23 results on '"Jurgen M.R. Ligthart"'
Search Results
2. The prognostic value of angiography-based vessel fractional flow reserve after percutaneous coronary intervention
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Tara Neleman, Alessandra Scoccia, Kaneshka Masdjedi, Mariusz Tomaniak, Jurgen M.R. Ligthart, Karen T. Witberg, Alise Vermaire, Quinten Wolff, Leon Visser, Paul Cummins, Isabella Kardys, Jeroen Wilschut, Roberto Diletti, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen, and Cardiology
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Fractional Flow Reserve, Myocardial ,Percutaneous Coronary Intervention ,Treatment Outcome ,SDG 3 - Good Health and Well-being ,Predictive Value of Tests ,Outcome Assessment, Health Care ,Humans ,Coronary Artery Disease ,Cardiology and Cardiovascular Medicine ,Coronary Angiography ,Prognosis ,Coronary Vessels ,Aged - Abstract
Background: Vessel Fractional Flow Reserve (vFFR) as assessed by three-dimensional quantitative coronary angiography has high correlation with pressure wire-based fractional flow reserve in both a pre- and post-PCI setting. The present study aims to assess the prognostic value of post-PCI vFFR on the incidence of target vessel failure (TVF), a composite endpoint of cardiac death, target vessel myocardial infarction and target vessel revascularization (TVR) at 5-year follow up. Methods: Post-PCI vFFR was calculated after routine PCI in a total of 748 patients (832 vessels) with available orthogonal angiographic projections of the stented segment. Results: Median age was 65 (IQR 55–74) years, 18.2% were diabetic, and 29.1% presented with stable angina. Median post-PCI vFFR was 0.91 (IQR 0.86–0.95). Vessels were categorized into tertiles based on post-PCI vFFR: low (vFFR
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- 2022
3. The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score
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Paul Cummins, Eline M.J. Hartman, Eric Boersma, Nicolas M. Van Mieghem, Felix Zijlstra, Shengnan Liu, Gijs van Soest, Maria Natalia Tovar Forero, Joost Daemen, Karen Witberg, Tara Neleman, Jurgen M.R. Ligthart, and Cardiology
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Male ,Automated quantification ,medicine.medical_treatment ,Pharmaceutical Science ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Severity of Illness Index ,Coronary calcification ,Coronary artery disease ,Automation ,0302 clinical medicine ,Risk Factors ,Intravascular ultrasound ,Myocardial Revascularization ,Clinical endpoint ,Myocardial infarction ,Stroke ,Genetics (clinical) ,0303 health sciences ,medicine.diagnostic_test ,Hazard ratio ,Middle Aged ,Prognosis ,Cohort ,Disease Progression ,Cardiology ,Molecular Medicine ,Female ,Original Article ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Revascularization ,Risk Assessment ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,Image Interpretation, Computer-Assisted ,Genetics ,medicine ,Humans ,Vascular Calcification ,Ultrasonography, Interventional ,Aged ,Retrospective Studies ,030304 developmental biology ,business.industry ,Reproducibility of Results ,medicine.disease ,business - Abstract
Background Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract
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- 2021
4. INTRAVASCULAR ULTRASOUND-BASED CULPRIT LESION PLAQUE CHARACTERIZATION AND THROMBUS ASSESSMENT IN PATIENTS PRESENTING WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
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Frederik T.W. Groenland, Tara Neleman, Anniek Ziedses Des Plantes, Alessandra Scoccia, Jurgen M.R. Ligthart, Karen Theodora Witberg, Karim D. Mahmoud, Rutger-Jan Nuis, Wijnand Den Dekker, Jeroen Wilschut, Roberto Diletti, Felix Zijlstra, Nicolas M. Van Mieghem, and Joost Daemen
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Cardiology and Cardiovascular Medicine - Published
- 2023
5. Comparison of diagnostic accuracy measures of novel 3D quantitative coronary angiography based software and diastolic pressure ratio for fractional flow Reserve. A single center pooled analysis of FAST EXTEND and FAST II studies
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Alessandra Scoccia, Tara Neleman, Mariusz Tomaniak, Kaneshka Masdjedi, Frederik T.W. Groenland, Isabella Kardys, Jurgen M.R. Ligthart, Nicolas M. Van Mieghem, Ernest Spitzer, Joost Daemen, and Cardiology
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Cardiology and Cardiovascular Medicine - Published
- 2022
6. Validation of Post-PCI FFR Gradients With IVUS-Detected Focal Lesions and Stent Underexpansion
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Tara Neleman, Alessandra Scoccia, Laurens J.C. van Zandvoort, Jurgen M.R. Ligthart, Karen T. Witberg, Mattie J. Lenzen, Eric Boersma, Rutger-Jan Nuis, Wijnand den Dekker, Roberto Diletti, Jeroen Wilschut, Felix Zijlstra, Nicolas M. Van Mieghem, and Joost Daemen
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General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
7. Procedural Performance of Ultrathin, Biodegradable-Polymer-Coated Stents Versus Durable-Polymer-Coated Stents Based on Intracoronary Imaging
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Annemieke C. Ziedses des Plantes, Tara Neleman, Maria N. Tovar Forero, Leon Visser, Alessandra Scoccia, Frederik T.W. Groenland, Jurgen M.R. Ligthart, Eric Boersma, Rutger-Jan Nuis, Wijnand den Dekker, Jeroen Wilschut, Roberto Diletti, Felix Zijlstra, Nicolas M. Van Mieghem, and Joost Daemen
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General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
8. PREDICTORS OF DISCREPANCY BETWEEN FRACTIONAL FLOW RESERVE (FFR) AND DIASTOLIC PRESSURE RATIO (DPR) IN INTERMEDIATE LESIONS - PREDICT STUDY
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Alessandra Scoccia, Tara Neleman, Eric Boersma, Jurgen M.R. Ligthart, Wijnand den Dekker, Roberto Diletti, Jeroen Wilschut, Felix Zijlstra, Nicolas M. Van Mieghem, and Joost Daemen
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Cardiology and Cardiovascular Medicine - Published
- 2022
9. CRT-600.02 Procedural Performance of Ultrathin, Biodegradable-Polymer-Coated Stents Versus Durable-Polymer-Coated Stents Based on Intracoronary Imaging
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Annemieke C. Ziedses des Plantes, Tara Neleman, Maria N. Tovar Forero, Leon Visser, Alessandra Scoccia, Frederik T.W. Groenland, Jurgen M.R. Ligthart, Eric Boersma, Rutger-Jan Nuis, Wijnand den Dekker, Jeroen Wilschut, Roberto Diletti, Felix Zijlstra, Nicolas M. Van Mieghem, and Joost Daemen
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Cardiology and Cardiovascular Medicine - Published
- 2022
10. CRT-100.78 Validation of Post-PCI FFR Gradients With IVUS-Detected Focal Lesions and Stent Underexpansion
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Tara Neleman, Alessandra Scoccia, Laurens J.C. van Zandvoort, Jurgen M.R. Ligthart, Karen T. Witberg, Mattie J. Lenzen, Eric Boersma, Rutger-Jan Nuis, Wijnand den Dekker, Roberto Diletti, Jeroen Wilschut, Felix Zijlstra, Nicolas M. Van Mieghem, and Joost Daemen
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Cardiology and Cardiovascular Medicine - Published
- 2022
11. Contributors
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Simone Balocco, R. Pawel Banys, Stéphane Carlier, Xavier Carrillo, Maria Elena de Ceglia, Zhi Chen, Francesco Ciompi, Wladyslaw Dabrowski, Stamatia Giannarou, Joan Antoni Gomez-Hospital, Josep Lluís Gómez-Huertas, Akira Iguchi, Tomas Kovarnik, Su-Lin Lee, Jurgen M.R. Ligthart, John J. Lopez, Josepa Mauri, Adam Mazurek, Piotr Musialek, Ricardo Ñanculef, Eric A. Osborn, Lukasz Partyka, Petia Radeva, Fernando Ramos, Josep Rigla, Juan Rigla, Yuki Sakaguchi, Elias Sanidas, Yusuke Seki, Milan Sonka, Justyna Stefaniak, Lukasz Tekieli, Giovanni J. Ughi, Beatriz Vaquerizo, Andreas Wahle, Karen Th. Witberg, Guang-Zhong Yang, Honghai Zhang, Ling Zhang, and Liang Zhao
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- 2020
12. Automated Quantitative Assessment of Coronary Calcification Using Intravascular Ultrasound
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Shengnan Liu, Gijs van Soest, Eline M.J. Hartman, Karen Witberg, Antonius F.W. van der Steen, Jolanda J. Wentzel, Jurgen M.R. Ligthart, Joost Daemen, Tara Neleman, and Cardiology
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medicine.medical_specialty ,Automated quantification ,Acoustics and Ultrasonics ,medicine.medical_treatment ,Biophysics ,Intravascular imaging ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,Automation ,0302 clinical medicine ,Intravascular ultrasound ,Calcified plaque ,medicine ,Quantitative assessment ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,cardiovascular diseases ,Vascular Calcification ,Coronary atherosclerosis ,Ultrasonography, Interventional ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Stent ,medicine.disease ,equipment and supplies ,Plaque, Atherosclerotic ,Stent placement ,surgical procedures, operative ,Coronary artery calcification ,cardiovascular system ,Radiology ,business ,Calcium score - Abstract
Coronary calcification represents a challenge in the treatment of coronary artery disease by stent placement. It negatively affects stent expansion and has been related to future adverse cardiac events. Intravascular ultrasound (IVUS) is known for its high sensitivity in detecting coronary calcification. At present, automated quantification of calcium as detected by IVUS is not available. For this reason, we developed and validated an optimized framework for accurate automated detection and quantification of calcified plaque in coronary atherosclerosis as seen by IVUS. Calcified lesions were detected by training a supported vector classifier per IVUS A-line on manually annotated IVUS images, followed by post-processing using regional information. We applied our framework to 35 IVUS pullbacks from each of the three commonly used IVUS systems. Cross-validation accuracy for each system was >0.9, and the testing accuracy was 0.87, 0.89 and 0.89 for the three systems. Using the detection result, we propose an IVUS calcium score, based on the fraction of calcium-positive A-lines in a pullback segment, to quantify the extent of calcified plaque. The high accuracy of the proposed classifier suggests that it may provide a robust and accurate tool to assess the presence and amount of coronary calcification and, thus, may play a role in image-guided coronary interventions.
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- 2020
13. Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine
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Stefan Roest, Nico Bruining, Alexia Rossi, Koen Nieman, Felix Zijlstra, Nienke S. van Ditzhuijzen, Monique T. Mulder, Jurgen M.R. Ligthart, Timothy Veldhof, Oana Sorop, Heleen M.M. van Beusekom, Marcel L. Dijkshoorn, Dirk J. Duncker, Karen Witberg, Mieke van den Heuvel, and Evelyn Regar
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0301 basic medicine ,Coronary imaging ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,near-infrared spectroscopy ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,PRECLINICAL RESEARCH ,0302 clinical medicine ,Optical coherence tomography ,Diabetes mellitus ,Internal medicine ,DM, diabetes mellitus ,medicine ,LL, lipid-laden ,FF, fast-food-fed ,Coronary atherosclerosis ,optical coherence tomography ,medicine.diagnostic_test ,OCT, optical coherence tomography ,business.industry ,NDM, no/non-diabetes mellitus ,animal model ,NIRS, near-infrared spectroscopy ,CCTA, coronary computed tomography angiography ,QCA, quantitative coronary angiography ,medicine.disease ,FIT, fibrous intimal thickening ,030104 developmental biology ,Increased risk ,lcsh:RC666-701 ,Angiography ,diabetes mellitus ,Cardiology ,LCP, lipid core plaque ,SNAP, S-nitroso-N-acetylpenicillamine ,Radiology ,coronary computed tomography angiography ,Cardiology and Cardiovascular Medicine ,Vascular function ,business ,coronary artery disease - Abstract
Visual Abstract, Highlights In swine with and without diabetes mellitus fed a fast-food diet: • OCT, NIRS, CCTA, vascular function testing, and histology can be consecutively and longitudinally performed to assess gradual coronary atherosclerosis development • OCT and NIRS enabled detailed assessment of early coronary atherosclerosis development, whereas CCTA was not able to detect discrete early atherosclerotic changes. • OCT, NIRS, vascular function testing, and histology demonstrated no differences in early atherosclerosis development., Summary Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared to non-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic and functional coronary atherosclerotic changes is gaining attention. To improve our understanding of early atherosclerosis development, we studied a swine model that gradually developed coronary atherosclerosis. Interestingly, optical coherence tomography, near-infrared spectroscopy (NIRS), vascular function, and histology demonstrated no differences between development of early atherosclerosis in fast-food-fed (FF) DM swine and that in FF-NDM swine. Coronary computed tomography angiography did not detect early atherosclerosis, but optical coherence tomography and near-infrared spectroscopy demonstrated coronary atherosclerosis development in FF-DM and FF-NDM swine.
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- 2016
14. Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine
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D. J. Duncker, Mie Kurata, Felix Zijlstra, Evelyn Regar, Heleen M.M. van Beusekom, Mieke van den Heuvel, Patrick W. Serruys, Karen Witberg, Brett E. Bouma, Nienke S. van Ditzhuijzen, Magdalena Murawska, Richard W. B. van Duin, Hector M. Garcia-Garcia, Gijs van Soest, Ilona Krabbendam-Peters, Jurgen M.R. Ligthart, Martin Villiger, Oana Sorop, University of Zurich, van Beusekom, Heleen M M, Cardiology, and Epidemiology
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Male ,Swine ,Physiology ,medicine.medical_treatment ,Biopsy ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Pathology and Laboratory Medicine ,Biochemistry ,Diagnostic Radiology ,0302 clinical medicine ,Endocrinology ,Spectrum Analysis Techniques ,Absorbable Implants ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,lcsh:Science ,Tomography ,Immune Response ,Mammals ,Multidisciplinary ,Tissue Scaffolds ,Radiology and Imaging ,near-Infrared Spectroscopy ,Coronary Vessels ,Lipids ,medicine.anatomical_structure ,Vertebrates ,Collagen ,medicine.symptom ,Anatomy ,Tomography, Optical Coherence ,Artery ,Research Article ,medicine.medical_specialty ,Histology ,Imaging Techniques ,Endocrine Disorders ,Immunology ,Urology ,Lumen (anatomy) ,Inflammation ,Infrared Spectroscopy ,610 Medicine & health ,1100 General Agricultural and Biological Sciences ,Research and Analysis Methods ,Calcification ,03 medical and health sciences ,Signs and Symptoms ,SDG 3 - Good Health and Well-being ,Diagnostic Medicine ,1300 General Biochemistry, Genetics and Molecular Biology ,Diabetes mellitus ,Neointima ,Diabetes Mellitus ,Distribution (pharmacology) ,Animals ,1000 Multidisciplinary ,business.industry ,lcsh:R ,Organisms ,Stent ,Biology and Life Sciences ,medicine.disease ,Atherosclerosis ,Surgery ,10020 Clinic for Cardiac Surgery ,Disease Models, Animal ,Metabolic Disorders ,Amniotes ,lcsh:Q ,business ,Physiological Processes ,Biomarkers - Abstract
Background: DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS. Aim: The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a ‘fast-food’ diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology. Methods: Fifteen male swine were evaluated. Eight received streptozotocin-injection to induce DM. After 9 months (M), 32 single BVS were implanted in epicardial arteries with a stent to artery (S/A)-ratio of 1.1:1 under quantitative coronary angiography (QCA) and OCT guidance. Lumen, scaffold, neointimal coverage and composition were assessed by QCA, OCT and near-infrared spectroscopy (NIRS) pre- and/or post-procedure, at 3M and 6M. Additionally, polarization-sensitive (PS)-OCT was performed in 7 swine at 6M. After sacrifice at 3M and 6M, histology and polymer degradation analysis were performed. Results: Late lumen loss was high (~60%) within the first 3M after BVS-implantation (P 0.20). Neointimal coverage was highly heterogeneous in all swine (DM vs. NDM P>0.05), with focal lipid accumulation, irregular collagen distribution and neointimal calcification. Likewise, polymer mass loss was low (~2% at 3M, ~5% at 6M;P>0.20) and not associated with DM or inflammation. Conclusion: Scaffold coverage showed signs of neo-atherosclerosis in all FF-DM and FF-NDM swine, scaffold polymer was preserved and the vascular response to BVS was not influenced by diabetes.
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- 2017
15. Distinct Pattern of Constrictive Remodeling in Radiotherapy-Induced Coronary Artery Disease
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Jurgen M.R. Ligthart, Tjebbe W. Galema, Menno van Gameren, Koen Nieman, Nicolas M. Van Mieghem, Cardiology, and Radiology & Nuclear Medicine
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medicine.medical_specialty ,medicine.medical_treatment ,Constriction, Pathologic ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Stable angina ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,Internal medicine ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Chemotherapy ,business.industry ,medicine.disease ,Coronary computed tomography ,Coronary Vessels ,Lymphoma ,Radiation therapy ,Stenosis ,Right coronary artery ,Cardiology ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 31-year-old woman with a history of chemotherapy and mediastinal radiation therapy for Hodgkin’s lymphoma presented with stable angina followed by a positive stress test. A coronary computed tomography scan revealed a high-grade ostial right coronary artery stenosis without calcium (Agatston
- Published
- 2016
16. Assessment of atherosclerotic plaques at coronary bifurcations with multidetector computed tomography angiography and intravascular ultrasound-virtual histology
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Chrysafios Girasis, Alexia Rossi, Salvatore Brugaletta, Stella-Lida Papadopoulou, Lisan A. Neefjes, Pim J. de Feyter, Hector M. Garcia-Garcia, Anoeshka S. Dharampal, Jurgen M.R. Ligthart, Patrick W. Serruys, Koen Nieman, Gabriel P. Krestin, Radiology & Nuclear Medicine, and Cardiology
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Male ,CT coronary angiography ,Iohexol ,Cardiac-Gated Imaging Techniques ,Diastole ,Contrast Media ,Coronary Artery Disease ,Coronary Angiography ,Statistics, Nonparametric ,Main vessel ,Risk Factors ,Multidetector computed tomography ,Intravascular ultrasound ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Ultrasonography, Interventional ,medicine.diagnostic_test ,business.industry ,Histology ,General Medicine ,Anatomy ,Middle Aged ,medicine.disease ,Plaque, Atherosclerotic ,Phenotype ,Atheroma ,Angiography ,cardiovascular system ,Female ,Tomography ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims We evaluated the distribution and composition of atherosclerotic plaques at bifurcations with intravascular ultrasound-virtual histology (IVUS-VH) and multidetector computed tomography (MDCT) in relation to the bifurcation angle (BA). Methods and results In 33 patients (age 63 ± 11 years, 79% male) imaged with IVUS-VH and MDCT, 33 bifurcations were matched and studied. The analysed main vessel was divided into a 5 mm proximal segment, the in-bifurcation segment, and a 5 mm distal segment. Plaque contours were manually traced on MDCT and IVUS-VH. Plaques with >10% confluent necrotic core and
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- 2012
17. Invasive coronary imaging in animal models of atherosclerosis
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Oana Sorop, H. M. M. van Beusekom, W. J. van der Giessen, Karen Witberg, D. J. Duncker, R. W. B. van Duin, Eveline Regar, M.M. Van Den Heuvel, Jurgen M.R. Ligthart, R. van Haeren, I. Krabbendam Peters, N. S. van Ditzhuijzen, and Cardiology
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Coronary imaging ,Endothelium ,business.industry ,Inflammation ,Clinical manifestation ,Disease ,medicine.disease ,Bioinformatics ,Human situation ,Coronary artery disease ,Pathogenesis ,medicine.anatomical_structure ,medicine ,medicine.symptom ,business ,Icin ,Cardiology and Cardiovascular Medicine - Abstract
Experimental disease models have enhanced our understanding of the pathogenesis of atherosclerosis development. For example, insight has been gained into the role of the endothelium, lipids, platelets and inflammation, as well as into potential diagnostic and therapeutic interventions. Moreover, transgenic and knock-out technologies have become a widespread approach and this is a growing field to assess the role of individual genes in vascular biology and pathology. However, atherosclerosis is most of all a multifactorial disease, influenced by a multitude of environmental factors. Therefore, it is important to also study non-transgenic animal models that closely resemble the human situation with atherosclerotic lesions at anatomical locations that mimic the clinical manifestation of the disease, e.g. coronary artery disease (CAD). Although no model completely mimics human atherosclerosis, much can be learned from existing models in the study of this disease, also with respect to the development of new interventions. Here, we describe the most relevant animal models of atherosclerosis, while focusing on CAD development and the use of coronary diagnostic and therapeutic interventions. In addition, we show examples of features of a large animal model of CAD including pictures of invasive coronary imaging.
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- 2011
18. Usefulness of multislice computed tomography for detecting obstructive coronary artery disease
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Arie Munne, Benno J. Rensing, Patrick W. Serruys, Robert-Jan van Geuns, Koen Nieman, Gabriel P. Krestin, Jurgen M.R. Ligthart, Peter M. T. Pattynama, Pim J. de Feyter, Cardiology, and Radiology & Nuclear Medicine
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Male ,medicine.medical_specialty ,Contrast Media ,Coronary Artery Disease ,Coronary Angiography ,Sensitivity and Specificity ,Coronary artery disease ,Electrocardiography ,Text mining ,Predictive Value of Tests ,Positive predicative value ,Image Processing, Computer-Assisted ,Humans ,Medicine ,Multislice ,business.industry ,Gold standard (test) ,Multislice computed tomography ,Middle Aged ,medicine.disease ,Spiral computed tomography ,Iopamidol ,Female ,Radiology ,Tomography ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
The latest generation of multislice spiral computed tomography (MSCT) scanners is capable of noninvasive coronary angiography. We evaluated its diagnostic accuracy to detect stenotic coronary artery disease (CAD). In 53 patients with suspected CAD, contrast-enhanced MSCT and conventional angiography were performed. The CT data were acquired within a single breathhold, and isocardiophasic slices were reconstructed by means of retrospective electrocardiographic gating. Coronary segments ofor = 2 mm in diameter, measured by quantitative angiography, were evaluated. In 70% of the 358 available segments, image quality was regarded as adequate for assessment. The overall sensitivity, specificity, and positive and negative predictive values to detector = 50% stenotic lesions in the assessable segments were 82% (42 of 51 lesions), 93% (285 of 307 nonstenotic segments), and 66% and 97%, respectively, regarding conventional quantitative angiography as the gold standard. Proximal segments were assessable in 92%, and distal segments and side branches in 71% and 50%, respectively. Including the undetected lesions in non-assessable segments, overall sensitivity decreased to 61% but remained 82% for lesions in proximal coronary segments. MSCT correctly predicted absent, single, or multiple lesions in 55% of patients. Thus, despite potentially high image quality, current MSCT protocols offer only reasonable diagnostic accuracy in an unselected patient group with a high prevalence of CAD.
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- 2002
19. Optical Coherence Tomography-Guided Bifurcation Stenting of a Coronary Artery Dissection
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Jurgen M.R. Ligthart, Shengxian Tu, Marc van der Linden, Nienke S. van Ditzhuijzen, Evelyn Regar, and Cardiology
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Stent ,Lumen (anatomy) ,Middle Aged ,Coronary Vessels ,Surgery ,Lesion ,Percutaneous Coronary Intervention ,Optical coherence tomography ,medicine ,Humans ,Female ,Stents ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Artery dissection ,Tomography, Optical Coherence ,Bifurcation lesion ,Coronary dissection - Abstract
Periprocedural guide wire-induced coronary artery dissection is a rare but potentially serious complication of percutaneous coronary intervention. Immediate stenting of the entry point is one of the therapeutic options but engaging the guide wire in the true lumen might be challenging. We report a case of a 55-year-old woman with a guide wire-induced coronary dissection that occurred during treatment of a bifurcation lesion. Optical coherence tomography was instrumental in distinguishing true from false lumen and thereby guide correct positioning of the guide wire to successfully treat the lesion using a dedicated bifurcation stent.
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- 2014
20. The impact of Fourier-Domain optical coherence tomography catheter induced motion artefacts on quantitative measurements of a PLLA-based bioresorbable scaffold
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D. J. Duncker, Nico Bruining, Jurgen M.R. Ligthart, M.M. Van Den Heuvel, Oana Sorop, Hector M. Garcia-Garcia, Antonios Karanasos, N. S. van Ditzhuijzen, Karen Witberg, Felix Zijlstra, H. M. M. van Beusekom, Eveline Regar, and Cardiology
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Male ,Cardiac Catheterization ,medicine.medical_specialty ,Time Factors ,Swine ,medicine.medical_treatment ,Coronary Artery Disease ,Prosthesis Design ,Cardiac Catheters ,Coronary artery disease ,Motion ,Percutaneous Coronary Intervention ,Optical coherence tomography ,Predictive Value of Tests ,Absorbable Implants ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Cardiac catheterization ,Observer Variation ,Fourier Analysis ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Percutaneous coronary intervention ,medicine.disease ,Coronary Vessels ,Surgery ,Coronary arteries ,Disease Models, Animal ,Catheter ,medicine.anatomical_structure ,Artifacts ,Cardiology and Cardiovascular Medicine ,business ,Tomography, Optical Coherence ,Biomedical engineering ,Artery - Abstract
Intracoronary Fourier-Domain optical coherence tomography (FD-OCT) enables imaging of the coronary artery within 2-4 seconds, a so far unparalleled speed. Despite such fast data acquisition, cardiac and respiratory motion can cause artefacts due to longitudinal displacement of the catheter within the artery. We studied the influence of longitudinal FD-OCT catheter displacement on serial global lumen and scaffold area measurements in coronary arteries of swine that received PLLA-based bioresorbable scaffolds. In 10 swine, 20 scaffolds (18 x 3.0 mm) were randomly implanted in two epicardial coronary arteries. Serial FD-OCT imaging was performed immediately after implantation (T1) and at 3 (T2) and 6 months (T3) follow-up. Two methods for the selection of OCT cross-sections were compared. Method A did not take into account longitudinal displacement of the FD-OCT catheter. Method B accounted for longitudinal displacement of the FD-OCT catheter. Fifty-one OCT pullbacks of 17 scaffolds were serially analyzed. The measured scaffold length differed between time points, up to one fourth of the total scaffold length, indicating the presence of longitudinal catheter displacement. Between method A and B, low error was demonstrated for mean area measurements. Correlations between measurements were high: R-2 ranged from 0.91 to 0.99 for all mean area measurements at all time points. Considerable longitudinal displacement of the FD-OCT catheter was observed, diminishing the number of truly anatomically matching cross-sections in serial investigations. Global OCT dimensions such as mean lumen and scaffold area were not significantly affected by this displacement. Accurate co-registration of cross-sections, however, is mandatory when specific regions, e.g. jailed side branch ostia, are analyzed.
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- 2014
21. Optical coherence tomography: potential clinical applications
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Jurgen M.R. Ligthart, Antonios Karanasos, Nico Bruining, Karen Witberg, Gijs van Soest, Eveline Regar, and Cardiology
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medicine.medical_specialty ,Histology ,genetic structures ,Stent thrombosis ,medicine.medical_treatment ,Coronary angiography ,Intravascular Imaging (U Landmesser, Section Editor) ,Intravascular imaging ,Fractional flow reserve ,Applied Microbiology and Biotechnology ,Percutaneous coronary intervention ,Atheromatosis ,Optical coherence tomography ,Stent coverage ,Intravascular ultrasound ,medicine ,Stent ,Plaque ,medicine.diagnostic_test ,Restenosis ,business.industry ,Procedural guidance ,Interventional radiology ,Cell Biology ,eye diseases ,Coronary arteries ,medicine.anatomical_structure ,Radiology ,sense organs ,business - Abstract
Optical coherence tomography (OCT) is a novel intravascular imaging modality using near-infrared light. By OCT it is possible to obtain high-resolution cross-sectional images of the vascular wall structure and assess the acute and long-term effects of percutaneous coronary intervention. For the time being OCT has been mainly used in research providing new insights into the pathophysiology of the atheromatic plaque and of the vascular response to stenting, however, it seems that there is potential for clinical application of OCT in various fields, such as pre-interventional evaluation of coronary arteries, procedural guidance in coronary interventions, and follow-up assessment of vascular healing after stent implantation. This review will focus on the potential and advantages of OCT in the clinical practice of a catheterization laboratory.
- Published
- 2012
22. Left Main Rapamycin-Coated Stent
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Koen Nieman, Pim J. de Feyter, Jurgen M.R. Ligthart, and Patrick W. Serruys
- Subjects
Neointimal hyperplasia ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Stent ,medicine.disease ,Spiral computed tomography ,medicine.anatomical_structure ,Physiology (medical) ,Angioplasty ,Conventional PCI ,medicine ,Multislice ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
A 47-year-old man with a history of recurrent coronary interventions underwent percutaneous coronary intervention (PCI) of the left main coronary artery with implantation of a rapamycin-coated stent (BX Velocity 4.0×18 mm). At 6-month follow-up, with no physical complaints, he underwent conventional and multislice spiral computed tomography (MSCT) coronary angiography. Intravenously contrast-enhanced MSCT (Siemens Somatom Plus 4 Volume Zoom, Siemens AG) showed a well-positioned stent in the left main coronary artery with no indication of lumen diameter reduction or neointimal hyperplasia (Figure 1). By means of virtual coronary angioscopy, a 3-dimensional reconstructed internal view is provided (Movie …
- Published
- 2002
23. TCT-388 Serial optical coherence tomography imaging of early atherosclerosis progression in diabetic versus non-diabetic swine
- Author
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Mieke van den Heuvel, Jurgen M.R. Ligthart, Felix Zijlstra, Heleen M.M. van Beusekom, Nienke S. van Ditzhuijzen, Oana Sorop, Evelyn Regar, Stefan Roest, and D. J. Duncker
- Subjects
medicine.medical_specialty ,Optical coherence tomography ,medicine.diagnostic_test ,business.industry ,medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Non diabetic - Full Text
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