1. Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis
- Author
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Dong Cui, Qing Jiao, Jianfeng Qiu, Lu Weizhao, Hongyu Li, Huayu Zhang, Weifang Cao, and Yue Zhao
- Subjects
Male ,Middle temporal gyrus ,Audiology ,Executive Function ,Superior temporal gyrus ,Functional connectivity ,0302 clinical medicine ,Parietal Lobe ,Neural Pathways ,Medicine ,Attention ,Child ,Default mode network ,Cerebral Cortex ,Principal Component Analysis ,General Neuroscience ,05 social sciences ,fMRI ,lcsh:QP351-495 ,Magnetic Resonance Imaging ,Temporal Lobe ,medicine.anatomical_structure ,Female ,Research Article ,medicine.medical_specialty ,Adolescent ,Rest ,behavioral disciplines and activities ,050105 experimental psychology ,lcsh:RC321-571 ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Inferior temporal gyrus ,Task-positive network ,mental disorders ,RSNs ,Humans ,ADHD ,0501 psychology and cognitive sciences ,ICA ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Resting state fMRI ,business.industry ,Default Mode Network ,Medial frontal gyrus ,lcsh:Neurophysiology and neuropsychology ,Superior frontal gyrus ,Attention Deficit Disorder with Hyperactivity ,Nerve Net ,business ,030217 neurology & neurosurgery - Abstract
Background ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Methods The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD. Results In comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p Conclusion The results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements.
- Published
- 2020