1. Plasma aldosterone and atrial mitochondrial functions of patients undergoing cardiac surgery
- Author
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Stéphane Allouche, Mathieu Chequel, Pierre Ollitrault, Paul Milliez, and Joachim Alexandre
- Subjects
medicine.medical_specialty ,Atrial Appendage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,Postoperative Complications ,0302 clinical medicine ,Mineralocorticoid receptor ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,030212 general & internal medicine ,Cardiac Surgical Procedures ,Aldosterone ,business.industry ,Perioperative ,medicine.disease ,Mitochondria ,Cardiac surgery ,medicine.anatomical_structure ,Mitochondrial respiratory chain ,chemistry ,Cardiology ,Molecular Medicine ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease ,Artery - Abstract
Aim: Mitochondrial dysfunction (MD) has been associated with poor outcomes after coronary artery bypass graft surgery. Methods: 58 consecutive patients from the ALDO-POAF Study (NCT02814903) were prospectively included. Plasma aldosterone was assessed at the time of the preoperative consultation and mitochondrial functional studies were performed using atrial appendage tissue collected during surgery. Results: Patients with the highest preoperative plasma aldosterone level had a lower mitochondrial respiratory chain functioning and a lower calcium retention capacity. Chronic kidney disease, patient’s age and preoperative high-aldosterone were independent predictors of MD in multivariate analysis. Conclusion: These exploratory data support the use of preventive strategies targeting aldosterone and/or mineralocorticoid receptor activation, in order to prevent perioperative MD and associated poor outcomes.
- Published
- 2020