering - Abstract
We applied sub-Hertz analysis of viscoelasticity (SAVE) to differentiate breast masses in pre-biopsy patients. Tissue response during external ramp-and-hold stress was ultrasonically detected. Displacements were used to acquire tissue viscoelastic parameters. The fast instantaneous response and slow creep-like deformations were modeled as the response of a linear standard solid from which viscoelastic parameters were estimated. These parameters were used in a multi-variable classification framework to differentiate malignant from benign masses identified by pathology. When employing all viscoelasticity parameters, SAVE resulted in 71.43% accuracy in differentiating lesions. When combined with ultrasound features and lesion size, accuracy was 82.24%. Adding a quality metric based on uniaxial motion increased the accuracy to 81.25%. When all three were combined with SAVE, accuracy was 91.3%. These results confirm the utility of SAVE as a robust ultrasound-based diagnostic tool for non-invasive differentiation of breast masses when used as stand-alone biomarkers or in conjunction with ultrasonic features.
- Published
- 2020
50. Volumetric imaging and morphometric analysis of breast tumor angiogenesis using a new contrast-free ultrasound technique: a feasibility study
- Author
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Juanjuan Gu, Redouane Ternifi, Soroosh Sabeti, Nicholas B. Larson, Jodi M. Carter, Robert T. Fazzio, Mostafa Fatemi, and Azra Alizad
- Subjects
Adult ,Microvessels ,Humans ,Feasibility Studies ,Female ,Breast Neoplasms ,Prospective Studies ,Breast ,Middle Aged ,Aged - Abstract
Background There is a strong correlation between the morphological features of new tumor vessels and malignancy. However, angiogenic heterogeneity necessitates 3D microvascular data of tumor microvessels for more reliable quantification. To provide more accurate information regarding vessel morphological features and improve breast lesion characterization, we introduced a quantitative 3D high-definition microvasculature imaging (q3D-HDMI) as a new easily applicable and robust tool to morphologically characterize microvasculature networks in breast tumors using a contrast-free ultrasound-based imaging approach. Methods In this prospective study, from January 2020 through December 2021, a newly developed q3D-HDMI technique was evaluated on participants with ultrasound-identified suspicious breast lesions recommended for core needle biopsy. The morphological features of breast tumor microvessels were extracted from the q3D-HDMI. Leave-one-out cross-validation (LOOCV) was applied to test the combined diagnostic performance of multiple morphological parameters of breast tumor microvessels. Receiver operating characteristic (ROC) curves were used to evaluate the prediction performance of the generated pooled model. Results Ninety-three participants (mean age 52 ± 17 years, 91 women) with 93 breast lesions were studied. The area under the ROC curve (AUC) generated with q3D-HDMI was 95.8% (95% CI 0.901–1.000), yielding a sensitivity of 91.7% and a specificity of 98.2%, that was significantly higher than the AUC generated with the q2D-HDMI (p = 0.02). When compared to q2D-HDMI, the tumor microvessel morphological parameters obtained from q3D-HDMI provides distinctive information that increases accuracy in differentiating breast tumors. Conclusions The proposed quantitative volumetric imaging technique augments conventional breast ultrasound evaluation by increasing specificity in differentiating malignant from benign breast masses.
- Published
- 2022
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