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The crystalline texture of arrays of low diameter Co nanowires (NWs) synthesized by electrodeposition using electrolytes with different acidities (pH in the range 2.0–6.6) was studied by the switching field distribution (SFD) and first order reversal curve (FORC) diagrams. Particularly, the SFD determined as the derivative d M / d H of the descending part of the major hysteresis loop has proven to be a reliable and powerful method for the identification of different crystalline textures in the NWs and the quantification of their corresponding texture percentages. The presence of the face centered cubic-like texture at low pH values and hexagonal close packed textures with the c-axis perpendicular and parallel to the NWs axis at higher pH values have been identified by performing multiple Gaussian fits to the SFD by virtue of their different magnetic behavior observed during reversal of the magnetization. The field position and size of each curve in the multiple Gaussian fit provide information about the corresponding magnetic contribution and volumetric texture percentage of each crystalline texture in the NWs, respectively. The analysis of the SFD has been complemented and validated with FORC diagram measurements, showing that the width of the coercive field distribution is in good agreement with the width of the SFD. Also, it has been found that the different branches observed in the FORC diagrams along the interaction axis provide further insight on the interaction between magnetocrystalline fields. This work provides a novel methodology for the use of magnetometry as a reliable technique for the study of the interplay between the microstructure and magnetic behavior of arrays of NWs.

The physiological and anatomical clinical characteristics of pregnant women make them susceptible to complications caused by coronavirus disease (COVID-19). Increased coagulation and risk of thromboembolic phenomena are common during pregnancy; they are further enhanced when associated with a thrombogenic pathology such as in COVID-19. The treatment of COVID-19 is controversial and limited, even for non-pregnant patients. During pregnancy, the options are even more restricted due to the teratogenicity of some drugs and anatomical and physiological difficulties, especially in advanced pregnancy in patients with respiratory failure. Therefore, the focus of treatment for pregnant patients should be centered on isolation, monitoring fetal and maternal vital signs, uterine activity, and general maternal-fetal well-being. The prescription of drugs and management orientation should be based on gestational age and maternal clinical conditions. The optimal type of delivery is guided by obstetric indications and COVID-19 disease severity. Breastfeeding should be encouraged with the use of masks and hand hygiene. The treatment of pregnant women with COVID-19 brings important peculiarities that should be considered in order to make better decisions for preserving the health of the mother and fetus.

Introdução: O estágio não obrigatório vem se mostrando cada vez mais importante para a formação do acadêmico de medicina e a consolidação do seu conhecimento, bem como oportunidade de experiências valiosas para o aprendizado prático. Assim, vivências proporcionadas por estágios voluntários contribuem para a formação de habilidades necessárias de um médico generalista, com capacidade de resolutividade, reflexão e integração do conhecimento. Objetivo: Relatar a experiência de um estágio voluntário em ginecologia e obstetrícia e a sua importância para a formação do estudante de medicina como generalista. Relato de experiência: O relato conta com experiências vividas por um discente durante o estágio não obrigatório extracurricular durante o período de outubro de 2020 à novembro 2020 em um hospital localizado em Belém-PA, supervisionado por uma docente especialista na área de ginecologia e obstetrícia. Discussão: O estágio voluntário é um elo entre o mercado de trabalho e a rotina do estudante, como uma forma de apresentação do estudante a sua rotina profissional. Assim, é permitido desfrutar de diversas áreas de aprendizagem, bem como acompanhar a rotina ambulatorial e ainda o bloco cirúrgico, aumentando assim a possibilidade de novas experiências. Conclusão: Nesse sentido, conclui-se que o estágio traz ao acadêmico de medicina grandes possibilidades referentes a aplicabilidade do conteúdo teórico aprendido durante a sua formação nas atividades que são propostas durante esse período, além de permitir uma formação generalista com maior qualidade devido as experiências que são desenvolvidas no estágio.

While relatively new, fetal surgery has become an indispensable part of the field of Obstetrics as it allows potentially life-threatening conditions to be corrected in utero. Imaging modalities such as ultrasound, magnetic resonance imaging, and computer tomography have become staples in fetal imaging, as they allow for comprehensive analysis of the fetal anatomy. Uses of these modalities can range from chromosomal diagnosis to surgical planning. Scientific development has not only allowed for visualization in the three-dimensional plane, but the implementation of virtual reality technology is also now a possibility. It is our belief that integrating virtual reality technology will help overcome hurdles currently faced by fetal surgeons including candidate selection and clearly observing fetal anatomy. Training opportunities are also probably, as surgeons and residents can use models created during these virtual reality experiences to study and prepare for complications that may arise during surgical intervention. This article is protected by copyright. All rights reserved.

Acute Lymphoblastic Leukemia (ALL) is the most frequent cancer in pediatric population. Although the treatment has improved and almost 85% of the children are cured about 20% suffer relapse, therefore finding molecules that participate in the pathogenesis of the disease for the identification of relapse and patients at risk is an urgent unmet need. Class I myosins are molecular motors involved in membrane tension, endocytosis, phagocytosis and cell migration and recently they have been shown important for development and aggressiveness of diverse cancer types, however Myo1g an hematopoietic specific myosin has not been studied in cancer so far. We evaluated the expression of Myo1g by qRT-PCR, Immunocytochemistry and Immunofluorescence in a cohort of 133 ALL patients and correlated the expression at diagnosis and after treatment with clinical features and treatment outcomes. We found high expression levels of Myo1g in Peripheral Blood Mononuclear Cells (PBMCs) from patients with ALL at diagnosis and those levels decreased after complete remission; furthermore, we found an increase in Myo1g expression on patients with 9:22 translocation and those who relapse. This study show that Myo1g is over expressed in ALL and that may participate in the pathogenesis of the disease specially in high-risk patients.

Goal: This research aims to examine the trade-off behaviour between productivity, quality and maintenance performance and evaluate the efficiency of the framework integrated to a time variability in operational management. Design / Methodology / Approach: The proposed framework integrates a stochastic analysis of process and TVM to manage process variability and analyse the trade-off behaviour between quality, productivity, and maintenance efficiency. The framework generates a control chart for each workstation and analyses the operator's time to execute an assembly process for six workstations. The processes are characterised and evaluated via stochastic simulation, resulting in a trade-off analysis with a multicriteria approach. Results: A relational graphic of performance dimensions shows that productivity and maintenance performance have a high dependency on time variability management, whereas quality has a minor impact over trade-off decisions. The proposed framework has a huge significance to operational management which allow to apply complex models to time variability analysis and organisation performance. Limitations of the investigation: The trade-off analysis in this study is limited to a constant trade-off model to validate the framework. Practical implications: This framework, used in association with traditional management philosophies, is a powerful tool that permits managers to develop a trade-off analysis and make decisions on workstations. Thus, a research field that correlates time variability with performance dimensions may be validated by this framework. Originality / Value: A framework that allows the use of MCDM to analyse the trade-off behaviour on organization performance and a trade-off analysis between performance dimensions and time variability management in operational performance.

Rapidly ageing population increases the demand for activities with learning and social stimulation. Museums are well placed to provide such a function. Objective: How and in what form are museums engaging with older populations. The review will focus on three aspects: (1) Identifying the frameworks and tools being used by and in museums with older people. (2) Assess variables used in research and in areas that supports knowledge creation. (3) Identify evidence in relation to the interactions between museums and older audiences. A review of 8 databases and 2 university repositories (English and Portuguese language). The search retrieved 810 potential sources (2002-2020), 39 sources met the inclusion criteria. They focused on the educational aspects of museums and were produced by disciplines like psychology and gerontology, museology, arts and education. Museums play an important role on health (emphasis on psychological and physical wellbeing), socialization (discussing stereotypes, reducing isolation, redefining social roles), socioeconomic aspects (with local focus on services, partnerships) and on creative aging (promoting non-formal education with lifelong learning at different levels). RESUMO O rápido envelhecimento da população aumenta a demanda por atividades com aprendizagem e estimulação social para público com 60 e mais anos. Os museus estão bem posicionados para oferecer tal função. Objetivo: como e de que forma os museus se relacionam com as populações mais velhas. A revisão enfoca os seguintes aspectos: Identificar metodologias usadas por e nos museus para atender pessoas idosas. Variáveis utilizadas por pesquisas e áreas que produzem evidências. Identificar evidências na literatura sobre as relações entre museus e públicos mais velhos. A revisão escopo em 8 bases de dados e 2 repositórios universitários (língua inglesa e portuguesa). A busca identificou 810 fontes potenciais de pesquisa (2002-2020), 39 fontes atenderam aos critérios de inclusão. As publicações se concentraram nos aspectos educacionais dos museus e foram produzidos por disciplinas como psicologia e gerontologia, museologia, artes e educação. Os museus desempenham um papel importante com estudos que impactam a saúde (ênfase no bem-estar psicológico e físico), socialização (discutir estereótipos, reduzir o isolamento, redefinir papéis sociais), aspectos socioeconômicos (com foco local em serviços, parcerias) e no envelhecimento criativo (promover a educação não formal com aprendizagem ao longo da vida em diferentes níveis).

O objetivo deste estudo foi relatar a experiencia de uma equipe multiprofissional no cuidado integral a usuarios diabeticos a partir de acoes de assistencia e gestao em saude no contexto de Saude da Familia. Trata-se de um estudo descritivo, com carater qualitativo, do tipo relato de experiencia, sob a otica de profissionais de saude inseridos no Programa de Residencia Medica e Multiprofissional em Saude da Familia da Fundacao Estatal Saude da Familia - FESF-SUS de Salvador, Bahia, Brasil. Essa experiencia ocorreu em uma Unidade de Saude da Familia, durante marco a agosto de 2021. As experiencias foram estruturadas em: acolhimento e vinculacao com os usuarios, desenvolvimento de atividades voltadas a educacao em saude e educacao permanente, elaboracao de materiais norteadores sobre o diabetes, realizacao de visitas domiciliares, atendimentos individualizados e compartilhados, acoes de telessaude/telemonitoramento, articulacoes com setores especializados da rede de saude municipal, bem como praticas corporais e integrativas e complementares. Apos as intervencoes da equipe multiprofissional os usuarios diabeticos melhoraram o perfil glicemico, ganharam mais autonomia, se vincularam aos profissionais, tiveram reducao de complicacoes fisicas e psicologicas em decorrencia da doenca, melhoraram seus habitos de vida e de saude bucal. Reconhece-se desta forma que as acoes de uma equipe multiprofissional, integrando diferentes saberes, pode auxiliar no cuidado integral ao portador de diabetes mellitus na Estrategia Saude da Familia (ESF), a medida em que consegue proporcionar tratamento especifico para essa doenca metabolica, contribuir para a promocao da saude, prevenir incidencia de agravos/doencas e promover melhorias das condicoes de vida.

First-order reversal curve diagrams, or FORC diagrams, have been studied to determine if the widths of their distributions along the interaction and coercivity axes can be related to the mean-field magnetization dependent interaction field (MDIF). Arrays of nanowires with diameters ranging from 18 up to 100 nm and packing fractions varying from 0.4 to 12% have been analyzed. The mean-field MDIF has been measured using the remanence curves and used as a measuring scale on the FORC diagrams. Based on these measurements, the full width of the interaction field distribution and the full width at half maximum (FWHM) of the FORC distribution profile along the interaction field direction are shown to be proportional to the MDIF, and the relation between them is found. Moreover, by interpreting the full width of the coercive field distribution in terms of the dipolar induced shearing, a simple relation is found between the width of this distribution and the MDIF. Furthermore, we show that the width of the FORC distribution along the coercive field axis is equal to the width of the switching field distribution obtained by the derivation of the DC remanence curve. This was further verified with the switching field distribution determined using in-field magnetic force microscopy (MFM) for very low density nanowires. The results are further supported by the good agreement found between the experiments and the values calculated using the mean-field model, which provides analytical expressions for both FORC distributions.

We experimentally investigate the nonlocal phase modulation of spatially separate continuous-variable twin beams via a four-wave mixing process. Two separated phase modulators interfere nonlocally to modify the beam correlations, resulting in the various covariance matrices.

Foundation: Cardiovascular diseases represent the leading cause of death in the world; specifically, sudden cardiovascular death causes 50% of all deaths from this cause.Objective: to describe the correlation between sociodemographic variables and risk factors in sudden cardiovascular death.Methods: a descriptive, correlational and cross-sectional study was carried out in the Havana municipality of Arroyo Naranjo, between 2007 and 2014. All cases of sudden cardiovascular death were included, treated at the Julio Trigo López Teaching Clinical-Surgical Hospital (N =605). Sociodemographic variables and risk factors were analyzed. The Chi-square statistical test and the Haberman Corrected Waste model were used.Results: in men, especially in black and mestizo skin, the most frequent risk factors were smoking, alcohol consumption and high blood pressure. Women were characterized by more physical inactivity, and were more affected by diabetes, dyslipidemias and elevated hematocrit values. Most of the deceased did not exceed secondary education, technical level or skilled worker.Conclusion: Sudden cardiovascular death, in the municipality of Arroyo Naranjo, Havana, essentially affects people over 50, a period of life in which risk factors such as hypertension, smoking and physical inactivity impact greater on mortality.

The open-source modeling framework MAgPIE (Model of Agricultural Production and its Impact on the Environment) combines economic and biophysical approaches to simulate spatially explicit global scenarios of land use within the 21st century and the respective interactions with the environment. Besides various other projects, it was used to simulate marker scenarios of the Shared Socioeconomic Pathways (SSPs) and contributed substantially to multiple IPCC assessments. However, with growing scope and detail, the non-linear model has become increasingly complex, computationally intensive and non-transparent, requiring structured approaches to improve the development and evaluation of the model.Here, we provide an overview on version 4 of MAgPIE and how it addresses these issues of increasing complexity using new technical features: modular structure with exchangeable module implementations, flexible spatial resolution, in-code documentation, automatized code checking, model/output evaluation and open accessibility. Application examples provide insights into model evaluation, modular flexibility and region-specific analysis approaches. While this paper is focused on the general framework as such, the publication is accompanied by a detailed model documentation describing contents and equations, and by model evaluation documents giving insights into model performance for a broad range of variables.With the open-source release of the MAgPIE 4 framework, we hope to contribute to more transparent, reproducible and collaborative research in the field. Due to its modularity and spatial flexibility, it should provide a basis for a broad range of land-related research with economic or biophysical, global or regional focus.

The potential use of magnetic nanoparticles (MNPs) in biomedicine as magnetic resonance, drug delivery, imagenology, hyperthermia, biosensors, and biological separation has been studied in different laboratories. One of the challenges on MNP elaboration for biological applications is the size, biocompatibility, heat efficiency, stabilization in physiological conditions, and surface coating. Magnetoliposome (ML), a lipid bilayer of phospholipids encapsulating MNPs, is a system used to reduce toxicity. Encapsulated MNPs can be used as a potential drug and a gene delivery system, and in the presence of magnetic fields, MLs can be accumulated in a target tissue by a strong gradient magnetic field. Here, we present a study of the effects of DC magnetic fields on encapsulated MNPs inside liposomes. Despite their widespread applications in biotechnology and environmental, biomedical, and materials science, the effects of magnetic fields on MLs are unclear. We use a modified coprecipitation method to synthesize superparamagnetic nanoparticles (SNPs) in aqueous solutions. The SNPs are encapsulated inside phospholipid liposomes to study the interaction between phospholipids and SNPs. Material characterization of SNPs reveals round-shaped nanoparticles with an average size of 12 nm, mainly magnetite. MLs were prepared by the rehydration method. After formation, we found two types of MLs: one type is tense with SNPs encapsulated and the other is a floppy vesicle that does not show the presence of SNPs. To study the response of MLs to an applied DC magnetic field, we used a homemade chamber. Digitalized images show encapsulated SNPs assembled in chain formation when a DC magnetic field is applied. When the magnetic field is switched off, it completely disperses SNPs. Floppy MLs deform along the direction of the external applied magnetic field. Solving the relevant magnetostatic equations, we present a theoretical model to explain the ML deformations by analyzing the forces exerted by the magnetic field over the surface of the spheroidal liposome. Tangential magnetic forces acting on the ML surface result in a press force deforming MLs. The type of deformations will depend on the magnetic properties of the mediums inside and outside the MLs. The model predicts a coexistence region of oblate–prolate deformation in the zone where χ = 1. We can understand the chain formation in terms of a dipole–dipole interaction of SNP.

Highly sensitive thermometric methods are essential to the evaluation of nanoplatforms for thermal applications. In this study, the dual-beam thermal lens technique was introduced to assess the optically induced temperature changes in colloidal samples of gold nanoparticles. Dual-beam measurements were performed on a 0.05 mg/mL gold nanospheres (50 nm diameter) aqueous solution and the localized nanoparticle temperature were determined. The system was able to detect temperature variations as low as 10-2 °C, with 0.2 °C-1 sensitivity in the assessment of metallic nanoparticle colloids. Furthermore, thermal lens measurements also allowed the acquisition of the nanoparticle absorption cross-section value, regardless of its scattering properties.

This paper's primary motivation is developing non-invasive glucose monitoring methods and devices by detecting hydrogen peroxide in fluids like tears, sweat, or saliva since it is a subproduct molecule of various biochemical processes directly correlated with glucose concentration. The availability of those mentioned tools could facilitate the rapid development of reliable and cheap sensors without the complications of using invasive methods, especially when blood samples are repeatedly required. Therefore, this work aims to lay the foundations for developing non-invasive and highly sensitive glucose detection methods as the ultimate proposal. Consequently, contributing to track and control the high glucose levels that cause significant health and economic problems in our society. Thus, this paper presents an approach for enhancing the hydrogen peroxide sensitivity in sensors nanostructured with nanowires. In contrast to most of the standard design methodologies, this scheme does not rely on phenomenological models but experimental data and statistical modeling. Firstly, for a sensor with a given design, the data obtained with cyclic voltammetry allows finding the potential at which the sensor's response is the highest for hydrogen peroxide's concentrations ranging from 0 to 20 millimoles. Secondly, after calculating the optimal potential, a linear regression correctly relates current density with the concentration, representing the sensor's sensitivity as such a linear model's slope. Finally, using planar (non- nanostructured) sensors as a benchmark, a statistical test allows concluding that the sensitivity is significantly higher for nanostructured sensors using gold and nickel self-supported nanowires arrays than planar.

Ninety-nine uncastrated males were randomly distributed into four grazing groups to examine variation in growth and carcass traits, due to the implant regime [Implantation of 72 miligrams (mg) of Ralgro® at day (d) 0 followed by its reimplantation at d 90 versus implantation of Revalor® at d 0 followed by 72 mg of Ralgro® at d 90)], and suplementation type [mineral supplementation (MS) versus strategic supplementation (SS)]. With a 2 x 2 factorial arrangement, the analysis of variance included the treatments and their interaction (implant regimen x supplementation) as fixed effects, and the breed type as a random eff ect. The interaction was not signifi cant; neither did the implant regimen on any growth trait (P > 0.05). Compared to MS, the SS group had a greater daily weight gain (779 vs. 541 grams; P < 0.001), required a shorter (38.3 d lesser) time of fattening to reach the end point (198.3 versus 236.6 d; P < 0.001) with a heavier liveweight (498.2 vs. 474. 4 kilograms; P = 0.02) at an earlier age (29.4 vs. 30. 8 months; P < 0.001), with a higher carcass dressing percentage (59.13 vs 57.62 %; P = 0.03) and younger carcass bone maturity (P < 0.001). With the exception of thoracic depth, carcass traits did not vary with the implant regimen (P > 0.05). The use of aggressive implant regimens to improve growth or carcass characteristics of grazing bulls is not justifi ed. SS is a feasible practice to improve fattening performance of grazing bulls but no benefi cial impact on their carcass quality was expected. Noventa y nueve machos sin castrar se distribuyeron al azar en cuatro grupos a pastoreo para examinar la variación en rasgos de crecimiento y en canal, debida a régimen de implantes [72 miligramos (mg) de Ralgro® el día (d) 0 seguido de su reimplante el d 90 versus implantación de Revalor® el d 0 seguido de 72 mg de Ralgro® el d 90] y suplementación [mezcla mineral (SM) versus suplemento estratégico (SE)]. El análisis de varianza con arreglo factorial 2 x 2 incluyó, como efectos fi jos, los tratamientos y su interaccion (régimen de implantes x suplementación) y tipo racial como efecto aleatorio. En rasgos de crecimiento, la interacción no fue significativa (P > 0,05); tampoco lo fué el régimen de implante (P > 0,05). El grupo con SE, con respecto al que recibió SM, tuvo mayor ganancia diaria de peso (779 vs. 541 gramos; P < 0,001) requirió 38,3 d menos de ceba [(198,3 versus 236,6 d; (P < 0,001)] para alcanzar mayor peso vivo fi nal (498,2 versus 474,4 kilogramos; P = 0,02) a una edad más temprana (29,4 versus 30,8 meses; P < 0,001), con mayor rendimiento en canal (59,13 versus 57,62 %; P = 0,03) y una menor madurez ósea de la canal (P < 0,001). A excepción de la profundidad torácica, los rasgos en canal no variaron con el régimen de implantes (P > 0,05). La falta de respuesta en crecimiento o rasgos importantes de la canal a estos regímenes agresivos de implantes, no permite justifi car su uso para cebar toros en pastoreo. La SE es una práctica factible para mejorar el desempeño de toros en la ceba a pastoreo, pero no puede esperarse benefi cio alguno en la calidad de sus canales. 53-60 nelson.huerta@ttu.edu

OBJECTIVE The objective of this study was to assess caesarean section (CS) rates before and after the implementation of the Project Appropriate Birth (PPA), based on the Robson ten group classification system. DESIGN A before-and-after study. SETTING Maternity hospital in South Brazil. POPULATION All pregnant women attending from April 2016 to April 2017 (period 1, pre-implementation of PPA) and from June 2017 to June 2018 (period 2, post-implementation of PPA). METHODS Maternal and obstetric characteristics were evaluated, including Robson's classification, based on the characteristics of pregnancy and childbirth. A chi-square test and crude and adjusted relative rates were used to analyse the study variables. The significance level was set at 5%. MAIN OUTCOME MEASURES The CS rate for each group, their contribution to the overall CS rate and the differences in these contributions before and after PPA implementation. RESULTS The CS rates decreased from 62.4 to 55.6%, which represented a 10.9% reduction after the implementation of the PPA. Pregnant women in Robson classification groups 1-4 had a 21.4% reduction in CS rates, ranging from 49.1 to 38.6%. The greatest contributors to the overall CS rates were group 5 and group 2, accounting for more than 60% of the CS deliveries. CONCLUSION The study results suggest that Project Appropriate Birth had an impact on the reduction of CS rates, especially in Robson classification groups 1 through 4, which indicates that providing mothers with evidence-based interventions for labour and childbirth assistance contributed to reduce CS rates. TWEETABLE ABSTRACT The Project Appropriate Birth is an innovative project that has demonstrated promising results, suggesting that interventions based on scientific evidence can lead to real changes in childbirth care, contributing to reduce CS rates. The aim of the PPA is to promote activities to improve childbirth care and encourage vaginal delivery. In this study, 6238 pregnant women admitted to the hospital for delivery were included and classified into one of the Robson 10-group classification. Findings revealed a 10.9% reduction in the overall CS rate and a 21.4% reduction for pregnant women in Robson classification groups 1 through 4, after the implementation of the PPA.

The study aims to highlight the contributions of academic leagues in university extension. This is an exploratory-descriptive study, with a qualitative approach, carried out with 31 students inserted in five Academic Leagues in the Nursing course at the State University Vale do Acaraú, in Sobral-Ceará, Brazil, from March to May 2017. Data collection occurred in three focus groups (A, B and C) using a guiding script and were analyzed using Minayo's thematic analysis. The research was approved by the Research Ethics Committee of that university, obtaining the Opinion Nr. 1,345,575. This study proves that the leagues contribute to the strengthening of teaching, research and extension. In addition, the findings demonstrate that students are moved to participate in the leagues by the desire to have other experiences in the field of Nursing, early insertion in the territory, curriculum qualification, reinforcement in teaching and learning. Also, that the leagues develop teaching-learning strategies, for example: theoretical training or theoretical cycle, construction and development of scientific events, among others. Thus, academic leagues are potentialities for the transformation of the health practices scenario, mediated by teaching, research, extension, assistance and social transformation actions., El estudio apunta a destacar las contribuciones de las ligas académicas en la extensión universitaria. Este es un estudio exploratorio descriptivo, con un enfoque cualitativo, realizado con 31 estudiantes insertados en cinco ligas académicas en el curso de Enfermería en la Universidade Estadual Vale do Acaraú en Sobral-Ceará, de marzo a mayo de 2017. La colección de los datos ocurrieron en tres grupos focales (A, B y C) a través de un guión guía y se analizaron utilizando el análisis temático de Minayo. La investigación fue aprobada por el Comité de Ética en Investigación de esa universidad, obteniendo la siguiente opinión: No. 1,345,575. Este estudio demuestra que las ligas contribuyen al fortalecimiento de la enseñanza, la investigación y la extensión. Además, los resultados demuestran que los estudiantes se mueven para participar en las ligas por el deseo de tener otras experiencias en el campo de la Enfermería, la inserción temprana en el territorio, la calificación del plan de estudios, el refuerzo en la enseñanza y el aprendizaje. Y que las ligas desarrollen estrategias de enseñanza-aprendizaje, por ejemplo: capacitación teórica o ciclo teórico, construcción y desarrollo de eventos científicos, entre otros. Así, las ligas académicas son potencialidades para la transformación del escenario de prácticas de salud, mediadas por acciones de enseñanza, investigación, extensión, asistencia y transformación social., O estudo visa destacar as contribuições das ligas acadêmicas na extensão universitária. Trata-se de um estudo exploratório-descritivo, com abordagem qualitativa,-março a maio de 2017. Os dados foram coletados em três grupos focais (A, B e C) por meio de um roteiro norteador e analisados mediante a análise temática de Minayo. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa da referida universidade obtendo o Parecer n° 1.345.575. Este estudo comprova que as ligas contribuem para o fortalecimento do ensino, da pesquisa e da extensão. Além disso, os achados demonstram que os discentes são movidos a participar das ligas pelo desejo de ter outras experiências no campo da Enfermagem, inserção precoce no território, qualificação do currículo, e reforço no ensino e aprendizagem. Também mostram que as ligas desenvolvem estratégias de ensino-aprendizagem, por exemplo: formação teórica ou ciclo teórico, construção e desenvolvimento de eventos científicos, dentre outros. Assim, as ligas acadêmicas são potencialidades para a transformação do cenário de práticas de saúde, mediadas por ações de ensino, pesquisa, extensão, assistência e transformação social.

La Cordillera Blanca está experimentando un rápido deshielo debido al calentamiento climático, especialmente desde finales del siglo XX. Este proceso ha resultado en la formación de nuevos lagos glaciares y un aumento en el volumen de los lagos existentes, algunos de los cuales representan un riesgo en forma de inundaciones por desbordamiento de lagos glaciares (GLOF); como el lago Parón en la Cordillera Blanca, que representa un peligro importante para la ciudad de Caraz y poblaciones menores ubicadas en la subcuenca Llullán-Parón. Aquí, modelamos un posible escenario de ruptura de presa y generación de GLOF en el lago Parón utilizando un procedimiento de modelado numérico novedoso que, entre otros factores, considera la estructura geológica de la presa natural. En general, este procedimiento incluye cuatro fases distintas: (1) estimación del impacto potencial de una avalancha de hielo en el lago Parón proveniente de los circos glaciares circundantes; (2) modelado de la posterior generación y propagación de ondas impulsivas; (3) análisis de los parámetros hidráulicos de una posible ruptura de la presa natural, considerando el material no erosionable dentro de estimaciones empíricas del hidrograma donde se interpreta la composición de la presa en base al mapeo geológico superficial y muestreo de sondeos realizados en la zona ; y (4) simulación de un GLOF potencial utilizando el modelo FLO-2D con datos de entrada de las fases anteriores. Los resultados del modelo indican que el lago Parón está en mayor riesgo por las avalanchas de hielo que se originan en el glaciar adyacente Hatunraju y que tales eventos tienen el potencial de generar ondas de impulso que podrían iniciar la erosión y una ruptura posterior de la presa natural. Considerando el peor de los escenarios de avalancha de hielo,3 / s. Este evento GLOF llegaría al área urbana de la ciudad de Caraz en alrededor de 36 a 42 minutos con tasas y alturas de inundación que fluctúan entre 11,2 m/s a 22,4 m/s y 9,9 m a 19,7 m, respectivamente.

The Cordillera Blanca is undergoing rapid deglaciation due to climatic warming, especially since the late 20th century. This process has resulted in the formation of new glacial lakes and an increase in the volume of existing lakes, some of which pose a risk in the form of Glacier Lake Outburst Floods (GLOF); such as Parón lake in the Cordillera Blanca, which represents a significant hazard to the Caraz city and smaller populations located in the Llullán-Parón sub-basin. Here, we model a potential dam breach and GLOF generation scenario at Parón lake using a novel numerical modelling procedure that, amongst other factors, considers the geological structure of the natural dam. Overall, this procedure includes four distinct phases: (1) estimation of the potential for ice avalanche impact on Parón lake sourced from surrounding glacial cirques; (2) modelling of subsequent impulsive wave generation and propagation; (3) analysis of the hydraulic parameters of a possible breach of the natural dam, considering the non-erodible material within empirical estimations of the hydrograph where the composition of the dam is interpreted based on surface geological mapping and drill sampling carried out in the area; and (4) simulation of a potential GLOF using the FLO-2D model with input data from the previous phases. Modelling results indicate that Parón lake is most at risk from ice avalanches that originate from the adjacent Hatunraju glacier and that such events have the potential to generate impulse waves that could initiate erosion and a subsequent breach of the natural dam. Considering a worst-case ice avalanche scenario, our results indicate the potential generation of a GLOF with average peaks flow of 25,264.22 m3/s. This GLOF event would reach the urban area of the Caraz city in around 36 - 42 minutes with now rates and flood heights fluctuating between 11.2 m/s to 22.4 m/s and 9.9 m to 19.7 m, respectively.

Goal: This research provides specific solution for dynamic scheduling of product-driven production with unique level of detail and original architecture. Design / Methodology / Approach: Design process of scheduling problem-solving MAS is divided into three steps: agent encapsulation of entities participating in scheduling, including concept of agents and responsibilities they assume, system architecture and topology of the agents network, detailed design of decision scheme of individual agents. Results: Production processes take place in dynamic environment and have to react to numerous real-time events, hence reschedule the production by a new design and implement agent-based model in order to solve dynamic flexible job shop scheduling problem in product-driven production environment. Limitations of the investigation: Designed model counts with simple agents behaving on condition-action rules. These agents could be replaced by more sophisticated types of agents such as utility-based or learning agents. Also the implemented coordination mechanism ensuring global view on the scheduling problem is rather simple. Practical implications: Via simulations of realistic production scenarios it was expected to prove an applicability of specific solution of how bringing the intelligence to the lower levels of control system may be used in dynamic scheduling. Based on elaboration of theoretical basis, principles were identified as suitable or widely used in design of such model. Originality / Value: This research provides specific real-time architecture for a multi-agents dynamic scheduling of product-driven production with unique level of detail and scenarios analysis.

Objective: To define the prevalence of adverse outcomes according to the gestational age of maternal infection in a large cohort of ZIKV-infected Brazilian women and their infants. Design: Prospective, population-based cohort study. Setting: Ribeirao Preto’s region private and public health facilities. Population: All pregnant women with confirmed ZIKV-infection and their infants. Methods: Prenatal/early neonatal data were obtained for all pairs. A subgroup of infants had cranial ultrasonography, eye fundoscopy, hearing, neurological exam, and Bayley III screening test within 3 months of age. Main Outcome Measures: Prevalence of pregnancy losses, anomalies detected at birth or within 3 months according to the gestational age of infection. Results: 511 women with ZIKV were identified from a total of 1116 women with flavivirus-type symptoms. Pregnancy losses 24/511(4.7%) and/or ZIKV-related anomalies occurred in 43/511(8.4%) mothers. Microcephaly or other CNS malformations were diagnosed in 1/4(25.0%) of the stillbirths and 19/489[3.9%;CI95%:2.5-5.9] of the live-born infants, with 13/513[2.5%;CI95%:1.5-4.3] neonates presenting major signs of CZS. Fetal abnormalities were 14.0(CI95%:7.6-26.0) times more likely with gestational infection

The#8222;gold standard#8220; for prenatal diagnosis of aneuploidies is provided by the karyotype, which has high accuracy, but is dependent on invasive procedures, which generate risk of fetal loss. Different methodologies of development of noninvasive prenatal genetic tests (NIPT) for tracking aneuploidies, including sex chromosomes, have been made available for clinical use, for some microdeletions and triploids and for exclusion of paternity. These exams make use of three methodological tools: s-MPS, t-MPS and SNP. Genetic tests, despite the high cost, cover a broader range of clinical applications, have the advantage that can be performed early, with high accuracy, and low false positive rate. Type of article: Review.Department of Obstetrics and Gynecology, Science College of Santa Casa of São Paulo (FSMSCSP), São Paulo-SP, Brazil.This study was a non-asystematic review, which searched PubMed / MEDLINE as a research source and aimed at the compilation of data, which allowed approaching the evolution, the technical and methodological advances of the available tests, the recognition of its benefits, limitations and future perspectives on NIPT.NIPT stand out for being applied earlier during the pregnancy with high accuracy and low false-positive rates, including a broad spectrum of clinical applications. The t-MPS is a recent technique used to evaluate aneuploidy that shows greater accuracy and lower cost than the s-MPS, but that is limited to being applied only to the most common aneuploidies. The SNP technique can search for more genetic conditions, besides presenting better accuracy.

A crescente preocupacao mundial em relacao aos danos ambientais causados pelos combustiveis fosseis tem estimulado o desenvolvimento de fontes alternativas de energia, como o biodiesel. Esse biocombustivel tem baixa toxicidade, e biodegradavel, emite enxofre e compostos aromaticos em baixa intensidade e e proveniente de fontes renovaveis.