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Cardiovascular disease (CVD) has been identified as a threat to human life for decades, with the majority of individuals dying as a result of delayed diagnosis and treatment. An electrocardiogram (ECG) plays a vital role in the prognosis of such an ailment. The presence of noise and artifacts complicates the accurate detection and identification of CVD. As a result, reliable signal recovery tasks necessitate noise removal, which is an inverse problem. The main noises present in electrocardiogram (ECG) signals are EMG noise, electrode motion artifact noise. In this paper, radial basis function (RBF) and multi swarm optimization neural network (MSONN) are used to denoise the ECG signal. The cut-off frequency is calculated using a low-pass filter. By using, fuzzy FIR filtering technique baseline wander noises can be removed. Results show that MOS based approach outperforms existing approaches in terms of accuracy and is observed to be 87% even when the dataset size is small. Further, noises if any exists are also removed by the use of cascaded multiplier less Fuzzy FIR filters

Banking is one of the most important ingredients in economic development, because of banks have direct contact with the public as well as the countries economic affairs. Thus, banking institutions are considered as a most influential pillars of Indian economy and interreference of banking sector among the public become digitalized and now the digital banking system has been covered almost entire economy in the state. In this context, study has been analyzed the effect of digital banking acceptance on digital banking usage among elder banking customers, because of previous references indicates that elder people were far away from digitalization due to lack of knowledge, awareness, negative attitude created by the lack of knowledge etc. meantime many reviews found that elder people are more eager to use the technology. Here, in this context study has been analyzed the factors which are leads to the digital banking acceptance among the elder banking customers. Study has also analyzed the mediator (Informal Joint Family Network) effect between Digital Banking Acceptance (DBA) and Digital Banking Usage (DBU).

Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that also act as co-activators for number of transcription factors including HIF1a, BRCA-1, p53, c-Myc and androgen receptor (AR). Both CBP and p300 possess bromodomain (BRD) and a lysine acetyltransferase (KAT) domain. These two closely related epigenetic modulators are known to play an oncogenic role in a variety of cancers. Functional synthetic lethal screens have identified preferential killing in CBP-deficient and/or MYC-dependent hematological cancer cells by suppression of the paralogue p300. CBP/p300 BRD inhibitor could also prevent AR and ER signaling, thereby potentially inhibiting growth of AR and ER -dependent cancer cells. Thus, targeting CBP/p300 represents an attractive approach for developing personalized cancer therapies. Experimental Results: Multiple potent and selective CBP/p300 BRD inhibitors that are structurally unrelated to known inhibitors were identified by iterative medicinal chemistry and SAR based approaches. The lead compound AU-18069 was optimized towards attaining good potency, selectivity, physicochemical properties and DMPK profile. AU-18069 potently inhibited proliferation of a wide range of cell lines derived from prostate cancer, breast cancer and CBP mutant/MYC-dependent hematological cancers. The lead compound demonstrated good PK profile in rodents as well as in dogs. Excellent anti-tumor efficacy was achieved in leukemia and lymphoma xenograft models at well-tolerated doses. Significant downregulation of c-Myc was observed in a single dose PK-PD study. Conclusion: Lead candidate AU-18069 demonstrated that selective CBP/p300 bromodomain inhibitors are efficacious in models of hematologic malignancies and solid cancers in vitro and in vivo. Further evaluation of efficacy in other xenograft models, as a single agent as well as in combination with other agents is planned. Long term toxicological and safety pharmacology evaluation in different species and other IND enabling studies are in progress to support progression of this compound to clinical trials. Citation Format: Chandrasekhar Abbineni, Saravanan Thiyagarajan, Aravind A B, Amit A Dhudashiya, Sivapriya Marappan, Naveen Kumar R, Raghavendra N R, Mamon Dey, Avinash Kumar, Uma Bharathi B V, Girish Aggunda Renukappa, N Venkata Siva Reddy, Asha Babu, Aakanksha J Shetty, Amith A, Narasimha Rao K, Suraj T Gore, Mahaboobi Jaleel, Ramesh S Senaiar, Vijaya Shankar Nataraj, Subhendu Mukherjee, Samiulla D S, Thomas Antony, Girish Daginakatte, Rajesh Eswarappa, Kavitha Nellore, Shekar Chelur, Murali Ramachandra, Susanta Samajdar. Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4114.

In this present work, waste engine oil was explored as a precursor for the synthesis of carbon dots (CDs) by hydrothermal route for the first time. The obtained CDs showed excellent water solubility, photostability, bright blue emission under UV light (wavelength 365 nm), pH stability, high quantum yield, and greater biocompatibility. It was thoroughly studied by vital characterization techniques such as HR-TEM, UV–Visible spectroscopy, FTIR, SEM, PSA, Fluorescence spectroscopy with lifetime analysis. The fluorescence of synthesized CDs was quenched by the addition of Fe3+ as it showed excellent selectivity and sensitivity towards Fe3+. The sensing probe showed a good linear response (R2 = 0.9986) with a limit of detection 0.055 μM in the linear range of 0.6–3.3 μM. Due to excellent fluorescence properties of CDs, it have been applied as fluorescent ink for information storage. In addition, CDs coated polymer matrix was made and used for bead-based detection of Fe3+. Finally, the presented system could be considered as an efficient probe for Fe3+ detection and paved a way for efficient utilization of waste into value-added products.

The diagnosis of Nodular Fasciitis is a very challenging on cytological aspirations. Even in histopathological sections, it can be sometimes be mistaken for soft tissue sarcomas due to its high cellularity, presence of mitotic figures, poor circumscription and degenerative myxoid areas. Most commonly, nodular fasciitis is seen on extremities; and sub-cutaneous form is most common. We are hereby reporting a case of nodular fasciitis at a rare site (head and neck area) in its rare form (intra-muscular type: originating within sternocleidomastoid muscle), which was clinically suspected as a malignancy arising from solitary thyroid nodule. Cytological diagnosis was issued as benign spindle cell lesion (where chances of a misdiagnosis as malignant are very high), thereby preventing radical surgery. It was subsequently confirmed as intra-muscular nodular fasciitis after histopathological examination.

OBJECTIVE: To validate questionnaire-based physical activity level (PAL) against accelerometry and a 24 h physical activity diary (24 h AD) as reference methods (Protocol 2), after validating these reference methods against the heart rate-oxygen consumption (HRVO2) method (Protocol 1). DESIGN: Cross-sectional study. SETTING: Two villages in Andhra Pradesh state and Bangalore city, South India. SUBJECTS: Ninety-four participants (fifty males, forty-four females) for Protocol 2; thirteen males for Protocol 1. RESULTS: In Protocol 2, mean PAL derived from the questionnaire (1.72 (sd 0.20)) was comparable to that from the 24 h AD (1.78 (sd 0.20)) but significantly higher than the mean PAL derived from accelerometry (1.36 (sd 0.20); P < 0.001). Mean bias of PAL from the questionnaire was larger against the accelerometer (0.36) than against the 24 h AD (-0.06), but with large limits of agreement against both. Correlations of PAL from the questionnaire with that of the accelerometer (r = 0.28; P = 0.01) and the 24 h AD (r = 0.30; P = 0.006) were modest. In Protocol 1, mean PAL from the 24 h AD (1.65 (sd 0.18)) was comparable, while that from the accelerometer (1.51 (sd 0.23)) was significantly lower (P < 0.001), than mean PAL obtained from the HRVO2 method (1.69 (sd 0.21)). CONCLUSIONS: The questionnaire showed acceptable validity with the reference methods in a group with a wide range of physical activity levels. The accelerometer underestimated PAL in comparison with the HRVO2 method.