1. In addition to mTOR and JAK/STAT, NLRP3 inflammasome is another key pathway activated in sarcoidosis
- Author
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Riteau, Nicolas, Bernaudin, Jean-François, Huppertz, Christine, Jäger, Benedikt, Wieczorek, Grazyna, Engelhard, Peggy, Oliver, Stephen, Bauernfeind, Franz-Georg, Littlewood-Evans, Amanda, Welte, Tobias, Hornung, Veit, Prasse, Antje, Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), and Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)
- Subjects
Pulmonary and Respiratory Medicine ,Granuloma ,Sarcoidosis ,integumentary system ,business.industry ,Inflammasomes ,TOR Serine-Threonine Kinases ,[SDV]Life Sciences [q-bio] ,JAK-STAT signaling pathway ,Inflammasome ,medicine.disease ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,NLR Family, Pyrin Domain-Containing 3 Protein ,Cancer research ,Medicine ,Humans ,030212 general & internal medicine ,business ,PI3K/AKT/mTOR pathway ,medicine.drug - Abstract
International audience; The study of Huppertz and co-workers addresses the role of the NLRP3 inflammasome in sarcoidosis. Employing both mouse model and human samples, they provide evidence of NLPR3 inflammasome activation and increased IL-1β production in lung granulomas. http://bit.ly/32a4GsI Cite this article as: Riteau N, Bernaudin J-F. In addition to mTOR and JAK/STAT, NLRP3 inflammasome is another key pathway activated in sarcoidosis.
- Published
- 2020