1. Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
- Author
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Barrachina, María N, Izquierdo, Irene, Hermida-Nogueira, Lidia, Sueiro, Aurelio M, Guitián, Esteban, Casanueva, Felipe F, Farndale, Richard W, Moroi, Masaaki, Jung, Stephanie M, Pardo, María, García, Ángel, Farndale, Richard [0000-0001-6130-8808], and Apollo - University of Cambridge Repository
- Subjects
2 Aetiology ,32 Biomedical and Clinical Sciences ,Hematology ,3101 Biochemistry and Cell Biology ,Cardiovascular ,lcsh:Computer applications to medicine. Medical informatics ,Stroke ,Clinical Research ,2.1 Biological and endogenous factors ,lcsh:R858-859.7 ,Obesity ,lcsh:Science (General) ,31 Biological Sciences ,Nutrition ,Cancer ,lcsh:Q1-390 - Abstract
This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.
- Published
- 2019