1. CDK4, CDK6/cyclin‐d1 complex inhibition and radiotherapy for cancer control: a role for autophagy
- Author
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Antonio Angrisani, Salvatore Cappabianca, Pierpaolo Pastina, Rocco Giannicola, Marcella Barbarino, Luciano Mutti, Pierpaolo Correale, Antonio Giordano, Clelia Miracco, Valerio Nardone, Alfonso Reginelli, Luigi Pirtoli, Nardone, V., Barbarino, M., Angrisani, A., Correale, P., Pastina, P., Cappabianca, S., Reginelli, A., Mutti, L., Miracco, C., Giannicola, R., Giordano, A., and Pirtoli, L.
- Subjects
Phase cell ,QH301-705.5 ,medicine.medical_treatment ,Antineoplastic Agents ,Review ,Catalysis ,Inorganic Chemistry ,Antineoplastic Agent ,Cyclin D1 ,Breast cancer ,Cancer control ,Neoplasms ,Combination strategy ,medicine ,Autophagy ,Animals ,Humans ,Physical and Theoretical Chemistry ,Biology (General) ,Molecular Biology ,Protein Kinase Inhibitors ,QD1-999 ,Spectroscopy ,biology ,Radiotherapy ,business.industry ,Animal ,Cyclin inhibitor ,Organic Chemistry ,Cell Cycle ,Cyclin-Dependent Kinase 4 ,General Medicine ,Chemoradiotherapy ,Cyclin-Dependent Kinase 6 ,medicine.disease ,Cyclin inhibitors ,Computer Science Applications ,Radiation therapy ,Chemistry ,biology.protein ,Cancer research ,Neoplasm ,Cyclin-dependent kinase 6 ,business ,Human - Abstract
The expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore. Even though a potential integration of CDK4 and CDK6 inhibitors with radiotherapy (RT) has been hypothesized, this kind of approach has not been sufficiently pursued, neither in preclinical nor in clinical studies. Similarly, the most recent discoveries focusing on autophagy, as a possible target pathway able to enhance the antitumor efficacy of CDK4 and CDK6 inhibitors is promising but needs more investigations. The aim of this review is to discuss the recent literature on the field in order to infer a rational combination strategy including cyclin-D1/CDK4-CDK6 inhibitors, RT, and/or other anticancer agents targeting G1-S phase cell cycle transition.
- Published
- 2021