291 results on '"Duarte, R"'
Search Results
2. Neoplastic tissue transfiguration in vivo by recombinant human transforming growth factor-β3
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Ripamonti, U, Swart, P, Dickens, C, and Duarte, R
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- 2023
Catalog
3. HLA class I and class II antigens in sarcoidosis
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Morar, R, Duarte, R, Wadee, A A, and Feldman, C
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Background. Sarcoidosis is a multisystem granulomatous disorder. Its exact cause is unknown, but it is believed that an external agent may cause the characteristic immune reaction in genetically susceptible individuals. There is therefore general recognition that genetic vulnerability to sarcoidosis is one of the potential risk factors. HLA is encoded by genes in the major histocompatibility complex on chromosome 6. These surface cells are important in presentation of antigen and play a key part in the body’s immune response to external antigens. Various HLA subtypes are more common in people with sarcoidosis than in those without. Variances in vulnerability, presentation, progression and prognosis have been related to different HLA phenotypes. HLA genes offer information into the factors driving sarcoidosis and prognosticating tools. However, in Africa, including South Africa (SA), there are no data on HLA types in relation to sarcoidosis.Objectives. To determine HLA class I and II associations in SA sarcoidosis patients.Methods. Phenotype frequencies of HLA-A, B and C and DQB1 and DRB1 were calculated for 51 consecutive patients with biopsy-proven sarcoidosis attending the respiratory clinic at Charlotte Maxeke Johannesburg Academic Hospital and 63 controls, who were potential organ donors. The frequencies of the tested HLA loci were determined by direct counting. The significance of the associations between the various loci tested for and the presence or absence of sarcoidosis was estimated from 2 × 2 tables using the χ2 test.Results. Of the 51 patients, 70.6% were female. The mean age was 44.6 years. Analysis of HLA class I and class II phenotypes in sarcoidosis patients revealed a significant association with HLA-B15, C4, C7, C12, C15, C16, C17, DQ3, DR8 and DR11. In addition, a significant negative (protective) association with HLA A9, A28, B12, B17 and DR2 was observed.Conclusion. This HLA study in SA patients suggests that genetic factors play a role in the causation of sarcoidosis. Some HLA subtypes have a significant association with sarcoidosis in SA patients, while other subtypes may be protective. The study supported the association of HLA antigens with sarcoidosis and implies that there is a genetic predisposition to sarcoidosis in the SA population. more...
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- 2023
4. Profiling Biomarkers in HIV Glomerular Disease – Potential for the Non-Invasive Diagnosis of HIVAN?
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Naicker S, Dix-Peek T, Klar RM, Kalunga G, Mosiane P, Dickens C, and Duarte R
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hiv chronic kidney disease ,transforming growth factor (tgf)-β isoforms ,cystatin c ,neutrophil gelatinase-associated lipocalin (ngal) ,bone morphogenetic protein (bmp)-7 ,RC870-923 ,urologic and male genital diseases ,Diseases of the genitourinary system. Urology - Abstract
Saraladevi Naicker,1,* Therese Dix-Peek,2,* Roland Manfred Klar,2 Glendah Kalunga,1 Pulane Mosiane,3 Caroline Dickens,2 Raquel Duarte2 1Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Department of Internal Medicine Laboratory, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 3Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa*These authors contributed equally to this workCorrespondence: Saraladevi NaickerDepartment of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaTel +27 83 6429575Email saraladevi.naicker@wits.ac.zaBackground: There is a wide spectrum of kidney pathology in human immunodeficiency virus (HIV) infection, affecting all structures of the kidney. The histology of HIV chronic kidney disease (CKD) is diverse, ranging from HIV-associated nephropathy (HIVAN) to focal glomerulosclerosis (FSGS), HIV-immune complex disease (HIV-ICD), other glomerulopathies and tubulo-interstitial nephritis. Definitive diagnosis is by kidney biopsy, an invasive procedure. However, serum and urinary biomarkers may be useful in predicting the histological diagnosis of HIVAN.Purpose: We wished to determine the utility of serum and urinary biomarkers in predicting the histological diagnosis of HIVAN.Patients and Methods: We measured neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, transforming growth factor (TGF)-β isoforms and bone morphogenetic protein (BMP)-7 in the serum and urine in patients with different histological forms of HIV glomerular disease.Results: In HIVAN, we demonstrated increased levels of serum cystatin C and increased levels of serum and urinary NGAL. Urinary TGF-β 1 and TGF-β 2 levels were elevated in HIV-positive patients with CKD but were not significantly different in the different HIV histologies, while urinary BMP-7 levels were elevated in minimal change disease.Conclusion: This study confirmed the presence of increased serum and urinary biomarkers of tubular injury in patients with HIVAN, and increased urinary biomarkers of fibrosis in HIV CKD, and may indicate their value as a non-invasive diagnostic tool for the diagnosis of HIVAN.Keywords: cystatin C, neutrophil gelatinase-associated lipocalin, NGAL, transforming growth factor (TGF)-β isoforms, bone morphogenetic protein (BMP)-7, HIV chronic kidney disease more...
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- 2021
5. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey
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Pagano, Livio, Salmanton-Garcia, J., Marchesi, F., Blennow, O., Gomes da Silva, M., Glenthoj, A., van Doesum, J., Bilgin, Y. M., Lopez-Garcia, A., Itri, F., Nunes Rodrigues, R., Weinbergerova, B., Farina, F., Dragonetti, Giulia, Berg Venemyr, C., van Praet, J., Jaksic, O., Valkovic, T., Falces-Romero, I., Martin-Perez, S., Jimenez, M., Davila-Valls, J., Schonlein, M., Ammatuna, E., Meers, S., Delia, M., Stojanoski, Z., Nordlander, A., Lahmer, T., Imre Pinczes, L., Buquicchio, C., Piukovics, K., Ormazabal-Velez, I., Fracchiolla, N., Samarkos, M., Mendez, G. -A., Hernandez-Rivas, J. -A., Espigado, I., Cernan, M., Petzer, V., Lamure, S., di Blasi, R., Marques de Almedia, J., Dargenio, M., Biernat, M. M., Sciume, M., de Ramon, C., de Jonge, N., Batinic, J., Aujayeb, A., Marchetti, M., Fouquet, G., Fernandez, N., Zambrotta, G., Sacchi, M. V., Guidetti, A., Demirkan, F., Prezioso, L., Racil, Z., Nucci, M., Mladenovic, M., Lievin, R., Hanakova, M., Grafe, S., Sili, U., Machado, M., Cattaneo, C., Adzic-Vukicevic, T., Verga, L., Labrador, J., Rahimli, L., Bonanni, Matteo, Passamonti, F., Pagliuca, A., Corradini, P., Hoenigl, M., Koehler, P., Busca, A., Cornely, O. A., Serrano, L., Ribera-Santa Susana, J. -M., Meletiadis, J., Tsirigotis, P., Coppola, N., Mikulska, M., Erben, N., Besson, C., Merelli, M., Gonzalez-Lopez, T. -J., Loureiro-Amigo, J., Garcia-Vidal, C., Kort, E. D., Cuccaro, A., Zompi, S., Reizine, F., Finizio, O., Dulery, R., Calbacho, M., Abu-Zeinah, G., Malak, S., Zdziarski, P., Varrichio, G., Tragiannidis, A., Plantefeve, G., Duarte, R., Danion, F., Tisi, M. C., Sakellari, I., Karthaus, M., Groh, A., Fung, M., Emarah, Z., Coronel-Ayala, O. -F., Ann Chai, L. Y., Brehon, M., Bonuomo, V., Wolf, D., Wittig, J., Vehreschild, M., Papa, M. V., Neuhann, J., Jimenez-Lorenzo, M. -J., Grothe, J., Gavriilaki, E., Garcia-Sanz, R., Garcia-Pouton, N., El-Ashwah, S. S., Eggerer, M., Cordoba, R., Colak, G. M., Arellano, E., Hematology, Pagano L., Salmanton-García J., Marchesi F., Blennow O., Gomes da Silva M., Glenthøj A., van Doesum J., Bilgin Y. M. , López-García A., Itri F., et al., and Gilead Sciences more...
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Internal Diseases ,Clinical Trials and Observations ,CELL BIOLOGY ,Cardiorespiratory Medicine and Haematology ,Sağlık Bilimleri ,Fundamental Medical Sciences ,Biochemistry ,İç Hastalıkları ,Clinical Medicine (MED) ,COVID-19 Testing ,BİYOKİMYA VE MOLEKÜLER BİYOLOJİ ,Biyokimya ,Monoclonal ,Klinik Tıp (MED) ,03.02. Klinikai orvostan ,Viral ,Lung ,Cancer ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina ,Lymphoid Neoplasia ,Myeloid Neoplasia ,Klinik Tıp ,Hücre Biyolojisi ,Temel Bilimler ,HEMATOLOJİ ,Life Sciences ,HÜCRE BİYOLOJİSİ ,Tıp ,MOLECULAR BIOLOGY & GENETICS ,Infectious Diseases ,Hematologic Neoplasms ,Medicine ,Natural Sciences ,Infection ,BIOCHEMISTRY & MOLECULAR BIOLOGY ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija ,Sitogenetik ,Biotechnology ,Adult ,Clinical Sciences ,Immunology ,Temel Tıp Bilimleri ,Histoloji-Embriyoloji ,Life Sciences (LIFE) ,Molecular Biology and Genetics ,Antiviral Agents ,Antibodies ,Vaccine Related ,Paediatrics and Reproductive Medicine ,HEMATOLOGY ,Biodefense ,Yaşam Bilimleri ,Health Sciences ,Humans ,CVOID19 ,Cytogenetic ,Free Research Articles ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine ,Moleküler Biyoloji ve Genetik ,Internal Medicine Sciences ,İmmünoloji ,SARS-CoV-2 ,Histology and Embryology ,Prevention ,COVID-19 ,Dahili Tıp Bilimleri ,CLINICAL MEDICINE ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology ,Settore MED/15 - MALATTIE DEL SANGUE ,Emerging Infectious Diseases ,Good Health and Well Being ,Yaşam Bilimleri (LIFE) ,Hematoloji ,Immunization - Abstract
Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult patients with HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing in 753 cases (49%), the Omicron variant was prevalent (517, 68.7%). Most of the patients received ≤2 vaccine doses before COVID-19 (1419, 91%), mostly mRNA-based (1377, 89%). Overall, 906 patients (59%) received COVID-19-specific treatment. After 30-day follow-up from COVID-19 diagnosis, 143 patients (9%) died. The mortality rate in patients with the Omicron variant was 7.9%, comparable to other variants, with a significantly lower 30-day mortality rate than in the prevaccine era (31%). In the univariable analysis, older age (P < .001), active HM (P < .001), and severe and critical COVID-19 (P = .007 and P < .001, respectively) were associated with mortality. Conversely, patients receiving monoclonal antibodies, even for severe or critical COVID-19, had a lower mortality rate (P < .001). In the multivariable model, older age, active disease, critical COVID-19, and 2-3 comorbidities were correlated with a higher mortality, whereas monoclonal antibody administration, alone (P < .001) or combined with antivirals (P = .009), was protective. Although mortality is significantly lower than in the prevaccination era, breakthrough COVID-19 in HM is still associated with considerable mortality. Death rate was lower in patients who received monoclonal antibodies, alone or in combination with antivirals., EPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223). more...
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- 2022
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6. Histopathological Pattern of Kidney Diseases Among HIV-Infected Treatment-Naïve Patients in Kano, Nigeria
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Abdu A, Atanda A, Bala SM, Ademola B, Nalado A, Obiagwu P, Duarte R, and Naicker S
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histology ,kidney disease ,hiv ,RC870-923 ,Diseases of the genitourinary system. Urology - Abstract
Aliyu Abdu,1 Akinfenwa Atanda,2 Sunusi M Bala,3 Babatunde Ademola,1 Aishat Nalado,1 Patience Obiagwu,4 Raquel Duarte,5 Saraladevi Naicker5 1Nephrology Unit, Department of Medicine, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria; 2Department of Histopathology, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria; 3Department of Medicine, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria; 4Department of Paediatrics, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria; 5Department of Medicine, University of Witwatersrand, Johannesburg, South AfricaCorrespondence: Aliyu AbduNephrology Unit, Department of Medicine, Aminu Kano Teaching Hospital, Bayero University, Kano, NigeriaEmail aliyuabdu2000@yahoo.co.ukIntroduction: Kidney biopsy in patients with HIV-associated kidney diseases allows for histopathologic diagnosis and institution of appropriate treatment as well as proper prognostication. There is a paucity of data on the histopathological pattern of HIV-associated kidney diseases in most sub-Saharan African countries. This study was aimed at evaluating the histopathologic patterns of kidney diseases seen among HIV-infected treatment-naive patients in our center as this will allow for proper diagnosis and institution of appropriate treatment.Methods: In this cross-sectional study, consecutive patients who satisfied inclusion criteria and consented to participate were recruited. Percutaneous kidney biopsies were carried out as day procedures under real-time ultrasound guidance using an automatic spring-loaded biopsy gun as per our unit protocols. Baseline investigations including urea, creatinine, electrolytes, CD4 count, complete blood count, and glomerular filtration rate (eGFR) calculations, urinalysis and urine protein creatinine ratios were done on all the participants.Results: Fifty-five patients who satisfied the inclusion criteria were studied. The mean age of the study population was 38.34± 9.26 years, with 32% females. Mean serum creatinine was 249.6± 164.6 μmol/L, and mean CD4 count was 238 ± 210 cells/mL. The commonest histological type was FSGS seen in 20 patients (37.7%), followed by HIVAN seen in 17 (32.1%) patients; chronic interstitial nephritis in 7 patients (13.2%) and 6 (11%) had no significant pathological finding. Compared to non-HIVAN, HIVAN patients tended to have higher systolic BP (p= 0.05); higher serum creatinine levels (p= 0.05); lower eGFR (0.03) and higher urine protein to creatinine ratio [uPCR; p= 0.02].Conclusion: Kidney involvement is still a form of presentation among HIV-infected treatment-naïve patients and though a wide range of glomerular and tubulointerstitial lesions may be seen, FSGS and HIVAN are still the most common. We recommend assessment of kidney function, including urinalysis, as part of the routine evaluation of newly diagnosed HIV patients and biopsy where indicated to prognosticate and institute appropriate early treatment.Keywords: HIV, kidney disease, histology more...
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- 2021
7. Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors
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Styczynski, J., Tridello, G., Koster, L., Iacobelli, S., Biezen, A. van, Werf, S. van der, Mikulska, M., Gil, L., Cordonnier, C., Ljungman, P., Averbuch, D., Cesaro, S., Camara, R. de la, Baldomero, H., Bader, P., Basak, G., Bonini, C., Duarte, R., Dufour, C., Kuball, J., Lankester, A., Montoto, S., Nagler, A., Snowden, J.A., Kroger, N., Mohty, M., Gratwohl, A., Infect Dis Working Party EBMT, UAM. Departamento de Medicina, Styczynski, J., Tridello, G., Koster, L., Iacobelli, S., van Biezen, A., van der Werf, S., Mikulska, M., Gil, L., Cordonnier, C., Ljungman, P., Averbuch, D., Cesaro, S., de la Camara, R., Baldomero, H., Bader, P., Basak, G., Bonini, C., Duarte, R., Dufour, C., Kuball, J., Lankester, A., Montoto, S., Nagler, A., Snowden, J. A., Kroger, N., Mohty, M., and Gratwohl, A. more...
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medicine.medical_specialty ,Medicina ,Epidemiology ,medicine.medical_treatment ,Hematopoietic stem cell transplantation ,Disease ,Infections ,survival ,Communicable Diseases ,Article ,Cohort Studies ,cause of death ,Internal medicine ,stem cell transplant ,medicine ,Humans ,Haematopoietic stem cell transplantation (HSCT) ,Risk factor ,Cause of death ,Transplantation ,Leukemia ,stem cell transplant, cause of death, survival ,business.industry ,Incidence (epidemiology) ,Hematopoietic Stem Cell Transplantation ,Retrospective cohort study ,Hematology ,Settore MED/15 ,Death ,Settore MED/01 ,surgical procedures, operative ,Risk factors ,Mycoses ,Cohort ,business ,Cohort study - Abstract
Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55′668 deaths in 114′491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of death at day 30 (very early), day 100 (early), at 1 year (intermediate) and at 5 years (late). Mortality from all causes decreased from cohort 1 (1980–2001) to cohort 2 (2002–2015) in all post-transplant phases after autologous HSCT. After allogeneic HSCT, mortality from infections, GVHD, and toxicity decreased up to 1 year, increased at 5 years; deaths from relapse increased in all post-transplant phases. Infections of unknown origin were the main cause of infectious deaths. Lethal bacterial and fungal infections decreased from cohort 1 to cohort 2, not unknown or mixed infections. Infectious deaths were associated with patient-, disease-, donor type, stem cell source, center, and country- related factors. Their impact varied over the post-transplant phases. Transplant centres have successfully managed to reduce death after HSCT in the early and intermediate post-transplant phases, and have identified risk factors. Late post-transplant care could be improved by focus on groups at risk and better identification of infections of “unknown origin”., The study was funded by the European Group for Blood and Marrow Transplantation EBMT more...
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- 2019
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8. Phenotypic and Genotypic Drug Susceptibility Assessment of Mycobacterium bovis Bacillus Calmette-Guérin Clinical Strains
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Sisco MC, Gomes da Silva M, Distasio de Carvalho L, Dias Campos CE, De Souza Caldas PC, Lopez B, Argüelles C, Carvalho AC, de Waard J, Suffys P, and Silva Duarte R
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resistance ,mycobacteria ,vaccine ,virus diseases ,bcg ,lcsh:RC109-216 ,lcsh:Infectious and parasitic diseases - Abstract
Maria Carolina Sisco,1,2 Marlei Gomes da Silva,1 Luciana Distasio de Carvalho,3 Carlos Eduardo Dias Campos,3 Paulo Cesar De Souza Caldas,3 Beatriz Lopez,4 Claudia Argüelles,5 Ana Carolina Carvalho,6 Jacobus de Waard,7,8 Philip Suffys,2 Rafael Silva Duarte1 1Laboratório de Micobactérias, Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2Laboratório de Biologia Molecular Aplicada às Micobactérias, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil; 3Laboratório de Referência Nacional Para Tuberculose e Micobacterioses, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Rio de Janeiro, Brazil; 4Instituto Nacional de Enfermedades Infecciosas, Buenos Aires, Argentina; 5Instituto Nacional de Producción de Biológicos – ANLIS Carlos G Malbrán, Buenos Aires, Argentina; 6Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Campus Macaé, Rio de Janeiro, Brazil; 7Departamento de Tuberculosis, Instituto Autónomo de Biomedicina Dr. Jacinto Convit, Caracas, Venezuela; 8One Health Research Group, Facultad de Ciencias de La Salud, Universidad de Las Américas, Quito, EcuadorCorrespondence: Philip Suffys Email psuffys@gmail.comPurpose: Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the only vaccine licensed against tuberculosis. Despite the protection offered by the vaccine, in some circumstances children and immunocompromised individuals can develop associated infections, known as BCGitis. Drug susceptibility patterns of BCG clinical strains have rarely been described. We aimed to describe the susceptibility pattern of BCG clinical strains isolated in two different countries.Methods: We performed culture-based drug susceptibility testing of thirty one BCG strains isolated from patients in Brazil (n=5, 16%) and Argentina (n=26, 84%) using the broth micro-dilution method (phenotypic method). Final antibiotic concentrations for susceptibility testing ranged from 0.5 to 16 mg/L for amikacin, 0.3125 to 10 mg/L for ethambutol, 0.05 to 1.6 mg/L for isoniazid and 0.25 to 8 mg/L for rifampicin, streptomycin and ofloxacin. Additionally, we compared the results with genetic data obtained by whole genome sequencing.Results: By using the phenotypic method we detected one strain resistant to ethambutol, three strains resistant to rifampicin and one resistant to isoniazid. Additionally, two strains that were phenotypically resistant to both isoniazid and rifampicin carried mutations in the katG and rpoB genes simultaneously.Conclusion: There is evidence of the emergence of BCG-resistant strains isolated from vaccine-related complications. We recommend drug susceptibility testing of the BCG strain causing the infection in order to prevent treatment failure.Keywords: BCG, mycobacteria, resistance, vaccine more...
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- 2021
9. Momentum-resolved resonant inelastic soft X-ray scattering (qRIXS) endstation at the ALS
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Chuang, YD, Feng, X, Cruz, A, Hanzel, K, Brown, A, Spucces, A, Frano, A, Lee, WS, Kim, J, Chen, YJ, Smith, B, Pepper, JS, Shao, YC, Huang, SW, Wray, LA, Gullikson, E, Shen, ZX, Devereaux, TP, Tremsin, A, Yang, W, Guo, J, Duarte, R, and Hussain, Z more...
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Resonant inelastic X-ray scattering ,Particle and Plasma Physics ,Chemical Physics ,Modular X-ray spectrometer ,Molecular ,Nuclear ,Condensed Matter Physics ,Physical Chemistry ,Atomic ,Physical Chemistry (incl. Structural) - Abstract
A momentum resolved resonant inelastic X-ray scattering (qRIXS) experimental station with continuously rotatable spectrometers and parallel detection is designed to operate at different beamlines at synchrotron and free electron laser (FEL) facilities. This endstation, currently located at the Advanced Light Source (ALS), has five emission ports on the experimental chamber for mounting the high-throughput modular soft X-ray spectrometers (MXS) [24]. Coupled to the rotation from the supporting hexapod, the scattered X-rays from 27.5° (forward scattering) to 152.5° (backward scattering) relative to the incident photon beam can be recorded, enabling the momentum-resolved RIXS spectroscopy. The components of this endstation are described in details, and the preliminary RIXS measurements on highly oriented pyrolytic graphite (HOPG) reveal the low energy vibronic excitations from the strong electron-phonon coupling at C K edge around σ* band. The grating upgrade option to enhance the performance at low photon energies is presented and the potential of this spectroscopy is discussed in summary. more...
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- 2022
10. Tuberculosis and COVID-19 co-infection: description of the global cohort
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Migliori, G. B., Casco, N., Jorge, A. L., Palmero, D. J., Alffenaar, J. -W., Denholm, J., Fox, G. J., Ezz, W., Cho, J. -G., Skrahina, A., Solodovnikova, V., Bachez, P., Piubello, A., Arbex, M. A., Alves, T., Rabahi, M. F., Pereira, G. R., Sales, R., Silva, D. R., Saffie, M. M., Miranda, R. C., Cancino, V., Carbonell, M., Cisterna, C., Concha, C., Cruz, A., Salinas, N. E., Revillot, M. E., Valdes, J. F., Fernandez, I., Flores, X., Tapia, P. G., Garavagno, A., Vera, C. G., Bahamondes, M. H., Merino, L. M., Munoz, E., Munoz, C., Navarro, I., Subiabre, J. N., Ortega, C., Palma, S., Pradenas, A. M., Pereira, G., Castillo, P. P., Pinto, M., Pizarro, R., Bidegain, F. R., Rodriguez, P., Sanchez, C., Salinas, A. S., Soto, A., Taiba, C., Venegas, M., Riquelme, M. S. V., Vilca, E., Villalon, C., Yucra, E., Li, Y., Guelvez, B., Plaza, R. V., Hoyos, K. Y. T., Andrejak, C., Blanc, F. -X., Dourmane, S., Froissart, A., Izadifar, A., Riviere, F., Schlemmer, F., Manika, K., Diallo, B. D., Hassane-Harouna, S., Artiles, N., Mejia, L. A., Gupta, N., Ish, P., Mishra, G., Sharma, S., Singla, R., Udwadia, Z. F., Alladio, F., Angeli, F., Calcagno, A., Centis, R., Codecasa, L. R., D'Ambrosio, L., De Lauretis, A., Esposito, S., Formenti, B., Gaviraghi, A., Giacomet, V., Goletti, D., Gualano, G., Matteelli, A., Motta, I., Palmieri, F., Pontali, E., Prestileo, T., Riccardi, N., Saderi, L., Saporiti, M., Sotgiu, G., Stochino, C., Tadolini, M., Torre, A., Villa, S., Visca, D., Danila, E., Diktanas, S., Ridaura, R. L., Lopez, F. L. L., Torrico, M. M., Rendon, A., Akkerman, O. W., Souleymane, M. B., Al-Abri, S., Alyaquobi, F., Althohli, K., Aizpurua, E., Gonzales, R., Jurado, J., Loban, A., Aguirre, S., Teixeira, R. C., De Egea, V., Irala, S., Medina, A., Sequera, G., Sosa, N., Vazquez, F., Llanos-Tejada, F. K., Manga, S., Villanueva-Villegas, R., Araujo, D., Duarte, R., Marques, T. S., Grecu, V. I., Socaci, A., Barkanova, O., Bogorodskaya, M., Borisov, S., Mariandyshev, A., Kaluzhenina, A., Vukicevic, T. A., Stosic, M., Beh, D., Ng, D., Ong, C. W. M., Solovic, I., Dheda, K., Gina, P., Caminero, J. A., Cardoso-Landivar, J., De Souza Galvao, M. L., Dominguez-Castellano, A., Garcia-Garcia, J. -M., Pinargote, I. M., Fernandez, S. Q., Sanchez-Montalva, A., Huguet, E. T., Murguiondo, M. Z., Bart, P. -A., Mazza-Stalder, J., Bakko, F., Barnacle, J., Brown, A., Chandran, S., Killington, K., Man, K., Papineni, P., Tiberi, S., Utjesanovic, N., Zenner, D., Hearn, J. L., Heysell, S., and Young, L. more...
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Pulmonary and Respiratory Medicine ,Cohort Studies ,Male ,Coinfection ,Humans ,Prospective Studies ,COVID-19 ,Tuberculosis ,Original Research Article - Abstract
BackgroundInformation on tuberculosis (TB) and coronavirus disease 2019 (COVID-19) is still limited. The aim of this study was to describe the features of the TB/COVID-19 co-infected individuals from a prospective, anonymised, multicountry register-based cohort with special focus on the determinants of mortality and other outcomes.MethodsWe enrolled all patients of any age with either active TB or previous TB and COVID-19. 172 centres from 34 countries provided individual data on 767 TB-COVID-19 co-infected patients, (>50% population-based).ResultsOf 767 patients, 553 (74.0%) out of 747 had TB before COVID-19 (including 234 out of 747 with previous TB), 71 (9.5%) out of 747 had COVID-19 first and 123 (16.5%) out of 747 had both diseases diagnosed within the same week (n=35 (4.6%) on the same day). 85 (11.08%) out of 767 patients died (41 (14.2%) out of 289 in Europe and 44 (9.2%) out of 478 outside Europe; p=0.03): 42 (49.4%) from COVID-19, 31 (36.5%) from COVID-19 and TB, one (1.2%) from TB and 11 from other causes. In the univariate analysis on mortality the following variables reached statistical significance: age, male gender, having more than one comorbidity, diabetes mellitus, cardiovascular disease, chronic respiratory disease, chronic renal disease, presence of key symptoms, invasive ventilation and hospitalisation due to COVID-19. The final multivariable logistic regression model included age, male gender and invasive ventilation as independent contributors to mortality.ConclusionThe data suggest that TB and COVID-19 are a “cursed duet” and need immediate attention. TB should be considered a risk factor for severe COVID disease and patients with TB should be prioritised for COVID-19 preventative efforts, including vaccination. more...
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- 2021
11. Conversion of noninvasive mechanical ventilator to provide invasive mechanical ventilation
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Nuno M. Mateus, Vítor A. Silva, Filipe S. Rêgo, Paulo Roberto C. Ferreira, Duarte R. Almeida, and Tiago S. Oliveira-E-Sá
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Mechanical ventilation ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Noninvasive Ventilation ,Ventilators, Mechanical ,Ventilator weaning ,Coronavirus disease 2019 (COVID-19) ,business.industry ,medicine.medical_treatment ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Respiration, Artificial ,Anesthesiology and Pain Medicine ,Mechanical ventilator ,medicine ,Humans ,Noninvasive ventilation ,Respiratory Insufficiency ,Intensive care medicine ,business ,Ventilator Weaning - Published
- 2021
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12. The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T's come into focus
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Passweg, J.R., Baldomero, H., Chabannon, C., Basak, G.W., Corbacioglu, S., Duarte, R., Dolstra, H., Lankester, A.C., Mohty, M., Montoto, S., Latour, R.P. de, Snowden, J.A., Styczynski, J., Yakoub-Agha, I., Kroger, N., European Soc Blood Marrow Transpla, UAM. Departamento de Medicina, University Hospital Basel [Basel], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Medical University of Warsaw - Poland, Universität Regensburg (UR), Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain], Radboud University Medical Center [Nijmegen], Leiden University Medical Center (LUMC), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Barts Health NHS Trust [London, UK], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Haematology & Department of Oncology, NHS & University of Sheffield, University of Technology and Life Sciences [ Bydgoszcz], CHU Lille, University Hospital Hamburg-Eppendorf, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), and Gestionnaire, HAL Sorbonne Université 5 more...
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[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology ,Oncology ,medicine.medical_specialty ,Myeloid ,Medicina ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,medicine.medical_treatment ,Hematopoietic stem cell transplantation ,Transplantation, Autologous ,Article ,Cell therapy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,hemic and lymphatic diseases ,Medicine ,Leukaemia ,Humans ,Transplantation, Homologous ,Aplastic anemia ,Cellular therapies ,Transplantation ,Haematological cancer ,Receptors, Chimeric Antigen ,European Society for Blood and Marrow Transplantation (EBMT) ,business.industry ,Multiple sclerosis ,Hematopoietic Stem Cell Transplantation ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Hematology ,medicine.disease ,Lymphoid malignancies ,3. Good health ,Europe ,Haematopoiesis ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Hematopoietic-cell transplantation (HCT) ,Car t cells ,business ,030215 immunology - Abstract
Hematopoietic-cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants performed in Europe and associated countries continues to rise with 47,468 HCT in 42,901 patients [19,630 allogeneic (41%) and 27,838 autologous (59%)] reported by 701 centers in 50 countries in 2018. Main indications were myeloid malignancies 10,679 (25%; 97% allogeneic), lymphoid malignancies 27,318 (64%; 20% allogeneic), solid tumors 1625 (4%; 2.9% allogeneic), and nonmalignant disorders 3063 (7%; 81% allogeneic). This year’s analysis focuses on cellular therapies with the marked growth in CAR T-cell therapies from 151 in 2017 to 301 patients reported in 2018. Other cellular therapy numbers show less significant changes. Important trends in HCT include a 49% increase in allogeneic HCT for chronic phase CML (although transplant numbers remain low) and a 24% increase in aplastic anemia. In autologous HCT, there is an ongoing increase in autoimmune diseases (by 19%), predominantly due to activity in multiple sclerosis. This annual report reflects current activity and highlights important trends, useful for health care planning. more...
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- 2020
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13. Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD): Current Perspectives
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Waziri B, Duarte R, and Naicker S
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updated pathogenesis ,urologic and male genital diseases ,management ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,emerging trends ,chronic kidney disease-mineral and bone disorder - Abstract
Bala Waziri,1,2 Raquel Duarte,1 Saraladevi Naicker1 1Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Department of Medicine, Ibrahim Badamasi Babangida Specialist Hospital, Minna, NigeriaCorrespondence: Bala WaziriDepartment of Medicine, Ibrahim Badamasi Babangida Specialist Hospital, Km 10, Paiko Road, Minna, NigeriaEmail balawaziri@gmail.comAbstract: Despite the availability of global and regional guidelines to curtail the adverse clinical outcomes associated with chronic kidney disease–mineral and bone disorder (CKD-MBD), most CKD patients are still affected by the consequences of abnormalities of CKD-MBD. This important clinical complication of CKD continues to be studied, in order to improve the understanding and management of CKD-MBD. Some notable discoveries include the role of fibroblast growth factor 23 (FGF23) in the pathogenesis of CKD-MBD, leading to a shift from the previous well-established classic trade-off hypothesis to the updated trade-off hypothesis. More recently, there has been a shift from the treatment of CKD-MBD based on a single level of biomarkers to serial measurements of calcium, phosphate and parathyroid hormone (PTH). Furthermore, some clinical trials have emerged after the 2009 Kidney Disease-Improving Global Outcomes (KDIGO) Guidelines, leading to the 2017 KDIGO updated recommendations. Hence, this review gives an overview of the rapidly evolving trends in CKD-MBD, linking the past and current concepts of CKD-MBD.Keywords: chronic kidney disease–mineral and bone disorder, updated pathogenesis, emerging trends, management more...
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- 2019
14. Exosomal microRNA profiling in early and late onset preeclamptic pregnant women reflects pathophysiology
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Pillay P, Vatish M, Duarte R, Moodley J, and Mackraj I
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Medicine (General) ,R5-920 ,Exosomal miRNA ,Exosomes ,Preeclampsia ,female genital diseases and pregnancy complications ,reproductive and urinary physiology ,Biomarkers - Abstract
Preenan Pillay,1 Manu Vatish,2 Raquel Duarte,3 Jack Moodley,4 Irene Mackraj51Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of Kwazulu-Natal, Durban, South Africa; 2Nuffield Department of Women’s and Reproductive Health, Women’s Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK; 3Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 4Women’s Health and HIV Research Group, Department of Obstetrics and Gynaecology, University of Kwazulu-Natal, Durban, South Africa; 5School of Laboratory Medicine and Medical Sciences, University of Kwazulu-Natal, Durban, South AfricaBackground: Preeclampsia is the leading cause of maternal and fetal mortality due to the inability to diagnose and treat the disorder early in pregnancy. This is attributed to the complex pathophysiology and unknown etiology of the disorder, which is modulated by several known and unknown factors. Exosomes have recently been implicated as possible mediators of the pathogenesis of preeclampsia, with, however, no evidence linking these nanovesicles to the pathophysiology of preeclampsia and its subtypes.Methods: To better understand the pathophysiological role of exosomes in preeclampsia, we have analyzed the exosomal microRNA in early and late onset preeclamptic women in comparison to their gestationally matched normotensive controls using Digital Direct Detection (NanoString Technologies).Results: For the first time, distinct exosomal microRNA signatures in early and late onset preeclampsia have been identified. Moreover, these signatures indicate that exosomes are involved in key pathological features associated with preeclampsia and differentiate between the subtypes.Conclusion: This study forms the basis for the diagnostic and functional validation of the identified signatures as biomarkers of preeclampsia and its subtypes.Keywords: biomarkers, preeclampsia, exosomes, microRNA more...
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- 2019
15. Remote Sensing Observations of Dominant Breaking Waves in Intermediate to Deep Water from a Lighthouse During Storm Conditions
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Filipot J, Eadi Stringari C, Duarte R, and Leckler F
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Remote sensing (archaeology) ,Breaking wave ,Storm ,Rogue wave ,oceanography ,Geology ,Physics::Atmospheric and Oceanic Physics ,Remote sensing ,Deep water - Abstract
Wave breaking is one of the most important yet poorly understood water wave phenomena. It is via wave breaking that waves dissipate most of their energy and the occurrence of wave breaking directly influences several environmental processes, from ocean-atmosphere gas exchanges to beach morphodynamics. Large breaking waves also represent a major threat for navigation and for the survivability of offshore structures. This paper provides a systematic search for intermediate to deep water breaking waves with particular focus on the elusive occurrence of plunging breakers. Using modern remote sensing and deep learning techniques, we identify and track the evolution of over four thousand unique wave breaking events using video data collected from La Jument lighthouse during ten North Atlantic winter storms. Out of all identified breaking waves (Nb=4683), ≈22% were dominant breaking waves, that is, waves that have speeds within [0.77cp, 1.43cp], where cp is the peak wave speed. Correlations between the occurrence rate of dominant breaking waves (that is, waves per area and time per peak wave period) and wave steepness and wave age were observed. As expected, the number of identified plunging waves was small and six waves of all detected breaking waves, or 0.13%, could undoubtedly be considered as plunging waves. Two waves were also identified as unusually large, or rogue waves. Although afflicted by several technical issues, the data presented here provides a good indication that the probability of occurrence of plunging waves should be better incorporated into the design of offshore structures, particularly the ones that aim to harvest energy in offshore environments. more...
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- 2021
16. SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
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COVIDSurg Collaborative, GlobalSurg Collaborative, A, M., Abdelhamid, M. H. S., Alhabdan, S., Nekoval, V., Nel, C., Nel, D., Nel, H., Nelihela, P., Nelissen, E., Nelli, T., Nelson, C., Nemeth, M., Nene, A., AlHADAD, M., Neo, E. L., Neo, E. N., Neri, C. M., Neshige, S., Nespoli, L. C., Nessa, A., Nessim, C., Neuerburg, C., Neves, F., Neves, M., Alhaddad, A., Newcomb, A., Newitt, L., Newman, J., Newman, M., Newman, S., Newton, L., Neykov, V., Nezerwa, Y., Nezi, G., Ng, B., Alhaddad, W., Ng, C. S. H., Ng, C. F., Ng, C. E., Ng, D., Ng, D. S. W., Ng, J. C. K., Ng, J. Y., Ng, J., Ng, K. K., Ng, K. C., Alhadeethi, A., Ng, M. Y., Ng, M., Ng, S., Ng We Yong, Y. J., Ng-Kamstra, J., Ngan, T. Y., Ngaserin, S., Ngeruka, M. L., Ngu, J., Alhadi, A., Ngulube, A., Nguyen, A., Nguyen, H. M. N., Nguyen, H., Nguyen, S., Ni Bhroin, O., Nia, A., Niazi, F. A. K., Niazi, M., Alhag, A., Niazi, S. U., Nichani, J., Nichita, M., Nicholas, E., Nicholson, K., Nicholus, M., Nicolaiciuc, S., Nicolas, B., Nicolás-López, T., Niculae, C., Alhaidari, A., Nidaw, M., Nielsen, M. F., Niemeier, A., Nieto Calvache, A. J., Nieto Rodriguez, J. M., Nieto-Moreno, A., Nieto-Moreno, E., Nigalye, N., Nikaj, H., Nikiteas, N., Alhaje, A., Nikolai, K., Nikolaieva, K., Nikolic, S., Nikoloudaki, Z., Nikolouzakis, T., Nikolovska, B., Nikoupour, H., Nikova, A., Nimako, B., Nimako-Mensah, J., Alhajji, Z., Nimale, S., Nimer, B., Ninan, J. E., Ninic, A., Ninkovic, M., Niño Corredor, R. A., Niquen-Jimenez, M., Nirgude, A., Niriella, S., Nisa, K., Abdeljalil, A., AlHajri, N., Nischwitz, S. P., Nishihara, N., Nishikawa, K., Niska, K., Nistor-Ciurba, C. C., Nitschke, C., Nixon, A., Niyongombwa, I., Nizami, M., Niziol, R., Alhakami, N., Njeze, N., Njim, T., Njuki, P. N., Nk, V., Nkole, T., Nkrumah, J., Nkubito, J. M. S., Nkunzimana, E., Nabugwu, I., Najiuba, H., Alhalal, H., Noah, K., Nocera, G., Noda, M., Noe, C., Noel, C., Noël, A., Nofal, S., Noguchi, H., Nogueiro, J., Noguera Roman, L., Alhamid, A., Nogués, A., Noguez Castillo, M., Noiret, B., Nolan, D., Noll, F., Nolte, P., Noltes, M., Noman, H., Nomura, T., Noone, A., Noor, A., Noor, D. F., Noor Mohamed, M. S., Noordin, S., Noori, E., Noori, F., Norawat, R., Nordberg, M., Noreen, D. Z., Noriega, D. C., Alhamid, M., Norman, L., Noro, S., Noronha, W. J., Norouzi, S., Norris, J., Norrish, A., Nortey, M., Norton, J., Norton, S., Norton, W., Alhammad, O., Notario, J., Noton, T., Notz, Q., Nouh, T., Noureen, D. S., Noureldin, Y., Novak, Z., Novello, S., Novembre, D., Novi, A., Alhammali, T., Novikov, D., Novikova, A., Novoa, B., Novotny, H. F. G., Novysedlák, R., Nowak, K., Nowar, M., Nowosielski, Y., Nsaful, J., Nshuti, S., AlHarazi, A., Ntaganda, E., Ntalouka, M., Ntege, A., Ntege, J., Ntezamizero, J., Ntirenganya, F., Ntoto, M. C. O., Ntziovara, A. M., Nubair, S., Nugent, T., Alharthi, B., Nugur, A., Nuh, A., Nunes, R., Nunes, S., Nunes Coelho, M., Nunez, J., Nuñez, J., Nuñez, R., Núñez, A., Núñez, B., Abdelkabir, M., Alharthi, M., Nuñez Del Barrio, H., Núñez Lucic, J., Núñez O'Sullivan, S., Nunez-Garcia, B., Núñez-González, RÁ, Nuño-Escobar, C., Nurgozhin, T., Nuseir, A., Nwabuoku, S. E., Nwachukwu, C., Alharthi, N., Nwachukwu, I., Nwafor, I., Nwagboso, C., Nwaorgu, O., Nwashilli, N., Nwegbu, C., Nwinee, H., Nwosu, D., Nyadu, B., Nyangoh Timoh, K., Alharthi, S., Nyarko, O. O., Nyarko Agyeman, Y., Nyeko-Lacek, M., Nygaard, R. M., Nyirahabakurama, D., Nyirahabimana, J., Nyirimodoka, A., O Connor, C., O'Banion, L. A., O'Brien, S., Alhasan, H., O'Connell, E., O'Connell, R., O'Connor, B., O'Connor, D. B., O'Connor, J., O'Connor, Z., O'Donnell, R., O'Donoghue, C., O'Donoghue, G., O'Farrell, E., ALhassan, A., O'Grady, M., O'Hagan, P., O'Kelly, J., O'Mara-Gardner, K., O'Neill, A., O'Neill, C., O'Neill, R., O'Shea, M., O'Sullivan, E., Obadan, I., Alhassan, B. A. B., Obahiagbon, O., Obaid, K., Obaid, M., Obara, S., Obateru, J., Obbeng, A., Obeidat, R., Obied, H., Obrist, C., Obuekwe, O., Alhassan, B., Obure, R., Ocampo, L., Ocampos, L., Ocampos Hernandez, M., Occhionorelli, S., Ochoa Carrillo, F. J., Ochoa Gaete, K., Ochoa Villalabeitia, B., Ocsan, R. J., Od, S., Alhassoun, T., Odai, E. D., Odedra, A., Odeh, A., Odejinmi, F., Odetto, D., Odeyemi, O., Odeyemi, P. O., Odicino, F., Odigie, P. V., Odonnell, E., Alhathal, N., Oduah, S., Odunafolabi, T., Oduola, O., Odutola, O., Offiong, R., Ofori, B., Ofori, E. O., Ofosu-Barko, B. B., Ogawa, M., Ogden, E., Alhattab, M., Ogenya, R., Ogihara, T., Ogu, R., Ogunade, O., Ogundele, I., Ogundoyin, O., Ogunkeyede, S. A., Ogunlaja, O., Ogunrewo, T., Abdelkader Salama, I., Alhawatmeh, M., Ogunsua, O., Oguttu, B., Oğuz, C., Ohama, S., Ohara, R., Ohazurike, E., Oikonomou, K., Ojeda Rojas, A. M., Ojeda Thies, C., Ojeda Villasboa, D. J., Alhazmi, A., Ojewola, R. W., Ojha, B. K., Ojo, O., Okada, H., Okada, R., Okada, S., Okada, T., Okafor, B., Alhazmi, B., Okail, M. H., Okamura, K., Okamura, Y., Okere, O., Okereke, C., Okhakhu, A., Okolie, L., Okonkwo, I., Okoro, K., Okoye, E., Alhazzaa, N., Okoye, O., Okpani, A., Okpani, C., Okugbo, S., Okunade, K., Okunlola, A., Okunowo, A., Okwara, B., Olabinjo, A., Oladejo, T., Alhefdhi, A., Oladiran, A., Olagunju, N., Olajide, A., Olajide, T. O., Olaogun, J., Olaomi, O., Olaosebikan, R., Olaoye, I., Olasehinde, O., Olatoke, S. A., Alhelal, B., Olave Montaño, V. D., Olawoye, O., Olayiwola, D. O., Olaywah, D., Olaywah, N., Oldani, M., Oldbury, M., Oldrà, G., Olea Vielba, C., Olearo, E., Alhelal, F., Olieman, A., Oliva, A. R., Oliva, J. R., Oliva, R., Olive, R., Oliveira, A., Oliveira, J., Oliveira, J. C. C., Oliver, T., Alhemyari, N., Oliver García, L., Oliver Guillen, J. R., Olivos, M., Ollat, D., Oller, I., Olliff, S., Ollivere, B., Olmedo Bareiro, R. I., Olmi, S., Olori, S., Alherabi, A., Olowogbayi, T., Olson, K. A., Olubayo, O. O., Olugbami, A., Oluka, D. D., Olulana, D., Olusanya, A., Olute, A., Oluwafemi, F., Olvera-Flores, O. E., Alhindi, R., Omar, K., Omar, M., Omar, M. W., Omar, N. G., Omar, O. M., Omar, S., Omar, W., Omar Abunaaja, H., Omara, U., Abdelkareem, M., Alhogbani, M., Omari, R. Y., Ombashi, S., Omeje, U. K., Omer, M. E. A., Ömer, ÖA., Ömeroğlu, S., Omigbodun, A., Omiragi, P., Omisanjo, O., Omotosho, P., Alhossaini, R., Omran, J., Onakoya, P., Onate, J., Oñate, M., Önder, A. B., Öney, M. D., Ong, B. S., Ong, C. F., Ong, D., Ong, J. H., Alhouni, T., Ong, L., Ong, M. T. Y., Ong Vaño, A. M., Oni, O., Oni, S., Onjefu, S., Ono, M., Onochie, E., Onorati, I., Onubogu, I. K., Alhouri, A., Onur, I. U., Onwuagha, I., Onyeagwara, N., Onyeji, J., Onyemaechi, N., Onzi, T. R., Oo, A., Ooi, C., Ooi, R., Ooi, S. Z. Y., ALhumaida, A., Oosterlinck, W., Oosterling, S., Oosthuizen, B., Opandoh, I. N. M., Opano, R., Opincans, J., Opoku Amankwaa, W., Oppah, I., Oppong, P. P., Oputa, V., Alhunaidi, O., Orădan, A., Oranu, E., Orazulike, N., Ordemar, J., Ordoñez, S., Organ, N., Organjee, A., Orgoi, S., Orhan, N., Orhan Sungur, M., Alhussaini, A., Orji, I. J., Orji, M., Ormeño, M., Ornaghi, S., Oropeza, M., Orozco-Chamorro, C. M., Orozco-Perez, J., Orsoo, S., Orta Díaz, M. D., Ortega, N., Alhussein, A., Ortega, S., Ortega Oria de Rueda, M., Ortega Vázquez, I., Ortega-Jiménez, J. A., Ortiz, E. V., Ortiz, L., Ortiz, M. R., Ortiz De La Cruz, F., Ortiz de Solórzano Aurusa, F. J., Ortiz López, D., Alhuthayl, M., Ortiz Silva, C., Ortiz Simón, A., Oruç, M., Oryadi Zanjani, L., Osabutey, A., Osagie, O., Osaki, S., Osborn, T., Osborne, L., Oscarsson, A., Ali, A. A. A., Osea, L., Oseghale, E., Osei-Bonsu, P., Osei-Poku, D., Osei-Tutu, E., Osemwegie, O., Osho, P., Osinaike, B., Osl, A., Osman, A., Abdelkarem, M. M., Ali, A. D., Osman, E., Osman, H., Osman, I., Osman, K., Osman, L., Osman, M., Osman, M. F., Osorio, D., Osorio, W. A., Ali, A. A., Ossman, M. A., Osterberg, E. C., Osterhoff, G., Ostrovsky, I. A., Osuna, L., Osuna-Rubio, J., Osuoji, R., Otaif, W., Otayfah, S., Otchwemah, R., Ali, A., Oteem, A., Oter, V., Othieno Misanga, H., Othiyil Vayoth, S., Othman, A., Othman, A. F., Othman, E., Othman, M., Othman, S., Otieno, J., Otify, M., Otiniano Alvarado, C. E., Otokwala, D. J., Ots, R., Otsuka, Y., Ott, J., Otte, H., Ottl, S., Ou, C. X. Y., Ali, A. M., Ouchi, T., Oudrhiri, M. Y., Ouf, A., Ould Si Amar, A., Ourieff, J., Ourô, S., Ousouss, S., Outani, O., Owaimer, R., Owais, Q., Owens, D., Owens, P., Ower, C., Owiedat, M., Owusu Adae, J., Oyama, T., Oyediji, F., Oyelakin, O., Oyeleye, O., Oyelowo, N., Oyende, O., Oyewole, O., Oyewusi, E., Oyinloye, O., Ozair, A., Özant, A., Ozben, V., Özcan, A., Özçay, N., OZcelık, M. F., Ozdemir, E., Ozdemir, K., Özdoğan, K., Özeller, E., Ozgediz, D., Özgen, U., Ozgur, I., Ozkan, O. F., Ozkent, M. S., Ozmen, M. M., Ozone, C., Özpak, S. S., Oztan, M. O., Ozua, J., P B, H., P L, T., Paal, P., Pabari, A., Pablo, C., Pacheco Sánchez, D., Pachl, M., Pacilio, C. A., Pacilli, M., Padilla-Valverde, D., Padmore, G., Páez, W., Pagano, G., Pagano, L., Page, R., Pagès, N., Abdelkarim, M., Ali, D., Pahalawatta, U., Paiano, L., Paiella, S., Paine, W., Pais, J., Paitici, S., Paiva, J., Paiva Vera, D. A., Paiva-Santos, F., Pajan, H., Pajić, S., Pal, U. S., Palacios, C., Palacios, J., Palapalle, N., Palayan, K., Palazon Bellver, P., Palines, A., Palla, E., Palm, H., Ali, F., Palma, M., Palma Caucig, N., Palmeri, M., Palmerini, E., Palmieri, G., Palmisano, S., Palomares Casasús, S., Palomino, L., Palomino Escalante, F., Palta Uribe, D. A., Ali, G., Paltoglou, N., Palumbo, A., Palumbo, M., Paluso Montero, A. V., Pamias, J., Panagiotidou, S., Panagiotou, P., Panayiotou, Y., Panayotova, G., Panchakshariah, S., Ali, I., Panciani, P. P., Panda, A., Panda, R., Pandey, A., Pandey, H., Pandey, S., Pañeda, L., Panesar, D., Pang, J. H., Panigrahi, S., Panis, C., Panjwani, T., Pannullo, M., Panov, I., Pansani, A., Pant, R., Panteli, C., Pantelidou, M., Pantoja Pachajoa, D. A., Pantos, P., Ali, I. A., Panuganti, V., Panyko, A., Paolini, B., Papa, A., Papaconstantinou, I., Papadia, A., Papadopoulos, V., Papadopoulou, T., Papagni, V., Papalampros, A., Papalexandris, S., Papalia, R., Papandrea, M., Papanikolaou, V., Papas, T., Papatheodorou, P., Papavasiliou, K., Papendick, N., Papidze, K., Pappas, S., Ali, M., Parab, D. M., Parab, S., Parada Rodriguez, A. M., Parakonthun, T., Paramasivan, A., Páramo Zunzunegui, J., Paranjape, C., Paraskevas, K. I., Paraskevopoulos, K., Pardes, R., Pardilho, A., Pardiwala, D., Paredes, I., Paredes, S., Paredes Caturiny, A., Pareed, D. D., Pareek, P., Pareja Ciuro, F., Parekh, J. N., Parello, A., Parente, A., Parfitt, C., Pargal, D. P., Parija, S., Paris, M., Park, A., Park, C., Park, F., Park, J. J., Park, J., Park, M., Park, P., Park, S. S. W., Parker, D., Parker, K. L., Parker, M. Y., Parker, R., Parkin, B., Parkin, C., Parkin, E., Parlanti, D., Parmar, C., Parodi, M., Parra Abaunza, K., Parra Baños, P. A., Parray, F., Parreira, P., Parri, P., Parrish, A., Parry, J., Parry, L., Parry-Smith, W., Parshad, R., Parsons, S., Parsons, T., Parulekar, R., Parveen, S., Parwaiz, H., Pascale, M. M., Pascarella, G., Ali, M. U., Pascua-Gómez, L. A., Pascual, Á, Pascual Arellano, M. P., Pascual Escudero, V., Pascual Miguelañez, I., Pascual Samaniego, M., Pascual-Cambero, P., Pasini, M., Pasquini, E., Passadore, M., Ali, N., Pastor, O., Pastor, T., Pastor Nieto, M. B., Pastor Zapata, A., Pata, F., Patabendige, M., Patachia, R., Patel, A., Patel, A. M. E., Ali, R., Patel, B., Patel, J., Patel, K., Patel, L., Patel, M., Patel, N., Patel, P., Ali, S., Patel, R., Patel, S., Patelis, N., Patell, M., Patena Forte, J., Paterson, A., Paterson, H., Pathak, M., Pathak, P., Pathak, S., Pathan, S., Pathmanaban, O., Pathmanathan, K., Patil, M., Patil, N., Patil, R., Patini, R., Patino-Jaramillo, N. 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F., Hussain, Z., Hussaini, D., Hussein, A., Hussein, B., Hussein, H., Hussein, R., Al Kharusi, S., Hussein Ali, H., Hussein Aly Salama Aly, H., Hussen, H., Hussey, R., Hutchinson, P., Hutter, J., Huwaysh, M., Huynh, V., Hviid, L., Hyasat, A., Al Khassawneh, A., Hyhlik-Duerr, A., Hyman, G. Y., Hynning, B., I A Alzeerelhouseini, H., I'Anson, C., Iacomino, A., Iakovou, D., Iannuccelli, M. G., Iba, Y., Ibáñez Nieto, M., Abdalla, A., Al Lahham, S., Ibáñez-Aguirre, F. J., Ibarrola Peña, J. C., Ibingira, T., Ibis, B., Ibraheem, G., Ibraheem, M., Ibrahem, O., Ibrahim, A., Al Maadany, F., Ibrahim, A. F., Ibrahim, F. A., Ibrahim, F., Ibrahim, H., Ibrahim, I., Ibrahim, I. H., Ibrahim, M., Ibrahim, M. R., Al Mahdawi, L., Ibrahim, M. W., Ibrahim, N., Ibrahim, S., Ibrahim, T., Ibrahim, Z., Ibrahim Elsayed, O., Al Mahdy, H., Ibrahim Mohammed Ali, M., Ibrahim Moussa Hamouda, N. M. S., Ibrahim Usman, M., Ida, M., Idarraga Ramírez, L. N., Iddrisu Baba, Y., Idi Marcel, E., Idier, L., Idiz, U. 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B., Muhammad, R., Muhammad, S., Muhammad Daneji, S., Muheilan, M., Muhemi, R., Muhmmed, K., Muhssein, H., Muhtaroğlu, A., Muhtaseb, M., Alexandrou, A., Muirhead, W., Muiru, C., Mujtaba, S. N., Mukase, S., Mukezamfura, R., Mukherjee, P., Mukherjee, S., Mukhtar, I. A., Alexe, V., Mulas Fernández, C., Mulchandani, M., Mulder, W. W., Muleta, L., Muleta, M. B., Mulita, F., Mulla, H., Mulla, O., Muller, B., Müller, A., Abdelgalel, K., Alezabi, B., Müller, K., Müller, S., Müller, T., Mulliri, A., Mulugeta, E., Mulugeta, G., Mumtaz, K., Munanzvi, K., Munarriz, M., AlFakhri, A., Munawwar, F., Muneza, S., Mungazi, S., Muniandy, M., Munini, M., Munir, M. M., Munoz, H., Munoz Abraham, A. S., Muñoz Botero, N. A., Muñoz Camarena, J. M., Alfarah, M., Muñoz de Nova, J. L., Muñoz Fernández, M. E., Muñoz Lindez, I., Muñoz Rodríguez, J. M., Muñoz Sornosa, E., Muñoz Vives, J. M., Muñoz-Bellvis, L., Munro, W., Munshi, F., Muntaka, A. M., Alfaro, H., Muntean, G. O., Muntean, M., Munteanu, A., Munton, H., Munyaneza, E., Munyif, H., Munyika, A., Mura, G., Murad, M., Muraglia, A., Alfaro-Goldaracena, A., Murakawa, T., Murali, S., Muralidharan, V., Muratore, A., Mureko, A., Murgese, A., Murgoitio, U., Muriel, M. E., Muriithi, F. G., Murillo, J., Alfarra, D., Murillo Castellanos, J. A., Murji, B., Murphy, B., Murphy, J., Murphy, M., Murphy, N., Murphy, S., Murray, D., Murray, E., Alfayez, F., Murray, I., Murray, J., Murtaza, G., Murugesan, A., Murugesan, K., Musa, D., Musa, E., Musa, R., Musa, S., Musa Adamu, D. K., Alfeqeeh, A., Musa Kirfi, A., Musaab, M., Musallam, N., Musana, O., Musawa, N., Muscat, E., Muscatello, L., Musetti, S., Musharraf, M. B., Mushawarima, T., Alferdaus, A., Mushiwokufa, W., Mushtaq, A., Mushtaq, H., Musina, A. M., Muslim, M., Muslumov, G., Musrati, F., Mustafa, A., Mustafa, D. F., Mustafa, I., Alfieri, A., Mustafa, N., Mustafa, S., Mustapha, M., Mustea, A., Musthafa, S., Mutabazi, E., Mutalima, N., Mutambanengwe, P. G. T., Mutarello, N., Abdelghafar, M., Alfieri, S., Muthkumaran, G., Muthu, S., Mutimamwiza, I., Mutsonziwa, N., Mutter, D., Mutyaba, F., Muwanga, T., Muwanguzi, P., Muzaffar, N., Muzaffar, R., Alfonso Carrillo, C., Mwachiro, M., Mwale, G., Mwangi, V., Mwaria, C., Myatt, R., Myers, J., Myint, Y., Myintmo, A., Myszkowski, S., N, R., Alford, S., N Mohammad, A., Na, H., Naabo, N., Naar, L., Nabawanuka, A., Nabi, M. S., Nabian, M. H., Nabil, A., Nabil, S., Alfraidy, D., Nachelleh, E., Nachum, E. R., Nacion, A. J. D., Nada, A., Nadal, L. R., Nadal Rodrigues, D., Nadeau, S., Nadeem, A., Nader, N. E., Nadia Maria, N., Älgå, A., Nadkarni, M., Nadreen, M., Naeem, M., Naeem, S., Naegele, F., Nael, A., Naem, A., Naem, J., Naffi, A. A., Nagachandra, G., Algadi, N., Nagamoto, S., Naganathar, S., Naganuma, H., Nagappa, M., Nagar, M., Nagarasa, P., Nagashima, F., Nagassima, K., Nageeb, A., Nageh, M. A., Algar-Yañez, B., Nageh, M., Naghibi, A., Nagiub, M., Nagorni, E. A., Nagpal, P., Nagra, R. N., Nagra, S., Nah, S. A., Nahal, E. A., Nahm, C., Algarni, M., Nahtomi Shick, O., Naieem, M., Naik, P., Nail, D., Naimy, G., Nair, A., Nair, A. K., Nair, D., Nair, G., Algarni, S., Nair, S., Nair, V. P., Naiya, H. I. I., Najafian Motahaver, N., Najera, R., Naji, N., Naji, O., Najjad, M. K. R., Najjar, M. S., Nakagawa, S., Alghamdi, A., Nakamura, Y., Nakanishi, R., Nakano, L., Nakanwagi, C., Nakas, A., Nakata, Y., Nakazawa, H., Nakirijja, T., Namikawa, T., Namrata, D., Abdelhafez, M., Namugenyi, C., Namutosi, E., Nana, G. R., Nanayakkara, A., Nankivell, P., Naoum, N., Napolitano, L., Nappi, F., Nappo, G., Naqi, S. A., Alghamdi, A. A., Naqui, Z., Naqvi, W., Naraen, A., Naranjo, S., Narasiman, V., Narasimhan, G., Narayan, S., Narayanan, V., Narayanasamy, K., Nardi, C., Naredla, P., Narendra, D., Narroway, H., Naseem, H., Naseem, M. Y., Naseer, M., Naseer, M. A., Nashed, E., Nashidengo, P. R., Nasir, A., Alghamdi, I., Nasir, M., Naskar, U., Nasreddin, M., Nasri, M. Z., Nassali, G., Nassanga, R., Nassar, A., Nassef, M. A., Alghamdi, R., Nasser, A., Nasser, N., Nasser, S., Nassif, M., Nassif, Y., Nassimu, M., Natal Álvarez, F., Nataraja, R., Nathan, M., Nathan, S. K., ALghamdi, S., Nathani, R., Nativ, H., Naumeri, F., Naunheim, M., Naureen, S., Nausheen, S., Navaratne, L., Navarrete-Peón, A., Navarro, A., Navarro, D., Alghamdi, S., Navarro, J. C., Navarro Casado, R., Navarro Martínez, S., Navarro-Alean, J., Navarro-Barrios, A., Navarro-Sánchez, A., Nawara, H., Nawawi, A., Nayak, P., Nayen, A., Alghazal, T., Nayyer, F., Naz, F., Nazal, M., Nazar, Z., Nazia, N., Nazimi, A. J., Nazir, S., Nazir, S. F., Nazir, U., Ncogoza, I., Alghazo, A., Ndabvonga, G., Ndatewapo, F., Ndayishyigikiye, M. D., Ndegbu, C., Ndizeye, O., Ndlovu, S., Ndong, A., Neagu, A., Neal, A., Neal, N., Alghuson, L., Neal-Smith, G., Neary, P., Negash, S., Negoi, I., Negreanu, L., Negrete Ocampo, J. R., Negussie, A., Nehe, A., Neidert, N., Collaborative, Covidsurg, Collaborative Dmitri Nepogodiev, Globalsurg, F Simoes, Joana F, Li, Elizabeth, Glasbey, Jame, Picciochi, Maria, K Kamarajah, Sivesh, Gujjuri, Rohan, Bhangu, Aneel, A, Maryam, A Azab, Mohammed, A Janjua, Dratif, A Zahran, Mohammed, A Abdelaziz, Areej, Luglio, Gaetano, Surgery, Medicine and Pharmacy academic/administration, Basic (bio-) Medical Sciences, Clinical sciences, Surgical clinical sciences, Faculty of Medicine and Pharmacy, Medical Oncology, Gastroenterology, Department of Surgery, HUS Abdominal Center, Chiantera, V, Pecoraro, F, COVIDSurg Collaborative, GlobalSurg Collaborative, Paediatric Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, AGEM - Endocrinology, metabolism and nutrition, Graduate School, Amsterdam Reproduction & Development (AR&D), Tytgat Institute for Liver and Intestinal Research, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laura Alberici, Filippo Antonacci, Alessandro Arena, Angela Belvedere, Fabio Bernagozzi, Paolo Bernante, Pietro Bertoglio, Lorenzo Bianchi, Maria Bisulli, Barbara Bonfanti, Safia Boussedra, Jury Brandolini, Crescenzo Cacciapuoti, Stefano Cardelli, Riccardo Casadei, Matteo Cescon, Alessandro Cipolli, Riccardo Cipriani, Alfredo Conti, Luca Contu, Francesco Costa, Niccolo’ Daddi, Eugenia De Crescenzo, Pierandrea De Iaco, Alessandra De Palma, Massimo Del Gaudio, Anna Nunzia Della Gatta, Giampiero Dolci, Giulia Dondi, Matteo Droghetti, Sergio Nicola Forti Parri, Elena Garelli, Chiara Gelati, Giuliana Germinario, Federico A. Giorgini, Carlo Ingaldi, Elio Jovine, Kenji Kawamukai, Antonio Lanci Lanci, Raffaele Lombardi, Maria Elisa Lozano Miralles, Claudio Marchetti, Michele Masetti, Francesco Minni, Daniele Morezzi, Daniele Parlanti, Alice Pellegrini, Anna Myriam Perrone, Anna paola Pezzuto, Marco Pignatti, Gianluigi Pilu, Valentina Pinto, Gilberto Poggioli, Silvana Bernadetta Puglisi, Diego Raimondo, Matteo Ravaioli, Claudio Ricci, Sara Ricciardi, Francesco Ricotta, Roberta Rizzo, Angela Romano, Matteo Rottoli, Riccardo Schiavina, Renato Seracchioli, Matteo Serenari, Margherita Serra, Leonardo Solaini, Piergiorgio Solli, Gioia Sorbi, Mario Taffurelli, Marta Tanzanu, Achille Tarsitano, Marco Tesei, Gabriele Vago, Tommaso Violante, Simone Zanotti, Tommaso Frisoni, pignatti marco, ERSÖZ, CEVPER, GlobalSurg Collaborative, COVIDSurg Collaborative, Nepogodiev, Dmitri, Simoes, Joana F. F., Glasbey, James C., Alser, Osaid, Boccalatte, Luis A., Calvache, Jose A., Duran, Irani, Elhadi, Muhammed, Elmujtaba, Mohammed, Emile, Sameh, Harrison, Ewen M., Hutchinson, Peter, Allen Ingabire, J. C., Isik, Arda, Kamarajah, Sivesh K., Karandikar, Sharad, Kauppila, Joonas H., Kembuan, Gabriele, Lederhuber, Han, Löffler, Markus W., Mann, Harvinder, Marson, Ella J., Mclean, Kenneth A., Munyaneza, Emmanuel, Norman, Lisa, Omar, Omar M., Pius, Riinu, Pockney, Peter, Rutegård, Martin, Stewart, Grant D., Taylor, Elliott H., Venn, Mary L., Aizza, Giada, Bellio, Gabriele, Bogoni, Selene, Bortul, Marina, Casagranda, Biagio, Cortinovis, Sara, de Manzini, Nicolo', Drigo, Davide, Germani, Paola, Mastronardi, Manuela, Paiano, Lucia, Palmisano, Silvia, Nepogodiev, D, Bhangu, A, Gallo, G, Picciariello, P, Abushanab, M, Fruscio, R, Ornaghi, S, Iovino, C, Rossi, S, and Simonelli, F more...
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Male ,COVID-19 Vaccine ,safe surgery ,vaccination modelling ,COVID-19 ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,MULTICENTER ,Comorbidity ,030230 surgery ,0302 clinical medicine ,phase 3 clinical trial (topic) ,Case fatality rate ,Prospective Studies ,SARS-CoV-2 , Vaccination , Safe surgery ,COVID-19/epidemiology ,SARS-CoV-2 ,vaccination ,education.field_of_study ,case fatality rate ,Vaccination ,Adolescent ,Adult ,Aged ,COVID-19 Vaccines ,Elective Surgical Procedures ,Female ,Humans ,Middle Aged ,Postoperative Complications ,Preoperative Period ,Young Adult ,health care policy ,030220 oncology & carcinogenesis ,cancer ,outcome ,mortality ,infection ,modelling ,Cohort study ,prospective study ,Human ,medicine.medical_specialty ,Article ,03 medical and health sciences ,SARS-CoV-2, vaccination ,SDG 3 - Good Health and Well-being ,COVID-19 Vaccines/pharmacology ,Vaccination/methods ,Elective surgery ,education ,Science & Technology ,Elective Surgical Procedure ,adult ,aged ,cancer grading ,cancer surgery ,computer assisted tomography ,elective surgery ,female ,follow up ,human ,incidence ,infection rate ,infection risk ,major clinical study ,male ,middle aged ,outcome assessment ,preoperative care ,sensitivity analysis ,seroprevalence ,Severe acute respiratory syndrome coronavirus 2 ,young adult ,surgery ,Cura preoperatòria ,Prospective Studie ,Surgery ,Human medicine ,Postoperative Complication ,610 Medizin und Gesundheit ,AcademicSubjects/MED00910 ,Settore MED/18 - CHIRURGIA GENERALE ,Settore MED/29 - CHIRURGIA MAXILLOFACCIALE ,ESTUDOS PROSPECTIVOS ,Vacunació ,Prospective cohort study ,Incidence (epidemiology) ,covid ,Elective Surgical Procedures/methods ,COVID, vaccination ,Original Article ,AcademicSubjects/MED00010 ,Life Sciences & Biomedicine ,international prospective cohort study ,Postoperative Complications/prevention & control ,Population ,SARS-CoV-2/immunology ,NO ,medicine ,ddc:610 ,LS7_4 ,business.industry ,Number needed to vaccinate ,Preoperative care ,3126 Surgery, anesthesiology, intensive care, radiology ,Settore MED/18 ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Emergency medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population., The aim of this study was to inform vaccination prioritization by modelling the impact of vaccination on elective inpatient surgery. The study found that patients aged at least 70 years needing elective surgery should be prioritized alongside other high-risk groups during early vaccination programmes. Once vaccines are rolled out to younger populations, prioritizing surgical patients is advantageous. more...
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17. TB and COVID-19 co-infection: rationale and aims of a global study
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Casco, N., Jorge, A. L., Palmero, D., Alffenaar, J. -W., Fox, G., Ezz, W., Cho, J. -G., Skrahina, A., Solodovnikova, V., Bachez, P., Arbex, M. A., Galvao, T., Rabahi, M., Pereira, G. R., Sales, R., Silva, D. R., Saffie, M. M., Miranda, R. C., Cancino, V., Carbonell, M., Cisterna, C., Concha, C., Cruz, A., Salinas, N. E., Revillot, M. E., Farias, J., Fernandez, I., Flores, X., Gallegos, P., Garavagno, A., Guajardo, C., Bahamondes, M. H., Merino, L. M., Munoz, E., Munoz, C., Navarro, I., Navarro, J., Ortega, C., Palma, S., Pardenas, A. M., Pereira, G., Castillo, P. P., Pinto, M., Pizarro, R., Rivas, F., Rodriguez, P., Sanchez, C., Serrano, A., Soto, A., Taiba, C., Venegas, M., Vergara, M. S., Vilca, E., Villalon, C., Yucra, E., Li, Y., Guelvez, B., Plaza, R., Tello, K., Andrejak, C., Blanc, F. -X., Dourmane, S., Froissart, A., Izadifar, A., Riviere, F., Schlemmer, F., Gupta, N., Ish, P., Mishra, G., Sharma, S., Singla, R., Udwadia, Z. F., Manika, K., Diallo, B. D., Hassane-Harouna, S., Artiles, N., Mejia, L. A., Alladio, F., Calcagno, A., Centis, R., Codecasa, L. R., D'Ambrosio, L., Formenti, B., Gaviraghi, A., Giacomet, V., Goletti, D., Gualano, G., Matteelli, A., Migliori, G. B., Motta, I., Palmieri, F., Prestileo, T., Riccardi, N., Saderi, L., Saporiti, M., Sotgiu, G., Stochino, C., Tadolini, M., Torre, A., Visca, D., Villa, S., Kuksa, L., Danila, E., Diktanas, S., Miliauskas, S., Ridaura, R. L., Lopez, F. L. L., Torrico, M. M., Rendon, A., Akkerman, O. W., Piubello, A., Souleymane, M. B., Aizpurua, E., Gonzales, R., Jurado, J., Loban, A., Aguirre, S., De Egea, V., Irala, S., Medina, A., Sequera, G., Sosa, N., Vazquez, F., Manga, S., Villanueva, R., Araujo, D., Duarte, R., Marques, T. S., Grecu, V. I., Socaci, A., Barkanova, O., Bogorodskaya, M., Borisov, S., Mariandyshev, A., Kaluzhenina, A., Stosic, M., Beh, D., Ng, D., Ong, C. W. M., Solovic, I., Dheda, D., Gina, P., Caminero, J. A., Cardoso-Landivar, J., De Souza Galvao, M. L., Dominguez-Castellano, A., Garcia-Garcia, J. -M., Pinargote, I. M., Fernandez, S. Q., Sanchez-Montalva, A., Huguet, E. T., Murguiondo, M. Z., Bruchfeld, J., Bart, P. -A., Mazza-Stalder, J., Tiberi, S., Arrieta, F., Heysell, S., Logsdon, J., Young, L., Department of Physics [Glasgow], University of Strathclyde [Glasgow], Instituto de Fisica Corpuscular (IFIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universitat de València (UV), Laboratoire d'Etude des Mécanismes Cognitifs (EMC), Université Lumière - Lyon 2 (UL2), Added Value Solutions (AVS), Universidade de Santiago de Compostela [Spain] (USC ), Departamento de Ingeniería Térmica y de Fluidos, Avda. Universidad 30, University Medical Center Göttingen (UMG), CHU Amiens-Picardie, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Réanimation Médicale [CHU Henri Mondor - APHP] (DHU A-TVB), CHU Henri Mondor-Université Paris-Est Créteil, Faculté de Médecine [Créteil] (UPEC-Médecine), Inter-University Centre for Astronomy and Astrophysics [Pune] (IUCAA), Alma Mater Studiorum University of Bologna (UNIBO), Laboratoire des EcoSystèmes et des Sociétés en Montagne (UR LESSEM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli Studi di Milano = University of Milan (UNIMI), Vilnius University [Vilnius], Instituto de Ciencias Nucleares [Mexico], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Instituto Mexicano del Petróleo (IMP), University of Cadiz, Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain], Bart's and The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Southwest Research Institute [Boulder] (SwRI), BIOLOGICAL AND AGRICULTURAL ENGINEERING NORTH CAROLINA STATE UNIVERSITY RALEIGH USA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Microbes in Health and Disease (MHD), Université Paris-Est Créteil, Faculté de Médecine [Créteil] (UPEC-Médecine)-CHU Henri Mondor, Università degli Studi di Milano [Milano] (UNIMI), and Universidad Nacional Autónoma de México (UNAM) more...
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Pulmonary and Respiratory Medicine ,Research design ,medicine.medical_specialty ,Tuberculosis ,Coronavirus disease 2019 (COVID-19) ,[SDV]Life Sciences [q-bio] ,MEDLINE ,Global Health ,medicine ,Global health ,Humans ,Multicenter Studies as Topic ,Prospective Studies ,Intensive care medicine ,Prospective cohort study ,Tuberculosis, Pulmonary ,ComputingMilieux_MISCELLANEOUS ,business.industry ,Coinfection ,COVID-19 ,Pulmonary ,medicine.disease ,Infectious Diseases ,Research Design ,business ,Co infection - Abstract
International audience
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18. Assessment of the association between Cytomegalovirus DNAemia and subsequent acute Graft-versus-Host Disease in allogeneic peripheral blood stem cell transplantation: A multicenter study from the Spanish Hematopoietic Transplantation and Cell Therapy Group
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Bueno F, Solano C, Vazquez L, Gimenez E, de la Camara R, Albert E, Rovira M, Espigado I, Martin Calvo C, Lopez-Jimenez J, Suarez-Lledo M, Chinea A, Esquirol A, Perez A, Bermudez A, Saldana R, Heras I, Gonzalez-Huerta A, Torrado T, Batlle M, Jimenez S, Vallejo C, Barba P, Cuesta M, Duarte R, Pinana J, Spanish Group of Hematopoietic Transplantation C, and Navarro D more...
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surgical procedures, operative ,hemic and lymphatic diseases ,virus diseases - Abstract
The potential role of active CMV infection in promoting acute Graft-versus-Host Disease (aGvHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. We further addressed this issue conducting a retrospective, observational, multicenter study of 632 patients subjected to allogeneic peripheral blood HSCT at 20 Spanish centers. Monitoring of CMV DNA load in plasma or whole blood was performed by real-time PCR assays. Cumulative incidence of CMV DNAemia was 48.9% (95% CI, 45%-52.9%), of any grade aGvHD, 45.6; 95% (CI, 41.3%-50.1%), and of grade II-IV aGvHD, 30.7 (95% CI, 24.9%-36.4%). Overall, development of CMV DNAemia at any level resulted in an increased risk of subsequent all grade (HR, 1.38; 95% CI, 1.08 - 1.76; P=0.009) or grade II-IV (HR, 1.58; 95% CI, 1.22 - 2.06; P=0.001) aGvHD. The increased risk of aGvHD linked to prior occurrence of CMV DNAemia was similar to the above when only clinically significant episodes were considered for the analyses (HR for all grade aGvHD, 1.48; 95% CI, 1.13 - 1.91; P=0.041, and HR for grade II-IV aGvHD, 1.53; 95% CI. 1.13-1.81; P=0.04). The CMV DNA doubling time in blood was comparable overall in episodes of CMV DNAemia whether followed by aGvHD or not. Whether CMV replication is a surrogate risk marker of aGvHD or it is causally involved is an important question to be addressed in future experimental research. This article is protected by copyright. All rights reserved. more...
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19. The School, the Family and the Community and the Knowledge of Domestic Rodents, as Invasive Exotic Species
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Fimia Duarte R
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20. Correction: The challenge of COVID-19 and hematopoietic cell transplantation: EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy (Bone Marrow Transplantation, (2020), 55, 11, (2071-2076), 10.1038/s41409-020-0919-0)
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Ljungman, P., Mikulska, M., de la Camara, R., Basak, G. W., Chabannon, C., Corbacioglu, S., Duarte, R., Dolstra, H., Lankester, A. C., Mohty, M., Montoto, S., Murray, J., de Latour, R. P., Snowden, J. A., Yakoub-Agha, I., Verhoeven, B., Kroger, N., Styczynski, J., and UAM. Departamento de Medicina more...
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CAR T cells ,European Society for Blood and Marrow Transplantation (EBMT) ,SARS-CoV-2 ,Medicina ,COVID-19 ,Hematopoietic cell transplantation (HCT) - Abstract
The original HTML and PDF versions of this article were updated shortly after publication to correct author Bregje Verhoeven’s name and affiliation. Bregje Verhoeven was incorrectly associated with Willem-Alexander Children’s Hospital, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands. The correct affiliation is Foundation Hematon, Utrecht, The Netherlands. This has now been corrected in both the PDF and HTML versions of the article. more...
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21. Insights into tuberculosis: A survival analysis of time to recurrence in Portugal, between 2002 and 2009
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Soares, P, Duarte, R, Gomes, Gabriela, Rocha, C, and Lopes, J S
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wf_205 ,wf_200 ,wf_205_1 - Abstract
Recurrence of TB has been associated with poor adherence to treatment, smoking, alcoholism, unemployment, drug abuse, the severity of pulmonary cavitation, HIV infection and duration of treatment.1 However, the risk factors can vary considerably across countries and between studies. Since little is known about risk factors for recurrence in Portugal, we aimed to identify predictors of treatment recurrence in the country. Surveillance data on TB for the period of 2002–2009 was provided by SVIG-TB, a database from the Portuguese National Health System. For this analysis, only cases of confirmed TB disease were considered, and patients that had information on the first and second TB episodes. The variables studied were chosen as TB risk factors according to previous reports about TB recurrence. The existence of missing data was assessed and missing data characterised (missingness between 0 and 10%). From this characterisation, we chose to explore multiple imputation using random-forest based on multivariate imputation by chained equations. We used a semi-parametric Cox regression model in which the event of interest was the second episode of TB, with time being measured from the end of treatment for a first TB episode. Patients without the second episode of TB before the end of the study were eliminated. A total of 8364 individuals were analysed, of which 145 (1.73%) had a recurrent TB episode during the time of the more...
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- 2020
22. Ethnic prevalence of anemia and predictors of anemia among chronic kidney disease patients at a tertiary hospital in Johannesburg, South Africa
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Nalado AM, Mahlangu JN, Waziri B, Duarte R, Paget G, Olorunfemi G, and Naicker S
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anaemia ,predictors ,iron deficiency anaemia ,risk factors ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,haemoglobin ,chronic kidney disease - Abstract
Aishatu Mohammed Nalado,1,2 Johnny N Mahlangu,3 Bala Waziri,1 Raquel Duarte,1 Graham Paget,1 Gbenga Olorunfemi,4 Saraladevi Naicker1 1Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa; 2Department of Internal Medicine, College of Health Sciences, Bayero University, Kano, Nigeria; 3School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 4Division of Epidemiology and Biostatistics, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa Introduction: Anemia is a complication of chronic kidney disease (CKD) that can greatly impact on its prognosis. However, the risk factors for anemia, including the influence of ethnicity, are not well established among the CKD population in Johannesburg.Methods: This was a cross-sectional study of 353 adult CKD patients attending the renal outpatient clinic of the Charlotte Maxeke Johannesburg Academic Hospital (Johannesburg, South Africa) from June 1, 2016 to December 30, 2016. Sociodemographic and clinical characteristics were obtained using a proforma. Blood samples were collected for serum electrolytes and hematological parameters. Predictors of low hemoglobin and iron deficiency anemia (IDA) were evaluated using multivariable binary logistic regression.Results: The mean age and prevalence of anemia among the CKD participants were 55.3±15.0 years and 43.18% (95% CI: 38.1%–48.4%), respectively. Blacks had the highest prevalence of anemia (46.9%), while Indians/Asians had the lowest (18.2%). Although the odds of anemia was 3.8-fold higher (odds ratio =3.8, P-value =0.059) among CKD stage V participants as compared to CKD stage I, the relationship between anemia and stages of CKD was non-linear. Diabetes mellitus (odds ratio =2.31, P-value =0.005) had a strong association with anemia among the CKD participants.Conclusion: Almost half of the CKD participants were anemic, and the odds of anemia did not increase linearly with increasing severity of CKD. There was a marked ethnic disparity in anemia prevalence. Our study highlights the need for risk-based management of anemia among CKD patients. Keywords: chronic kidney disease, hemoglobin, risk factors, iron deficiency anemia, ethnicity, Johannesburg, South Africa, kidney stage   more...
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- 2019
23. Atherosclerotic vascular disease and its correlates in stable black South African kidney transplant recipients
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Oguntola SO, Hassan MO, Duarte R, Dix-Peek T, Dickens C, Olorunfemi G, Vachiat A, Paget G, Manga P, and Naicker S
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lipoprotein ratios ,atherosclerotic vascular disease ,carotid intima media thickness ,kidney transplant recipients ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 - Abstract
Stephen Olawale Oguntola,1 Muzamil Olamide Hassan,2 Raquel Duarte,3,* Therese Dix-Peek,3 Caroline Dickens,3 Gbenga Olorunfemi,4 Ahmed Vachiat,5 Graham Paget,1 Pravin Manga,5 Saraladevi Naicker1,* 1Department of Internal Medicine, Division of Nephrology, University of Witwatersrand, Johannesburg, South Africa; 2Department of Internal Medicine, Dialysis Unit, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Nigeria; 3Department of Internal Medicine Laboratory, University of Witwatersrand, Johannesburg, South Africa; 4Department of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa; 5Department of Internal Medicine, Division of Cardiology, University of Witwatersrand, Johannesburg, South Africa *These authors contributed equally to this work Background: Despite remarkable improvement in renal function attributable to kidney transplantation, the burden of cardiovascular disease (CVD) among kidney transplant recipients (KTRs) remains high in the post-transplant period. Aggressive use of statins in KTRs may make lipoprotein ratios correlate better with atherosclerotic vascular disease (AsVD) when compared with traditional lipid profile parameters. We therefore evaluated the clinical and echocardiographic correlates of AsVD among non-diabetic, stable, black KTRs in South Africa.Methods: This was a cross-sectional study of 41 adult (18–65 years), non-diabetic, stable KTRs and 41 age- and sex-matched healthy controls. An interviewer-administered questionnaire was used to obtain information on participants’ sociodemographic and cardiovascular risk factors. Anthropometric parameters were measured. Urine and blood samples were obtained and analyzed. Echocardiography was performed and carotid intima media thickness (CIMT) was assessed in both right and left carotid arteries. Spearman’s rank correlation and binary logistic regression were performed to determine the relationship between CVD risk factors and AsVD. Results: AsVD was present in 46.3% of KTRs compared to 17.1% of healthy controls (p=0.004). Left ventricular hypertrophy was present in 92.7% of the KTRs. There were statistically significant differences in waist–hip ratio, systolic blood pressure, mean arterial pressure, urine albumin–creatinine ratio, serum fibrinogen, serum creatinine, estimated glomerular filtration rate, left atrial diameter, left ventricular mass (LVM), and left ventricular mass index (LVMI) between KTRs and controls. A positive relationship was seen between CIMT and certain risk factors for CVD including LVM, LVMI, and mitral valve deceleration time, (p  more...
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- 2018
24. Is the use of unrelated donor transplantation leveling off in Europe? The 2016 European Society for Blood and Marrow Transplant activity survey report
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Passweg, J.R., Baldomero, H., Bader, P., Basak, G.W., Bonini, C., Duarte, R., Dufour, C., Kroeger, N., Kuball, J., Lankester, A., Montoto, S., Nagler, A., Snowden, J.A., Styczynski, J., Mohty, M., Transpl, ESBM, Passweg, J. R., Baldomero, H., Bader, P., Basak, G. W., Bonini, C., Duarte, R., Dufour, C., Kroger, N., Kuball, J., Lankester, A., Montoto, S., Nagler, A., Snowden, J. A., Styczynski, J., and Mohty, M. more...
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Oncology ,medicine.medical_specialty ,Myeloid ,Transplantation, Autologous ,Article ,03 medical and health sciences ,0302 clinical medicine ,Unrelated Donor ,immune system diseases ,Internal medicine ,hemic and lymphatic diseases ,Surveys and Questionnaires ,Medicine ,Humans ,Transplantation, Homologous ,Autoimmune disease ,Transplantation ,business.industry ,Hematopoietic Stem Cell Transplantation ,Allogeneic hct ,Hematology ,medicine.disease ,Europe ,Haematopoiesis ,medicine.anatomical_structure ,surgical procedures, operative ,Bone transplantation ,030220 oncology & carcinogenesis ,Transplantation, Haploidentical ,Hodgkin lymphoma ,business ,Unrelated Donors ,030215 immunology - Abstract
Hematopoietic cell transplantation (HCT) is an established procedure for acquired and congenital disorders of the hematopoietic system. In 2016, there was a tendency for continued activity in this field with 43,636 HCT in 39,313 patients [16,507 allogeneic (42%), 22,806 autologous (58%)] reported by 679 centers in 49 countries in 2016. The main indications were myeloid malignancies 9547 (24%; 96% allogeneic), lymphoid malignancies 25,618 (65%; 20% allogeneic), solid tumors 1516 (4%; 2% allogeneic), and non-malignant disorders 2459 (6%; 85% allogeneic). There was a remarkable leveling off in the use of unrelated donor HCT being replaced by haploidentical HCT. Continued growth in allogeneic HCT for marrow failure, AML, and MPN was seen, whereas MDS appears stable. Allogeneic HCT for lymphoid malignancies vary in trend with increases for NHL and decreases for Hodgkin lymphoma and myeloma. Trends in CLL are not clear, with recent increases after a decrease in activity. In autologous HCT, the use in myeloma continues to expand but is stable in Hodgkin lymphoma. There is a notable increase in autologous HCT for autoimmune disease. These data reflect the most recent advances in the field, in which some trends and changes are likely to be related to development of non-transplant technologies. more...
- Published
- 2018
25. Mathematical Modeling of Population Dynamics of the Aedes aegypti (Diptera: Culicidae) Mosquito with Some Climatic Variables in Villa Clara, Cuba
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Fimia Duarte R
- Published
- 2020
- Full Text
- View/download PDF
26. The Methodology of Regressive Objective Regression According to the New SARSCoV-2 COVID-19 Pandemic in the Municipality of Santa Clara and Cuba
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Fimia Duarte R
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- 2020
- Full Text
- View/download PDF
27. The EBMT activity survey report 2017: a focus on allogeneic HCT for nonmalignant indications and on the use of non-HCT cell therapies
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Passweg, J.R., Baldomero, H., Basak, G.W., Chabannon, C., Corbacioglu, S., Duarte, R., Kuball, J., Lankester, A., Montoto, S., de Latour, R.P., Snowden, J.A., Styczynski, J., Yakoub-Agha, I., Arat, M., Mohty, M., Kröger, N., European Society for Blood and Marrow Transplantation (EBMT), EBMT, and UAM. Departamento de Medicina more...
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Male ,Oncology ,medicine.medical_specialty ,Transplantation Conditioning ,Myeloid ,Medicina ,Thalassemia ,Hematopoietic cell transplantation (HCT) ,History, 21st Century ,Article ,Cell therapy ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Surveys and Questionnaires ,Internal medicine ,hemic and lymphatic diseases ,medicine ,Humans ,Transplantation, Homologous ,Aplastic anemia ,Thrombopoietin ,Allogeneic ,Haematological cancer ,Transplantation ,Hematology ,business.industry ,Hematopoietic Stem Cell Transplantation ,Myeloid malignancies ,medicine.disease ,Lymphoid malignancies ,Hemoglobinopathies ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cord blood ,Anemia patients ,Female ,business ,030215 immunology - Abstract
Hematopoietic cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants done in Europe and associated countries continues to rise with 45,418 HCT in 41,100 patients [(17,155 allogeneic (42%) and 23,945 autologous (58%)] reported by 683 centers in 50 countries in 2017. Main indications were myeloid malignancies 10,147 (25%; 96% allogeneic), lymphoid malignancies 26,488 (64%; 19% allogeneic), solid tumors 1,607 (3.9%; 2% allogeneic), and nonmalignant disorders 2,667 (7%; 81% allogeneic). Trends in donor choice seen before continue, with growing numbers of haploidentical HCT and decreasing use of cord blood. Of interest is that after many years of continued growth, the number of patients receiving an allogeneic HCT for marrow failure is decreasing slightly (p < 0.001). Such a change may be explained by the use of thrombopoietin analogs in aplastic anemia patients. Other nonmalignant indications, however continue to grow, most importantly HCT for hemoglobinopathies by 36%, equally for thalassemias and sickle cell disease. Non-HCT cell therapies have increased by 28% since 2015 and genetically modified T cells is type of cell therapy with the fastest growth. These annual reports reflect current activity and trends and are useful for health-care planning. more...
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- 2019
28. Should we worry about bedaquiline exposure in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis?
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Alffenaar, J. -W. C., Akkerman, O. W., Tiberi, S., Sotgiu, G., Migliori, G. B., Montaner, P. G., Palmero, D. J., Denholm, J., Douglas, P., Lau, J. S., Tramontana, A. R., Aleksa, A., Artsukevich, J., Sanukevich, T., Skrahina, A., Solodovnikova, V., Payen, M. -C., Dalcolmo, M., Gaga, M., Manika, K., Papavasileiou, A., Amale, R., Ganatra, S., Mullerpattan, J., Sadutshang, T. D., Topgyal, S., Udwadia, Z. F., Centis, R., Codecasa, L., D'Ambrosio, L., Gualano, G., Palmieri, F., Papalia, A., Pontali, E., Saderi, L., Spanevello, A., Toscanini, F., Viggiani, P., Manga, S., Duarte, R., Cordeiro, C. R., Belilovski, E., Borisov, S. E., Filippov, A., Maryandyshev, A., Dheda, K., Enwerem, M., Esmail, A., Fadul, M., Mastrapa, B. L., Teran Troya, J. L., Oelofse, S., Leyet, R. R., Caminero, J. A., Garcia-Garcia, J. -M., Garcia-Fuertes, J. -A., Martinez, I. C., Bruchfeld, J., Forsman, L. D., Jonsson, J., Kunst, H., White, V., and Zumla, A. more...
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Standard of care ,media_common.quotation_subject ,Extensively Drug-Resistant Tuberculosis ,Antitubercular Agents ,World health ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Nothing ,Tuberculosis, Multidrug-Resistant ,Medicine ,Humans ,030212 general & internal medicine ,Diarylquinolines ,Intensive care medicine ,media_common ,business.industry ,Conflict of interest ,Guideline ,Precision medicine ,030228 respiratory system ,chemistry ,Worry ,Bedaquiline ,business - Abstract
Recently, the World Health Organization (WHO) released the updated guideline on the treatment for multi-drug resistant tuberculosis (MDR-TB) treatment regimens based on new experimental and observational evidence [1]. In this new guidance the most important drugs are the late-generation fluoroquinolones ( i.e. , levofloxacin and moxifloxacin), linezolid, and bedaquiline. Despite the new guidance MDR- and extensively drug resistant (XDR) TB treatment is challenging due to the risk of drug-related adverse events (AE) and drug-drug interactions (DDI). Precision medicine-based approach to minimise the risk of resistance emergence and amplification and to provide patients with the highest standard of care has been recommended [2]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Dr. Alffenaar has nothing to disclose. Conflict of interest: Dr. Akkerman has nothing to disclose. Conflict of interest: Dr. Tiberi has nothing to disclose. Conflict of interest: Dr. Sotgiu has nothing to disclose. Conflict of interest: Dr. Migliori has nothing to disclose. more...
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- 2019
29. Are acceptance and mindfulness-based interventions 'value for money'? : evidence from a systematic literature review
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Duarte, R., Lloyd, A., Andronis, L., and White, R.
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BF ,RA ,RC - Abstract
Objectives:\ud Acceptance and mindfulness‐based interventions (A/MBIs) are recommended for people with mental health conditions. Although there is a growing evidence base supporting the effectiveness of different A/MBIs for mental health conditions, the economic case for these interventions has not been fully explored. The aim of this systematic review was to identify and appraise all available economic evidence of A/MBIs for the management of mental health conditions.\ud \ud Methods:\ud Eight electronic bibliographic databases (MEDLINE, MEDLINE In‐Process & Other Non‐Indexed Citations, EMBASE, Web of Science, NHS Economic Evaluation Database (EED), Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment (HTA) database, and EconLit) were searched for relevant economic evaluations published from each database's inception date until November 2017. Study selection, quality assessment, and data extraction were carried out according to published guidelines.\ud \ud Results:\ud Ten relevant economic evaluations presented in 11 papers were identified. Seven of the included studies were full economic evaluations (i.e., costs and effects assessed), and three studies were partial economic evaluations (i.e., only costs were considered in the analysis). The A/MBIs that had been subjected to economic evaluation were acceptance and commitment therapy (ACT), dialectical behaviour therapy (DBT), mindfulness‐based cognitive therapy (MBCT), and mindfulness‐based stress reduction (MBSR). In terms of clinical presentations, the evaluation of cost‐effectiveness of A/MBIs has been more focused on depression and emotional unstable personality disorder with three and four economic evaluations, respectively. Three out of seven full economic evaluations observed that A/MBIs were cost‐effective for the management of mental health conditions. Nevertheless, the heterogeneity of included populations, interventions, and economic evaluation study types limits the extent to which firm conclusions can currently be made.\ud \ud Conclusion:\ud This first substantive review of economic evaluations of A/MBIs indicates that more research is needed before firm conclusions can be reached on the cost‐effectiveness of A/MBIs for mental health conditions. more...
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- 2019
30. The number of parking functions with center of a given length
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Duarte, R, António Guedes de Oliveira, Rui Duarte, and Faculdade de Ciências
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Matemática, Matemática ,Lattice (group) ,0102 computer and information sciences ,Center (group theory) ,01 natural sciences ,Combinatorics ,Set (abstract data type) ,Search algorithm ,FOS: Mathematics ,Mathematics - Combinatorics ,0101 mathematics ,Mathematics ,Discrete mathematics ,Matemática [Ciências exactas e naturais] ,Backtracking ,Applied Mathematics ,010102 general mathematics ,Mathematics [Natural sciences] ,Function (mathematics) ,Shi arrangement ,05A19 ,Ish arrangement ,010201 computation theory & mathematics ,Bijection ,Tree (set theory) ,Combinatorics (math.CO) ,Mathematics, Mathematics ,Parking functions - Abstract
Let $1\leq r\leq n$ and suppose that, when the Depth-first Search Algorithm is applied to a given rooted labelled tree on $n+1$ vertices, exactly $r$ vertices are visited before backtracking. Let $R$ be the set of trees with this property. We count the number of elements of $R$. For this purpose, we first consider a bijection, due to Parkinson, Yang and Yu, that maps $R$ onto the set of parking function with center (defined by the authors in a previous article) of size $r$. A second bijection maps this set onto the set of parking functions with run $r$, a property that we introduce here. We then prove that the number of length $n$ parking functions with a given run is the number of length $n$ rook words (defined by Leven, Rhoades and Wilson) with the same run. This is done by counting related lattice paths in a ladder-shaped region. We finally count the number of length $n$ rook words with run $r$, which is the answer to our initial question., Comment: 15 pages. Version 2: some typos corrected more...
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- 2019
31. Nutrient fluxes and net metabolism in a coastal lagoon SW peninsula of Baja California, Mexico
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Cervantes Duarte, R.
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lcsh:Agriculture ,lcsh:GE1-350 ,lcsh:S ,LOICZ model ,coastal upwelling ,lcsh:Environmental sciences - Abstract
Fluxes of nutrients and net metabolism were estimated in coastal lagoon Magdalena Bay using LOICZ biogeochemical model. In situ data were obtained from 14 sites in the lagoon and also from a fixed site in the adjacent ocean area. Intense upwelling (February to July) and faint upwelling (August to January) were analyzed from monthly time series. The Temperature, nitrite + nitrate, ammonium and phosphate within the lagoon showed significant differences (p more...
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- 2016
32. Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant
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Faraci, M., Diesch, T., Labopin, M., Dalissier, A., Lankester, A., Gennery, A., Sundin, M., Uckan-Cetinkaya, D., Bierings, M., Peters, A.M.J., Garwer, M., Schulz, A., Michel, G., Giorgiani, G., Gruhn, B., Locatelli, F., Giardino, S., Uyttebroeck, A., Rialland, F., Itala-Remes, M., Dreger, P., Shaw, P.J., Bordon, V., Schlegel, P.G., Mellgren, K., Moraleda, J.M., Patrick, K., Schneider, P., Jubert, C., Lawitschka, A., Salooja, N., Basak, G.W., Corbacioglu, S., Duarte, R., Bader, P., and Pediat Transplant Complications Wo more...
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Treo ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Cyclophosphamide ,Adolescent ,Puberty, Precocious ,Treosulfan ,medicine ,Humans ,pubertal stage ,Child ,Gonads ,Busulfan ,Retrospective Studies ,Transplantation ,business.industry ,Late effect ,Hematopoietic Stem Cell Transplantation ,gonadal damage ,Hematology ,Allografts ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Prepubertal stage ,Child, Preschool ,Female ,busulfan ,treosulfan ,Transplantation Conditioning ,medicine.symptom ,business ,Chemoradiotherapy ,medicine.drug - Abstract
Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P = .02). Spontaneous menarche was more frequent after Treo than after Bu (P < .001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P = .03 and P = .04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population. more...
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- 2019
33. Introducing risk inequality metrics in tuberculosis policy development
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Gomes, M. G. M., Oliveira, J. F., Bertolde, A., Ayabina, D., Nguyen, T. A., Maciel, E. L., Duarte, R., Nguyen, B. H., Shete, P. B., and Lienhardt, Christian
- Abstract
Global stakeholders including the World Health Organization rely on predictive models for developing strategies and setting targets for tuberculosis care and control programs. Failure to account for variation in individual risk leads to substantial biases that impair data interpretation and policy decisions. Anticipated impediments to estimating heterogeneity for each parameter are discouraging despite considerable technical progress in recent years. Here we identify acquisition of infection as the single process where heterogeneity most fundamentally impacts model outputs, due to selection imposed by dynamic forces of infection. We introduce concrete metrics of risk inequality, demonstrate their utility in mathematical models, and pack the information into a risk inequality coefficient (RIC) which can be calculated and reported by national tuberculosis programs for use in policy development and modeling. more...
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- 2019
34. Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry
- Author
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Salamero O, Mart?nez-Cuadr?n D, Sobas M, Benavente C, Vives S, De la Serna J, P?rez-Encinas M, Escoda L, Gil C, Brunet S, Ramos F, Esteve J, Amigo M, Krsnik I, Manso F, Arias J, Gonz?lez-Campos J, Serrano J, Oleksiuk J, Barrios M, Garc?a-Boyero R, Novo A, Sanz M, Montesinos P, Helbig G, Holowiecka A, Armatys A, Hawrylecka D, Golos A, Ejduk A, Majcherek M, Skret A, Czyzewska J, Grosicki S, Zarzycka E, Watek M, Piatkowska-Jakubas B, Holojda J, Pluta A, Podhorecka M, Gromek T, Guzicka E, Charlinski G, Paluszewska M, de Heredia J, Hern?ndez J, Rom?n A, de la Serna J, Negri S, Ray?n C, Fern?ndez-Calvo F, D?az-Mediavilla J, Tormo M, Olave M, Amutio E, Pedro C, Gorosquieta A, Viguria M, Zudaire M, Molero T, Sayas M, Guardia R, Rivas C, Esquembre C, Garc?a R, Alcal? A, L?pez J, Rubio V, Linares M, Ribera J, San Miguel J, Deb?n G, de la C?mara R, Molines A, Loureiro C, Allegue M, Amador L, Mart? J, Madero L, Lassaletta A, Cabezudo M, Garc?a-Larana J, Rojas R, Ortega F, Pe?arrubia M, Puente F, Lopez-Ibor B, Bergua J, Ib??ez J, S?nchez P, Font L, Guinea J, Montero A, Gonz?lez M, Mart?n G, Mart?nez J, Verdeguer A, Garc?a P, Conde E, Garc?a J, Capote F, Bueno J, Bastida P, Rubio A, Fuster J, Gonz?lez J, P?rez I, Molina J, Mateos M, Ardaiz M, Rodr?guez-Calvillo M, Poder?s C, Arn?n M, Duarte R, D?az-Morfa M, Mart?n-Chac?n E, Calvo-Villas J, Garc?a-Belmonte D, Hern?ndez-Maraver D, Miskiewicz W, PETHEMA Grp, and PALG Grp more...
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induction mortality in APL ,APL real life outcomes ,Elderly APL ,APL prognostic factors ,neoplasms - Abstract
Acute promyelocytic leukemia is infrequent among patients aged >= 75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were >= 75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population. more...
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- 2019
35. An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens
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Sobas M, Montesinos P, Boluda B, Bernal T, Vellenga E, Nomdedeu J, Gonzalez-Campos J, Chillon M, Holowiecka A, Esteve J, Bergua J, Gonzalez-Sanmiguel J, Gil-Cortes C, Tormo M, Salamero O, Manso F, Fernandez I, de la Serna J, Moreno M, Perez-Encinas M, Krsnik I, Ribera J, Escoda L, Lowenberg B, Sanz M, de Heredia J, Hernandez J, Arias J, Ramos F, Roman A, Negri S, Rayon C, Fernandez-Calvo F, Diaz-Mediavilla J, Gil C, Olave M, Amutio E, Pedro C, Gorosquieta A, Viguria M, Zudaire M, Molero T, Sayas M, Guardia R, Esquembre C, Garcia R, Alcala A, Lopez J, Rubio V, Amigo M, Linares M, San Miguel J, Coruna A, Deben G, de la Camara R, Molines A, Loureiro C, Allegue M, Amador L, Marti J, Madero L, Lassaletta A, Cabezudo M, Garcia-Larana J, Rojas R, Ortega F, Penarrubia M, Puente F, Lopez-Ibor B, Brunet S, Ibanez J, Sanchez P, Novo A, Guinea J, Montero A, Gonzalez M, Martin G, Martinez J, Verdeguer A, Garcia P, Conde E, Garcia J, Capote F, Bueno J, Bastida P, Rubio A, Fuster J, Gonzalez J, Perez I, Molina J, Mateos M, Ardaiz M, Rodriguez-calvillo M, Poderos C, Arnan M, Duarte R, Diaz-Morfa M, Martin-Chacon E, Calvo-Villas J, Garcia-Belmonte D, Hernandez-Maraver D, Ossenkoppele G, van der Lelie J, Sonneveld P, Zijlmans M, Maertens J, de Valk B, Wijermans P, de Groot M, Schouten H, Biesma D, van Marwijk M, de Lisa E, Golos A, Ejduk A, Armatys A, Zarzycka E, Knopinska W, Miskiewicz W, Jastrzab B, Pluta A, Paluszewska M, Podhorecka M, Gromek T, Jakubas B, Majcherek M, Skret A, Watek M, Charlinski G, Calbecka M, Becht R, Gadomska A, Rzenno E, Piszcz J, Grosicki S, Palmer L, Ciarlo S, Bezares F, Rojas F, Longoni H, Gelemur M, Fazio P, Canepa C, Saba S, Balladares G, Negri P, Giunta M, Milone J, Lafalse D, Sossa C, Jaramillo F, Mayer J, Protivankova M, Scwarz J, PETHEMA Cooperative Grp, HOVON Cooperative Grp, PALG Cooperative Grp, and GATLA Cooperative Grp more...
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relapse ,Acute promyelocytic leukemia ,CD56 ,ATRA ,chemotherapy ,prognostic - Abstract
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = .007). In the multivariate analysis, CD56 + (p < .0001), higher relapse-risk score (p = .001), and male gender (p = .05) retained the independent predictive value. CD56+ APL also showed a greater risk of CNS relapse (6% versus 1%, p < .001) and lower 5-year OS (75% versus 83%, p = .003). The AIDA-based LPA2012 trial, with an intensified consolidation schedule for CD56+ APL, will elucidate whether an intensified consolidation schedule could mitigate the relapse rate in this setting. more...
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- 2019
36. Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry
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Salamero, O, Martinez-Cuadron, D, Sobas, M, Benavente, C, Vives, S, De la Serna, J, Perez-Encinas, M, Escoda, L, Gil, C, Brunet, S, Ramos, F, Esteve, J, Amigo, M, Krsnik, I, Manso, F, Arias, J, Gonzalez-Campos, J, Serrano, J, Oleksiuk, J, Barrios, M, Garcia-Boyero, R, Novo, A, Sanz, MA, Montesinos, P, Helbig, G, Holowiecka, A, Armatys, A, Hawrylecka, D, Golos, A, Ejduk, A, Majcherek, M, Skret, A, Czyzewska, J, Grosicki, S, Zarzycka, E, Watek, M, Piatkowska-Jakubas, B, Holojda, J, Pluta, A, Podhorecka, M, Gromek, T, Guzicka, E, Charlinski, G, Paluszewska, M, de Heredia, JMB, Hernandez, JM, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Tormo, M, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Rivas, C, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Linares, M, Ribera, JM, San Miguel, JDG, Deben, G, de la C?mara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Bergua, JM, Ibanez, J, Sanchez, P, Font, LL, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Hernandez, JA, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, and Miskiewicz, W more...
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induction mortality in APL ,APL real life outcomes ,Elderly APL ,APL prognostic factors ,neoplasms - Abstract
Acute promyelocytic leukemia is infrequent among patients aged >= 75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were >= 75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population. more...
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- 2019
37. Mycobacterial blood cultures in the diagnosis of tuberculosis in HIV-infected patients: are they useful?
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Ceia, F., Santos-Silva, A., Alves, Joana, Silva-Pinto, A., Oliveira, Olena Radomska, Cláudia Carvalho, Ana, Ramos, Angélica, Carvalho, T., Sarmento, A., Duarte, R., and Universidade do Minho
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Science & Technology ,Ciências Médicas::Medicina Básica - Abstract
Accepted manuscript, This work was supported by contributions from Iceland, Liechtenstein and Norway through the European Economic Area Grants under the Public Health Initiatives Programme (PT 06, grant number 138DT1)., info:eu-repo/semantics/acceptedVersion more...
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- 2019
38. Particle transport in gravel-bed rivers: Revisiting passive tracer data
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Vázquez-Tarrío, D., Recking, A., Liébault, F., Tal, M., Menendez-Duarte, R., INDUROT, University of Oviedo, 33600 Mieres, Spain, Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), UNIVERSITY OF OVIEDO ESP, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Centre National de la Recherche Scientifique (CNRS) more...
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gravel-bed rivers ,[SDE]Environmental Sciences ,sediment dispersion ,bedload transport ,[SDU.STU.GM]Sciences of the Universe [physics]/Earth Sciences/Geomorphology ,ComputingMilieux_MISCELLANEOUS ,tracers - Abstract
International audience; Data from tracer experiments were compiled and analysed in order to explore the role of geomorphological, hydrological and sedimentological constraints on fluvial gravel transport in gravel-bed rivers. A large data set from 217 transport episodes of tagged stones were compiled from 33 scientific papers. Our analyses showed that while magnitude of peak discharge is a major control on gravel transport and mobility, tracer travel distances show some scale dependence on the morphological configuration of the channel. Our results also highlight differences in the way tracers are displaced between step-pool and riffle and pool channels. The riffle-pool sequence seems to be a more efficient trap for travelling gravels than the step-pool pair. In addition, in step-pool channels there are clear differences in tracer transport between observations of first displacements after tracer seeding (unconstrained-stone conditions), and second and subsequent observations of tracer displacements (constrained-stone conditions). The comparison between tracer experiments under constrained conditions and those under unconstrained conditions also highlights the importance of bed state and structures in gravel mobility. The results of this study confirm that sediment transport in gravel-bed rivers is a complex process, whereby sedimentological and geomorphological controls are superimposed on the hydraulic forcing. more...
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- 2019
- Full Text
- View/download PDF
39. An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens
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Sobas, M, Montesinos, P, Boluda, B, Bernal, T, Vellenga, E, Nomdedeu, J, Gonzalez-Campos, J, Chillon, M, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, J, Gil C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de la Serna, J, Moreno, M, Perez-Encinas, M, Krsnik, I, Ribera, J, Escoda, L, Lowenberg, B, Sanz, M, de Heredia, J, Hernandez, J, Arias, J, Ramos, F, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, F, Diaz-Mediavilla, J, Gil, C, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, M, Guardia, R, Esquembre, C, Garcia, R, Alcala, A, Lopez, J, Rubio, V, Amigo, M, Linares, M, San Miguel, J, Coruna, A, Deben, G, de la Camara, R, Molines, A, Loureiro, C, Allegue, M, Amador, L, Marti, J, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, M, Puente, F, Lopez-Ibor, B, Brunet, S, Ibanez, J, Sanchez, P, Novo, A, Guinea, J, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, F, Bueno, J, Bastida, P, Rubio, A, Fuster, J, Gonzalez, J, Perez, I, Molina, J, Mateos, M, Ardaiz, M, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, J, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, G, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, P, de Groot, M, Schouten, H, Biesma, D, van Marwijk, M, de Lisa, E, Golos, A, Ejduk, A, Armatys, A, Zarzycka, E, Knopinska, W, Miskiewicz, W, Jastrzab, B, Pluta, A, Paluszewska, M, Podhorecka, M, Gromek, T, Jakubas, B, Majcherek, M, Skret, A, Watek, M, Charlinski, G, Calbecka, M, Becht, R, Gadomska, A, Rzenno, E, Piszcz, J, Grosicki, S, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, Scwarz, J, PETHEMA Cooperative Grp, HOVON Cooperative Grp, PALG Cooperative Grp, and GATLA Cooperative Grp more...
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relapse ,Acute promyelocytic leukemia ,CD56 ,ATRA ,chemotherapy ,prognostic - Abstract
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = .007). In the multivariate analysis, CD56 + (p < .0001), higher relapse-risk score (p = .001), and male gender (p = .05) retained the independent predictive value. CD56+ APL also showed a greater risk of CNS relapse (6% versus 1%, p < .001) and lower 5-year OS (75% versus 83%, p = .003). The AIDA-based LPA2012 trial, with an intensified consolidation schedule for CD56+ APL, will elucidate whether an intensified consolidation schedule could mitigate the relapse rate in this setting. more...
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- 2019
40. Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7)
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Greinix H, Slavin M, De Greef J, Maertens J, Hubacek P, Racil Z, Lundgren J, Bergeron A, Cordonnier C, Di Blasi R, Herbrecht R, Lortholary O, Robin C, Thiebaut A, Einsele H, Lehrnbecher T, Maschmeyer G, Mellinghoff S, Penack O, Roilides E, Kassa C, Averbuch D, Busca A, Cesaro S, Crocchiolo R, Gallo G, Mikulska M, Nosari A, Pagano L, Viscoli C, Blijlevens N, Donnelly P, Koltan P, Styczynski J, de Sousa A, Klyasova G, Aljurf M, Drgona L, de la Camara R, Duarte R, Martino R, Navarro D, Rovira M, Einarsdottir S, Ljungman P, Paukssen K, Wenneras C, Calandra T, Akova M, de Lavallade H, Ward K, Hill J, Dubel L, Mills L, Rupp M, Sanchez S, Zeitler S, and 2017 European Conf Infect Leuka more...
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- 2019
41. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA
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McGuire D, Alexander J, Johansen O, Perkovic V, Rosenstock J, Cooper M, Wanner C, Kahn S, Toto R, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George J, von Eynatten M, Marx N, Aizenberg D, Fiorella A, Edgardo N, Belen C, Alonso P, Walter M, Maia K, Guillermo S, Leandro B, Constanza R, Alejandra N, Melina C, Ariel I, Rodrigo C, Alvarez C, Jorge M, Gabriel C, German S, Bartolacci I, Bolobanich G, Tale T, Meritano M, Echeverria M, Gerrini S, Alvarez M, Torrijos N, Berli M, Coggiola J, Castaneda G, Rode R, Milessi R, Roude A, Bono J, Caresani J, Arias V, Westberg J, Allende G, Liberman A, Bordonava A, Almagro S, Gerbaudo C, Schiavi L, Budassi N, Cecilia M, Buncuga M, Carlos S, Osvaldo T, Mercedes S, Calella P, Agustina V, Aljandro M, Alberto D, Fiorella M, Cantero M, Cariganano M, Anadon P, Cartasegna L, Gabriela M, Fernanda A, Alberto R, Chacon C, Jazmin F, Colombo H, Coni E, Mattausch S, Thomsenhall K, della Torre M, Morandini M, Berra F, Margarita H, Commendatore V, Tedesco J, Bolzan P, Cuneo C, Narcisa G, Caputi V, Pablo S, Sandra G, Pacora F, Tinari M, Jure H, Parody M, Toranzo A, Frechtel G, Yohena S, Lovecchio S, Muller C, Martin S, Olivera C, Breyaui M, Bianchi G, Garcia C, Luciana V, Florencia F, Ruben G, Gelersztein E, Rey G, Sanchez C, Fornasari L, Di Pierro L, Giacomi G, Miguel S, Laura T, Gonzalo C, Ramon C, Glenny J, Koretzky M, Porto A, Tiberio O, Ellenberg A, Saurral R, Igarzabal C, Vilamajo O, Matkovich J, de Lapertosa S, Villagra M, Cuzziol G, de la Cruz M, Pinchetti R, Mierez M, Lopez C, Gorosito V, Gabito A, Kleiban A, Grosembacher L, Adrian P, Paula R, Javier G, Kraft F, Andres F, Krynski F, Nicolas P, Marcelo F, Alfredo F, de la Fuente R, Natalia C, Luquez H, Recuero Y, Becchetti N, Ruiz M, Costantino M, Vazquez G, Guzman C, Pelatia P, Maffei L, Sassone S, Yantorno M, Prado G, Khron B, Maldonado N, Gustavo L, Veronica V, Marino J, Elizabeth A, Alejandra C, Oscar R, Azize G, Gallardo M, Escudero M, Vargas E, Ramos H, Lucero C, Najenson M, Crocci I, Chiesa A, Nardone L, Dominguez S, Zanini A, Manghi F, Grossman M, Giudice G, Romeo A, Piskorz D, Miguel C, Susana D, Noeli U, Rosa S, Martin V, Soledad A, Virginia M, Lorena G, Prado A, Veronica L, Eduardo H, Adolfo P, Florencia W, Rista L, Scolari C, Rojas N, Bertolio V, Zarandon R, Jair S, Orlando C, Sanabria H, Ignacio D, Viviana C, Marina R, Sarjanovich R, Scaro G, Huerta C, Mana M, Gutierrez M, Dain A, Gavicola R, Sessa H, Sacripanti J, Felman R, Vilarino P, Sicer M, Lagrutta M, Sala J, Casabella T, Cecilia H, Carlos B, Vines G, Javier R, Vico M, Lanchiotti P, Martella C, Torres L, Villarino A, Molina M, Martinez J, Farias C, Bertola S, Rojas M, Guzman P, Nisi J, Martinez D, Barrionuevo M, Vita N, Lopez A, Vottero E, Giuliano M, Paron L, Vogel D, Mele P, Imposti H, Dominguez A, Zaidman C, Fernando G, Beck M, Beltrame P, Chemello D, Junior R, Abreu A, Fernandes V, Saboia J, Rodrigues L, Carvalho M, Gurgel M, Gadelha D, Ramos C, Borba V, Golbert M, Pitthan M, Golbert L, Valentini R, Canani L, Gross J, Valenti A, Sartori C, Dutra O, Azevedo E, Azevedo A, Vaz R, Vaz H, da Costa F, da Costa L, Panarotto D, Lain F, Camazzola F, Dellomea B, Rech R, Pizzato P, Nunes C, Jaeger C, Silveira D, Wagner L, Machado L, Rea R, de Bem A, Alves J, Jonasson T, Malucelli F, Betti R, Lerario A, Lisboa H, Bem J, Tres G, Tavares C, Nardi A, Pozzatto M, Backes L, Reolao J, Scariot E, Ziguer E, Baldissera D, Griz L, Antunes D, Victor F, Freire K, Barros A, Costi B, Sa M, Carneiro A, Felicio J, Felicio K, Penha P, Ferreira J, Melo F, Alves A, Souza A, Costa L, Pinheiro D, Turatti L, Augusto G, Leanca C, Santomauro A, Forti A, Sena R, Marinho A, Facanha C, de Souza K, de Souza A, de Queiroz W, Leite S, Vieira S, Gubert L, Olsen A, Piazzetta G, Fuck A, Ferreira M, Fortes J, Brandao T, Alves F, Radice E, dos Santos J, de Almeida R, Franco D, Saporito W, Eliaschewitz F, de Siqueira K, Bona R, Genestreti P, de Castro D, Visconti G, Sampaio C, Palhares F, Konigsfeld H, Alves E, Feder C, Leao B, Saraiva J, Rodovalho S, Costa M, Pires N, Figueiredo E, Werner G, Garcia J, de Paiva I, Quirino B, Botelho R, da Silva R, Navarro A, Lourenco C, Pereira A, Arantes F, Boner D, Saad J, Falchetto E, Washizu E, Mandil A, Pimenta N, Tofani F, Fonseca T, Teixeira L, Maia L, Lemos M, Mouco O, Nakazone M, Weiand L, Bohn J, Hissa M, Araripe F, Carvalho F, Cancado G, Wang R, Chacra A, Fusaro A, de Mendonca E, Cercato C, Halpern A, Alves B, Braile M, Sestito R, Mustafa E, Ferreira V, Sbardellini B, de Almeida P, Guimaraes F, Piedade M, Bienert I, Braga J, Daher R, Hirakawa T, Terra E, Farias E, Figueiredo M, Lima L, Moraes K, Avelino I, Flato U, Plavnik F, Portes E, Moreira M, Vendramini M, Veloso R, Padilha M, Rodrigues A, Adam R, Santos S, Sayeg N, Guerrero D, Madeira M, Siqueira J, Pinheiro R, Villacorta A, Mellazi A, Braga T, Kaiser S, Paolino B, Lefterov I, Marinchev A, Angelova S, Klyuchkova N, Lybomirova Z, Kerekovski Y, Kuneva T, Penkova D, Levterov G, Videnova E, Georgieva P, Shinkov A, Borissova A, Vlahov J, Dakovska-Dekova L, Lucheva M, Luchev P, Temelkova M, Borisova K, Tsenov S, Andreeva V, Margaritov V, Arasheva G, Lozanov L, Borisov R, Gorcheva D, Henein S, Whatley S, Boutros M, Kalyniuk N, Berlingieri J, Nisker W, Hoag G, Hepburn D, Harvey M, Manjoo P, Yale J, Sherman M, Tsoukas M, Rehman W, Mason M, Santerre M, De Kock J, Barkhuizen F, Rooke C, Gill C, Kooy J, Burgoyne G, de Kock J, Degen G, Hockman L, Invik R, Roberts P, Ward K, Alasaad H, Susan A, Davies V, Gupta N, Milhalidis J, Grossman L, Agawal N, Yared Z, Rwaheed, Nouhad S, Nahla A, Khandwala H, Warwick A, Wadehra D, Manan A, Vecchiarelli J, Aslam N, Ferrao A, St-Maurice F, Collette R, Davey B, Nawaz S, Coutu B, Costi P, Greiss I, Mansour F, Raymond J, St-Phard W, Nadra I, Della Siega A, Barahona L, Klinke P, Contractor H, Fryer M, Chandra N, Conti B, Telzer L, Sorensen S, Lounsbury N, Martin E, Mitchell L, Pelzer E, Nelson S, Jones M, Cox J, Luco G, Trhoughton T, Labonte R, Chouinard G, Frechette A, Rheaume M, Cusson J, Faucher J, Dery V, Kelly A, Miranda B, Al-Kayssi N, Malette P, Rheault P, Fredette P, Dumas R, Palardy J, Belanger A, Boucher P, Doyon B, Charbonneau J, Bailey G, Odendaal M, Stephan K, Badenhorst J, Knight D, Thurgood A, Johnston M, Cooper-Rosen E, Jagger R, Green M, Weisnagel S, Gangloff A, Bergeron J, Pesant Y, Chevalier P, Woo V, Hurd C, Ruckert G, Lira J, Navarro G, Venegas M, Gonzalez P, Montecinos H, Vidal G, Fernandez M, Varas J, Fernandez C, Aguilar J, Marin R, Kindel C, Yovaniniz P, Gherman O, Aravena M, Carvajal J, Macias E, Corrado P, Lazcano M, Garrido B, Charme G, Carrasco J, Vignolo P, Saavedra S, Gajardo V, Saavedra C, Santamaria D, del Castillo B, Balda I, Zurvarra V, Fu G, Jiang D, Huang H, Wang M, Song J, Lu W, Lin Y, Lu Z, Shi Y, Zhong M, Zhao X, Chen D, Zhang G, He Y, Shi P, Chu K, Gao Q, Deng W, Zhang J, Zhang Y, Chen H, Liu E, Xie Y, Lin R, Tan W, Yuan Z, Wang Y, Ren J, Yu H, Luo M, Ma W, Shi W, Xu H, Xu M, Liu G, Dong Y, Bai B, Guo R, Liu X, Gao Y, Li S, Xu X, Liu P, Dong X, Wang S, Fu F, Jiang Q, Meng C, Yin X, Lu Y, Cui Y, Su G, Miao W, Wei F, Zhao Q, Li Z, Gao X, Lozno H, Prada W, Figueroa W, Ordonez A, Quintero E, Vallejo G, Contreras C, Escobar J, Alvaran J, Ortiz L, Marin M, Montoya C, Mendoza J, Manjarres J, Navarro B, Martinez G, Bonfanti A, Perci X, de la Hoz L, Arroyo J, Rendon C, Lopez J, Escobar N, Franco J, Lozano M, Zapata C, Ibarra L, Barrero A, Sarmiento A, Lozada H, Olitte M, Florez L, Munoz C, Quintero G, Correa G, Ruiz S, Dorado A, Causa A, Palma E, Morales A, Arteaga J, Beltran J, Granados M, Rubio A, Dada F, Bueno W, Rivera R, Corredor K, Romero V, Accini F, Palmera J, Ruiz G, Ortega M, Sanchez A, Lora Y, Cano J, Duque S, Thiriez S, Castano M, Giraldo P, Boljkovac Z, Grcic I, Balen M, Zukanovic S, Jeric M, Dvorscak D, Car S, Knezevic A, Herceg D, Franov B, Miskovic V, Bakula M, Hadak A, Superba M, Rubes J, Gornik I, Hamzic J, Ballek L, Sedlackova L, Hejlova J, Galatikova D, Huskova A, Zak P, Flekac M, Mraz M, Potuznik P, Palova S, Novak P, Okenka L, Matuska J, Rohac F, Vondrak K, Reichert P, Shamasna A, Skopek J, Lejskova M, Jiruska M, Lang P, Podoubsky R, Svobodova J, Cifkova R, Jozifova M, Krajcoviechova A, Wolfhart P, Sulc P, Silhova E, Cechakova M, Machova V, Balkova J, Peterka M, Votocek S, Prosecky R, Valis M, Barton P, Tomek J, Pumprla J, Axmannova M, Vitaskova R, Sincl F, Horanska P, Richter B, Malicherova E, Roderova E, Jenickova P, Winkelmann B, Finger C, Klausmann G, Milek K, Schwabe M, Weiss N, Mahlmann A, Werth S, Schmidt C, Schoell I, London M, Steidl E, Orban K, Taeschner H, Bonigut S, Schiefke I, Schwittay A, Kornmann O, Eich A, Franke S, Kis J, Szobota E, Danos P, Beke E, Grosz A, Csecsei G, Ferenczy J, Filo A, Ferencz I, Mihaly E, Baranyi T, Revesz K, Schlezak J, Harcsa E, Dombroczki Z, Kocsis I, Juhasz E, Literati-Nagy B, Kulcsar E, Bezzeg K, Kemeny V, Peterfai E, Buday B, Keltai K, Balo T, Somogyi A, Nagy G, Oroszlan T, Bagosi Z, Bujtor Z, Tabak A, Ferencz V, Domjan B, Tanczer T, Palinkas A, Karolyi H, Kovacs K, Csaszar I, Palhegyi E, Engelhalter G, Horthy R, Vanko E, Szabo G, Sipos G, Szigyarto M, Sebo N, Paragh G, Zsiros N, Szentimrei R, Pal D, Kobling T, Szanto I, Varadi Z, Bajnok L, Szujo S, Nemes O, Bajnok A, Mezosi E, Bodis B, Marton Z, Konyves L, Farago M, Kiss G, Kiss O, Nagy E, Takacs R, Nyitray S, Abraham G, Fehertemplomi K, Deak L, Dezso E, Karneili E, Deeb D, Zloczower M, Mahmid R, Zolotov S, Hochberg I, Elias M, Goldstein L, Poletaev V, Rock W, Koren O, Saliba W, Wolf F, Adawi F, Nimer A, Mosenzon O, Raz I, Potekhin M, Cahn A, Yulian T, Zvulunov E, Israel H, Shpitz D, Bar-Or I, Chananashvili L, Irena L, Dessau H, Halabe A, Vishlitzky V, Nabriski D, Baraf L, Itelman M, Schiff E, Willner N, Fireman-Klein E, Svistunov V, Dotan Y, Pavlichev O, Saig L, Bashkin A, Kuyantseva E, Gershkov S, Nodelman M, Arbel Y, Bogomolny N, Leshem-Rubinow E, Rofe M, Chorin E, Havkuk O, Wainstein J, Feldman D, Fujino Y, 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Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, Gmytrasiewicz M, Zambrzycki J, Krysiak-Kowaluk H, Klodawska K, Klszczewski Z, Zieleniewski J, Opadczuk P, Urbanska K, Faran-Grabowska K, Szczepanik T, Siegel A, Kleczek A, Kincel K, Nowak D, Slowik-Gomulka L, Watemborska-Matuszyk G, Lampart J, Strozik-Krecichwost A, Dziewit T, Broncel M, Wojcik-Odyniec J, Jakubczyk E, Wierzbicka K, Witowicz A, Jedrych B, Korczyk P, Socik-Pojawa M, Monteiro P, Monteiro S, Mendes P, Soares F, Mendes S, Leite L, Vicente J, Santos M, Ferreira A, Alves P, Rosario F, Garrao A, Duarte L, Rogado C, Duarte R, Laginha T, Matos P, Raposo J, Mariz J, Teixeira J, Capela C, Leitao A, Cardiga R, Alface M, Augusto S, Basto L, Cunha A, Rei D, Dantas J, Verdasca I, Andrade L, Silva A, Suarez M, Dias V, Silva J, Pereira N, Goncalves M, Goncalves A, Silveira A, Sampaio A, Dias A, Diogo M, Vilaca C, Cif A, Calin T, Elena S, Crisan C, Adina S, Ramona S, Anghel V, Simona C, Turcu L, Mihaela V, Cosma D, Cristina H, Marius-Calin H, Negrisanu G, Andreea-Andrada M, Maria-Mihaela 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M, Rebecca J, Barker T, Seaton B, Campbell E, Kompanik H, Jayson L, Huffman C, Bialow M, McDonnell G, McCaffrey J, Manis C, DeLuca E, Levins J, Bartlett M, Anorga K, Franco M, Gentry P, Hodge D, Pohil R, Rschultz, Leggett R, Blair L, Gisler J, Niegos F, Osburn M, Parma K, Schendel S, Stines L, Winnie M, Wu P, Canales J, Yu J, Cornett G, Beavins J, Hyde D, Zapinski D, Johnson T, Levinson D, Ahmed A, Kenny B, Kuehl A, Bates C, Jantzi C, Ananthula P, Shafer J, Louthan J, Bays A, Stapleton A, Staton P, Strum D, Taylor P, Smith A, Rapp R, Bao S, Randolph C, MacGillivray B, Schuster R, Harden T, Barnella C, Dunnam T, Whiles R, Bolick C, Brockmyre A, Plucker S, Marshall C, Poteet C, Morin D, Tavel E, Averill N, McFann A, Purcell D, Dixon T, Corey E, Goss J, Drescher R, Irfan M, Naeem M, Egelhof R, Mehta P, Koehler T, Walia J, Fernandez J, Bedel G, Preet R, Bhuchar S, Ahmed F, Onyema D, Benchabbat A, Kohanbash L, Miller P, Lalinde M, Carrithers E, Patterson R, Raube-Miceli A, Martinez A, 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Earl J, McNeill R, Farrington C, Carr K, Nabat M, Matthew S, Yvette E, Handelsman Y, Delkhah S, Ismail Y, Janna C, Akhtar A, Neiman A, Blumenthal S, Colleen V, Schmidt D, Ashraf E, Bhargava A, Khoo T, Langel C, Theuma P, Wright D, Fitzgerald K, Hitchcock J, Capasso-Gulve E, Wolff E, Umpierrez G, Priyathama V, Francisco P, Dawn S, Quraishi A, Kahn B, Ferro F, Hertz B, Phelps J, Campbell A, Downing J, Pangtay D, Pangatay S, Villagran-Solis K, Haseeb M, Rettig K, Kwan R, Cox R, Slimak V, So A, Schmedtje J, Chang A, Douglas Z, McGarity W, Jestel J, Kanade P, Julie J, Asher R, Canaan Y, Perez A, Alonso I, Cutchin R, Koser A, Adeola Y, Brito S, Stocks J, Frandsen B, Weigelt M, Stehouwer E, Ince C, Stephen P, Shadi B, Jeffrey C, Thethi T, Carpio G, McDuffie R, Moreau C, Stell C, Katalenich B, McKendall-Lewis C, Htun W, Conroy K, Lovre D, Galagan R, Olmeda C, Sihota A, Barton A, Beasley R, Nankivel P, Aberle M, Machin I, Porras J, Rodriguez D, Albornoz A, Haidar A, Lopez-Santini R, Rivero G, Robins G, Colyar L, Hutchins C, Sturm D, Hart K, Phillips T, Montgomery C, Albrecht W, Fehlis K, Overman D, Box M, Villarreal-Martinez D, David-Svatek D, Ajani D, Shaikh Z, Wheeler K, Brown M, Ghosh C, Bandukwala I, Kleber S, Madden J, Bishara M, Perry K, Paoli-Bruno J, Abreu E, Espiritu R, Zmeili O, Christensen T, Grubb S, Beloff S, Caugh A, van Dijk C, Yalavarthy R, DeGraauw J, Fabian S, Gillum D, Corrigan G, Singh H, Jensen K, DeMore S, Montague T, Zieve F, Levy J, Fredrickson S, Tarkington P, Chapla P, Salacata A, Walls U, Iyer R, Nguyen K, Lettman J, Appleman B, Safavie F, Scaliem L, Eder F, Maklad S, Schlaen B, Molstead J, Hartwell J, Hubish D, Little R, Rando K, Kelly R, Drury M, Young P, Wininger S, Harman A, Daza R, Robbin S, Sanchez M, Rivera I, Garcia-Estrada M, Iglesias N, Dobs A, Andrade A, Falkowski S, Parrott T, Koon A, Wood T, Burkett E, Chavous K, Gupta A, Estes C, Loud D, Rhodes S, Chen M, Bromley L, Palma R, Kattan D, Kirk U, Tatu H, Stamatin R, Lupea S, Frasie M, Colfer H, Kane L, Teklinski A, Gadowski G, Levanovich P, Saba F, Confident L, Hossain S, Steinberg B, Philippe B, Choroenthkongtrakal S, Boccalano F, Anand R, Syam V, Manohar A, Suresh P, Madhusudhan P, Patel P, Cambier P, Klonaris J, Cheng W, Fisher S, Schelle M, Reese L, McLean S, Poock J, Hoens J, Rosie A, Welshons R, Dean J, Kuhlman P, Luke R, Lohrbauer L, Cunningham M, Buday P, Lehmann M, Chrzanowski K, Fletcher A, Hargrove J, Harris F, Debs-Perez G, Maiquez A, Cordoves L, Georgescu M, Tayoun H, Munoz F, Ortiz D, Munoz G, Hamzeh I, Misra A, Zhang L, Forgosh L, Loria K, Roncari C, Hommerding J, Morris G, Lebron C, Blake K, LaVenture K, Lange C, Levinson L, Baungarten T, Edevante S, Shawley S, Moyer H, Elliott K, Iachini K, Rajan R, Davis C, Shattuck A, Simon W, Lakin G, Secrist N, Buth D, Steere D, Talbot K, Singh N, Mascolo R, Sloan S, Kmetzo J, Brown J, Carter L, Lawrence M, Arauz-Pacheco C, Lender D, Kozlow W, Cavanaugh L, Wilson J, Gujja P, Akhter F, Khan M, Mohammed A, Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators more...
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cardiovascular disease ,type 2 diabetes mellitus ,heart failure ,chronic kidney diseases - Abstract
Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increased HF risk. We performed secondary analyses of HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin), a cardiovascular outcomes trial that enrolled participants with type 2 diabetes mellitus and atherosclerotic cardiovascular disease and/or kidney disease. Methods: Participants in 27 countries with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease were randomized 1:1 to receive once daily oral linagliptin 5 mg or placebo, on top of standard of care. All hospitalization for HF (hHF), cardiovascular outcomes, and deaths were prospectively captured and centrally adjudicated. In prespecified and post hoc analyses of HF and related events, Cox proportional hazards models adjusting for region and baseline history of HF were used. Recurrent hHF events were analyzed using a negative binomial model. In a subset of participants with left ventricular ejection fraction captured within the year before randomization, HF-related outcomes were assessed in subgroups stratified by left ventricular ejection fraction > or 50%. Results: CARMELINA enrolled 6979 participants (mean age, 65.9 years; estimated glomerular filtration rate, mL/min per 1.73m(2); hemoglobin A1c, 8.0%; 62.9% men; diabetes mellitus duration, 14.8 years), including 1873 (26.8%) with a history of HF at baseline. Median follow-up was 2.2 years. Linagliptin versus placebo did not affect the incidence of hHF (209/3494 [6.0%] versus 226/3485 [6.5%], respectively; hazard ratio [HR], 0.90; 95% CI, 0.74-1.08), the composite of cardiovascular death/hHF (HR, 0.94; 95% CI, 0.82-1.08), or risk for recurrent hHF events (326 versus 359 events, respectively; rate ratio, 0.94; 95% CI, 0.75-1.20). There was no heterogeneity of linagliptin effects on hHF by history of HF at baseline, baseline estimated glomerular filtration rate or urine albumin-creatinine ratio, or prerandomization left ventricular ejection fraction. Conclusions: In a large, international cardiovascular outcome trial in participants with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease, linagliptin did not affect the risk of hHF or other selected HF-related outcomes, including among participants with and without a history of HF, across the spectrum of kidney disease, and independent of previous left ventricular ejection fraction. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01897532. more...
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- 2019
42. Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy
- Author
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Labrador J, Luno E, Vellenga E, Brunet S, Gonzalez-Campose J, Chillon M, Holowiecka A, Esteve J, Bergua J, Gonzalez-Sanmiguel J, Gil C, Tormo M, Salamero O, Manso F, Fernandez I, de laSerna J, Moreno M, Perez-Encinas M, Krsnik I, Ribera J, Cervera J, Calasanz M, Boluda B, Sobas M, Lowenberg B, Sanz M, Montesinos P, Palmer L, Ciarlo S, Bezares F, Rojas F, Longoni H, Gelemur M, Fazio P, Canepa C, Saba S, Balladares G, Negri P, Giunta M, Milone J, Prates M, Lafalse D, Sossa C, Jaramillo F, Mayer J, Protivankova M, Scwarz J, Holowiecka-Goral A, Jakubas B, Skret-Norwicz A, Bizgalska-Skrzypek P, Pluta A, Becht R, Kielbinski M, Watek M, Paluszewska M, Gadomska A, Rzenno E, Piszcz J, Ejduk A, Dobrzanska J, Calbecka M, Kostyra A, Malek M, Grosicki S, Knopinska W, Beltran de Heredia J, Hernandez J, Arias J, Ramos F, Roman A, de la Serna J, Negri S, Rayon C, Fernandez-Calvo F, Diaz-Mediavilla J, Olave M, Amutio E, Pedro C, Gorosquieta A, Viguria M, Zudaire M, Molero T, Sayas M, Guardia R, Rivas C, Esquembre C, Garcia R, Alcala A, Lopez J, Rubio V, Amigo M, Linares M, Gonzalez San Miguel J, Deben G, Escoda L, de la Camara R, Molines A, Loureiro C, Allegue M, Amador L, Marti J, Madero L, Lassaletta A, Cabezudo M, Garcia-Larana J, Rojas R, Ortega F, Penarrubia M, Puente F, Lopez-Ibor B, Ibanez J, Sanchez P, Novo A, Font L, Guinea J, Montero A, Gonzalez M, Martin G, Martinez J, Verdeguer A, Garcia P, Conde E, Garcia J, Capote F, Bueno J, Bastida P, Rubio A, Fuster J, Gonzalez J, Perez I, Molina J, Mateos M, Ardaiz M, Rodriguez-calvillo M, Poderos C, Arnan M, Duarte R, Diaz-Morfa M, Martin-Chacon E, Calvo-Villas J, Garcia-Belmonte D, Hernandez-Maraver D, Ossenkoppele G, van der Lelie J, Sonneveld P, Zijlmans M, Maertens J, de Valk B, Wijermans P, de Groot M, Schouten H, Biesma D, Kooy M, de Lisa E, PETHEMA Grp, HOVON Grp, PALG Grp, and GATLA Grp more...
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relapse ,complex karyotype ,Acute promyelocytic leukemia ,ATRA ,chemotherapy ,prognostic - Abstract
Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of >= 2 ACA, and a very CK (CK+) as >= 3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with more...
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- 2019
43. Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy
- Author
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Labrador, J, Luno, E, Vellenga, E, Brunet, S, Gonzalez-Campose, J, Chillon, MC, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, JD, Gil, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de laSerna, J, Moreno, MJ, Perez-Encinas, M, Krsnik, I, Ribera, JM, Cervera, J, Calasanz, MJ, Boluda, B, Sobas, M, Lowenberg, B, Sanz, MA, Montesinos, P, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Prates, MV, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, Scwarz, J, Holowiecka-Goral, A, Jakubas, B, Skret-Norwicz, A, Bizgalska-Skrzypek, P, Pluta, A, Becht, R, Kielbinski, M, Watek, M, Paluszewska, M, Gadomska, A, Rzenno, E, Piszcz, J, Ejduk, A, Dobrzanska, J, Calbecka, M, Kostyra, A, Malek, M, Grosicki, S, Knopinska, W, de Heredia, JMB, Hernandez, JM, Arias, J, Ramos, F, Roman, A, de la Serna, J, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Rivas, C, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Amigo, ML, Linares, M, San Miguel, JDG, Deben, G, Escoda, L, de la Camara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Bergua, JM, Ibanez, J, Sanchez, P, Novo, A, Font, LL, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Gonzalez, J, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Hernandez, JA, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, GJ, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, PW, de Groot, MR, Schouten, HC, Biesma, DH, Kooy, MV, and de Lisa, E more...
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relapse ,complex karyotype ,Acute promyelocytic leukemia ,ATRA ,chemotherapy ,prognostic - Abstract
Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of >= 2 ACA, and a very CK (CK+) as >= 3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with more...
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- 2019
44. An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens
- Author
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Sobas, M, Montesinos, P, Boluda, B, Bernal, T, Vellenga, E, Nomdedeu, J, Gonzalez-Campos, J, Chillon, M, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, JD, Gil-Cortes, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de la Serna, J, Moreno, MJ, Perez-Encinas, M, Krsnik, I, Ribera, JM, Escoda, L, Lowenberg, B, Sanz, MA, de Heredia, JMB, Hernandez, JM, Arias, J, Ramos, F, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Gil, C, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Amigo, ML, Linares, M, San Miguel, JDG, Coruna, A, Deben, G, de la Camara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Brunet, S, Ibanez, J, Sanchez, P, Novo, A, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Gonzalez, J, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, GJ, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, PW, de Groot, MR, Schouten, HC, Biesma, DH, van Marwijk, M, de Lisa, E, Golos, A, Ejduk, A, Armatys, A, Zarzycka, E, Knopinska, W, Miskiewicz, W, Jastrzab, B, Pluta, A, Paluszewska, M, Podhorecka, M, Gromek, T, Jakubas, B, Majcherek, M, Skret, A, Watek, M, Charlinski, G, Calbecka, M, Becht, R, Gadomska, A, Rzenno, E, Piszcz, J, Grosicki, S, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, and Scwarz, J more...
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relapse ,Acute promyelocytic leukemia ,CD56 ,ATRA ,chemotherapy ,prognostic - Abstract
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = .007). In the multivariate analysis, CD56 + (p < .0001), higher relapse-risk score (p = .001), and male gender (p = .05) retained the independent predictive value. CD56+ APL also showed a greater risk of CNS relapse (6% versus 1%, p < .001) and lower 5-year OS (75% versus 83%, p = .003). The AIDA-based LPA2012 trial, with an intensified consolidation schedule for CD56+ APL, will elucidate whether an intensified consolidation schedule could mitigate the relapse rate in this setting. more...
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- 2019
45. Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy
- Author
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Labrador, J, Luno, E, Vellenga, E, Brunet, S, Gonzalez-Campose, J, Chillon, MC, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, JD, Gil, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de laSerna, J, Moreno, MJ, Perez-Encinas, M, Krsnik, I, Ribera, JM, Cervera, J, Calasanz, MJ, Boluda, B, Sobas, M, Lowenberg, B, Sanz, MA, Montesinos, P, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Prates, MV, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, Scwarz, J, Jakubas, B, Skret-Norwicz, A, Bizgalska-Skrzypek, P, Pluta, A, Becht, R, Kielbinski, M, Watek, M, Paluszewska, M, Gadomska, A, Rzenno, E, Piszcz, J, Ejduk, A, Dobrzanska, J, Calbecka, M, Kostyra, A, Malek, M, Grosicki, S, Knopinska, W, de Heredia, JMB, Hernandez, JM, Arias, J, Ramos, F, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Rivas, C, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Amigo, ML, Linares, M, San Miguel, JDG, Deben, G, Escoda, L, de la Camara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Ibanez, J, Sanchez, P, Novo, A, Font, LL, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Hernandez, JA, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, GJ, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, PW, de Groot, MR, Schouten, HC, Biesma, DH, Kooy, MV, and de Lisa, E more...
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relapse ,complex karyotype ,Acute promyelocytic leukemia ,ATRA ,chemotherapy ,prognostic - Abstract
Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of >= 2 ACA, and a very CK (CK+) as >= 3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with more...
- Published
- 2019
46. Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry
- Author
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Salamero, O, Martinez-Cuadron, D, Sobas, M, Benavente, C, Vives, S, De la Serna, J, Perez-Encinas, M, Escoda, L, Gil, C, Brunet, S, Ramos, F, Esteve, J, Amigo, M, Krsnik, I, Manso, F, Arias, J, Gonzalez-Campos, J, Serrano, J, Oleksiuk, J, Barrios, M, Garcia-Boyero, R, Novo, A, Sanz, MA, Montesinos, P, Helbig, G, Holowiecka, A, Armatys, A, Hawrylecka, D, Golos, A, Ejduk, A, Majcherek, M, Skret, A, Czyzewska, J, Grosicki, S, Zarzycka, E, Watek, M, Piatkowska-Jakubas, B, Holojda, J, Pluta, A, Podhorecka, M, Gromek, T, Guzicka, E, Charlinski, G, Paluszewska, M, de Heredia, JMB, Hernandez, JM, Roman, A, de la Serna, J, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Tormo, M, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Rivas, C, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Amigo, ML, Linares, M, Ribera, JM, San Miguel, JDG, Deben, G, de la Camara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Bergua, JM, Ibanez, J, Sanchez, P, Font, LL, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Gonzalez, J, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Hernandez, JA, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, and Miskiewicz, W more...
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induction mortality in APL ,APL real life outcomes ,Elderly APL ,APL prognostic factors - Abstract
Acute promyelocytic leukemia is infrequent among patients aged >= 75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were >= 75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population. more...
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- 2019
47. Deepwater species. Handbook of fish age estimation protocols and validation methods
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Albert, O.T., Stransky, C. (Christoph), Landa, J. (Jorge), and Duarte, R.
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Centro Oceanográfico de Santander ,Pesquerías - Abstract
Assessment of individual age through the use of calcified structures (scales, otoliths, opercular bones, fin rays, etc.) has been proven to be very useful in assessing the status of any fish stock. According to Panfili et al. (2002), data on age and growth of fish are essential for understanding vital traits of species and populations (e.g. lifespan, age at recruitment, age at sexual maturity, reproduction periods, migrations, mortality) and the study of population demographic structure and its dynamics (e.g. age-based stock assessment). The age profile of a fish stock can be indicative of its general “health”, as one will expect to see evidence of a broad range of ages in a healthy population. A lack of young fish may indicate recruitment failure, which will have repercussions in future years, while a lack of older fish can signal overexploitation of the stock. Fisheries scientists are especially concerned with the dynamics of exploited populations, with the view to providing advice about the sustainable harvesting of the resource. In the ICES Area, this task is generally focused on providing a quantitative assessment and forecast on a stock, with age data at its core. Hilborn and Walters (1992) pointed out that the “aim of such studies is not only to assess the state of stocks and fisheries relative to historical states, biological reference points or management targets, but also to evaluate the consequences for both fish stocks and fishermen, of alternative management scenarios.” Therefore, it is clear that reliable age–length data are important for the management and sustainable exploitation of fish stocks. The need for reliable data is especially acute in times when stock levels are low and errors in predictions can have devastating effects on the resources, Sí more...
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- 2019
48. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk The CARMELINA Randomized Clinical Trial
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Rosenstock J, Perkovic V, Johansen O, Cooper M, Kahn S, Marx N, Alexander J, Pencina M, Toto R, Wanner C, Zinman B, Woerle H, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George J, von Eynatten M, McGuire D, Aizenberg D, Fiorella A, Edgardo N, Belen C, Alonso P, Walter M, Maia K, Guillermo S, Leandro B, Constanza R, Alejandra N, Melina C, Ariel I, Rodrigo C, Alvarez C, Jorge M, Gabriel C, German S, Bartolacci I, Bolobanich G, Tale T, Meritano M, Echeverria M, Gerrini S, Alvarez M, Torrijos N, Berli M, Coggiola J, Castaneda G, Rode R, Milessi R, Roude A, Bono J, Caresani J, Arias V, Westberg J, Allende G, Liberman A, Bordonava A, Almagro S, Gerbaudo C, Schiavi L, Budassi N, Cecilia M, Buncuga M, Carlos S, Osvaldo T, Mercedes S, Calella P, Agustina V, Aljandro M, Alberto D, Fiorella M, Cantero M, Cariganano M, Anadon P, Cartasegna L, Gabriela M, Fernanda A, Alberto R, Chacon C, Jazmin F, Colombo H, Coni E, Mattausch S, Thomsenhall K, della Torre M, Morandini M, Berra F, Margarita H, 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Semenyuk I, Fishchuk O, Mostovoy Y, Tkachenko T, Ovcharuk M, Rasputina L, Vakaliuk I, Tymochko N, Drapchak I, Petrovska L, Lai W, Yen H, Voon W, Lin T, Cheng K, Chiu C, Chu C, Hsu P, Chiang C, Li Y, Kuo C, Lin S, Chao T, Yu W, Sung S, Wang K, Lu T, Shih K, Wu C, Chiang F, Hwang J, Tsai C, Juang J, Jeng J, Tang S, Lai C, Cheng C, Hsieh I, Hsieh M, Chen C, Lee C, Pai P, Ko P, Wang T, Chen T, Wu H, Chang S, Chen K, Hsieh L, Chou C, Jiang J, Lee M, Huang J, Chen J, Chiu K, Tsai L, Chen P, Saxena M, Collier D, Vaidya B, Harman S, Ramell M, Davies M, Chatterjee S, Meakin L, Quinn M, Bain S, Mallipedhi A, Min T, Bashir J, Blagden M, Ali J, McCrimmon R, Brennan G, Malcolm E, McDonald D, Pearson E, Illsley G, Darzy K, Winocour P, Hanif W, Cockwell P, Charlton M, Thekkepat S, Howat I, Devers M, Patrick J, Wyatt N, Smith C, Singh B, Nicholas J, Gillani S, Green F, Bell E, Boyle J, MacKin S, Livingstone R, Arif A, Syed M, Hammoud J, Sparks J, Anderson M, Tumey R, Condit J, Reddy M, Abalos-Galito M, Rebecca J, Barker T, Seaton B, Campbell E, Kompanik H, Jayson L, Huffman C, Bialow M, McDonnell G, McCaffrey J, Manis C, DeLuca E, Levins J, Bartlett M, Anorga K, Franco M, Gentry P, Hodge D, Pohil R, Rschultz, Leggett R, Blair L, Gisler J, Niegos F, Osburn M, Parma K, Schendel S, Stines L, Winnie M, Wu P, Canales J, Yu J, Cornett G, Beavins J, Hyde D, Zapinski D, Johnson T, Levinson D, Ahmed A, Kenny B, Kuehl A, Bates C, Jantzi C, Ananthula P, Shafer J, Louthan J, Bays A, Stapleton A, Staton P, Strum D, Taylor P, Smith A, Rapp R, Bao S, Randolph C, MacGillivray B, Schuster R, Harden T, Barnella C, Dunnam T, Whiles R, Bolick C, Brockmyre A, Plucker S, Marshall C, Poteet C, Morin D, Tavel E, Averill N, McFann A, Purcell D, Dixon T, Corey E, Goss J, Drescher R, Irfan M, Naeem M, Egelhof R, Mehta P, Koehler T, Walia J, Fernandez J, Bedel G, Preet R, Bhuchar S, Ahmed F, Onyema D, Benchabbat A, Kohanbash L, Miller P, Lalinde M, Carrithers E, Patterson R, Raube-Miceli A, Martinez A, Harris B, Levy R, Siev E, Berlin H, DiMattia M, Sugimoto D, Dugas J, Benson M, Stegemoller R, Schmoll M, Kinnaman S, O'Connor T, Powel T, Rudolph L, Lewiecki M, Best E, Chavez J, Garcia M, Cohen R, Colman D, Ocampo M, Heaney L, Rappley G, Quezada I, Santos V, Nikfarjam A, Reyes M, Rodriguez R, Josephs L, Hernandez R, Flores P, Espinoza L, Mejia W, Pedraza Z, Castaneda R, Laguerre J, Cook R, Patel R, Werner H, Blank R, Small S, Andersen J, Holmes D, Farmer M, Wiener V, Pharr W, Bray B, Beekman J, Anderson A, Andrawis N, Gabra N, Moche T, Marty S, Galvez O, Reyes R, Garcia R, Lerma G, Pliquin B, Mayfield R, Durham N, Phillips R, Baran A, Kondo N, Dempsey S, Kufs W, Laddis T, Zimmer K, Van Depol M, Dweck L, Kestler M, Werner N, Ashraf M, Quick A, Schallert G, Sligh T, Trueba P, Batista J, Martinez T, Moya J, Amarales V, Santos E, Torres P, Diaz T, Diaz J, Hodish I, Else T, Buras E, Moratis A, Valika S, Rahman A, Malalis W, Box E, Box P, Kerwood B, Nagaeva J, Metz C, Hinnant J, Griswell D, Philbeck A, Dukkipati R, Shaarawy R, Patak R, Kaye W, Steinsapir J, Horowitz B, Denenberg M, Reynolds C, Jenkinsdr M, Adlakha A, Hicklin H, Peelman J, Lerman S, Lamkin S, Smith S, Gould G, Cheung D, Stephen Z, Leigh T, Norwood P, Chelsea F, Trejo R, Neolms K, Bache R, Dinnerstein A, Sachson R, Aronoff S, Mendez A, Brooks S, Jones L, Dorfman S, Schill J, Leuck, Miklius A, Maw K, Hahn J, Gamarra L, Buynak R, Smith M, Ames J, Volom P, Anderson R, Desouza C, Shivaswamy V, Lefebvre G, Schweppe L, Berenguer R, Nelson R, Mas L, Gonzalez N, Palacio J, Bartkowiak A, Dilling J, Jordan T, Geishauser J, Jordan R, Arias E, Griffin C, Fisher M, Bryant C, Schnitz W, Kipgen W, Kasper J, Lopez R, Wright E, Thomas J, Weinstein D, Emerick G, Mendelson R, Aqua K, Lafaille J, Seco G, Garcia G, Cubillas M, de Souza J, Schneider A, Tjaden J, Goswami G, Schubart U, Kishore P, Bravo W, Guerrero J, Bertoli-Avella M, Reyes C, Dominguez M, Ramos S, Columbie A, Ares-Romero P, Hechavarria J, Villaverde M, Doyle N, Sherrod T, Krishnaswamy K, Aamir S, Giddaluri P, Guevara S, Kazmi P, Thomas P, Popeil L, Albright D, Pimentel S, Mould E, Cox M, Alderson T, Conrow J, Sandberg J, Raam S, Suresh B, Lafave J, Lorenz T, Johnston J, Fereidouni S, Mahadevan A, West R, Nelson A, Scott K, Ansari S, Khan B, Rastogi A, Saumell F, Gonzalez G, Torres E, Elias R, Hart T, Lozano J, Gudavilla G, Savin V, Khan A, Wiegmann T, Goel A, Gomes M, Fernandez-Gonzalez M, Gustavo F, Ivan C, Chiong R, Llerena S, Jimenez M, Oram D, George D, Lewis J, Kiefer J, Dollman A, Edje L, Pastor F, Kandath D, Lorch D, Graves A, Powell R, Hooker T, Shah S, Gomez N, Miranda F, Rosales J, Bayona I, Gomez Y, Guedes R, Rodriguez Y, Wahlen J, Jonathan W, Spencer H, Michael W, Kumar U, Govindariju K, Ordonez S, Aguirre H, Sulur P, Agarwal N, Peters L, Kaviani B, Fomenko O, Firek A, Loreen W, Ronald F, Olha F, Parrillo J, Janovitz R, Hutchinson R, Delgado E, Ashley A, Robinson S, Barbel-Johnson K, Timothy L, William C, Al-Karadsheh A, Hooper L, Suarez J, Perez D, Guerrero V, Tung D, Loo C, Sodolak K, Michaelis C, Jackson R, Covington D, Wise J, Tran T, Messina T, Torres D, Falcone J, Barettella M, Patel K, Ribo A, Mattews T, Amendolare D, McGeehan J, Corder C, Black C, Hearne S, Bounds C, Cinderella J, Etherton J, Kiem S, Treuth M, Burke B, Tivikaran V, Howard S, Miller C, Neff H, Giullian J, Mcrae J, Surratt D, Phillips J, Kretchmar J, Valdes M, Cruz J, Navarro E, Zewail A, Tai-Chi-Kwo, Stevens J, Diane S, Kim T, Gregory L, Neal S, William S, Sangrigoli R, Gejer E, Stoller S, Jeffrey D, Colar S, Kenneth W, Farris N, Mooney S, Jamal A, Nitin B, Syed R, Andrew Y, Christopher W, Abid R, Claudio G, Mojtaba M, Amna R, Michael B, Vincent T, Cherlin R, Ashton R, Pudi K, Julian W, Stephen K, Ronald A, Frias J, Kelly S, Hsia S, Clemens P, Cara H, Farley B, Raible L, Oliveros O, Hafeez H, Pecci P, Bagga-Malhotra S, Reza R, Jamal M, Mulgado M, Guevara A, Vela M, Ochoa H, Melliza T, Pena G, Awua-Larbi S, Shafi M, Alausa T, Polster S, Earl J, McNeill R, Farrington C, Carr K, Nabat M, Matthew S, Yvette E, Handelsman Y, Delkhah S, Ismail Y, Janna C, Akhtar A, Neiman A, Blumenthal S, Colleen V, Schmidt D, Ashraf E, Bhargava A, Khoo T, Langel C, Theuma P, Wright D, Fitzgerald K, Hitchcock J, Capasso-Gulve E, Wolff E, Umpierrez G, Priyathama V, Francisco P, Dawn S, Quraishi A, Kahn B, Ferro F, Hertz B, Phelps J, Campbell A, Downing J, Pangtay D, Pangatay S, Villagran-Solis K, Haseeb M, Rettig K, Kwan R, Cox R, Slimak V, So A, Schmedtje J, Chang A, Douglas Z, McGarity W, Jestel J, Kanade P, Julie J, Asher R, Canaan Y, Perez A, Alonso I, Cutchin R, Koser A, Adeola Y, Brito S, Stocks J, Frandsen B, Weigelt M, Stehouwer E, Ince C, Stephen P, Shadi B, Jeffrey C, Thethi T, Carpio G, McDuffie R, Moreau C, Stell C, Katalenich B, McKendall-Lewis C, Htun W, Conroy K, Lovre D, Galagan R, Olmeda C, Sihota A, Barton A, Beasley R, Nankivel P, Aberle M, Machin I, Porras J, Rodriguez D, Albornoz A, Haidar A, Lopez-Santini R, Rivero G, Robins G, Colyar L, Hutchins C, Sturm D, Hart K, Phillips T, Montgomery C, Albrecht W, Fehlis K, Overman D, Box M, Villarreal-Martinez D, David-Svatek D, Ajani D, Shaikh Z, Wheeler K, Brown M, Ghosh C, Bandukwala I, Kleber S, Madden J, Bishara M, Perry K, Paoli-Bruno J, Abreu E, Espiritu R, Zmeili O, Christensen T, Grubb S, Beloff S, Caugh A, van Dijk C, Yalavarthy R, DeGraauw J, Fabian S, Gillum D, Corrigan G, Singh H, Jensen K, DeMore S, Montague T, Zieve F, Levy J, Fredrickson S, Tarkington P, Chapla P, Salacata A, Walls U, Iyer R, Nguyen K, Lettman J, Appleman B, Safavie F, Scaliem L, Eder F, Maklad S, Schlaen B, Molstead J, Hartwell J, Hubish D, Little R, Rando K, Kelly R, Drury M, Young P, Wininger S, Harman A, Daza R, Robbin S, Sanchez M, Rivera I, Garcia-Estrada M, Iglesias N, Dobs A, Andrade A, Falkowski S, Parrott T, Koon A, Wood T, Burkett E, Chavous K, Gupta A, Estes C, Loud D, Rhodes S, Chen M, Bromley L, Palma R, Kattan D, Kirk U, Tatu H, Stamatin R, Lupea S, Frasie M, Colfer H, Kane L, Teklinski A, Gadowski G, Levanovich P, Saba F, Confident L, Hossain S, Steinberg B, Philippe B, Choroenthkongtrakal S, Boccalano F, Anand R, Syam V, Manohar A, Suresh P, Madhusudhan P, Patel P, Cambier P, Klonaris J, Cheng W, Fisher S, Schelle M, Reese L, McLean S, Poock J, Hoens J, Rosie A, Welshons R, Dean J, Kuhlman P, Luke R, Lohrbauer L, Cunningham M, Buday P, Lehmann M, Chrzanowski K, Fletcher A, Hargrove J, Harris F, Debs-Perez G, Maiquez A, Cordoves L, Georgescu M, Tayoun H, Munoz F, Ortiz D, Munoz G, Hamzeh I, Misra A, Zhang L, Forgosh L, Loria K, Roncari C, Hommerding J, Morris G, Lebron C, Blake K, LaVenture K, Lange C, Levinson L, Baungarten T, Edevante S, Shawley S, Moyer H, Elliott K, Iachini K, Rajan R, Davis C, Shattuck A, Simon W, Lakin G, Secrist N, Buth D, Steere D, Talbot K, Singh N, Mascolo R, Sloan S, Kmetzo J, Brown J, Carter L, Lawrence M, Arauz-Pacheco C, Lender D, Kozlow W, Cavanaugh L, Wilson J, Gujja P, Akhter F, Khan M, Mohammed A, Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators more...
- Abstract
IMPORTANCE Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease. OBJECTIVE To evaluate the effect of linagliptin, a selective DPP-4 inhibitor, on CV outcomes and kidney outcomes in patients with type 2 diabetes at high risk of CV and kidney events. DESIGN, SETTING, AND PARTICIPANTS Randomized, placebo-controlled, multicenter noninferiority trial conducted from August 2013 to August 2016 at 605 clinic sites in 27 countries among adults with type 2 diabetes, hemoglobin A(1c) of 6.5% to 10.0%, high CV risk (history of vascular disease and urine-albumin creatinine ratio [UACR] > 200mg/g), and high renal risk (reduced eGFR and micro-or macroalbuminuria). Participants with end-stage renal disease (ESRD) were excluded. Final follow-up occurred on January 18, 2018. INTERVENTIONS Patients were randomized to receive linagliptin, 5 mg once daily (n = 3494), or placebo once daily (n = 3485) added to usual care. Other glucose-lowering medications or insulin could be added based on clinical need and local clinical guidelines. MAIN OUTCOMES AND MEASURES Primary outcomewas time to first occurrence of the composite of CV death, nonfatalmyocardial infarction, or nonfatal stroke. Criteria for noninferiority of linagliptin vs placebo was defined by the upper limit of the 2-sided 95% CI for the hazard ratio (HR) of linagliptin relative to placebo being less than 1.3. Secondary outcome was time to first occurrence of adjudicated death due to renal failure, ESRD, or sustained 40% or higher decrease in eGFR from baseline. RESULTS Of 6991 enrollees, 6979 (mean age, 65.9 years; eGFR, 54.6 mL/min/1.73m2; 80.1% with UACR > 30mg/g) received at least 1 dose of study medication and 98.7% completed the study. During a median follow-up of 2.2 years, the primary outcome occurred in 434 of 3494 (12.4%) and 420 of 3485 (12.1%) in the linagliptin and placebo groups, respectively, (absolute incidence rate difference, 0.13 [95% CI,-0.63 to 0.90] per 100 person-years) (HR, 1.02; 95% CI, 0.89-1.17; P more...
- Published
- 2019
49. The polygenic nature of telomere length and the anti-ageing properties of lithium
- Author
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Coutts, F., Palmos, A. B., Duarte, R. R. R., de Jong, S., Lewis, C. M., Dima, D., and Powell, T. R.
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QH426 ,RC - Abstract
Telomere length is a promising biomarker for age-related disease and a potential anti-ageing drug target. Here, we study the genetic architecture of telomere length and the repositioning potential of lithium as an anti-ageing medication. LD score regression applied to the largest telomere length genome-wide association study to-date, revealed SNP-chip heritability estimates of 7.29%, with polygenic risk scoring capturing 4.4% of the variance in telomere length in an independent cohort (p = 6.17 × 10-5). Gene-enrichment analysis identified 13 genes associated with telomere length, with the most significant being the leucine rich repeat gene, LRRC34 (p = 3.69 × 10-18). In the context of lithium, we confirm that chronic use in a sample of 384 bipolar disorder patients is associated with longer telomeres (p = 0.03). As complementary evidence, we studied three orthologs of telomere length regulators in a Caenorhabditis elegans model of lithium-induced extended longevity and found all transcripts to be affected post-treatment (p 0.05). Consequently, this suggests that lithium may be catalysing the activity of endogenous mechanisms that promote telomere lengthening, whereby its efficacy eventually becomes limited by each individual's inherent telomere maintenance capabilities. Our work indicates a potential use of polygenic risk scoring for the prediction of adult telomere length and consequently lithium's anti-ageing efficacy. more...
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- 2018
50. Transcatheter aortic valve implantation for aortic stenosis in high surgical risk patients: A systematic review and meta-analysis
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Liu, Z, Kidney, E, Bem, D, Bramley, G, Bayliss, S, de Belder, MA, Cummins, C, and Duarte, R
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Male ,Drug Research and Development ,Systematic Reviews ,Cardiovascular Procedures ,MEDLINE ,Cardiology ,lcsh:Medicine ,Surgical and Invasive Medical Procedures ,Vascular Surgery ,Research and Analysis Methods ,Pathology and Laboratory Medicine ,Transcatheter Aortic Valve Replacement ,Signs and Symptoms ,Mathematical and Statistical Techniques ,Risk Factors ,Diagnostic Medicine ,Medicine and Health Sciences ,Humans ,Clinical Trials ,Statistical Methods ,lcsh:Science ,Aged, 80 and over ,Stenosis ,Pharmacology ,lcsh:R ,Aortic Valve Stenosis ,Research Assessment ,Randomized Controlled Trials ,Physical Sciences ,Female ,lcsh:Q ,Clinical Medicine ,Mathematics ,Statistics (Mathematics) ,Research Article ,Meta-Analysis - Abstract
Background Symptomatic aortic stenosis has a poor prognosis. Many patients are considered inoperable or at high surgical risk for surgical aortic valve replacement (SAVR), reflecting their age, comorbidities and frailty. The clinical effectiveness and safety of TAVI have not been reviewed systematically for these high levels of surgical risk. This systematic review compares mortality and other important clinical outcomes up to 5 years post treatment following TAVI or other treatment in these risk groups. Methods A systematic review protocol was registered on the PROSPERO database (CRD42016048396). The Cochrane Library, Centre for Reviews and Dissemination Databases, MEDLINE, EMBASE, and ZETOC were searched from January 2002 to August 2016. Clinical trials or matched studies comparing TAVI with other treatments for AS in patients surgically inoperable or operable at a high risk were included. Data extraction and quality assessment were conducted by two reviewers. Data were pooled using random-effects meta-analysis. The main outcomes were all-cause mortality, efficacy and major complications. Results Three good quality randomised controlled trials (RCTs) were included. Patients’ mean age ranged from 83- 85 years, around half were female and New York Heart Association (NYHA) functional class III or IV ranged from 83.8% to 94.2% with frequent comorbidities. In 358 surgically inoperable patients from one RCT, TAVI was superior to medical therapy for all-cause mortality at 1 year (hazard ratio (HR) 0.58, 95% confidence interval (CI) 0.36−0.92), 2 years (HR 0.50, 95% CI 0.39−0.65), 3 years (HR 0.53, 95% CI 0.41to 0.68) and 5 years (HR 0.50, 95% CI 0.39−0.65), and NYHA class III or IV at 2 years (TAVI 16.8% (16/95), medical therapy 57.5% (23/40), p In a meta-analysis including 1,494 high risk surgically operable patients from two non-inferiority RCTs TAVI showed no significant differences from SAVR in all-cause mortality at two years (HR 1.03, 95% CI 0.82−1.29) and up to 5 years (HR 0.83, 95% CI 0.83−1.12). There were no statistically significant differences in major vascular complications and myocardial infarction at any time point, discrepant results for major bleeding on variable definitions and no differences in stroke rate at any time point. Using the GRADE tool, this evidence was considered of low quality. Conclusions Symptomatic aortic stenosis can be lethal without intervention but surgical resection is contraindicated for some patients and high risk for others. We found that all-cause mortality up to 5 years of follow-up did not differ significantly between TAVI and SAVR in patients surgically operable at a high risk, but favoured TAVI over medical therapy in patients surgically inoperable. TAVI is a viable life-extending treatment option in these surgical high risk groups. more...
- Published
- 2018
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