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İnşaat taahhüt işletmelerinde esas faaliyet konusunu oluşturan işlerin tamamlanması genellikle bir takvim yılından daha uzun sürmektedir. Bu durumun bir sonucu olarak bir takvim yılını esas alan muhasebe dönemini aşan finansal olayların etkilerinin finansal tablolara alınmasında çeşitli sorunlar ortaya çıkmaktadır. Bu çalışmanın amacı, inşaat taahhüt işletmelerinin faaliyetlerine ilişkin sonuçların finansal tablolarda ne şekilde raporlanacağının açıklanması ve vergi mevzuatı açısından inşaat taahhüt sözleşmelerine ilişkin bir yöntem önerisinin sunulmasıdır. Bu çalışma, ekonomi içerisinde önemli bir paya sahip olan inşaat taahhüt işletmelerinin faaliyetlerinin, özellikle vergi mevzuatına göre raporlama yaptıklarında finansal tablolarında oluşan anomalinin, vergi mevzuatına en yakın olacak şekilde nasıl düzeltileceğine ilişkin bir çözüm önerisi sunması açısından önemlidir. Çalışmada teorik olarak hazırlanmış örnek bir olay üzerinden uzun vadeli inşaat taahhüt işlerine ilişkin raporlama yöntemleri karşılaştırılmış ve bu raporlama şekillerinin etkileri hem vergisel açıdan hem de finansal analiz açısından incelenmiştir.

İnsanoğlunun enerji gereksinimi dünya nüfusunun artışına paralel olarak artmaktadır. Endüstrileşmenin başlangıcından beri dünyanın enerji ihtiyacını karşılamak amacıyla başlıca petrol, kömür ve doğal gaz gibi fosil kaynaklar kullanılmıştır. Ancak, yakın gelecekte bu kaynakların dünyanın enerji gereksinimini sağlayamayacak seviyeye geleceği ve tükeneceği öngörülmektedir. İnsanoğlunun bu artan enerji ihtiyacı karşılanırken atmosfere sera gazlarının salınmaması, sera gazların olumsuz etkilerinin engellenmesi veya azaltılması bir gerekliliktir. Bu da ancak çevreyi kirletmeyen, sürdürülebilir ve yenilenebilir alternatif enerji kaynaklarının kullanılması ile mümkün olacaktır. Biyokütle bu alternatif enerji kaynakları arasında öne çıkan seçeneklerden biridir. Biyokütlenin enerji kaynağı olarak kullanılabilmesi için uygun madde formuna dönüştürülmesi gerekmektedir. Piroliz yöntemi, biyokütlenin katma değerli katı, sıvı ve gaz ürünlere dönüştürülmesini sağlamaktadır. Bu çalışmada piroliz teknolojisi ile üretilen katı ürün olan biyoçarın özellikleri, kullanım alanları ve anaerobik parçalanma prosesi üzerindeki etki mekanizmaları ele alınmıştır.

In this proposed study, hydrogen and power generation by low-temperature geothermal energy supported Kalina cycle is thermodynamically investigated with an energy and exergy efficiencies approaches. This combined plant includes a Kalina cycle and a PEM electrolysis for power and hydrogen generation. The key purpose of this paper is to generate power and hydrogen in an environmentally benign way. Furthermore, environmental impact analysis is discussed to investigate the carbon dioxide emission that will be released if the power and amount of hydrogen obtained are produced with natural gas. As coming to the examination results, the energy and exergy performance of the overall plant 7.94% and 37.64%, respectively. Also, the net power and hydrogen production rates are computed as 100.5 kW and 0.0001191 kgs-1.

In this paper, we consider hybrid numbers with Gaussian Mersenne coefficients and investigate their interesting properties such as the Binet formula, Cassini, Catalan, Vajda, D’Ocagne and Honsberger identities. Moreover, we illustrate the results with some examples.

Sumac (R. coriaria L.) is a subtropic and temperate climate plant with medicinal and aromatic properties which has a natural distribution in many regions of Anatolia. Sumac which is used as a food additive in the food industry due to the flavoring substances has been in high demand in recent years. Besides the beneficial secondary metabolites, it is used in the field of medicine and pharmacy. Sumac (R. coriaria) which grows spontaneously in the natural environment without any agricultural practices is collected by the local people in the region and supplied to the local market. Since this situation, the ideas of creating modern orchards for sumac have begun to emerge. For this reason, selection breeding studies have been planned in sumac (R. coriaria L.). This study was carried out at the East Mediterranean Transition Zone Agricultural Research Institute during 2019-2021 years. Approximately 300 different sumac genotypes were observed and botanically 92 genotypes were found positive in this study. It was determined that the wet weight values of the clusters in the examined sumac genotypes varied between 5.63-87.74 g as a result of the statistical analysis. The highest cluster weight varied between 87.74, 78.92, and 70.81 g in GN26, GN86, and GN90 genotypes respectively. The lowest cluster wet weight was found in GN28 (5.63 g) and GN41 (6.00 g) genotypes in the study. It was found in the study that the cluster powder efficiency values varied between 30.62% and 72.49% and the average cluster powder efficiency was 49.15%. It was determined that the results obtained from about 20 sumac genotypes were found to be positive in the statistical analyzes made on the characteristics examined in this study. It is aimed to use this sumac (R. coriaria L.) genotypes in the modern sumac cultivation planned for the future.

Three new copper(II) 5,5-diethylbarbiturate (barb) complexes of nicotinamide (nia), 2,2′-bipyridine (bpy) and triethanolamine (tea), trans-[Cu(barb)2(nia)2]⋅2H2O (1), cis-[Cu(barb)2(bpy)]⋅3H2O (2) and [Cu2(barb)2(tea)2]⋅2H2O (3), were synthesized and characterized by elemental analysis, spectroscopic (UV-Vis and FTIR) and magnetic moment measurements. Single crystal X-ray crystallographic measurements showed that 1 and 2 are mononuclear, while 3 is binuclear, in which two copper centers were bridged by deprotonated ethanol groups of two tea ligands. The barb ligand in these complexes is a bidentate N, O-donor. Thermal analysis (TG/DTA) studies in air indicated that the complexes first dehydrated and then the decomposition of nia, bpy or tea ligands occurred. The last exothermic stage was associated with degradation of the barb moiety to yield CuO as the end product.

Ekonomik küreselleşme kripto varlıklar ile çok farklı bir niteliğe bürünmekte bireyler tarafından farklı şekillerde algılanabilmektedir. Bu nedenle, bu araştırma kripto varlıkların, yatırımcılar açısından ne ifade ettiğini ve bu bağlamda kamu otoritesinin nasıl konumlandığını ortaya çıkarmayı amaçlamaktadır. Bu araştırmanın temel problemi kripto varlıklar bireyler tarafından nasıl algılanmakta ve metaforik olarak nasıl temsil edilmektedir şeklindedir. Bu bağlamda kamu otoritesi, köşeyi dönme fikri, bireysel yatırım tercihleri, kripto paraya bakış ve dini tercihler şeklinde beliren temalar eşliğinde kripto varlıklara yönelik metaforik algılar ortaya konulmuştur. Uygun örnekleme tekniğinin benimsendiği bu araştırmada karma yöntem kullanılmıştır. Araştırmanın nicel verileri sabit format anket tekniği ile; nitel verileri ise açık uçlu görüşme tekniği kullanılarak Google formlar aracılığıyla gerçekleştirilmiştir. Nicel veri analizi esnasında temel istatistiki teknikler kullanırken; nitel veriler içerik analizi tekniği ile çözümlenmiştir. Çalışmanın en temel bulgusu olarak; kripto varlıklara karşı temel bir güvensizlik olduğu, yatırım amacı olarak kripto varlıkların klasik varlıklardan çok sonra yer aldığı ve genel olarak kumar şeklinde algılandığı ifade edilebilir.

Bu çalışmada, Andrey Tarkovski'nin filmlerinde karşılaşılan resimler, Gilles Deleuze'ün “Zaman-İmge” kavramı ile Antonin Artaud’nun “vahşet sineması”, “titreşim” ve “şok etkisi” kavramlarının ışığı altında tartışılmaktadır. Sinema tarihini İkinci Dünya Savaşı öncesi ve sonrası olmak üzere yeni bir taksonomiye tabi tutan Deleuze, savaş sonrası sinemanın Zaman-İmge sineması olduğunu savunur. Sinemanın ilk döneminde zaman harekete bağımlıyken, savaştan sonra hareketin zamana tabi olduğu bir sinema anlayışı gelişmiştir. Deleuze’ün zaman öncelikli sinema düşüncesi, Henri Bergson’dan olduğu kadar Tarkovski’nin fikirlerinden de kaynaklanır. Zaman-İmge dönemi Hareket-İmge Krizi ile başlar ve ardından yeni yönetmenlerin yapımlarıyla sürekli bir dönüşüme uğrar. Tarkovski'nin filmleri Zaman-İmge dönemindedir. Onun sinemasında savaştan söz edilecekse, silahlar değil, savaş karşıtı düşünceler ateşlenmelidir. Bunu İvan'ın Çocukluğu'nda Albrecht Dürer'in “Kıyamet” gravürleriyle yapar. Artaud’nun vahşet sineması da tam olarak böyledir. Resimlerle karşılaşmalar izleyicinin duyu-motor alışkanlıklarını kırma işlevine sahiptir. Tarkovski’ye göre, insan bir başyapıtla karşılaştığında, sanatçıya ilham veren o sesi de duymaya başlar. İzleyicinin derin bir sarsıntı ve şok yaşadığı böylesi anlar, adeta ruhsal bir temizlenme sağlar. Örneğin Leonardo Da Vinci’nin resimleri de böyledir. Onun resmettiği yüzler, yüce düşüncelerin izlerini taşır. Tarkovski, kariyerinin başından sonuna kadar filmlerinde, özellikle Rönesans dönemi Avrupa sanatçıları olmak üzere, farklı sanatçıların resimlerine yer vermeye devam eder. Resimleri sırasıyla Andrey Rublev, Solaris, Mirror, Nostalghia, Stalker ve Kurban filmlerinde, "düşündürücü şok" etkisini yaratmak için kullanır. Resimler, dünyaya inanmayı bırakan insanoğlunun yeniden inanmasını sağlamaktadır. Deleuze’e göre modern sinemanın en belirgin vasıflarından biri de budur.

Bridges are an essential component of the transportation system and safety and sustainability of bridges are critical for the efficient operation thereof. Due to scarcity of resources, an economical way should be determined to design and maintain bridges and the transportation system in general. Reliability indexes are widely used in the analysis of these concepts within a semi-probabilistic approach. However, advances in computer technology allow implementing a fully-probabilistic approach. This study represents a simulation-based reliability analysis of steel girder bridges in the railway lines. Statistical parameters of the bridges are determined both analysing the existing body of knowledge available in the literature and conducting specimen tests. The Bayesian approach is used to update the statistical properties of the steel material. Basic Monte Carlo Simulation (MCS) is used to simulate the load and resistance of the bridge. The reliability of the bridges is determined according to their ultimate limit states and statistical load distribution. By using simulation, the consistency of the log-normal marginal distribution obtained is analysed herein.

Yapılan araştırmada, Milli Eğitim Bakanlığına bağlı örgün eğitim kurumlarında ilk defa sınıf öğretmeni olarak göreve başlayan öğretmenlerin meslekteki ilk yıllarında yaşadıkları sorunları tespit ederek çözüm önerileri sunmak amaçlanmaktadır. Belirtilen amaç doğrultusunda araştırmada sınıf öğretmenleri ile görüşmeler yapılarak “Sınıf öğretmenliğinin ilk yıllarında yaşanan sorunlar nelerdir?” ve “Sınıf öğretmenliğinin ilk yıllarında yaşanan sorunlara yönelik çözüm önerileri nelerdir?” problemlerine cevap aranmıştır. Araştırmanın örneklemini amaçlı örnekleme türlerinden ölçüt örnekleme yolu ile 2022-2023 eğitim-öğretim yılında belirlenen 17 sınıf öğretmeni oluşturmaktadır. Araştırmada öğretmenliğin ilk yıllarında sınıf öğretmenlerinin öğrencilerle, öğretmenlerle, velilerle ve okulun diğer paydaşları ile ilişki ve iletişim konusunda sorun yaşadıkları belrilenmiştir. Ayrıca araç-gereç temini, bakım-onarım işleri ve okul çevresi ile ilişkiler bağlamında sorun yaşadıkları belirlenmiştir. Araştırmada öğrenci bağlamında disiplin, devamsızlık, okul yönetimlerinin taleplerinin yoğunluğu ve okul çevresini kontrol edememe konusunda yaşanan zorluklar yaşadıkları belrilenmiştir. Öğretmen bağlamında ise öğretmen desteğinin azlığı, öğretmenlerin ilgisizliği, talep fazlalığı ve memnuniyetsizlik; veli bağlamında veliler ile görüşememe, veli desteğinin azlığı, iş yoğunluğu ve okul faaliyetlerine katılmama; finansman bağlamında ödenek yetersizliği, ödeneklerin zamanında gelmemesi, çalışan temizlik personelinin eksikliği ile bakım ve onarım maliyetlerinin çokluğu konularında zorluklar yaşandığı belirlenmiştir. Ayrıca araştırmada sınıf öğretmenlerinden, okul çalışanlarından, öğretmenlerden ve velilerden destek alarak mesleklerinin ilk yıllarında yaşadıkları zorluklarla mücadele ettikleri belirlenmiştir. &nbsp

The purpose of this paper is to define and construct new number systems, called the harmonic complex Fibonacci sequences (HCF) and the harmonic hybrid Fibonacci (HHF) sequences. These sequences are defined by inspiring the well-known harmonic and hybrid numbers in literature. We give some fundamental definitions and theorems about these sequences in detail. Moreover, we examine some algebraic properties such as Binet-like-formula, partial sums related to these sequences. Finally, we provide a Maple 13 source code to verify the sequences easily.

Ergenlik bireyin yaşamındaki önemli değişimlerin yaşandığı bir dönemdir. Ergenlik döneminde birey geleceğe ilişkin birçok plan yapar. Bazı araştırma sonuçları ergenlik dönemindeki bireylerin yanlış kararlar almaya eğilimli olabileceğini, bireye bu dönemde gerekli rehberlik yapılmadığı takdirde hem bireyin kendisi, ebeveynleri, arkadaşları ve akrabaları için problemli bir döneme dönüşebileceğini ortaya koymaktadır. Bu nedenle bu araştırmanın sonuçlarının gelecekte yapılacak çeşitli araştırmalara yön vereceği düşünülmektedir. Dünya sağlık örgütünün ergenlik dönemi tarifi ve ülkemizde öğrencilerin sınıf seviyeleri ve yaşları birlikte değerlendirildiğinde bu dönemin lise eğitimi içinde bir döneme rastladığını söylemek yanlış olmaz. Diğer taraftan günlük yaşamda önemli bir yer tutan ve oldukça yaygın olarak kullanılan metaforlar çeşitli disiplinlerde araştırma konusu olarak karşımıza çıkmaktadır. Bireyin yaşamında önemli bir yer tutan ve ergenlik dönemini de içine alan lise öğrencilerinin geleceğe ilişkin ürettikleri metaforları ortaya çıkarmak bu araştırmanın temel amacıdır. Nitel araştırma deseninde tasarlanan bu araştırmanın verileri Türkiye'de öğrenim gören 144 lise öğrencisinden elde edilmiş ve içerik analizi yönteminden yararlanılarak analiz edilmiştir. Araştırma sonunda dört tema altında toplanan on beş kategoride 96 metafor oluşturulmuştur. Son olarak araştırma bulguları literatürde yer alan çeşitli araştırma sonuçları ile birlikte değerlendirilerek çeşitli öneriler geliştirilmiştir., Adolescence is a period of significant changes, during which the individual makes many plans for the future. Some researches reveal that individuals in adolescence may also be prone to making wrong decisions, if they are deprived of the necessary guidance during this period. It can be a problematic period for the individual, parents, friends, relatives etc. Thus, the researchers think that the results of this study will guide various future studies. This period coincides with high school period taking The World Health Organization's definition of adolescence, grade levels and ages of students in our country into consideration. Moreover, metaphors which have an important place in daily life and are widely used, can be a research topic in various disciplines. The purpose of this research is to reveal the metaphors produced by high school students about future. The research data, have been collected from 144 high school students living in Turkey and analyzed by means of content analysis. At the end of the research, 96 metaphors have been created in fifteen categories on four themes. Finally, the findings have been discussed taking the results of various studies in the literature into consideration, and some suggestions have also been made.

This paper focuses on a specially constructed matrix whose entries are harmonic Fibonacci numbers and considers its Hadamard exponential matrix. A lot of admiring algebraic properties are presented for both of them. Some of them are determinant, inverse in usual and in the Hadamard sense, permanents, some norms, etc. Additionally, a MATLAB-R2016a code is given to facilitate the calculations and to further enrich the content.

We consider the Gaussian Leonardo numbers and investigate some of their amazing characteristic properties, including their generating function, the associated Binet formula and Cassini identity, and their matrix representation. Then, we define the hybrid Gaussian Leonardo numbers and obtain some of their particular properties. Furthermore, we define nn Hessenberg matrices whose permanents yield the Leonardo and Gaussian Leonardo sequences.

Ozan Önal, günümüzde eser vermekte olan bir Türk şairidir. Şiirlerinde genel olarak hasret, vatan, keder, emek, ayrılık, kahramanlık, aşk, çile gibi izlekleri işlediği görülür. Şair oluşturduğu şiir atmosferi ile halk şiirinin sesini çağdaş şiire taşımış, geçmişten süregelen kültürel hassasiyetleri modern bir biçimle anlatma yoluna gitmiştir. Milliyetçi düşüncenin ağır bastığı yapıtlarında, Hüseyin Nihal Atsız, Ziya Gökalp, Namık Kemal, Cengiz Aytmatov ve Yahya Kemal gibi birçok şair ve yazarın tesiri görülür. Eserlerinden yola çıkılarak Türk ve İslam kültürünü, sözlü ve yazılı edebiyatı yakından takip ettiği görülen şairin, duygu ve tarihi harmanlayarak kaleme aldığı şiirlerinde kökünü beslendiği kaynaklardan alan mistik bir derinlik derinlik de bulunur. Bu çalışmada, şairin eserleri iki temel izlek çerçevesinde ele alınmış ve anlam kapsamını genişleten metinlerle ilişkisi açığa çıkarılmaya çalışılmıştır.

Renewable energy sources have great importance to deal with environmental detriments. To clean and sustainable future, various design renewable energy-assisted plants are of great importance. The current study examines the design and investigation of a double-flash binary geothermal energy-powered integrated system for useful products. For the purpose of producing hydrogen, power, heating, and drying, the proposed work basically consists of two steam turbines, a transcritical carbon dioxide Rankine cycle (tCO2-RC ) , a PEM electrolyzer, a domestic water heater (DHW), and a dryer. The chief target of this research study is to develop a more efficient plant as well as multigeneration productions. Additionally, detailed parametric modeling is carried out using energetically and exergetically approaches to examine this designed plant in the context of thermodynamic analysis. The variation of some parameters that influence the plant's performance, such as geothermal water temperature, flash pressure, and ambient temperature, are parametrically investigated. Subsequently, the thermodynamic simulation results show that the advised integrated plant produces 4431 kW electrical power. Also, the amount of the hydrogen generation capacity is 0.006809 kgs−1. The tCO2-RC sub-plant's energetic and exergetic performance is determined as 6.18% and 27.14%, respectively. Furthermore, the suggested integrated plant's energetic and exergetic performances are 26.20% and 37.49%. From the results, it can be finalized that the integration of various systems with the geothermal power plant is successfully possible and, in this way, there will be an increase in system performances.

In this research, the Servperf method is used to analyze the quality of health and safety services. The main purpose of this article is to determine the quality level of preventive health and safety services provided in the workplaces within the framework of the perception of the employees who benefit from these services. The questionnaire prepared in accordance with the Servperf method was applied to 412 employees working in various sectors, and the results were classified according to age, gender, education level, sector, and the way of providing (internal & external) services. Descriptive statistics were used in the evaluation of results. The total perceived Servperf score of the health and safety services was 2.84, medium level. As the age and education level of the employees increases, the satisfaction level and Servperf scores of the service quality decrease. The satisfaction score of the construction workers is significantly lower than the other sectors. Satisfaction levels of employees in the workplaces where services are provided internally are higher than those of the workplaces offering external sources. Despite legal regulations related to preventive health and safety services, accidents have not decreased in Turkey. The quality of the service provided by external health and safety units is significantly low. Competition arising from the marketization of occupational health and safety services reduces the quality of the service provided. For these reasons, the number of research aimed at determining the quality of these services should be increased both in Turkey and in the world.

Objective: The aim of the study is to update our understanding of the clinicopathological features of odontogenic keratocysts in a series of 43 cases from a single center.Material and Methods: This retrospective study included 51 specimens from 43 patients diagnosed between 2010 and 2020. Microscopic findings, patients’ age, gender, lesion location, and presence or absence of recurrence were noted.Results: The study group included 22 men and 21 women with a mean age of 38.72 /year. In 37 patients, the lesion occurred in the mandible, while in 6 patients it was found in the maxilla. Three patients were associated with nevoid basal-cell carcinoma syndrome. Three patients had multiple odontogenic cysts. Satellite cysts were present on the cyst walls in 5 of the 43 cases. Epithelial islands were present in 4 of the cases. In 28 cases, moderate to severe inflammation was observed in the cyst wall. Among them, in 18 cases, classical odontogenic keratocyst features were lost in some areas in the cyst epithelium. Elongation of rete ridges and radicular cyst-like areas were observed in 12 cases. In only 41.66% of patients, the odontogenic keratocyst or keratocystic odontogenic tumor terms were given in the provisional diagnoses. Clinically, the most frequently confused lesions in the differential diagnosis were dentigerous cyst, radicular cyst, residual cyst, and ameloblastoma. No recurrence was observed in any of the patients.Conclusion: Concomitant inflammation can cause changes in the epithelium and may hide the diagnostic features of odontogenic keratocysts. Therefore, careful examination is required for accurate diagnosis.

Tumoral and pseudotumoral lesions of the hand and wrist are commonly encountered in routine clinical practice. Although most of them arc benign, radiological differential diagnosis of these lesions is difficult, because of their nonspecific imaging findings, except ganglia, localized type of tenosynovial giant cell tumors and lipomas. Digital radiography, computed tomography, and ultrasound may be useful in identification of the lesions in the wrist and hand, but magnetic resonance imaging with superior contrast and spatial resolution is the most important imaging modality.

Pulmonary hypertension (PH) is a common complication of end-stage heart failure (ESHF) and associated with increased mortality. The definition of PH has recently been changed from a mean pulmonary arterial pressure (PAPm) ≥25 mmHg to a PAPm20 mmHg. Since this change, there are no data evaluating group 2 PH subgroups on outcomes. The purpose of this study was to determine the impact of updated group 2 PH subgroups on outcomes, as well as to evaluate the clinical, echocardiographic, and haemodynamic characteristics of subgroups, and determine predictors of PH in patients with ESHF.A total of 416 patients with ESHF with left ventricular ejection fraction (LVEF) ≤25% were divided into three groups. Pulmonary hypertension was defined as PAPm20 mmHg. Primary outcome was defined as left ventricular assist device (LVAD) implantation, urgent heart transplantation (HT), or death. Secondary outcome was defined as LVAD implantation and HT.Over a median follow-up of 503.5 days, combined pre- and postcapillary PH (Cpc-PH) displayed greater risk of primary outcome than those with isolated postcapillary (Ipc-PH) (hazard ratio [HR], 1.57; 95% confidence interval [CI], 1.29-1.91; p0.001) and those with no PH (HR, 2.47; 95% CI, 1.68-3.63; p0.001). Patients with Ipc-PH demonstrated greater risk than those with no PH (HR, 1.57; 95% CI, 1.57-1.90; p0.001). Likelihood ratios of updated PH criteria and old PH criteria (PAPm ≥25 mmHg) in identifying primary outcome were 75.6 (RPulmonary hypertension increases the risk of LVAD, urgent HT, or death, and Cpc-PH further increases risk in patients with ESHF. Compared to the previous definition, a new PH definition better discriminates death, going to urgent HT, or LVAD implantation for PH subgroups.

Our purpose was to comparatively investigate the expressions of nidogen-1 (NID1) and legumain (LGMN) in patients with endometrial cancer, endometrial intraepithelial neoplasia, and proliferative endometrium.A cross-sectional, single-center study was performed by the obstetrics and gynecology and pathology departments of our institution. The relationships between descriptive data, clinicopathologic information, and immunohistochemical expressions of NID1 and LGMN were investigated.The histological grades of endometrial cancers (n = 124) as classified by FIGO included 1 (41, 21.1%), 2 (48, 24.7%), and 3 (35, 18.0%). The medians and ranges of deep and superficial NID1 expressions were 50.00 (0-285) and 5.00 (0-100), respectively. The intensity of legumain expression was noted as negative (30, 24.2%), mild (16, 12.9%), moderate (27, 21.8%), or strong (51, 41.1%). Median disease-free survival and overall survival were 75.00 (range: 1 to 170) months and 77.00 (range: 1 to 170) months, respectively. Patients with more intense expression of NID1 and LGMN displayed a higher histological grade. These patients were more likely to have a positive peritoneal cytology, larger tumor size, higher tendency for myometrial or lymphovascular invasion, involvement of ovaries, cervix, omentum, as well as lymph node metastasis, and recurrence.Our data indicated that the expressions of NID1 and LGMN may have important diagnostic implications in endometrial pathologies. Further studies should be performed to understand the significance of NID1 and LGMN in the pathogenesis of endometrial tumors.

Renewable energy-based hydrogen production plants can offer potential solutions to both ensuring sustainability in energy generation systems and designing environmentally friendly systems. In this combined work, a novel solar energy supported plant is proposed that can generate hydrogen, electricity, heating, cooling and hot water. With the suggested integrated plant, the potential of solar energy usage is increased for energy generation systems. The modeled integrated system generally consists of the solar power cycle, solid oxide fuel cell plant, gas turbine process, supercritical power plant, organic Rankine cycle, cooling cycle, hydrogen production and liquefaction plant, and hot water production sub-system. To conduct a comprehensive thermodynamic performance analysis of the suggested plant, the combined plant is modeled according to thermodynamic equilibrium equations. A performance assessment is also conducted to evaluate the impact of several plant indicators on performance characteristics of integrated system and its sub-parts. Hydrogen production rate in the suggested plant according to the performance analysis performed is realized as 0.0642 kg/s. While maximum exergy destruction rate is seen in the solar power plant with 8279 kW, the cooling plant has the lowest exergy destruction rate as 1098 kW. Also, the highest power generation is obtained from gas turbine cycle with 7053 kW. In addition, energetic and exergetic efficiencies of solar power based combined cycle are found as 56.48% and 54.06%, respectively.

Background: Right ventricular (RV) failure is an important cause of morbidity and mortality in patients with left ventricular (LV) end-stage heart failure (ESHF). Pulmonary artery pulsatility index (PAPi) and RV stroke work index (RVSWI) are invasive parameters related to RV function. This study aimed to investigate the prognostic impact of PAPi and RVSWI in these patients. Methods and Results: In this study, 416 patients with ESHF were included. The adverse cardiac event (ACE) was defined as LV assist device implantation, urgent heart transplantation, or cardiac mortality. There were 218 ACE cases and 198 non-ACE cases over a median follow-up of 503.50 days. Patients with ACE had lower PAPi and similar RVSWI compared to those without ACE (3.1 ± 1.9 vs. 3.7 ± 2.3, p = 0.003 and 7.3 ± 4.9 vs. 6.9 ± 4.4, p = 0.422, respectively). According to the results of multivariate analysis, while PAPi (from 2 to 5.65) was associated with ACE, RVSWI (from 3.62 to 9.75) was not associated with ACE (hazard ratio [HR]: 0.75, 95% confidence interval [CI] [0.55–0.95], p = 0.031; HR: 0.79, 95% CI: [0.58–1.09], p = 0.081, respectively). Survival analysis revealed that PAPi ≤2.56 was associated with a higher ACE risk compared to PAPi >2.56 (HR: 1.46, 95% CI: 1.11–1.92, p = 0.006). PAPi ≤2.56 could predict ACE with 56.7% sensitivity and 51.3% specificity at 1 year. Furthermore, the association between RVSWI and ACE was nonlinear (J-curve pattern). Low and high values seem to be associated with higher ACE risk compared to intermediate values. Conclusion: The low PAPi was an independent risk for ACE and it had a linear association with it. However, RVSWI seems to be have a nonlinear association with ACE (J-curve pattern).

The aetiology of heart failure may have different effects on right ventricular (RV) function, pulmonary pressures and RV afterload. Pulmonary arterial capacitance (PAC) and pulmonary artery pulsatility index (PAPi) are novel haemodynamic indices used in determining RV afterload and RV function, respectively. We aimed to investigate whether there was a difference in PAC and PAPi between ischaemic cardiomyopathy (ICMP) and non-ischaemic cardiomyopathy (NICMP) in patients with end-stage heart failure.A total of 215 subjects undergoing evaluation for heart transplantation or left ventricular (LV) assist device were classified into two groups: ICMP (ICMP was associated with lower PAC and higher PAPi. These results indicated that an ischaemic aetiology is associated with higher RV afterload and better RV function in the end-stage heart failure.

The aim of this article is to provide quantitative information about occupational health and safety professionals' working conditions and professional independence. The data were obtained through questionnaires applied to employees in the field of occupational health and safety. The validity value of the questions in the questionnaires was calculated as 0.901. The obtained data were analyzed with descriptive statistical techniques. According to the results, the wages and job satisfaction level of occupational health and safety professionals are average, but below what it should be. Health and safety professionals are employed above legal limits. Some of them cannot adequately benefit from their rights such as overtime pay, annual leave, rest breaks and severance pay. On the other hand, there is no job security to ensure the professional independence of health and safety professionals.

Objective In this study, we aimed to report early outcomes of catheter-directed thrombolysis (CDT) with alteplase in patients with subacute limb ischemia and to assess whether there is a link between malnutrition (determined by Controlling Nutritional Status [CONUT] score) and response to thrombolysis and bleeding. Methods This was a retrospective study conducted between 2007 and 2020 with 118 patients with Rutherford class 3 (34.7%), class 4 (40.7%), and class 5 (24.6%) symptoms owing to infraaortic subacute thrombotic occlusion who were treated with catheter-directed thrombolysis. Results Immediate technical success (Thrombolysis in Myocardial Infarction [TIMI] grade 2/3) was achieved in 56%, overall technical success after all adjunctive procedures was seen in 83.9%. Clinical success was obtained in 74.5% within 30 days. Major bleeding occurred in 11.8%. When we excluded access site hematomas, the rate of major bleeding was 5.1%. In-hospital mortality rate was 5.1%, and the amputation rate within 30 days was 12.7%. Any-degree malnutrition was detected in 48.3% according to CONUT score (≥2). Any-degree malnutrition was associated with failed thrombolysis and bleeding. The CONUT score predicted insufficient lytic response even after adjustment for confounding factors; however, serum C-reactive protein or neutrophil/lenfosit ratio did not. Other predictors of immediate technical failure after thrombolysis were symptom duration, Rutherford class 4/5 symptoms, and worsened distal runoff. Conclusion In patients with subacute limb ischemia, CDT combined with adjunctive interventions was effective in many patients at the expense of a substantial risk of bleeding and death. Malnutrition was associated with insufficient lytic response and bleeding. Physicians should be aware of malnutrition and consider the nutritional status of patients with limb ischemia when selecting appropriate treatment.

Identifying Kirsten rat sarcoma (KRAS) mutation status is important for metastatic colorectal cancer treatment. Validating KRAS mutation profile on neuroimaging without histopathologic analysis would be beneficial. We aimed to differentiate Kirsten rat sarcoma (KRAS) gene mutation profile according to diffusion tensor imaging (DTI) metrics obtained from colorectal brain metastases (CRBM). Total of 8 patients with 17 CRBM included with known KRAS gene mutation status. All patients were categorized into two groups according to the KRAS mutation status as positive (+) (n: 5, 11 lesions) and negative (-) (wild type) (n: 3, 6 lesions). DTI values of the BMs were evaluated by consensus of two radiologists. Apparent diffusion coefficient (ADC), normalized apparent diffusion coefficient (nADC) and fractional anisotropy (FA) values of the two groups were compared. For comparison the Mann-Whitney U test was used. KRAS mutation (+) group showed significantly lower ADC and nADC values on CRBM rather than the wild-type. Comparison of the FA values of the two groups did not reveal any statistical significance. In conclusion, decreased ADC and nADC values of CRBM are correlated with presence of KRAS mutation. Lower ADC and nADC values obtained from CRBM can be utilized to insight KRAS mutation profile. [Med-Science 2021; 10(3.000): 886-9]

The circular carbon economy (CCE) concept provides a holistic, flexible and pragmatic framework for countries to plan their energy and economic transitions to lower carbon dioxide and greenhouse gas emission levels and, ultimately, net-zero emissions. The CCE Index measures countries’ progress in and potential for reaching CCEs. It is a composite indicator comprising 43 individual, quantitative variables or indicators. The datasets underlying each indicator are harmonized across countries and derived from robust and reputable sources.

Purpose- This study investigated the financial effects of the environment of uncertainty and fear resulting from terrorist attacks on sub-sectors such as industry, tourism, and service. Methodology- In order to examine the interaction between the variables, EGARCH models, which are frequently used in the econometric literature and take into account the asymmetric effect of shocks, were used. Unlike studies in the literature, terrorist attacks not only within the country but also outside the country were taken into consideration in this study. Findings- According to the findings obtained, the terrorist attacks and uncertainty environment in both Turkey in the developing country status and the US in the developed country status have an adverse affect the sub-sectors in financial markets at different levels. This adverse impact has been found that is not equal for each sub-sectors, and the tourism sector is more affected by terrorist attacks compared to the industrial and service sectors. Also, it has been found that news about terrorist attacks affected volatility more than good news in the same period. Conclusion- Considering the borderless structure and the size of the trade volume of financial markets in the globalizing world, it cannot be thought that terrorist attacks will not affect another country while they occur in one country. In view of the share of the tourism sector in the GDP of Turkey and the rational behavior of human factors in an environment of uncertainty and fear, the fact that the environment of uncertainty most affects this sector gives a result that is in line with expectations. In addition, it has been determined that financial market shocks resulting from the activities classified as terrorism experienced by countries with a large economic volume and market share in the world, especially the USA, have a short-term spill over effect on the global market. In this context, although ensuring goverment security creates an environment of trust, measures to be taken with the joint work of global security organizations to minimize these effects will help to protect the stable structure of the markets more effectively. Keywords: Financial markets, terrorism, exponential GARCH, sectoral analysis, volatility. JEL Codes: C22, C58, E44

The effect of malnutrition on outcomes after carotid artery stenting (CAS) is not well known. This study reports the relationship between malnutrition and post-procedure 30-day major adverse events (MAEs). A total of 978 patients hospitalized for CAS were enrolled in the study. Controlling nutritional status (CONUT) score, the nutritional risk index (NRI), and the prognostic nutritional index (PNI) were calculated. MAEs (myocardial infarction, stroke/transient ischemic attack and mortality) were compared. According to the CONUT score, NRI, and PNI, 9.4%, 41%, and 11.4% patients were moderately or severely malnourished, respectively; 74.8% were at least mildly malnourished by at least 1 score. Forty-seven patients (4.8%) had a post-procedure 30-day MAE. Continuous classifications of the indexes were independently associated with higher MAE. CONUT showed the highest predictive ability, whereas NRI had the lowest (C-index: CONUT, 0.701; NRI, 0.681; PNI, 0.688). According to categorical classification of indexes, only CONUT and PNI showed predictive ability for MAE. Malnutrition assessment could identify patients with CAS at elevated risk for MAE. CONUT, NRI, and PNI continuous scores were independent prognostic factors for the post-procedure 30-day MAE. According to our study, CONUT showed the highest predictive ability.

In this study, seismic fragility analysis of multi-span steel truss bridges still giving service in railway network of Turkey was aimed. For this purpose, two representative multi-span steel truss bridges were selected in Turkish railway lines. A detailed three-dimensional inelastic finite element (FE) model for each bridge was created using commercial FE software. These models were used to perform non-linear time history analyses for each of the selected 30 ground motions scaled to 10 different peak ground acceleration (PGA) values to assess seismic demands of the bridges. To develop fragility curves, probabilistic seismic demand models (PSDMs) were defined. The most appropriate ground motion intensity measure (IM) for PSDMs of both bridges was determined among 11 IMs and the PGA was found as the optimal IM. Finally, the fragility curves for both the components and structural systems of the bridges were developed. The results clearly showed that the multi-span continuous (MSC) steel truss bridge is more vulnerable than the multi-span simply supported (MSSS) steel truss bridge, and for both bridge types, steel bearings are the most vulnerable components. Additionally, top wind braces for the MSC bridge as well as transverse beams and truss vertical members for the MSSS bridge were found as the most vulnerable superstructure members.

Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanicolaou) smear ve HPV tarama testlerinin önemi bilinmektedir. Bu çalışma ile üçüncü basamak tek merkez servikal tarama testi- biyopsi sonuçlarını karşılaştırmalı analiz ederek sunmayı amaçladık. Gereç ve Yöntemler Çalışmaya 3.basamak tek bir merkezde jinekolojik onkoloji polikliniğine başvuran ve kolposkopik biyopsi yapılan 272 hasta dâhil edildi. Olguların Pap smear sonuçları Betesta sistemine göre klasifiye edildi. HPV-DNA tiplendirmesi PCR yöntemi ile yapıldı. Tüm servikal biyopsi örneklerinden elde edilen H&E, p16 ve ki 67 boyalı preperatlar ışık mikroskobunda değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırmalı analiz edildi. Bulgular ve sonuç HPV tarama testi, Ko-test ve Pap smear yöntemlerinin biyopsi ile uyumlarının karşılaştırılmasında HPV tarama testi anlamlı bulunmuştur (p0,05). Servikal smear testi genel topluma uygulanan bir tarama testi olup kuşkulu olgularda HPV testi yaptırmak serviks kanserini tarama açısından daha faydalı bulunmuştur.

In this manuscript, a new series of 1,2,4-triazole-3-ones containing imin function was synthesized from 5-(4-bromobenzyl)-4-amino-2H-1,2,4-triazol-3(4H)-one and aromatic aldehyde by using microwave irradiation technique via schiff base reaction. Firstly, ethyl imido-p-bromophenylacetate hydrochloride (2) was synthesized according to the pinner method in the literature. Then, compound 2 was reacted with ethyl carbazate to synthesized ethyl p-bromophenylacetate etoxycarbonylhydrazone (3) compound. Then, 5-(4-bromobenzyl)-4- amino-2H-1,2,4-triazol-3(4H)-one (4) was synthesized from the reaction of ethyl p-bromophenylacetate etoxycarbonylhydrazone (3) with hydrazine monohydrate. Then, it was converted to their corresponding triazole containing Schiff bases (5a-e) with the reaction of corresponding aromatic aldehydes in ethanol by using the microwave irradiation method. This microwave technique has some advantages, including rapid and uniform heating, higher product yield and purity, mild reaction conditions, low energy requirement and shorter reaction time. The chemical structures of newly synthesized triazole containing schiff bases were identified using IR, 1HNMR, and mass spectroscopy data.